B I Escher

Summary

Affiliation: Swiss Federal Institute of Aquatic Science and Technology
Country: Switzerland

Publications

  1. ncbi request reprint Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Dubendorf
    Environ Sci Technol 36:4201-17. 2002
  2. ncbi request reprint Passive sampling of herbicides combined with effect analysis in algae using a novel high-throughput phytotoxicity assay (Maxi-Imaging-PAM)
    Beate I Escher
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, CH 8600, Dubendorf, Switzerland
    J Environ Monit 8:456-64. 2006
  3. ncbi request reprint Screening test battery for pharmaceuticals in urine and wastewater
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Duebendorf, Switzerland
    Environ Toxicol Chem 24:750-8. 2005
  4. ncbi request reprint International workshop. Internal exposure--linking bioavailability to effects
    Beate Escher
    Eawag, Switzerland
    Environ Sci Pollut Res Int 12:57-60. 2005
  5. ncbi request reprint Internal exposure: linking bioavailability to effects
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG
    Environ Sci Technol 38:455A-462A. 2004
  6. ncbi request reprint Monitoring the removal efficiency of pharmaceuticals and hormones in different treatment processes of source-separated urine with bioassays
    Beate I Escher
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Sci Technol 40:5095-101. 2006
  7. ncbi request reprint Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach
    Beate I Escher
    Department of Environmental Toxicology, Department of Urban Water Management, Swiss Federal Institute of Aquatic Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 40:7402-8. 2006
  8. ncbi request reprint In vitro assessment of modes of toxic action of pharmaceuticals in aquatic life
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 39:3090-100. 2005
  9. doi request reprint Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel
    Beate I Escher
    Swiss Federal Institute of Aquatic Science and Technology, Eawag, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 27:909-18. 2008
  10. doi request reprint Toxic equivalent concentrations (TEQs) for baseline toxicity and specific modes of action as a tool to improve interpretation of ecotoxicity testing of environmental samples
    Beate I Escher
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, Dubendorf, CH 8600, Switzerland
    J Environ Monit 10:612-21. 2008

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Dubendorf
    Environ Sci Technol 36:4201-17. 2002
    ....
  2. ncbi request reprint Passive sampling of herbicides combined with effect analysis in algae using a novel high-throughput phytotoxicity assay (Maxi-Imaging-PAM)
    Beate I Escher
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, CH 8600, Dubendorf, Switzerland
    J Environ Monit 8:456-64. 2006
    ..There was good agreement between diuron equivalent concentrations from chemical analysis and diuron equivalent concentrations determined with the IPAM...
  3. ncbi request reprint Screening test battery for pharmaceuticals in urine and wastewater
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Duebendorf, Switzerland
    Environ Toxicol Chem 24:750-8. 2005
    ..Results of preliminary experiments with raw and treated urine and wastewater indicate the suitability of the proposed test battery for screening urine and wastewater...
  4. ncbi request reprint International workshop. Internal exposure--linking bioavailability to effects
    Beate Escher
    Eawag, Switzerland
    Environ Sci Pollut Res Int 12:57-60. 2005
  5. ncbi request reprint Internal exposure: linking bioavailability to effects
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG
    Environ Sci Technol 38:455A-462A. 2004
  6. ncbi request reprint Monitoring the removal efficiency of pharmaceuticals and hormones in different treatment processes of source-separated urine with bioassays
    Beate I Escher
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Sci Technol 40:5095-101. 2006
    ..The results of this study present a method to assess the micropollutant removal efficiency, and therefore, support the choice of an appropriate urine processing technique for real-world applications...
  7. ncbi request reprint Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach
    Beate I Escher
    Department of Environmental Toxicology, Department of Urban Water Management, Swiss Federal Institute of Aquatic Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 40:7402-8. 2006
    ..It can be applied to other classes of pollutants, e.g., biocides, as well as to environmental transformation products of pollutants...
  8. ncbi request reprint In vitro assessment of modes of toxic action of pharmaceuticals in aquatic life
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 39:3090-100. 2005
    ....
  9. doi request reprint Membrane-water partitioning, membrane permeability, and baseline toxicity of the parasiticides ivermectin, albendazole, and morantel
    Beate I Escher
    Swiss Federal Institute of Aquatic Science and Technology, Eawag, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 27:909-18. 2008
    ..Overall, we did not find any unexpected effect on nontarget endpoints...
  10. doi request reprint Toxic equivalent concentrations (TEQs) for baseline toxicity and specific modes of action as a tool to improve interpretation of ecotoxicity testing of environmental samples
    Beate I Escher
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, Dubendorf, CH 8600, Switzerland
    J Environ Monit 10:612-21. 2008
    ..The proposed method allows for easier interpretation and communication of effect-based water quality monitoring data and provides a basis for comparative analysis with chemical analytical monitoring...
  11. doi request reprint Monitoring of the ecotoxicological hazard potential by polar organic micropollutants in sewage treatment plants and surface waters using a mode-of-action based test battery
    Beate I Escher
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, Dubendorf, CH 8600, Switzerland
    J Environ Monit 10:622-31. 2008
    ..Treatment efficiency was high (typically over 90%) but varied from bioassay to bioassay, which is expected because each bioassay detects different types of micropollutants and therefore we cannot expect a common answer...
  12. ncbi request reprint Baseline toxicity (narcosis) of organic chemicals determined by in vitro membrane potential measurements in energy-transducing membranes
    Beate I Escher
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Dubendorf
    Environ Sci Technol 36:1971-9. 2002
    ..A potential application of the proposed test system lies, therefore, in assessing the cumulative baseline toxicity in complex environmental mixtures...
  13. ncbi request reprint Interaction of phenolic uncouplers in binary mixtures: concentration-additive and synergistic effects
    B I Escher
    Swiss Federal Institute for Environmental Science and Technology, Eawag, Dubendorf
    Environ Sci Technol 35:3905-14. 2001
    ..In future work, this synergistic effect observed in-vitro has to be validated in-vivo to deduce its implications for the risk assessment process...
  14. ncbi request reprint Elimination of beta-blockers in sewage treatment plants
    M Maurer
    Swiss Federal Institute for Aquatic Science and Technology Eawag, 8600 Dubendorf, Switzerland
    Water Res 41:1614-22. 2007
    ..These results are also confirmed by measurements in two municipal STPs for atenolol, sotalol and propranolol. The estimated eliminations are slightly too high for metoprolol...
  15. ncbi request reprint Reducing micropollutants with source control: substance flow analysis of 212 pharmaceuticals in faeces and urine
    J Lienert
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH 8600, Duebendorf, Switzerland
    Water Sci Technol 56:87-96. 2007
    ..Nonetheless, together with other good arguments for this innovation, removal of pharmaceuticals is a welcome side effect...
  16. doi request reprint Mode of action-based classification and prediction of activity of uncouplers for the screening of chemical inventories
    S Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    SAR QSAR Environ Res 19:433-63. 2008
    ..Nevertheless, uncoupling can be an important mode of action as highlighted with several examples ranging from pesticide metabolites to persistent organic compounds...
  17. ncbi request reprint Acute toxicity of (chloro-)catechols and (chloro-)catechol-copper combinations in Escherichia coli corresponds to their membrane toxicity in vitro
    N Schweigert
    Swiss Federal Institute for Environmental Science and Technology, , Switzerland
    Environ Toxicol Chem 20:239-47. 2001
    ..We have proposed a mechanistic model to explain the diverging effects of copper on the uncoupling activities of the different catechols...
  18. ncbi request reprint Evaluation of bioanalytical assays for toxicity assessment and mode of toxic action classification of reactive chemicals
    Angela Harder
    Swiss Federal Institute for Environmental Science and Technology EAWAG, PO Box 611, CH 8600 Duebendorf, Switzerland
    Environ Sci Technol 37:4962-70. 2003
    ..The work presented here is a contribution for an alternative hazard and effect assessment of organic pollutants based on mode of toxic action classification...
  19. doi request reprint The role of hydrodynamics, matrix and sampling duration in passive sampling of polar compounds with Empore SDB-RPS disks
    Etiënne L M Vermeirssen
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    J Environ Monit 10:119-28. 2008
    ..09 L day(-1) for clarithromycin, 0.14 L day(-1) for sulfamethoxazole and 0.25 L day(-1) for carbamazepine. The results show that under controlled conditions, SDB disks can be effectively used as passive sampling devices...
  20. ncbi request reprint Applicability and limitation of OSARs for the toxicity of electrophilic chemicals
    Angela Harder
    Swiss Federal Institute for Environmental Science and Technology EAWAG, PO Box 611, CH 8600 Duebendorf, Switzerland
    Environ Sci Technol 37:4955-61. 2003
    ....
  21. doi request reprint Toward a class-independent quantitative structure--activity relationship model for uncouplers of oxidative phosphorylation
    Simon Spycher
    Department of Environmental Toxicology, UTOX, Swiss Federal Institute of Aquatic Science and Technology, Eawag, CH 8600 Dubendorf, Switzerland
    Chem Res Toxicol 21:911-27. 2008
    ..The applicability domain, limitations of the model, and ideas for future research are critically discussed...
  22. ncbi request reprint A modified parallel artificial membrane permeability assay for evaluating the bioconcentration of highly hydrophobic chemicals in fish
    Jung Hwan Kwon
    Department of Environmental Toxicology Utox, Swiss Federal Institute of Aquatic Science and Technology EAWAG, Uberlandstrasse 133, P O Box 611, 8600 Dubendorf, Switzerland
    Environ Sci Technol 42:1787-93. 2008
    ..Combination with metabolic clearance rates using a battery of metabolic degradation assays would enhance the applicability for metabolizable chemicals...
  23. ncbi request reprint Ecotoxicological assessment of surface waters: a modular approach integrating in vitro methods
    Nina Schweigert
    Dep of Environmental Microbiology and Molecular Ecotoxicology, Swiss Federal Institute for Environmental Science and Technology EAWAG, CH Dübendorf, Germany
    ALTEX 19:30-7. 2002
    ..If a toxic potential is identified in a water sample, this sample can be investigated more thoroughly in a second tier where organisms are used. In this paper we focus mainly on the general approach and the description of the first tier...
  24. ncbi request reprint Acute toxicity of triorganotin compounds: different specific effects on the energy metabolism and role of pH
    Rene W Hunziker
    Swiss Federal Institute for Environmental Science and Technology, Duebendorf
    Environ Toxicol Chem 21:1191-7. 2002
    ..It was concluded that chromatophores of R. sphaeroides are a useful system to discriminate various effects of toxicants on the energy metabolism of a cell...
  25. doi request reprint Rapid exposure assessment of PSII herbicides in surface water using a novel chlorophyll a fluorescence imaging assay
    Renee Muller
    The National Research Centre for Environmental Toxicology EnTOX, The University of Queensland, Brisbane, QLD 4108, Australia
    Sci Total Environ 401:51-9. 2008
    ..Overall, the technique provides a valuable bioanalytical tool for rapid and inexpensive effects-based assessment of PS II impacting herbicides in environmental mixtures...
  26. ncbi request reprint Efficient removal of estrogenic activity during oxidative treatment of waters containing steroid estrogens
    Yunho Lee
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH 8600, Dubendorf, Switzerland
    Environ Sci Technol 42:6333-9. 2008
    ..Therefore, oxidative wastewater treatment may serve as a powerful tool to remove estrogenic activity induced by steroid estrogens...
  27. ncbi request reprint Dynamic permeation method to determine partition coefficients of highly hydrophobic chemicals between poly(dimethylsiloxane) and water
    Jung Hwan Kwon
    Department of Environmental Toxicology Utox, Swiss Federal Institute of Aquatic Science and Technology EAWAG, Uberlandstrasse 133, 8600, Dubendorf, Switzerland
    Anal Chem 79:6816-22. 2007
    ..A good linear correlation was obtained between the logarithm of the 1-octanol/water partition coefficient (log Kow) from the literature and log KPDMSw over 6 orders of magnitude...
  28. ncbi request reprint Screening method for ecotoxicological hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes
    Judit Lienert
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, CH 8600 Duebendorf, Switzerland
    Environ Sci Technol 41:4471-8. 2007
    ..Because of scientific limitations of the model and inconsistent literature data the results are somewhat uncertain. However, this new approach allows first tier screening of single drugs, thus supporting decision-making...
  29. ncbi request reprint Challenges in ecotoxicology
    Rik I L Eggen
    Swiss Federal Institute for Environmental Science and Technology EAWAG
    Environ Sci Technol 38:58A-64A. 2004
  30. ncbi request reprint A quantitative structure--activity relationship model for the intrinsic activity of uncouplers of oxidative phosphorylation
    Simon Spycher
    Computer Chemie Centrum and Institute of Organic Chemistry, University of Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052 Erlangen, Germany
    Chem Res Toxicol 18:1858-67. 2005
    ..The properties of these different measures of lipophilicity were critically discussed...
  31. ncbi request reprint Including mixtures in the determination of water quality criteria for herbicides in surface water
    Nathalie Chèvre
    Swiss Federal Institute for Aquatic Science and Technology Eawag, Duebendorf, Switzerland
    Environ Sci Technol 40:426-35. 2006
    ....
  32. ncbi request reprint The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes
    Sibylle M Kaiser
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Science and Technology Eawag, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 40:1784-91. 2006
    ....
  33. ncbi request reprint Mixture toxicity of reactive chemicals by using two bacterial growth assays as indicators of protein and DNA damage
    Manuela Richter
    Department of Environmental Toxicology, Swiss Federal Institute for Aquatic Sciences and Technology Eawag, CH 8600 Dubendorf, Switzerland
    Environ Sci Technol 39:8753-61. 2005
    ....
  34. ncbi request reprint Organic pollutant removal versus toxicity reduction in industrial wastewater treatment: the example of wastewater from fluorescent whitening agent production
    Annette Köhler
    ETH Zurich, Safety and Environmental Technology Group, 8093 Zurich, Switzerland
    Environ Sci Technol 40:3395-401. 2006
    ..Therefore, simultaneously conducting TOC measurements and toxicity tests, as demonstrated in the current work, is recommended...
  35. ncbi request reprint The challenge of micropollutants in aquatic systems
    Rene P Schwarzenbach
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Science 313:1072-7. 2006
    ..Third, usage and disposal strategies, coupled with the search for environmentally more benign products and processes, should aim to minimize introduction of critical pollutants into the aquatic environment...
  36. ncbi request reprint Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae
    Christian Niederer
    Swiss Federal Institute of Technology, CH 8092 Zurich, Switzerland
    Environ Toxicol Chem 23:697-704. 2004
    ..The application of the developed test systems on Scenedesmus vacuolatus after short-term exposure of 2 h showed that these tests can be used as fast screening tests for algal toxicity and in mode-of-action-based test batteries...
  37. ncbi request reprint Methodology and evaluation of a highly sensitive algae toxicity test based on multiwell chlorophyll fluorescence imaging
    Ulrich Schreiber
    Julius von Sachs Institut fur Biowissenschaften, Lehrstuhl Botanik I, University of Wurzburg, D 97082 Wurzburg, Germany
    Biosens Bioelectron 22:2554-63. 2007
    ..3) Continuous actinic light may be problematic, as it induces complex physiological reactions that limit the performance of the approach; it is not required for assessment of diuron-type inhibitors at high measuring light intensity...
  38. ncbi request reprint Comparative analysis of estrogenic activity in sewage treatment plant effluents involving three in vitro assays and chemical analysis of steroids
    Barbara V Rutishauser
    Swiss Federal Institute for Environmental Science and Technology EAWAG, CH 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 23:857-64. 2004
    ..The present study indicates that all three in vitro systems, with the yeast-based system being the easiest and most robust, are applicable for the screening of estrogenic activity in effluent samples...
  39. ncbi request reprint Quantification of solute-solute interactions using negligible-depletion solid-phase microextraction: measuring the affinity of estradiol to bulk organic matter
    Peta A Neale
    School of Engineering and Electronics, The University of Edinburgh, Edinburgh EH9 3JL, United Kingdom
    Environ Sci Technol 42:2886-92. 2008
    ..Further, this novel method can be applied to a range of trace contaminants...
  40. ncbi request reprint Toxic ratio as an indicator of the intrinsic toxicity in the assessment of persistent, bioaccumulative, and toxic chemicals
    Valérie Maeder
    Swiss Federal Institute of Technology, Institute for Chemical and Bioengineering, CH 8093 Zurich, Switzerland
    Environ Sci Technol 38:3659-66. 2004
    ..The toxicity of specifically toxic hydrophilic substances is given additional emphasis by high TR values. These classification changes require that the interpretation of the B and T dimensions in PBT assessments is redefined...