Genomes and Genes
Affiliation: Swiss Federal Institute of Technology
- Aylett C, Ban N. Eukaryotic aspects of translation initiation brought into focus. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed publisher..This article is part of the themed issue 'Perspectives on the ribosome'. ..
- Hentschel J, Burnside C, Mignot I, Leibundgut M, Boehringer D, Ban N. The Complete Structure of the Mycobacterium smegmatis 70S Ribosome. Cell Rep. 2017;20:149-160 pubmed publisher..Our results provide a foundation for understanding the idiosyncrasies of mycobacterial translation and reveal atomic details of the structure that will facilitate the design of anti-tubercular therapeutics. ..
- Erzberger J, Stengel F, Pellarin R, Zhang S, Schaefer T, Aylett C, et al. Molecular architecture of the 40Sâ‹…eIF1â‹…eIF3 translation initiation complex. Cell. 2014;158:1123-1135 pubmed publisher..The structures of eIF3 components reported here also have implications for understanding the architecture of the mammalian 43S preinitiation complex and the complex of eIF3, 40S, and the hepatitis C internal ribosomal entry site RNA. ..
- Greber B, Bieri P, Leibundgut M, Leitner A, Aebersold R, Boehringer D, et al. Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome. Science. 2015;348:303-8 pubmed publisher..Furthermore, the structure contributes to a mechanistic understanding of aminoglycoside ototoxicity. ..