Nenad Ban

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. Aylett C, Sauer E, Imseng S, Boehringer D, Hall M, Ban N, et al. Architecture of human mTOR complex 1. Science. 2016;351:48-52 pubmed publisher
    ..Consistent with a role in substrate recognition and delivery, the conserved amino-terminal domain of Raptor is juxtaposed to the kinase active site. ..
  2. Greber B, Ban N. Structure and Function of the Mitochondrial Ribosome. Annu Rev Biochem. 2016;85:103-32 pubmed publisher
    ..We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi. ..
  3. Ramrath D, Niemann M, Leibundgut M, Bieri P, Prange C, Horn E, et al. Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes. Science. 2018;362: pubmed publisher
    ..Our results also reveal the "minimal" set of conserved rRNA and protein components shared by all ribosomes that help us define the most essential functional elements. ..
  4. Kummer E, Leibundgut M, Rackham O, Lee R, Boehringer D, Filipovska A, et al. Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. Nature. 2018;560:263-267 pubmed publisher
  5. Voigts Hoffmann F, Schmitz N, Shen K, Shan S, Ataide S, Ban N. The structural basis of FtsY recruitment and GTPase activation by SRP RNA. Mol Cell. 2013;52:643-54 pubmed publisher
    ..The complete conservation of the key residues of the SRP-RNA and the SRP protein implies that the suggested chemical mechanism of GTPase activation is applicable across all kingdoms. ..
  6. Kobayashi K, Jomaa A, Lee J, Chandrasekar S, Boehringer D, Shan S, et al. Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex. Science. 2018;360:323-327 pubmed publisher
    ..We provide biochemical evidence that the guanosine triphosphate hydrolysis of SRP·SR is delayed at this stage, possibly to provide a time window for signal sequence handover to the translocon. ..
  7. Bieri P, Greber B, Ban N. High-resolution structures of mitochondrial ribosomes and their functional implications. Curr Opin Struct Biol. 2018;49:44-53 pubmed publisher
    ..The polypeptide tunnel is optimized for the synthesis of hydrophobic proteins and their co-translational membrane insertion. ..
  8. Greber B, Gerhardy S, Leitner A, Leibundgut M, Salem M, Boehringer D, et al. Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation. Cell. 2016;164:91-102 pubmed publisher
    ..We provide genetic and biochemical evidence that failure to insert the C terminus of Rei1 precludes subsequent steps of 60S maturation. ..
  9. Bieri P, Leibundgut M, Saurer M, Boehringer D, Ban N. The complete structure of the chloroplast 70S ribosome in complex with translation factor pY. EMBO J. 2017;36:475-486 pubmed publisher
    ..The small subunit is locked by pY in a non-rotated state, in which the intersubunit bridges to the large subunit are stabilized. ..

More Information

Publications14

  1. Aylett C, Ban N. Eukaryotic aspects of translation initiation brought into focus. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed publisher
    ..This article is part of the themed issue 'Perspectives on the ribosome'. ..
  2. Hentschel J, Burnside C, Mignot I, Leibundgut M, Boehringer D, Ban N. The Complete Structure of the Mycobacterium smegmatis 70S Ribosome. Cell Rep. 2017;20:149-160 pubmed publisher
    ..Our results provide a foundation for understanding the idiosyncrasies of mycobacterial translation and reveal atomic details of the structure that will facilitate the design of anti-tubercular therapeutics. ..
  3. Erzberger J, Stengel F, Pellarin R, Zhang S, Schaefer T, Aylett C, et al. Molecular architecture of the 40Sâ‹…eIF1â‹…eIF3 translation initiation complex. Cell. 2014;158:1123-1135 pubmed publisher
    ..The structures of eIF3 components reported here also have implications for understanding the architecture of the mammalian 43S preinitiation complex and the complex of eIF3, 40S, and the hepatitis C internal ribosomal entry site RNA. ..
  4. Greber B, Bieri P, Leibundgut M, Leitner A, Aebersold R, Boehringer D, et al. Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome. Science. 2015;348:303-8 pubmed publisher
    ..Furthermore, the structure contributes to a mechanistic understanding of aminoglycoside ototoxicity. ..
  5. Weisser M, Schäfer T, Leibundgut M, Böhringer D, Aylett C, Ban N. Structural and Functional Insights into Human Re-initiation Complexes. Mol Cell. 2017;67:447-456.e7 pubmed publisher