Roman Ashauer

Summary

Affiliation: Swiss Federal Institute of Aquatic Science and Technology
Country: Switzerland

Publications

  1. pmc Environmental risk assessment of fluctuating diazinon concentrations in an urban and agricultural catchment using toxicokinetic-toxicodynamic modeling
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 45:9783-92. 2011
  2. doi Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Toxicol Chem 30:2519-24. 2011
  3. doi Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 103:38-45. 2011
  4. doi Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dubendorf, Switzerland
    J Environ Monit 12:2056-61. 2010
  5. doi Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 29:1625-36. 2010
  6. doi Toxicokinetic and toxicodynamic modeling explains carry-over toxicity from exposure to diazinon by slow organism recovery
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 44:3963-71. 2010
  7. doi Toxicodynamic assumptions in ecotoxicological hazard models
    Roman Ashauer
    Eawag Aquatic Research, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 27:1817-21. 2008
  8. doi Toxicokinetic and toxicodynamic model for diazinon toxicity--mechanistic explanation of differences in the sensitivity of Daphnia magna and Gammarus pulex
    Andreas Kretschmann
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Toxicol Chem 31:2014-22. 2012
  9. doi Toxicokinetic model describing bioconcentration and biotransformation of diazinon in Daphnia magna
    Andreas Kretschmann
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland
    Environ Sci Technol 45:4995-5002. 2011
  10. pmc Significance of xenobiotic metabolism for bioaccumulation kinetics of organic chemicals in Gammarus pulex
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3498-508. 2012

Detail Information

Publications19

  1. pmc Environmental risk assessment of fluctuating diazinon concentrations in an urban and agricultural catchment using toxicokinetic-toxicodynamic modeling
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 45:9783-92. 2011
    ..However, the improved prediction of toxicity for fluctuating concentrations may be small compared to uncertainty due to limited diversity of toxicity data to base the extrapolation factors on...
  2. doi Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal endpoints: a brief discussion of concepts
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Toxicol Chem 30:2519-24. 2011
    ..We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined...
  3. doi Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Aquat Toxicol 103:38-45. 2011
    ..Thus, G. pulex is generally equally sensitive towards organic xenobiotics as D. magna...
  4. doi Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dubendorf, Switzerland
    J Environ Monit 12:2056-61. 2010
    ..We provide a general introduction to the concept of TK-TD modelling for environmental scientists and discuss opportunities as well as current limitations...
  5. doi Bioaccumulation kinetics of organic xenobiotic pollutants in the freshwater invertebrate Gammarus pulex modeled with prediction intervals
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 29:1625-36. 2010
    ..45 to 20 d, and bioaccumulation factors ranged from 1.7 to 4,449 L/kg. The identified compounds with unexpectedly long elimination times should be given priority in future studies investigating the biotransformation of these compounds...
  6. doi Toxicokinetic and toxicodynamic modeling explains carry-over toxicity from exposure to diazinon by slow organism recovery
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 44:3963-71. 2010
    ..The slow organism recovery and carry-over toxicity was caused by slow toxicodynamic recovery; toxicokinetic processes alone would have resulted in a recovery time of only 1-2 days...
  7. doi Toxicodynamic assumptions in ecotoxicological hazard models
    Roman Ashauer
    Eawag Aquatic Research, Uberlandstrasse 133, 8600 Dubendorf, Switzerland
    Environ Toxicol Chem 27:1817-21. 2008
    ..Such analysis aids in the selection of appropriate ecotoxicological models...
  8. doi Toxicokinetic and toxicodynamic model for diazinon toxicity--mechanistic explanation of differences in the sensitivity of Daphnia magna and Gammarus pulex
    Andreas Kretschmann
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    Environ Toxicol Chem 31:2014-22. 2012
    ..pulex compared to D. magna. The present study substantiates theoretical considerations that mechanistically based effect models are helpful to explain sensitivity differences among different aquatic invertebrates...
  9. doi Toxicokinetic model describing bioconcentration and biotransformation of diazinon in Daphnia magna
    Andreas Kretschmann
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland
    Environ Sci Technol 45:4995-5002. 2011
    ..Such a TK model containing detailed biotransformation processes is an important tool for estimation of the toxic potential of chemicals, particularly, when active metabolites are formed inside an organism...
  10. pmc Significance of xenobiotic metabolism for bioaccumulation kinetics of organic chemicals in Gammarus pulex
    Roman Ashauer
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3498-508. 2012
    ..Many metabolites reached higher internal concentrations than their parents, characterized by large metabolite enrichment factors...
  11. pmc The insecticide imidacloprid causes mortality of the freshwater amphipod Gammarus pulex by interfering with feeding behavior
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland
    PLoS ONE 8:e62472. 2013
    ..Using a multiple stressor toxicokinetic-toxicodynamic modeling approach, we showed that both starvation and other toxic effects of imidacloprid play a role for determining mortality in constant exposure to the insecticide...
  12. doi Mechanistic toxicodynamic model for receptor-mediated toxicity of diazoxon, the active metabolite of diazinon, in Daphnia magna
    Andreas Kretschmann
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland
    Environ Sci Technol 45:4980-7. 2011
    ..Furthermore, the model enabled the prediction of the time-dependent diazoxon concentration directly present at the target site...
  13. doi Comparative toxicokinetics of organic micropollutants in freshwater crustaceans
    Junho Jeon
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 47:8809-17. 2013
    ....
  14. ncbi Importance of toxicokinetics for interspecies variation in sensitivity to chemicals
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 48:5946-54. 2014
    ..Sensitivity to propiconazole was comparable among all species and, when expressed as internal lethal concentrations, falls in the range of baseline toxicity. ..
  15. pmc Toxicokinetic-toxicodynamic modelling of survival of Gammarus pulex in multiple pulse exposures to propiconazole: model assumptions, calibration data requirements and predictive power
    Anna Maija Nyman
    Department of Environmental Toxicology, Eawag, Swiss Federal Institute of Aquatic Science and Technology, Uberlandstrasse 133, 8600, Dubendorf, Switzerland
    Ecotoxicology 21:1828-40. 2012
    ..e. the time-weighted average concentration was equal. We studied mode of toxic action of propiconazole and it likely acts as a baseline toxicant in G. pulex during 10-days of exposure for the endpoint survival...
  16. doi Crucial role of mechanisms and modes of toxic action for understanding tissue residue toxicity and internal effect concentrations of organic chemicals
    Beate I Escher
    Department of Environmental Toxicology Utox, Swiss Federal Institute of Aquatic Science and Technology EAWAG, Uberlandstrasse 133, PO Box 611, 8600 Dubendorf, Switzerland
    Integr Environ Assess Manag 7:28-49. 2011
    ..We believe that this mechanistic understanding of tissue residue toxicity will lead to improved environmental risk assessment...
  17. pmc Measured and modeled toxicokinetics in cultured fish cells and application to in vitro-in vivo toxicity extrapolation
    Julita Stadnicka-Michalak
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dubendorf, Switzerland ETH Zürich, Institute of Biogeochemistry and Pollutant Dynamics, Zurich, Switzerland EPF Lausanne, School of Architecture, Civil and Environmental Engineering, Lausanne, Switzerland
    PLoS ONE 9:e92303. 2014
    ..85, p = 0.0008, F-test). This ratio can be predicted from the log KOW of the chemical (77% of variance explained), comprising a promising model to predict lethal effects on fish based on in vitro data. ..
  18. pmc Predicting concentrations of organic chemicals in fish by using toxicokinetic models
    Julita Stadnicka
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dubendorf, Switzerland
    Environ Sci Technol 46:3273-80. 2012
    ..All the models can be used to predict concentrations in different fish species without additional experiments. However, further development of TK models is required for polar, ionizable, and easily biotransformed compounds...
  19. ncbi New ecotoxicological model to simulate survival of aquatic invertebrates after exposure to fluctuating and sequential pulses of pesticides
    Roman Ashauer
    Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom
    Environ Sci Technol 41:1480-6. 2007
    ..The Threshold Damage Model is particularly useful because its parameters can be used to calculate recovery times, toxicokinetics are separated from toxicodynamics, and parameter values reflect the mode of action...