Affiliation: Swiss Federal Institute of Technology
Grigolato F, Arosio P. Sensitivity analysis of the variability of amyloid aggregation profiles. Phys Chem Chem Phys. 2019;21:1435-1442 pubmed publisher
..The accurate control of the initial conditions is therefore crucial to decrease this variability. ..
Owczarz M, Bolisetty S, Mezzenga R, Arosio P. Sol-gel transition of charged fibrils composed of a model amphiphilic peptide. J Colloid Interface Sci. 2015;437:244-251 pubmed publisher
..The gel structure can be well described in the frame of the fractal gel theory considering the network as a collection of fibrillar aggregates characterized by self-similar structure with a fractal dimension of 1.34. ..
Linsenmeier M, Arosio P. Engineering Aspects of Protein Interactions and Self-assembly. Chimia (Aarau). 2018;72:304-308 pubmed publisher
Grignaschi E, Cereghetti G, Grigolato F, Kopp M, Caimi S, Faltova L, et al
. A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro. J Biol Chem. 2018;293:11424-11432 pubmed publisher
..Together, our results highlight striking structural similarities between functional and dysfunctional amyloids and reveal the crucial role of hydrophobic/hydrophilic interfaces in regulating Cdc19 aggregation. ..
Kopp M, Arosio P. Microfluidic Approaches for the Characterization of Therapeutic Proteins. J Pharm Sci. 2018;107:1228-1236 pubmed publisher
..After briefly summarizing currently available experimental approaches, we highlight the emerging possibilities offered by advances in microfluidic technology for the analysis of therapeutic proteins during manufacturing and formulation. ..
Arosio P. Biophysical Aspects of Alzheimer's Disease: Implications for Pharmaceutical Sciences : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla. Pharm Res. 2017;34:2628-2636 pubmed publisher
Charmet J, Arosio P, Knowles T. Microfluidics for Protein Biophysics. J Mol Biol. 2018;430:565-580 pubmed publisher