Simon M Ametamey

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. ncbi request reprint Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    J Nucl Med 47:698-705. 2006
  2. doi request reprint Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks
    Aileen Höhne
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Bioconjug Chem 19:1871-9. 2008
  3. doi request reprint A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors
    Tobias L Ross
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Institute of Pharmaceutical Science, ETH Zurich, Zurich, Switzerland
    J Nucl Med 51:1756-62. 2010
  4. ncbi request reprint Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Switzerland
    J Nucl Med 48:247-52. 2007
  5. doi request reprint Organofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability: experimental data and theoretical calculations (PET = positron emission tomography)
    Aileen Höhne
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    Chemistry 15:3736-43. 2009
  6. ncbi request reprint Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5
    Michael Honer
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
    Nucl Med Biol 34:973-80. 2007
  7. doi request reprint Direct one-step 18F-labeling of peptides via nucleophilic aromatic substitution
    Jessica Becaud
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Bioconjug Chem 20:2254-61. 2009
  8. doi request reprint Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5
    Christophe Lucatelli
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, 8093 Zurich, Switzerland Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    Nucl Med Biol 36:613-22. 2009
  9. doi request reprint Development of [(18)F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5)
    Selena Milicevic Sephton
    Department of Chemistry and Applied Biosciences ETH Hönggerberg, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Chimia (Aarau) 66:201-4. 2012
  10. doi request reprint Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9
    Svetlana V Selivanova
    Center for Radiopharmaceutical Sciences, ETH Zurich, CH 8093 Zurich, Switzerland
    J Med Chem 56:4912-20. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    J Nucl Med 47:698-705. 2006
    ....
  2. doi request reprint Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks
    Aileen Höhne
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Bioconjug Chem 19:1871-9. 2008
    ..c. a. radiolabeling method for the synthesis of new 18F-labeled bombesin derivatives. This innovative approach represents a general, straightforward access to radiolabeled peptides as PET imaging probes...
  3. doi request reprint A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumors
    Tobias L Ross
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Institute of Pharmaceutical Science, ETH Zurich, Zurich, Switzerland
    J Nucl Med 51:1756-62. 2010
    ..The purpose of this study was to investigate the potential of 2'-(18)F-fluorofolic acid as a PET agent for folate receptor-positive tumors...
  4. ncbi request reprint Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Switzerland
    J Nucl Med 48:247-52. 2007
    ..3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime (11C-ABP688), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent...
  5. doi request reprint Organofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability: experimental data and theoretical calculations (PET = positron emission tomography)
    Aileen Höhne
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    Chemistry 15:3736-43. 2009
    ..This model permits the facilitated development of improved building blocks for the synthesis of novel (18)F-silyl-modified biomolecules for PET imaging...
  6. ncbi request reprint Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5
    Michael Honer
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
    Nucl Med Biol 34:973-80. 2007
    ..FE-DABP688 was radiolabeled with fluorine-18 and characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5)...
  7. doi request reprint Direct one-step 18F-labeling of peptides via nucleophilic aromatic substitution
    Jessica Becaud
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Bioconjug Chem 20:2254-61. 2009
    ..The results of the one-step [18F]-fluorination of tetrapeptides and bombesin peptides show that the direct 18F-labeling of peptides is feasible under mild conditions and in good radiochemical yields...
  8. doi request reprint Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5
    Christophe Lucatelli
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, 8093 Zurich, Switzerland Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
    Nucl Med Biol 36:613-22. 2009
    ..18F]-FPECMO was characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5)...
  9. doi request reprint Development of [(18)F]-PSS223 as a PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGluR5)
    Selena Milicevic Sephton
    Department of Chemistry and Applied Biosciences ETH Hönggerberg, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Chimia (Aarau) 66:201-4. 2012
    ..Our results show favourable in vitro binding properties; however rapid defluorination of [(18)F]-PSS223 does not allow visualization of mGluR5 in the rat brain...
  10. doi request reprint Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9
    Svetlana V Selivanova
    Center for Radiopharmaceutical Sciences, ETH Zurich, CH 8093 Zurich, Switzerland
    J Med Chem 56:4912-20. 2013
    ..18)F-7 was obtained in up to 20% radiochemical yield (decay corrected), high radiochemical purity, and >90 GBq/μmol specific radioactivity. The radiolabeled compound showed excellent stability in vitro and in mice in vivo...
  11. doi request reprint Radiofluorinated histamine H₃ receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation
    Svetlana V Selivanova
    Center for Radiopharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich Swiss Federal Institute of Technology, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Bioorg Med Chem 20:2889-96. 2012
    ..4)=0.35 ± 0.09). In vitro autoradiography showed specific binding in H(3)R-rich brain regions such as striatum and cortex. However, in vivo PET imaging of the rat brain with (18)F-ST889 was not successful. Possible reasons are discussed...
  12. ncbi request reprint Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in mice
    Michael Honer
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, CH 8093 Zurich, Switzerland
    Nucl Med Biol 33:607-14. 2006
    ..This study describes our efforts to adopt the methodology of human Parkinson's disease (PD) PET studies to mice...
  13. ncbi request reprint NanoPET imaging of [(18)F]fluoromisonidazole uptake in experimental mouse tumours
    Matthias T Wyss
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    Eur J Nucl Med Mol Imaging 33:311-8. 2006
    ..The purpose of this study was to assess the potential and utility of ultra-high-resolution hypoxia imaging in various murine tumour models using the established hypoxia PET tracer [(18)F]fluoromisonidazole ([(18)F]FMISO)...
  14. ncbi request reprint Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors
    Andrea Bettio
    Department of Chemistry and Applied Biosciences of ETH, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Zurich, Switzerland
    J Nucl Med 47:1153-60. 2006
    ..The 18F-labeled alpha/gamma-FBA-folate counterpart was examined for in vivo tumor targeting efficiency in nude mice bearing folate receptor-positive tumor cells...
  15. doi request reprint Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative
    Tobias L Ross
    Animal Imaging Center PET, Center for Pharmaceutical Science of ETH, PSI and USZ, 8093 Zurich, Switzerland
    Bioconjug Chem 19:2462-70. 2008
    ..The new tracer showed good in vitro but limited in vivo properties. Ultimately, the (18)F-click folate emphasizes the potential of (18)F-labeled folates for receptor-based tumor PET imaging...
  16. doi request reprint Silicon-based building blocks for one-step 18F-radiolabeling of peptides for PET imaging
    Linjing Mu
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Honggerberg, D CHAB IPW HCI H427, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Angew Chem Int Ed Engl 47:4922-5. 2008
  17. doi request reprint Molecular imaging with PET
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    Chem Rev 108:1501-16. 2008
  18. ncbi request reprint Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 35:766-70. 2008
    ..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)...
  19. ncbi request reprint 18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 31:312-6. 2004
    ..Future studies are now needed to determine the degree of this limitation in human cancer patients...
  20. ncbi request reprint Dynamic imaging of striatal D2 receptors in mice using quad-HIDAC PET
    Michael Honer
    Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen, Switzerland
    J Nucl Med 45:464-70. 2004
    ..The aim of this study was to establish the tomograph's utility in a biologic application and to demonstrate the feasibility of rapid dynamic neuroreceptor imaging in mice...
  21. ncbi request reprint Influence of ceftriaxone treatment on FDG uptake--an in vivo [18F]-fluorodeoxyglucose imaging study in soft tissue infections in rats
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Nucl Med Biol 31:875-82. 2004
    ..The change of FDG uptake over time in treated and untreated infections is complex and further in vivo experiments have to be initiated to investigate the potential value of clinical FDG PET in therapy monitoring of infection...
  22. ncbi request reprint 18F-choline images murine atherosclerotic plaques ex vivo
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, University of Zurich, Cardiovascular Center, Switzerland
    Arterioscler Thromb Vasc Biol 26:584-9. 2006
    ..Similarly, enhanced uptake of 18F-fluorocholine (18F-FCH) was associated with macrophages surrounding an abscess. As macrophages are important determinants of plaque vulnerability, we tested 18F-FCH for plaque imaging...
  23. ncbi request reprint Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator
    Matthias T Wyss
    PET Center, University Hospital Zurich, Division of Nuclear Medicine, Ramistrasse 100, 8091 Zurich, Switzerland
    Neuroimage 35:1086-92. 2007
    ..The study furthermore demonstrates the usefulness of a beta-scintillator, if necessary in connection with autoradiography, to evaluate new receptor tracers...
  24. ncbi request reprint Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methods
    Valerie Treyer
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 48:1207-15. 2007
    ..The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers...
  25. ncbi request reprint Measurement of tumor hypoxia in spontaneous canine sarcomas
    Matthias Bruehlmeier
    Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Radiol Ultrasound 46:348-54. 2005
    ..Comparisons of the [18F]FMISO with [15O]H2O PET images in two cases showed that tumor hypoxia occurred in the tumor center with low perfusion, whereas perfusion was heterogeneous in a nonhypoxic tumor...
  26. ncbi request reprint Measurement of the extracellular space in brain tumors using 76Br-bromide and PET
    Matthias Bruehlmeier
    Paul Scherrer Institute, Center for Radiopharmaceutical Science, Villigen, Switzerland
    J Nucl Med 44:1210-8. 2003
    ..Although T2-weighted magnetic resonance (T2-MR) images represent brain edema by its increased water content, they do not differentiate ECS enlargement from increased intracellular water content...
  27. ncbi request reprint Synthesis and in vitro and in vivo evaluation of [11C]methyl-BIII277CL for imaging the PCP-binding site of the NMDA receptor by pet
    Marko Kokic
    Center for Radiopharmaceutical Science of the ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH 5232 Villigen PSI, Switzerland
    J Recept Signal Transduct Res 22:123-39. 2002
    ..36 mL/mL(tissue)/min and k2 = 0.37min(-1)) in pig cortex. [11C]methyl-BIII277CL, due to the lack of specificity in vivo, may not be a candidate for imaging the PCP-binding site of the NMDA receptor...
  28. ncbi request reprint PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester function
    Roland D Schönbächler
    Center for Radiopharmaceutical Science, 5232 Villigen PSI, Switzerland
    Nucl Med Biol 29:19-27. 2002
    ..These preliminary results suggest that [(11)C]-beta-CPPIT may be a useful PET radioligand for the visualization and quantification of dopamine transporters in man...