Research Topics
Species | Simon M AmetameySummaryAffiliation: Swiss Federal Institute of Technology Country: Switzerland Publications
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Publications
Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5Simon M Ametamey
Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
J Nucl Med 47:698-705. 2006....- Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688Simon M Ametamey
Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Switzerland
J Nucl Med 48:247-52. 2007..3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime (11C-ABP688), a noncompetitive and highly selective antagonist for the metabotropic glutamate receptor subtype 5 (mGluR5), was evaluated for its potential as a PET agent... - Molecular imaging with PETSimon M Ametamey
Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH, CH-8093 Zurich, Switzerland
Chem Rev 108:1501-16. 2008 - Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteersValerie Treyer
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Eur J Nucl Med Mol Imaging 35:766-70. 2008..In this study, we assessed the whole-body biodistribution and radiation dosimetry of the new glutamatergic ligand (11)C-ABP688. This ligand binds specifically to the metabotropic glutamatergic receptor of subtype 5 (mGluR5)... 
18F-labeled bombesin analog for specific and effective targeting of prostate tumors expressing gastrin-releasing peptide receptorsMichael Honer
Department of Chemistry and Applied Biosciences, Center for Radiopharmaceutical Sciences of ETH, PSI, and USZ, Zurich, Switzerland
J Nucl Med 52:270-8. 2011..In the present study, we developed an (18)F-labeled bombesin analog, (18)F-BAY 86-4367, which is currently being clinically tested for use in PET of prostate cancer...- Evaluation of the metabotropic glutamate receptor subtype 5 using PET and 11C-ABP688: assessment of methodsValerie Treyer
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
J Nucl Med 48:1207-15. 2007..The purpose of this study was to evaluate different methods for the analysis of human (11)C-ABP688 data acquired from 6 healthy, young volunteers... - Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivativeTobias L Ross
Animal Imaging Center PET, Center for Pharmaceutical Science of ETH, PSI and USZ, 8093 Zurich, Switzerland
Bioconjug Chem 19:2462-70. 2008..The new tracer showed good in vitro but limited in vivo properties. Ultimately, the (18)F-click folate emphasizes the potential of (18)F-labeled folates for receptor-based tumor PET imaging... - Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocksAileen Höhne
Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
Bioconjug Chem 19:1871-9. 2008..c. a. radiolabeling method for the synthesis of new 18F-labeled bombesin derivatives. This innovative approach represents a general, straightforward access to radiolabeled peptides as PET imaging probes... - A new 18F-labeled folic acid derivative with improved properties for the PET imaging of folate receptor-positive tumorsTobias L Ross
Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Institute of Pharmaceutical Science, ETH Zurich, Zurich, Switzerland
J Nucl Med 51:1756-62. 2010..The purpose of this study was to investigate the potential of 2'-(18)F-fluorofolic acid as a PET agent for folate receptor-positive tumors... - Influence of ceftriaxone treatment on FDG uptake--an in vivo [18F]-fluorodeoxyglucose imaging study in soft tissue infections in ratsMatthias T Wyss
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Nucl Med Biol 31:875-82. 2004..The change of FDG uptake over time in treated and untreated infections is complex and further in vivo experiments have to be initiated to investigate the potential value of clinical FDG PET in therapy monitoring of infection... - Syntheses and pharmacological characterization of novel thiazole derivatives as potential mGluR5 PET ligandsCindy A Baumann
Center for Radiopharmaceutical Sciences, ETH Zurich Swiss Federal Institute of Technology, Zurich, Switzerland
Bioorg Med Chem 18:6044-54. 2010..Thus, although [(18)F]-FTECMO is an excellent ligand for the detection of mGluR5 in vitro, its in vivo characteristics are not optimal for the imaging of mGluR5 in rats in vivo... - In vitro and in vivo characterization of novel 18F-labeled bombesin analogues for targeting GRPR-positive tumorsLinjing Mu
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Zurich, Switzerland
Bioconjug Chem 21:1864-71. 2010..In vivo PET imaging allowed for the visualization of PC-3 tumor in nude mice suggesting that [(18)F]7b is a promising PET tracer candidate for the diagnosis of GRPR-positive tumors in humans... - In vitro and in vivo evaluation of [18F]-FDEGPECO as a PET tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)Cindy A Wanger-Baumann
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH Zurich, Zurich, Switzerland
Neuroimage 56:984-91. 2011..These favorable characteristics warrant further evaluation in humans... - Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5Michael Honer
Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
Nucl Med Biol 34:973-80. 2007..FE-DABP688 was radiolabeled with fluorine-18 and characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5)... - [18F]fluoro-deoxy-glucose folate: a novel PET radiotracer with improved in vivo properties for folate receptor targetingCindy R Fischer
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
Bioconjug Chem 23:805-13. 2012..i.). No radiometabolites were detected in blood, urine, and liver tissue up to 30 min after injection of [(18)F]3. [(18)F]-fluoro-deoxy-glucose-folate ([(18)F]3) is thus a promising PET radioligand for imaging FR-positive tumors... - 5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PETStefanie D Krämer
Center for Radiopharmaceutical Sciences ETH PSI USZ, Institute of Pharmaceutical Sciences ETH, Zurich, Switzerland
J Nucl Med 53:434-42. 2012..In this work, we evaluated the in vitro and in vivo characteristics of the (18)F-labeled tryptophan analog 5-(2-(18)F-fluoroethoxy)-l-tryptophan ((18)F-l-FEHTP) as a PET probe for tumor imaging... - Structure-activity relationships of fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyloxime (ABP688) derivatives and the discovery of a high affinity analogue as a potential candidate for imaging metabotropic glutamate recepors subCindy A Baumann
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH Zurich, Zurich, Switzerland
J Med Chem 53:4009-17. 2010..61 +/- 0.19 nM and K(D2) = 13.73 +/- 4.69 nM) too. These data strongly suggest the further evaluation of [(18)F]38 as a candidate for imaging the mGluR5... - Direct one-step 18F-labeling of peptides via nucleophilic aromatic substitutionJessica Becaud
Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
Bioconjug Chem 20:2254-61. 2009..The results of the one-step [18F]-fluorination of tetrapeptides and bombesin peptides show that the direct 18F-labeling of peptides is feasible under mild conditions and in good radiochemical yields... - Organofluorosilanes as model compounds for 18F-labeled silicon-based PET tracers and their hydrolytic stability: experimental data and theoretical calculations (PET = positron emission tomography)Aileen Höhne
Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
Chemistry 15:3736-43. 2009..This model permits the facilitated development of improved building blocks for the synthesis of novel (18)F-silyl-modified biomolecules for PET imaging... - Synthesis and evaluation of novel α-fluorinated (E)-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone-O-methyl oxime (ABP688) derivatives as metabotropic glutamate receptor subtype 5 PET radiotracersSelena Milicevic Sephton
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
J Med Chem 55:7154-62. 2012..E)-[(18)F]-16 (K(d) = 70 nM) exhibited excellent specificity for mGluR5 in autoradiographic studies on horizontal rat brain slices in vitro... - Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5Christophe Lucatelli
Center for Radiopharmaceutical Science of ETH, PSI and USZ, 8093 Zurich, Switzerland Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
Nucl Med Biol 36:613-22. 2009..18F]-FPECMO was characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5)... - NanoPET imaging of [(18)F]fluoromisonidazole uptake in experimental mouse tumoursMatthias T Wyss
Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
Eur J Nucl Med Mol Imaging 33:311-8. 2006..The purpose of this study was to assess the potential and utility of ultra-high-resolution hypoxia imaging in various murine tumour models using the established hypoxia PET tracer [(18)F]fluoromisonidazole ([(18)F]FMISO)... - Radiosynthesis and preclinical evaluation of 3'-Aza-2'-[(18)F]fluorofolic acid: a novel PET radiotracer for folate receptor targetingThomas Betzel
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
Bioconjug Chem 24:205-14. 2013..i. These characteristics indicate that this new (18)F-labeled 3'-azafolate is an appropriate tool for imaging FR-positive (malignant) tissue... - Single-step radiofluorination of peptides using continuous flow microreactorSvetlana V Selivanova
Center for Radiopharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
Org Biomol Chem 10:3871-4. 2012..Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome. Rapid reaction optimization was possible... - Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in miceMichael Honer
Center for Radiopharmaceutical Science of ETH, PSI and USZ, CH 8093 Zurich, Switzerland
Nucl Med Biol 33:607-14. 2006..This study describes our efforts to adopt the methodology of human Parkinson's disease (PD) PET studies to mice... - Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumorsAndrea Bettio
Department of Chemistry and Applied Biosciences of ETH, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Zurich, Switzerland
J Nucl Med 47:1153-60. 2006..07 %ID/g (P = 0.001). CONCLUSION: This new 18F-labeled folic acid derivative is a promising tool for PET imaging of folate receptor-positive tumors... - Radioligands for the PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5)Linjing Mu
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
Curr Top Med Chem 10:1558-68. 2010..In this review paper, emphasis is given to the radiosynthesis, in vitro and in vivo characterization of recently published mGluR5 PET tracers... 
Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic responseNovella Calcinaghi
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
J Cereb Blood Flow Metab 31:e1-10. 2011..Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions...- Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor subtype 5Selena Milicevic Sephton
Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH Zurich Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
Am J Nucl Med Mol Imaging 2:14-28. 2012.... - Silicon-based building blocks for one-step 18F-radiolabeling of peptides for PET imagingLinjing Mu
Center for Radiopharmaceutical Science of ETH, PSI and USZ, , D-CHAB IPW HCI H427, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
Angew Chem Int Ed Engl 47:4922-5. 2008 - 18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PETMatthias T Wyss
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Eur J Nucl Med Mol Imaging 31:312-6. 2004..Future studies are now needed to determine the degree of this limitation in human cancer patients... - Synthesis and characterization of a C6 nucleoside analogue for the in vivo imaging of the gene expression of herpes simplex virus type-1 thymidine kinase (HSV1 TK)Anass Johayem
Center for Radiopharmaceutical Science of the ETH, PSI, USZ, and D-CHAB, , Wolfgang-Pauli-Strasse 10, CH-8093 Zurich
Chem Biodivers 3:274-83. 2006..Thus, DHBT (1) represents a promising precursor of a nontoxic reporter probe for the monitoring of HSV1 TK gene expression by means of positron-emission tomography (PET)... - Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PETMichael Honer
Center for Radiopharmaceutical Science, Eidgenoessische Technische Hochschule, Zurich, Switzerland
Transl Oncol 3:264-75. 2010..These conclusions warrant clinical testing... - Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleepKatharina Hefti
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
Biol Psychiatry 73:161-8. 2013..We hypothesized that prolonged wakefulness would increase mGluR5 availability in human brain... - Measurement of tumor hypoxia in spontaneous canine sarcomasMatthias Bruehlmeier
Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
Vet Radiol Ultrasound 46:348-54. 2005..Comparisons of the [18F]FMISO with [15O]H2O PET images in two cases showed that tumor hypoxia occurred in the tumor center with low perfusion, whereas perfusion was heterogeneous in a nonhypoxic tumor... - Dynamic imaging of striatal D2 receptors in mice using quad-HIDAC PETMichael Honer
Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen, Switzerland
J Nucl Med 45:464-70. 2004..The aim of this study was to establish the tomograph's utility in a biologic application and to demonstrate the feasibility of rapid dynamic neuroreceptor imaging in mice... - 18F-choline images murine atherosclerotic plaques ex vivoChristian M Matter
Cardiovascular Research, Institute of Physiology, University of Zurich, Cardiovascular Center, Switzerland
Arterioscler Thromb Vasc Biol 26:584-9. 2006..Similarly, enhanced uptake of 18F-fluorocholine (18F-FCH) was associated with macrophages surrounding an abscess. As macrophages are important determinants of plaque vulnerability, we tested 18F-FCH for plaque imaging... - Quantitative evaluation of 11C-ABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillatorMatthias T Wyss
PET Center, University Hospital Zurich, Division of Nuclear Medicine, Ramistrasse 100, 8091 Zurich, Switzerland
Neuroimage 35:1086-92. 2007..The study furthermore demonstrates the usefulness of a beta-scintillator, if necessary in connection with autoradiography, to evaluate new receptor tracers... - PET imaging of dopamine transporters in the human brain using [(11)C]-beta-CPPIT, a cocaine derivative lacking the 2 beta-ester functionRoland D Schönbächler
Center for Radiopharmaceutical Science, 5232 Villigen PSI, Switzerland
Nucl Med Biol 29:19-27. 2002..These preliminary results suggest that [(11)C]-beta-CPPIT may be a useful PET radioligand for the visualization and quantification of dopamine transporters in man... - Synthesis and in vitro and in vivo evaluation of [11C]methyl-BIII277CL for imaging the PCP-binding site of the NMDA receptor by petMarko Kokic
Center for Radiopharmaceutical Science of the ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH-5232 Villigen PSI, Switzerland
J Recept Signal Transduct Res 22:123-39. 2002..36 mL/mL(tissue)/min and k2 = 0.37min(-1)) in pig cortex. [11C]methyl-BIII277CL, due to the lack of specificity in vivo, may not be a candidate for imaging the PCP-binding site of the NMDA receptor... - Measurement of the extracellular space in brain tumors using 76Br-bromide and PETMatthias Bruehlmeier
Paul Scherrer Institute, Center for Radiopharmaceutical Science, Villigen, Switzerland
J Nucl Med 44:1210-8. 2003..Although T2-weighted magnetic resonance (T2-MR) images represent brain edema by its increased water content, they do not differentiate ECS enlargement from increased intracellular water content...