Christian L Althaus

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Individual and population level effects of partner notification for Chlamydia trachomatis
    Christian L Althaus
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS ONE 7:e51438. 2012
  2. doi request reprint Towards more robust estimates of the transmissibility of Chlamydia trachomatis
    Christian L Althaus
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:402-4. 2012
  3. pmc Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J R Soc Interface 9:136-46. 2012
  4. pmc Impaired immune evasion in HIV through intracellular delays and multiple infection of cells
    Christian L Althaus
    Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands
    Proc Biol Sci 279:3003-10. 2012
  5. pmc Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection
    Christian L Althaus
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e16468. 2011
  6. doi request reprint Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
  7. pmc Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy
    Christian L Althaus
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    Mol Syst Biol 6:348. 2010
  8. pmc Reassessing the human immunodeficiency virus type 1 life cycle through age-structured modeling: life span of infected cells, viral generation time, and basic reproductive number, R0
    Christian L Althaus
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Virol 83:7659-67. 2009
  9. doi request reprint Case and partnership reproduction numbers for a curable sexually transmitted infection
    Janneke C M Heijne
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland
    J Theor Biol 331:38-47. 2013
  10. pmc The role of reinfection and partner notification in the efficacy of Chlamydia screening programs
    Janneke C M Heijne
    Division of Clinical Epidemiology and Biostatistics, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J Infect Dis 203:372-7. 2011

Detail Information

Publications15

  1. pmc Individual and population level effects of partner notification for Chlamydia trachomatis
    Christian L Althaus
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    PLoS ONE 7:e51438. 2012
    ..trachomatis at the population level. The findings of this study demonstrate the difference between individual and population level outcomes of public health interventions for STIs...
  2. doi request reprint Towards more robust estimates of the transmissibility of Chlamydia trachomatis
    Christian L Althaus
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:402-4. 2012
    ..Using a mathematical model that takes into account the dynamics of chlamydia transmission and sexual partnership formation, we report refined estimates of chlamydia transmissibility in heterosexual partnerships...
  3. pmc Transmission of Chlamydia trachomatis through sexual partnerships: a comparison between three individual-based models and empirical data
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J R Soc Interface 9:136-46. 2012
    ..We suggest that the Gini coefficient is a useful measure for calibrating infectious disease models that include risk structure and highlight the need to estimate this measure for other STIs...
  4. pmc Impaired immune evasion in HIV through intracellular delays and multiple infection of cells
    Christian L Althaus
    Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, The Netherlands
    Proc Biol Sci 279:3003-10. 2012
    ..In summary, slow escape rates do not necessarily imply inefficient CTL-mediated killing of HIV-infected cells, but are at least partly a result of the specific characteristics of the viral life cycle...
  5. pmc Implications of CTL-mediated killing of HIV-infected cells during the non-productive stage of infection
    Christian L Althaus
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e16468. 2011
    ..This indicates a potentially important role of CTL-mediated killing during the non-productive stage of HIV-infected cells...
  6. doi request reprint Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
    ..However, due to the slower turnover of the infection, a substantial reduction in prevalence can only be achieved after screening for several years or decades...
  7. pmc Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy
    Christian L Althaus
    Theoretical Biology, Utrecht University, Utrecht, The Netherlands
    Mol Syst Biol 6:348. 2010
    ..Finally, our systems approach to modeling virus dynamics offers a promising framework to infer the extracellular dynamics of cell populations from their intracellular reaction networks...
  8. pmc Reassessing the human immunodeficiency virus type 1 life cycle through age-structured modeling: life span of infected cells, viral generation time, and basic reproductive number, R0
    Christian L Althaus
    Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Virol 83:7659-67. 2009
    ..We discuss the implications of these findings for the life span of infected cells, the viral generation time, and the basic reproductive number, R0...
  9. doi request reprint Case and partnership reproduction numbers for a curable sexually transmitted infection
    Janneke C M Heijne
    Institute of Social and Preventive Medicine ISPM, University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland
    J Theor Biol 331:38-47. 2013
    ..We showed that re-infection within partnerships means that curable STIs can be sustained endemically even when the average number of secondary cases a person produces during his or her infectious period is below one...
  10. pmc The role of reinfection and partner notification in the efficacy of Chlamydia screening programs
    Janneke C M Heijne
    Division of Clinical Epidemiology and Biostatistics, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    J Infect Dis 203:372-7. 2011
    ..Effective management of sex partners to prevent reinfection might need to be strengthened in chlamydia control programs...
  11. doi request reprint Direct and indirect effects of screening for Chlamydia trachomatis on the prevention of pelvic inflammatory disease: a mathematical modeling study
    Sereina A Herzog
    From the Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemiology 24:854-62. 2013
    ..Screening could improve outcomes by identifying and treating chlamydial infections before they progress to PID (direct effect) or by reducing chlamydia transmission (indirect effect)...
  12. doi request reprint Describing the progression from Chlamydia trachomatis and Neisseria gonorrhoeae to pelvic inflammatory disease: systematic review of mathematical modeling studies
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Sex Transm Dis 39:628-37. 2012
    ..A systematic review was conducted to determine how the natural history of Chlamydia trachomatis or Neisseria gonorrhoeae infection and progression to PID have been described in mathematical modeling studies...
  13. pmc Timing of progression from Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study
    Sereina A Herzog
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    BMC Infect Dis 12:187. 2012
    ..This study investigates three hypothetical processes for the timing of progression: at the start, at the end, or throughout the duration of chlamydia infection...
  14. pmc Dynamics of immune escape during HIV/SIV infection
    Christian L Althaus
    Theoretical Biology, Utrecht University, The Netherlands
    PLoS Comput Biol 4:e1000103. 2008
    ....
  15. doi request reprint Effectiveness and cost-effectiveness of traditional and new partner notification technologies for curable sexually transmitted infections: observational study, systematic reviews and mathematical modelling
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Health Technol Assess 18:1-100, vii-viii. 2014
    ..Systematic reviews and mathematical modelling can be used to synthesise information about the effects of new interventions to enhance the outcomes of partner notification...