Martin Ackermann

Summary

Affiliation: Swiss Federal Institute of Technology
Country: Switzerland

Publications

  1. pmc Experimental evolution of aging in a bacterium
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    BMC Evol Biol 7:126. 2007
  2. pmc A simple screen to identify promoters conferring high levels of phenotypic noise
    Nikki E Freed
    Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
    PLoS Genet 4:e1000307. 2008
  3. pmc Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice
    Roger M Wanner
    Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
    BMC Genomics 9:249. 2008
  4. doi request reprint Self-destructive cooperation mediated by phenotypic noise
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, 8092 Zurich, Switzerland
    Nature 454:987-90. 2008
  5. pmc DNA sequences shaped by selection for stability
    Martin Ackermann
    Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 2:e22. 2006
  6. pmc On the evolutionary origin of aging
    Martin Ackermann
    Institute of Integrative Biology, ETHZ, 8092 Zurich, Switzerland
    Aging Cell 6:235-44. 2007
  7. doi request reprint Stabilization of cooperative virulence by the expression of an avirulent phenotype
    Médéric Diard
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Nature 494:353-6. 2013
  8. pmc The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1
    Alexander Sturm
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 7:e1002143. 2011
  9. pmc Patterns of evolutionary conservation of essential genes correlate with their compensability
    Tobias Bergmiller
    Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland
    PLoS Genet 8:e1002803. 2012
  10. pmc Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD
    Tobias Bergmiller
    Department of Environmental Sciences, ETH Zurich, Switzerland, and Department of Environmental Microbiology, Eawag, Switzerland
    BMC Microbiol 11:118. 2011

Collaborators

Detail Information

Publications23

  1. pmc Experimental evolution of aging in a bacterium
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    BMC Evol Biol 7:126. 2007
    ..We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished...
  2. pmc A simple screen to identify promoters conferring high levels of phenotypic noise
    Nikki E Freed
    Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
    PLoS Genet 4:e1000307. 2008
    ..Typhimurium genome. This approach can be applied to many other bacterial and eukaryotic systems as a simple method for identifying genes with noisy expression...
  3. pmc Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice
    Roger M Wanner
    Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
    BMC Genomics 9:249. 2008
    ..Here, we analyzed how these opposing forces shaped genome stability in the human pathogen Mycobacterium tuberculosis. M. tuberculosis lacks a mismatch repair system, and this renders nucleotide repeats particularly unstable...
  4. doi request reprint Self-destructive cooperation mediated by phenotypic noise
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, 8092 Zurich, Switzerland
    Nature 454:987-90. 2008
    ....
  5. pmc DNA sequences shaped by selection for stability
    Martin Ackermann
    Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
    PLoS Genet 2:e22. 2006
    ..This indicates that selection for stability, rather than for the generation of variation, substantially influences how information is encoded in the genome...
  6. pmc On the evolutionary origin of aging
    Martin Ackermann
    Institute of Integrative Biology, ETHZ, 8092 Zurich, Switzerland
    Aging Cell 6:235-44. 2007
    ..Aging might thus be a more fundamental aspect of cellular organisms than assumed so far...
  7. doi request reprint Stabilization of cooperative virulence by the expression of an avirulent phenotype
    Médéric Diard
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
    Nature 494:353-6. 2013
    ..This points to a key role of bistable virulence gene expression in stabilizing cooperative virulence and may lead the way to new approaches for controlling pathogens...
  8. pmc The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1
    Alexander Sturm
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    PLoS Pathog 7:e1002143. 2011
    ..This raises important questions about compensating mechanisms during host infection which ensure successful propagation of the genotype...
  9. pmc Patterns of evolutionary conservation of essential genes correlate with their compensability
    Tobias Bergmiller
    Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland
    PLoS Genet 8:e1002803. 2012
    ....
  10. pmc Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjD
    Tobias Bergmiller
    Department of Environmental Sciences, ETH Zurich, Switzerland, and Department of Environmental Microbiology, Eawag, Switzerland
    BMC Microbiol 11:118. 2011
    ..Here, we put ygjD under control of an inducible promoter, and used time-lapse microscopy and single cell analysis to investigate the phenotypic consequences of the depletion of YgjD protein from growing cells...
  11. doi request reprint Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment
    Patrick Kaiser
    Institute of Microbiology, Eidgenössische Technische Hochschule ETH, Zurich, Switzerland
    PLoS Biol 12:e1001793. 2014
    ..Administration of LPS or CpG, known elicitors of innate immune defense, reduced the loads of tolerant bacteria. Thus, manipulating innate immunity may augment the in vivo activity of antibiotics...
  12. pmc Evolution of stress response in the face of unreliable environmental signals
    Markus Arnoldini
    Institute of Biogeochemistry and Pollutant Dynamics, Department of Environmental Systems Science, ETH Zurich, Switzerland
    PLoS Comput Biol 8:e1002627. 2012
    ....
  13. pmc Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae
    Bärbel Stecher
    Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1269-74. 2012
    ..These blooms may favor reassortment of plasmid-encoded genes between pathogens and commensals fostering the spread of fitness-, virulence-, and antibiotic-resistance determinants...
  14. ncbi request reprint Evolution of cooperation: two for one?
    Martin Ackermann
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Curr Biol 14:R73-4. 2004
    ..How can cooperation thrive in a selfish world? Recent evolution experiments show how bacteria themselves can generate conditions that make cooperation a winning strategy. At least in the short term...
  15. pmc Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1
    Tobias Bergmiller
    ETH Zurich, Department of Environmental Sciences, Zurich, Switzerland
    J Bacteriol 193:5216-21. 2011
    ..In addition, they raise questions about functional differences between cells of different ages and the coupling of cell division to cell size...
  16. doi request reprint Bacteria as a new model system for aging studies: investigations using light microscopy
    Martin Ackermann
    Institute of Integrative Biology, ETH Zurich, Switzerland
    Biotechniques 44:564-7. 2008
    ..This indicates that aging is a more fundamental property of organisms than was previously assumed. Bacteria can now be used as very simple model system for investigating why and how organisms age...
  17. pmc Metabolic specialization and the assembly of microbial communities
    David R Johnson
    Department of Environmental Systems Science, Swiss Federal Institute of Technology Zurich ETHZ, Zurich, Switzerland
    ISME J 6:1985-91. 2012
    ....
  18. pmc The role of bacteriocins as selfish genetic elements
    R Fredrik Inglis
    Department of Environmental Sciences, ETH Zurich, Zurich, Switzerland
    Biol Lett 9:20121173. 2013
    ..This suggests that bacteriocins can act primarily as selfish genetic elements promoting their own transmission in the population, which may help explain their unique ecology and evolution...
  19. pmc Division of labour and the evolution of multicellularity
    Iaroslav Ispolatov
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, Canada
    Proc Biol Sci 279:1768-76. 2012
    ..Stickiness can increase evolutionarily owing to the fitness advantage generated by the division of labour between cells in an aggregate...
  20. doi request reprint Bacterial growth properties at low optical densities
    Maja Novak
    Institute of Integrative Biology, ETH Zurich, Zurich 8093, Switzerland
    Antonie Van Leeuwenhoek 96:267-74. 2009
    ..Significant adaptation of the evolved populations to the nutrient conditions in which they evolved for 20,000 generations was observed...
  21. ncbi request reprint Senescence in a bacterium with asymmetric division
    Martin Ackermann
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Science 300:1920. 2003
  22. ncbi request reprint The effect of multifunctionality on the rate of evolution in yeast
    Marcel Salathé
    Mol Biol Evol 23:721-2. 2006
    ..However, the magnitude of this effect is small, and the results do not support the notion that multifunctionality limits a gene's rate of evolution...
  23. ncbi request reprint Evolution of niche width and adaptive diversification
    Martin Ackermann
    Division of Biological Sciences, University of California, San Diego, California 92093, USA
    Evolution 58:2599-612. 2004
    ..These results refine the conditions for adaptive diversification due to competition and formulate them in a way that might be more amenable for experimental investigations...