Affiliation: Swiss Federal Institute of Technology
- Experimental evolution of aging in a bacteriumMartin Ackermann
Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
BMC Evol Biol 7:126. 2007..We tested the generality of this theory by experimental evolution with Caulobacter crescentus, a bacterium whose asymmetric division allows mother and daughter to be distinguished...
- A simple screen to identify promoters conferring high levels of phenotypic noiseNikki E Freed
Institute of Integrative Biology, Eidgenossische Technische Hochschule ETH Zurich, Zurich, Switzerland
PLoS Genet 4:e1000307. 2008..Typhimurium genome. This approach can be applied to many other bacterial and eukaryotic systems as a simple method for identifying genes with noisy expression...
- Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choiceRoger M Wanner
Institut fur Medizinische Mikrobiologie, Universitat Zurich, Gloriastrasse 30 32, CH 8006 Zurich, Switzerland
BMC Genomics 9:249. 2008..Here, we analyzed how these opposing forces shaped genome stability in the human pathogen Mycobacterium tuberculosis. M. tuberculosis lacks a mismatch repair system, and this renders nucleotide repeats particularly unstable...
- Self-destructive cooperation mediated by phenotypic noiseMartin Ackermann
Institute of Integrative Biology, ETH Zurich, 8092 Zurich, Switzerland
Nature 454:987-90. 2008....
- DNA sequences shaped by selection for stabilityMartin Ackermann
Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
PLoS Genet 2:e22. 2006..This indicates that selection for stability, rather than for the generation of variation, substantially influences how information is encoded in the genome...
- On the evolutionary origin of agingMartin Ackermann
Institute of Integrative Biology, ETHZ, 8092 Zurich, Switzerland
Aging Cell 6:235-44. 2007..Aging might thus be a more fundamental aspect of cellular organisms than assumed so far...
- Stabilization of cooperative virulence by the expression of an avirulent phenotypeMédéric Diard
Institute of Microbiology, ETH Zurich, Wolfgang Pauli Str 10, 8093 Zurich, Switzerland
Nature 494:353-6. 2013..This points to a key role of bistable virulence gene expression in stabilizing cooperative virulence and may lead the way to new approaches for controlling pathogens...
- The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1Alexander Sturm
Institute of Microbiology, ETH Zurich, Zurich, Switzerland
PLoS Pathog 7:e1002143. 2011..This raises important questions about compensating mechanisms during host infection which ensure successful propagation of the genotype...
- Patterns of evolutionary conservation of essential genes correlate with their compensabilityTobias Bergmiller
Department of Environmental Systems Science, ETH Zurich, Zurich, Switzerland
PLoS Genet 8:e1002803. 2012....
- Single-cell time-lapse analysis of depletion of the universally conserved essential protein YgjDTobias Bergmiller
Department of Environmental Sciences, ETH Zurich, Switzerland, and Department of Environmental Microbiology, Eawag, Switzerland
BMC Microbiol 11:118. 2011..Here, we put ygjD under control of an inducible promoter, and used time-lapse microscopy and single cell analysis to investigate the phenotypic consequences of the depletion of YgjD protein from growing cells...
- Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatmentPatrick Kaiser
Institute of Microbiology, Eidgenössische Technische Hochschule ETH, Zurich, Switzerland
PLoS Biol 12:e1001793. 2014..Administration of LPS or CpG, known elicitors of innate immune defense, reduced the loads of tolerant bacteria. Thus, manipulating innate immunity may augment the in vivo activity of antibiotics...
- Evolution of stress response in the face of unreliable environmental signalsMarkus Arnoldini
Institute of Biogeochemistry and Pollutant Dynamics, Department of Environmental Systems Science, ETH Zurich, Switzerland
PLoS Comput Biol 8:e1002627. 2012....
- Gut inflammation can boost horizontal gene transfer between pathogenic and commensal EnterobacteriaceaeBärbel Stecher
Institute of Microbiology, ETH Zurich, 8093 Zurich, Switzerland
Proc Natl Acad Sci U S A 109:1269-74. 2012..These blooms may favor reassortment of plasmid-encoded genes between pathogens and commensals fostering the spread of fitness-, virulence-, and antibiotic-resistance determinants...
- Evolution of cooperation: two for one?Martin Ackermann
Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
Curr Biol 14:R73-4. 2004..How can cooperation thrive in a selfish world? Recent evolution experiments show how bacteria themselves can generate conditions that make cooperation a winning strategy. At least in the short term...
- Pole age affects cell size and the timing of cell division in Methylobacterium extorquens AM1Tobias Bergmiller
ETH Zurich, Department of Environmental Sciences, Zurich, Switzerland
J Bacteriol 193:5216-21. 2011..In addition, they raise questions about functional differences between cells of different ages and the coupling of cell division to cell size...
- Bacteria as a new model system for aging studies: investigations using light microscopyMartin Ackermann
Institute of Integrative Biology, ETH Zurich, Switzerland
Biotechniques 44:564-7. 2008..This indicates that aging is a more fundamental property of organisms than was previously assumed. Bacteria can now be used as very simple model system for investigating why and how organisms age...
- Metabolic specialization and the assembly of microbial communitiesDavid R Johnson
Department of Environmental Systems Science, Swiss Federal Institute of Technology Zurich ETHZ, Zurich, Switzerland
ISME J 6:1985-91. 2012....
- The role of bacteriocins as selfish genetic elementsR Fredrik Inglis
Department of Environmental Sciences, ETH Zurich, Zurich, Switzerland
Biol Lett 9:20121173. 2013..This suggests that bacteriocins can act primarily as selfish genetic elements promoting their own transmission in the population, which may help explain their unique ecology and evolution...
- Division of labour and the evolution of multicellularityIaroslav Ispolatov
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia, Canada
Proc Biol Sci 279:1768-76. 2012..Stickiness can increase evolutionarily owing to the fitness advantage generated by the division of labour between cells in an aggregate...
- Bacterial growth properties at low optical densitiesMaja Novak
Institute of Integrative Biology, ETH Zurich, Zurich 8093, Switzerland
Antonie Van Leeuwenhoek 96:267-74. 2009..Significant adaptation of the evolved populations to the nutrient conditions in which they evolved for 20,000 generations was observed...
- Senescence in a bacterium with asymmetric divisionMartin Ackermann
Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Science 300:1920. 2003
- The effect of multifunctionality on the rate of evolution in yeastMarcel Salathé
Mol Biol Evol 23:721-2. 2006..However, the magnitude of this effect is small, and the results do not support the notion that multifunctionality limits a gene's rate of evolution...
- Evolution of niche width and adaptive diversificationMartin Ackermann
Division of Biological Sciences, University of California, San Diego, California 92093, USA
Evolution 58:2599-612. 2004..These results refine the conditions for adaptive diversification due to competition and formulate them in a way that might be more amenable for experimental investigations...