Research Topics
| Pietro L VernazzaSummaryAffiliation: St. Gallen Country: Switzerland Publications
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Detail Information
Publications
Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicenter, randomized, double-blind, phase IIb trialPietro Vernazza
Cantonal Hospital, St Gallen, Switzerland
J Acquir Immune Defic Syndr 62:171-9. 2013..A 96-week clinical study was planned to estimate the antiviral activity and safety of lersivirine in treatment-naive HIV-1-infected patients...
Partners of people on ART - a New Evaluation of the Risks (The PARTNER study): design and methodsAlison Rodger
Research Department of Infection and Population Health, University College London, London, UK
BMC Public Health 12:296. 2012..There are no data on risk of transmission for anal sex in MSM when the index partner is on ART...- Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort StudyJan Fehr
Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel, Petersgraben 4, CH 4031 Basel, Switzerland
J Transl Med 9:14. 2011..The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients... - Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a childPietro L Vernazza
Division of Infectious Diseases, Kantonsspital St Gallen, Switzerland
AIDS 25:2005-8. 2011..In 53 cases, natural conception was attempted using the proposed method. Pregnancy rates were high and reached a plateau of 75% after six cycles. Advanced age in the female partner was a predictor for infertility in these couples... 
HIV transmission hunting--the chase for low risk eventsPietro L Vernazza
Kantonsspital St. Gallen, St. Gallen, Switzerland
Antivir Ther 13:641-2. 2008- The role of compartment penetration in PI-monotherapy: the Atazanavir-Ritonavir Monomaintenance (ATARITMO) TrialPietro Vernazza
Division of Infectious Diseases, Department of Internal Medicine, Cantonal Hospital St Gallen, 9007 St Gallen, Switzerland
AIDS 21:1309-15. 2007..Ritonavir-boosted protease-inhibitor (PI)-monotherapies are an attractive alternative, but limited compartmental penetration of PI remains a concern... - Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort StudyP L Vernazza
Department of Medicine, Kantonsspital St Gallen, Switzerland
AIDS 14:117-21. 2000..The amount of HIV in semen likely influences infectiousness. Antiretroviral therapy decreases HIV-RNA in semen, but data on HIV concentrations in semen in a large cohort of men with suppressed HIV-RNA in blood is unavailable... - [HIV superinfection: myth or reality?]P L Vernazza
Departement Innere Medizin, Kantonsspital St Gallen
Schweiz Med Wochenschr 130:1101-4. 2000..We review the available data on superinfection and conclude that HIV-discordant couples should be informed of the theoretical risk of superinfection, especially where only one partner is receiving effective antiretroviral treatment... - Ritonavir boosted indinavir treatment as a simplified maintenance "mono"-therapy for HIV infectionChristian Kahlert
Division of Infectious Diseases, Cantonal Hospital St Gallen, Switzerland
AIDS 18:955-7. 2004 - Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadirChristine Gutmann
Cantonal Hospital St Gallen, St Gallen, Switzerland
AIDS 24:2347-54. 2010..Monotherapy with ritonavir-boosted lopinavir (LPV/r-MT) is the most widely studied strategy. However, efficacy of LPV/r-MT in compartments remains to be shown... - High risk behaviour and fertility desires among heterosexual HIV-positive patients with a serodiscordant partner--two challenging issuesLaura Panozzo
Division of Infectious Diseases, Cantonal Hospital St Gallen, Switzerland
Swiss Med Wkly 133:124-7. 2003..Issues related to fertility intentions and sexual relations need to be addressed more frequently by health care providers. Non-anonymous data collection on condom use may underestimate high risk behaviour... - Antiretroviral therapy to reduce the sexual transmission of HIVStephen Taylor
Department of Sexual Medicine, Brimingham Heartlands Hospital, Birmingham B9 5SS, UK
J HIV Ther 8:55-66. 2003..In the worst-case scenario, antiretroviral therapy may simply increase the transmission of drug-resistant virus... - Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovirViktor von Wyl
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
Clin Infect Dis 46:1299-309. 2008..We aimed to identify predictors for the emergence of K65R, using clinical data and genotypic resistance tests from the Swiss HIV Cohort Study... - Self-reported non-adherence to antiretroviral therapy repeatedly assessed by two questions predicts treatment failure in virologically suppressed patientsTracy R Glass
Basel Institute for Clinical Epidemiology, University Hospital Basel, Basel, Switzerland
Antivir Ther 13:77-85. 2008..The aim of this study was to explore the predictive value of longitudinal self-reported adherence data on viral rebound... - Brief but efficient: acute HIV infection and the sexual transmission of HIVChristopher D Pilcher
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Infect Dis 189:1785-92. 2004..We examined whether viral dynamics in the genital tract during the natural history of acute human immunodeficiency virus type 1 (HIV-1) infection could explain efficient heterosexual transmission of HIV... - CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapyMarcel Wolbers
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
Antivir Ther 12:889-97. 2007..This study aimed to identify predictive factors for long-term CD4+ T-cell increase in treatment-naive patients starting combination antiretroviral therapy (cART)... - Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: a comparison of different regimen typesViktor von Wyl
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Ramistr 100, CH 8091 Zurich, Switzerland
Arch Intern Med 167:1782-90. 2007..Differences between these regimen types in the extent of the emergence of drug resistance on virological failure and the implications for further treatment options have rarely been assessed... - Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort StudyTracy R Glass
Basel Institute for Clinical Epidemiology, University Hospital Basel, CH-4056 Basel, Switzerland
J Acquir Immune Defic Syndr 41:385-92. 2006..CONCLUSIONS: Younger age, lack of social support, and complexity of therapy are important factors that are related to nonadherence with ART. Investment in behavioral dimensions of HIV is crucial to improve adherence in ART recipients... - Is unsafe sexual behaviour increasing among HIV-infected individuals?Tracy R Glass
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
AIDS 18:1707-14. 2004..The number of new diagnoses of HIV infection is rising in the northwestern hemisphere and it is becoming increasingly important to understand the mechanisms behind this trend... - Ecological study of the predictors of successful management of dyslipidemia in HIV-infected patients on ART: the Swiss HIV Cohort StudyTracy R Glass
Basel Institute for Clinical Epidemiology, University Hospital Basel, Switzerland
HIV Clin Trials 8:77-85. 2007..Based on a health care system approach, we investigated predictors for normalization of dyslipidemia in HIV-infected individuals receiving ART... - HIV-discordant couples and parenthood: how are we dealing with the risk of transmission?Pietro L Vernazza
AIDS 20:635-6. 2006 - Can antiretroviral therapy be used to prevent sexual transmission of human immunodeficiency virus type 1?Mina Hosseinipour
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Infect Dis 34:1391-5. 2002..In this article, we explore the rationale for using antiretroviral therapy to prevent sexual transmission of HIV, as well as the limitations of this approach... - Adverse events to antiretrovirals in the Swiss HIV Cohort Study: effect on mortality and treatment modificationOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Switzerland
Antivir Ther 12:1157-64. 2007..Antiretroviral therapy (ART) decreases morbidity and mortality in HIV-infected patients but is associated with considerable adverse events (AEs)...