Burkhard Ludewig

Summary

Affiliation: St. Gallen
Country: Switzerland

Publications

  1. pmc Immunopathological basis of virus-induced myocarditis
    Reinhard Maier
    Research Department, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Clin Dev Immunol 11:1-5. 2004
  2. pmc Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation
    Lucas Onder
    Institute of Immunobiology, Kantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland
    J Exp Med 210:465-73. 2013
  3. pmc A Novel Bacterial Artificial Chromosome-Transgenic Podoplanin-Cre Mouse Targets Lymphoid Organ Stromal Cells in vivo
    Lucas Onder
    Institute of Immunobiology, Cantonal Hospital St Gallen St Gallen, Switzerland
    Front Immunol 2:50. 2011
  4. pmc Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity
    Christian Perez-Shibayama
    Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland
    PLoS ONE 8:e81442. 2013
  5. pmc Tight control - decision-making during T cell-vascular endothelial cell interaction
    Sonja Firner
    Institute of Immunobiology, Kantonsspital St Gallen, St Gallen Switzerland
    Front Immunol 3:279. 2012
  6. pmc A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections
    Gennady Bocharov
    Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
    PLoS Pathog 6:e1001017. 2010
  7. pmc Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans
    Horst von Bernuth
    Pediatric Pneumology and Immunology, Charité Hospital Humboldt University, Berlin, Germany
    Eur J Immunol 42:3126-35. 2012
  8. doi request reprint A global "imaging'' view on systems approaches in immunology
    Burkhard Ludewig
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 42:3116-25. 2012
  9. ncbi request reprint Determining control parameters for dendritic cell-cytotoxic T lymphocyte interaction
    Burkhard Ludewig
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 34:2407-18. 2004
  10. pmc Molecular characterization of virus-induced autoantibody responses
    Burkhard Ludewig
    Department of Pathology, Institute of Experimental Immunology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 200:637-46. 2004

Detail Information

Publications67

  1. pmc Immunopathological basis of virus-induced myocarditis
    Reinhard Maier
    Research Department, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Clin Dev Immunol 11:1-5. 2004
    ..In this article, we review recent studies on the role of viruses, with particular emphasis on CVB3, and different immunological effector mechanisms in initiation and progression of myocarditis...
  2. pmc Endothelial cell-specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation
    Lucas Onder
    Institute of Immunobiology, Kantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland
    J Exp Med 210:465-73. 2013
    ..Thus, this study identifies ECs as an important LTβR-dependent lymphoid tissue organizer cell population and indicates that continuous triggering of the LTβR on LN ECs is critical for lymphocyte homeostasis...
  3. pmc A Novel Bacterial Artificial Chromosome-Transgenic Podoplanin-Cre Mouse Targets Lymphoid Organ Stromal Cells in vivo
    Lucas Onder
    Institute of Immunobiology, Cantonal Hospital St Gallen St Gallen, Switzerland
    Front Immunol 2:50. 2011
    ..Taken together, stromal pdpn-Cre expression is well-suited to characterize the phenotype and to dissect the function of lymphoid organ stromal cells...
  4. pmc Dendritic cell-specific delivery of Flt3L by coronavirus vectors secures induction of therapeutic antitumor immunity
    Christian Perez-Shibayama
    Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland
    PLoS ONE 8:e81442. 2013
    ..Thus, specific in vivo targeting of DCs with coronavirus vectors in conjunction with appropriate conditioning of the microenvironment through Flt3L represents an efficient strategy for the generation of therapeutic antitumor immunity. ..
  5. pmc Tight control - decision-making during T cell-vascular endothelial cell interaction
    Sonja Firner
    Institute of Immunobiology, Kantonsspital St Gallen, St Gallen Switzerland
    Front Immunol 3:279. 2012
    ..Thus, antigen-specific T cell-EC interaction is characterized by a tightly controlled balance between immunological ignorance, immune activation, and tolerization...
  6. pmc A systems immunology approach to plasmacytoid dendritic cell function in cytopathic virus infections
    Gennady Bocharov
    Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
    PLoS Pathog 6:e1001017. 2010
    ..Taken together, this systems immunology analysis suggests that antiviral therapy against cytopathic viruses should primarily limit viral replication within peripheral target organs...
  7. pmc Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans
    Horst von Bernuth
    Pediatric Pneumology and Immunology, Charité Hospital Humboldt University, Berlin, Germany
    Eur J Immunol 42:3126-35. 2012
    ....
  8. doi request reprint A global "imaging'' view on systems approaches in immunology
    Burkhard Ludewig
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 42:3116-25. 2012
    ..Both dynamic and global organ imaging technologies will be instrumental in facilitating comprehensive multiscale systems immunology analyses as discussed in this review...
  9. ncbi request reprint Determining control parameters for dendritic cell-cytotoxic T lymphocyte interaction
    Burkhard Ludewig
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Eur J Immunol 34:2407-18. 2004
    ..Taken together, our study indicates that the availability of high avidity T cells in the recipient in combination with the optimal application regimen is of prime importance for successful DC-based immunotherapy...
  10. pmc Molecular characterization of virus-induced autoantibody responses
    Burkhard Ludewig
    Department of Pathology, Institute of Experimental Immunology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 200:637-46. 2004
    ....
  11. pmc The in and out of monocytes in atherosclerotic plaques: Balancing inflammation through migration
    Burkhard Ludewig
    Research Department, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Proc Natl Acad Sci U S A 101:11529-30. 2004
  12. ncbi request reprint Immunopathogenesis of atherosclerosis
    Burkhard Ludewig
    Research Departmrnt, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    J Leukoc Biol 76:300-6. 2004
    ..Recognition of atherogenesis as a pathogen-driven, immunopathological process makes this disease amenable to new treatment strategies such as vaccination or immunomodulation...
  13. ncbi request reprint Dendritic cell homeostasis in the regulation of self-reactivity
    Burkhard Ludewig
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Curr Pharm Des 9:221-31. 2003
    ....
  14. ncbi request reprint Dendritic cell-independent B cell activation during acute virus infection: a role for early CCR7-driven B-T helper cell collaboration
    Elke Scandella
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 178:1468-76. 2007
    ....
  15. doi request reprint Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity
    Qian Chai
    Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    Immunity 38:1013-24. 2013
    ..Thus, myofibroblasic FRC precursors are able to generate the basic T cell zone infrastructure, whereas LTβR-dependent maturation of FRCs guarantees full immunocompetence and hence optimal LN function during infection...
  16. pmc IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells
    Beatrice Bolinger
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 40:733-43. 2010
    ..Thus, IFNGR signaling in ECs activates a potent peripheral negative feedback circuit that protects vascularized grafts from occlusive TV...
  17. doi request reprint Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection
    Luisa Cervantes-Barragan
    Institute of Immunobiology, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    J Immunol 188:3678-85. 2012
    ..Taken together, these results suggest that Tregs preserve CNS immune privilege through selective control of CNS-specific Th cells while keeping protective antiviral immunity fully operative...
  18. ncbi request reprint Molecular mapping of autoimmune B cell responses in experimental myocarditis
    Philippe Krebs
    Research Department, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    J Autoimmun 28:224-33. 2007
    ..The induction of myhcalpha peptide-specific Th cells in the course of both infections suggests that infection-associated determinant spreading on the Th cell level paves the way for a focused and dominant anti-myhcalpha B cell response...
  19. ncbi request reprint Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation
    Philippe Krebs
    Research Department, Kantonsspital St Gallen, Rorschacherstrasse 95, CH 9007 St Gallen, Switzerland
    Arterioscler Thromb Vasc Biol 27:2206-13. 2007
    ..The purpose of this study was to examine the relative contribution of different immunopathological mechanisms during murine cytomegalovirus (MCMV)-mediated acceleration of atheroma formation in apolipoprotein E-deficient (apoE-/-) mice...
  20. ncbi request reprint Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 182:1099-106. 2009
    ....
  21. pmc Plasmacytoid dendritic cells control T-cell response to chronic viral infection
    Luisa Cervantes-Barragan
    Institute of Immunobiology, Kantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland
    Proc Natl Acad Sci U S A 109:3012-7. 2012
    ..Thus pDCs provide an essential link between innate and adaptive immunity to chronic viral infection, likely through the secretion of IFN-I and other cytokines...
  22. ncbi request reprint Impact of CCR7 on priming and distribution of antiviral effector and memory CTL
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    J Immunol 173:6684-93. 2004
    ..Taken together, the CCR7-dependent organization of the T cell zone does not appear to be a prerequisite for antiviral effector CTL differentiation and the sustenance of antiviral memory responses in lymphoid or peripheral tissues...
  23. pmc Immunopathological basis of lymphocytic choriomeningitis virus-induced chorioretinitis and keratitis
    Martin S Zinkernagel
    Research Department, Kantonal Hospital St Gallen, Rorschacherstrasse 95, 9007 St Gallen, Switzerland
    J Virol 83:159-66. 2009
    ..Thus, antibody- and/or T-cell-based vaccination protocols could be employed as preventive strategies against LCMV-mediated chorioretinitis...
  24. ncbi request reprint Quantification and characterization of myosin peptide-specific CD4+ T cells in autoimmune myocarditis
    Reinhard Maier
    Research Department, Kantonal Hospital St Gallen, 9007 St Gallen, Switzerland
    J Immunol Methods 304:117-25. 2005
    ..Taken together, the combination of both methods appears to be most appropriate for a comprehensive ex vivo single cell analysis of Th cells in heart-specific autoimmune disorders...
  25. ncbi request reprint CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    J Immunol 175:7109-16. 2005
    ..These experiments revealed that CXCR5 is critical for the coordinated interaction of antiviral T and B cells through its impact on initial B cell expansion and the recruitment of Ag-specific B and Th cells to germinal centers...
  26. pmc Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines
    Roland Zust
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    PLoS Pathog 3:e109. 2007
    ..Taken together, the presented attenuation strategy provides a paradigm for the development of highly efficient coronavirus vaccines...
  27. ncbi request reprint Expression of lymphotoxin beta governs immunity at two distinct levels
    Tobias Junt
    Institute of Experimental Immunology, Zurich, Switzerland
    Eur J Immunol 36:2061-75. 2006
    ..ii) Expression of LTbeta on non-lymphocytes governs antiviral immunity by enhancing antigen presentation on antigen-presenting cells. This prevents cytotoxic T lymphocytes exhaustion or death of the host by uncontrolled virus spread...
  28. doi request reprint Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone
    Elke Scandella
    Research Department, Kantonal Hospital of St Gallen, 9007 St Gallen, Switzerland
    Nat Immunol 9:667-75. 2008
    ..Thus, crosstalk between lymphoid tissue-inducer cells and stromal cells is reactivated in adults to maintain secondary lymphoid organ integrity and thereby contributes to the preservation of immunocompetence...
  29. pmc Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen
    Beatrice Bolinger
    Research Department, Kantonal Hospital, St Gallen, Switzerland
    Blood 111:4588-95. 2008
    ....
  30. ncbi request reprint Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy
    Veronika Nindl
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 42:2311-21. 2012
    ..This novel TCR transgenic mouse model permits the identification of the central pathophysiological and immunological processes involved in the transition from autoimmune myocarditis to DCM...
  31. pmc IL-7-producing stromal cells are critical for lymph node remodeling
    Lucas Onder
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Blood 120:4675-83. 2012
    ..Taken together, this study identifies LN LECs as a major source of IL-7 and shows that IL-7-producing stromal cells are critical for reconstruction and remodeling of the distinct LN microenvironment...
  32. pmc T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease
    Cristina Gil-Cruz
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen CH 9007, Switzerland
    Proc Natl Acad Sci U S A 109:1233-8. 2012
    ..These data indicate that the CD40-mediated collaboration of T and B cells is critical to secure neuroprotective IgM responses during viral CNS infection...
  33. ncbi request reprint IFN-γ-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi
    Christian Perez-Shibayama
    Institute of Immunobiology, Kantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre Siglo XXI, Mexican Social Security Institute, Mexico City, C P 06020 Mexico
    J Immunol 192:5192-200. 2014
    ..Typhi clearance. In conclusion, repeated vaccination with S. Typhi porins programs type I T follicular helper cell responses that contribute to the diversification of B cell memory and promote the generation of protective IgM Abs. ..
  34. pmc Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage
    Maria Iolyeva
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Blood 122:2271-81. 2013
    ..Overall, our data point toward an unexpected new role for IL-7 as a potential autocrine mediator of lymphatic drainage. ..
  35. ncbi request reprint Dendritic cell-based multi-epitope immunotherapy of hormone-refractory prostate carcinoma
    Ying Waeckerle-Men
    Research Department, Cantonal Hospital St Gallen, 9007, St Gallen, Switzerland
    Cancer Immunol Immunother 55:1524-33. 2006
    ..In this trial, we determined the immunostimulatory capacity of autologous DC pulsed with multiple T cell epitopes derived from four different prostate-specific antigens in patients with advanced hormone-refractory prostate cancer...
  36. doi request reprint Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Hepatology 52:25-32. 2010
    ..In the absence of Kupffer cells, hepatocytes were not able to suppress virus replication, even in the presence of IFN-I, leading to prolonged viral replication and severe T cell-dependent immunopathology...
  37. ncbi request reprint Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus
    Philippe Krebs
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 174:4559-66. 2005
    ..Our results indicate first that CTL deletion in the course of adenoviral vaccination is preceded by their functional impairment and second, that the outcome of rec-AdV vaccination depends critically on the Ag load in peripheral tissues...
  38. ncbi request reprint Dendritic cells generated from patients with androgen-independent prostate cancer are not impaired in migration and T-cell stimulation
    Ying Waeckerle-Men
    Research Department, Cantonal Hospital St Gallen, St Gallen, Switzerland
    Prostate 64:323-31. 2005
    ..In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system...
  39. doi request reprint Systemic minor histocompatibility antigen expression in blood endothelial cells prevents T cell-mediated vascular immunopathology
    Sonja Caviezel-Firner
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Eur J Immunol 43:3233-43. 2013
    ..Taken together, these results indicate that antigen distribution in the vascular bed determines the impact of coinhibition and, as a consequence, critically impinges on T cell-mediated vascular immunopathology...
  40. pmc Mouse hepatitis virus liver pathology is dependent on ADP-ribose-1''-phosphatase, a viral function conserved in the alpha-like supergroup
    Klara Kristin Eriksson
    Kantonal Hospital St Gallen, Research Department and Institute of Pathology, 9007 St Gallen, Switzerland
    J Virol 82:12325-34. 2008
    ..Collectively, our data demonstrate that the MHV X domain exacerbates MHV-induced liver pathology, most likely through the induction of excessive inflammatory cytokine expression...
  41. doi request reprint Aggravation of viral hepatitis by platelet-derived serotonin
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Schmelzberstrasse 12, CH 8091 Zurich, Switzerland
    Nat Med 14:756-61. 2008
    ..Thus, vasoactive serotonin supports virus persistence in the liver and aggravates virus-induced immunopathology...
  42. ncbi request reprint Autoimmunity seen through the SEREX-scope
    Philippe Krebs
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Autoimmun Rev 2:339-45. 2003
    ..Recent studies indicate that the SEREX approach may also be utilized for the analysis of complex immune responses involved in autoimmune diseases...
  43. doi request reprint Hematopoietic cell-derived interferon controls viral replication and virus-induced disease
    Philipp A Lang
    Institute of Experimental Immunology, University Hospital of Zurich, Zurich, Switzerland
    Blood 113:1045-52. 2009
    ..These data suggest that during systemic viral infection primarily hematopoietic cell-derived IFN-I controls viral replication and viral-induced disease...
  44. pmc Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
    Roland Zust
    Institute of Immunobiology, Kantonal Hospital St Gallen, St Gallen, Switzerland
    Nat Immunol 12:137-43. 2011
    ..This link between Mda5-mediated sensing of viral RNA and 2'-O-methylation of mRNA suggests that RNA modifications such as 2'-O-methylation provide a molecular signature for the discrimination of self and non-self mRNA...
  45. ncbi request reprint Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, Switzerland, and Abeteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany
    Blood 109:1131-7. 2007
    ..Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections...
  46. pmc Towards a coronavirus-based HIV multigene vaccine
    Klara K Eriksson
    Research Department, Kantonal Hospital Saint Gallen, Saint Gallen 9007, Switzerland
    Clin Dev Immunol 13:353-60. 2006
    ..It is thus most likely that pre-existing immunity against HCoV 229E will not significantly impact on the vaccination efficiency if HCoV 229E-based vectors are used in humans...
  47. ncbi request reprint Antiviral immune responses in the absence of organized lymphoid T cell zones in plt/plt mice
    Tobias Junt
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Immunol 168:6032-40. 2002
    ....
  48. ncbi request reprint Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE
    Veronika Pochanke
    Institute for Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 37:1275-84. 2007
    ..Here, we show that even such low levels of parasite-specific IgE are sufficient to prime mast cells in vivo and mediate degranulation...
  49. ncbi request reprint Efficient transduction of dendritic cells using coronavirus-based vectors
    Klara K Eriksson
    Kantonal Hospital St Gallen, Switzerland
    Adv Exp Med Biol 581:203-6. 2006
  50. ncbi request reprint Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy
    Ying Waeckerle-Men
    Research Department, Cantonal Hospital St Gallen, CH 9007 St Gallen, Switzerland
    J Immunol Methods 287:109-24. 2004
    ..It should therefore be feasible to further develop this antigen loading strategy for clinical use in immunotherapy against viral infections and tumors...
  51. pmc Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire
    Weldy V Bonilla
    Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Clin Invest 116:156-62. 2006
    ....
  52. ncbi request reprint Efficient boosting of the antiviral T cell response in B cell-depleted patients with autoimmune rheumatic diseases following influenza vaccination
    Rüdiger B Müller
    Division of Rheumatology, Department of Internal Medicine, Kantonsspital St Gallen, St Gallen, Switzerland
    Clin Exp Rheumatol 31:723-30. 2013
    ..In this study we assessed whether B cell depletion with rituximab influences of the antiviral immune response in 2009 H1N1 influenza virus-vaccinated patients...
  53. ncbi request reprint Tracking arterial smooth muscle-specific T cells in the inflamed vasculature
    Burkhard Ludewig
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Switzerland
    Adv Exp Med Biol 512:183-9. 2002
  54. ncbi request reprint Arterial inflammation and atherosclerosis
    Burkhard Ludewig
    Institute of Experimental Immunology, Department of Pathology, University of Zurich, Zurich, Switzerland
    Trends Cardiovasc Med 12:154-9. 2002
    ..The evidence to date suggests that the mutual chronic perpetuation of immune mediated vascular inflammation and cholesterol-induced atherosclerosis is a key step in atherogenesis...
  55. doi request reprint Liposome-based vaccines
    Reto A Schwendener
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 605:163-75. 2010
    ..Our data show that liposomal formulations of peptide or plasmid-DNA vaccines are highly effective at direct in vivo antigen loading and activation of DC leading to protective antiviral and anti-tumor immune responses...
  56. ncbi request reprint CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2
    Elke Scandella
    Department of esearch, Cantonal Hospital St Gallen, Switzerland
    Blood 103:1595-601. 2004
    ..Hence, our data provide insight into CCL19/CCL21-triggered signal transduction pathways and identify a novel function for PGE2 in controlling the migration of mature MoDCs by facilitating CCR7 signal transduction...
  57. doi request reprint Ciprofloxacin and epirubicin synergistically induce apoptosis in human urothelial cancer cell lines
    Daniel S Engeler
    Institute of Immunobiology, Cantonal Hospital of St Gallen, St Gallen, Switzerland daniel engeler kssg ch
    Urol Int 88:343-9. 2012
    ..To assess the potential role of combination therapy, cytotoxic effects of ciprofloxacin and epirubicin alone and in combination were determined...
  58. doi request reprint Identification of protective B cell antigens of Legionella pneumophila
    Stefan S Weber
    Institute of Microbiology, Swiss Federal Institute of Technology, Zurich, CH 8093 Zurich, Switzerland
    J Immunol 189:841-9. 2012
    ..pneumophila Ags. The recognized Ags were indeed conserved across host species, because Abs specific for all three selected Ags could be detected in patient sera, rendering the identified protein Ags potential vaccine candidates...
  59. ncbi request reprint Identification and evaluation of coronavirus replicase inhibitors using a replicon cell line
    Elke Scandella
    Kantonal Hospital St Gallen, Switzerland
    Adv Exp Med Biol 581:609-13. 2006
  60. pmc Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses
    Gennady Bocharov
    Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, University of London, United Kingdom
    J Virol 78:2247-54. 2004
    ..Viruses with lower growth rates may persist in the host because they "sneak through" immune surveillance...
  61. ncbi request reprint Rapid molecular dissection of viral and bacterial immunomes
    Ugur Sahin
    III Department of Internal Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Eur J Immunol 36:1049-57. 2006
    ..The established approach is rapid, making it an attractive procedure for the comprehensive dissection of immunomes of known human pathogens and newly emerging infectious agents...
  62. ncbi request reprint Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells
    Yanhua Hu
    Institute for Pathophysiology, University of Innsbruck Medical School, Innsbruck, Austria
    Circulation 106:1834-9. 2002
    ..The traditional hypothesis that SMCs in the lesion are derived from the media of the donor vessel has been challenged by recent observations, but the cell origin is still not well established...
  63. ncbi request reprint Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice
    Tae Bong Kang
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 181:2522-32. 2008
    ....
  64. ncbi request reprint Virus scores a perfect 10
    Paul Klenerman
    Nat Med 12:1246-8. 2006
  65. ncbi request reprint A mathematical approach for optimizing dendritic cell-based immunotherapy
    Gennady Bocharov
    Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia
    Methods Mol Med 109:19-34. 2005
    ..We present here a workable computational methodology for developing meaningful data- and hypothesis-driven mathematical models for DC-based immunotherapy with a particular focus on numerical parameter estimation and sensitivity analysis...
  66. doi request reprint Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence
    Tobias Junt
    Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland
    Nat Rev Immunol 8:764-75. 2008
    ..In this Review, we discuss recent insights into the function and plasticity of the SLO microenvironment with regards to antimicrobial immune defence...