C Sandi

Summary

Country: Switzerland

Publications

  1. pmc Chronic restraint stress induces an isoform-specific regulation on the neural cell adhesion molecule in the hippocampus
    K Touyarot
    Dept of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Neural Plast 9:147-59. 2002
  2. ncbi request reprint Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning
    Carmen Sandi
    Department of Psychobiology CS, JJM, MIC, NDK, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria, Madrid, Spain
    Biol Psychiatry 54:599-607. 2003
  3. ncbi request reprint Mid-life stress and cognitive deficits during early aging in rats: individual differences and hippocampal correlates
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Neurobiol Aging 27:128-40. 2006
  4. ncbi request reprint [Glucocorticoid involvement in memory consolidation]
    C Sandi
    Brain and Mind Institute, Ecole Polytechnique Fédperale de Lausanne, Lausana, Suiza
    Rev Neurol 37:843-8. 2003
  5. ncbi request reprint A model for the involvement of neural cell adhesion molecules in stress-related mood disorders
    Carmen Sandi
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuroendocrinology 85:158-76. 2007
  6. doi request reprint From high anxiety trait to depression: a neurocognitive hypothesis
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Trends Neurosci 32:312-20. 2009
  7. doi request reprint Glucocorticoids act on glutamatergic pathways to affect memory processes
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Trends Neurosci 34:165-76. 2011
  8. pmc Neurobiological and endocrine correlates of individual differences in spatial learning ability
    Carmen Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Learn Mem 11:244-52. 2004
  9. doi request reprint Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Eur J Neurosci 28:1836-48. 2008
  10. ncbi request reprint Stress, cognitive impairment and cell adhesion molecules
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology, EPFL, CH 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:917-30. 2004

Collaborators

Detail Information

Publications47

  1. pmc Chronic restraint stress induces an isoform-specific regulation on the neural cell adhesion molecule in the hippocampus
    K Touyarot
    Dept of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Neural Plast 9:147-59. 2002
    ..As NCAM-140 is involved in cell-cell adhesion and neurite outgrowth, these findings suggest that this molecule might be one of the molecular mechanisms involved in the complex interactions among neurodegeneration-related events...
  2. ncbi request reprint Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning
    Carmen Sandi
    Department of Psychobiology CS, JJM, MIC, NDK, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria, Madrid, Spain
    Biol Psychiatry 54:599-607. 2003
    ..At the infragranular zone of the dentate gyrus, neurons expressing the polysialylated form of the neural cell adhesion molecule (NCAM PSA) transiently increase their frequency 12 hours after training in different tasks...
  3. ncbi request reprint Mid-life stress and cognitive deficits during early aging in rats: individual differences and hippocampal correlates
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Neurobiol Aging 27:128-40. 2006
    ....
  4. ncbi request reprint [Glucocorticoid involvement in memory consolidation]
    C Sandi
    Brain and Mind Institute, Ecole Polytechnique Fédperale de Lausanne, Lausana, Suiza
    Rev Neurol 37:843-8. 2003
    ..This review focus on the involvement of glucocorticoids and their receptors in a variety of animal models for learning and memory...
  5. ncbi request reprint A model for the involvement of neural cell adhesion molecules in stress-related mood disorders
    Carmen Sandi
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuroendocrinology 85:158-76. 2007
    ....
  6. doi request reprint From high anxiety trait to depression: a neurocognitive hypothesis
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Trends Neurosci 32:312-20. 2009
    ..Our model highlights the importance of developing prevention programs addressed to restrain, in high anxious individuals, the triggering of a dysfunctional neurocognitive cascade while coping with stress...
  7. doi request reprint Glucocorticoids act on glutamatergic pathways to affect memory processes
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Trends Neurosci 34:165-76. 2011
    ..The model suggests that direct modulation of glutamatergic pathways by glucocorticoids could serve as an important mechanism for these hormones to directly alter cognitive functions...
  8. pmc Neurobiological and endocrine correlates of individual differences in spatial learning ability
    Carmen Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Learn Mem 11:244-52. 2004
    ....
  9. doi request reprint Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Eur J Neurosci 28:1836-48. 2008
    ..Furthermore, they show that CRFR1 antagonists can prevent changes induced by chronic stress, in particular in those animals that are highly anxious...
  10. ncbi request reprint Stress, cognitive impairment and cell adhesion molecules
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Swiss Federal Institute of Technology, EPFL, CH 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:917-30. 2004
    ..These findings highlight cell adhesion molecules as potential therapeutic targets to treat stress-related cognitive disturbances...
  11. ncbi request reprint Acute stress-induced impairment of spatial memory is associated with decreased expression of neural cell adhesion molecule in the hippocampus and prefrontal cortex
    Carmen Sandi
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Biol Psychiatry 57:856-64. 2005
    ..There is, however, an insufficient understanding of the molecular mechanisms involved in stress effects on brain and behavior...
  12. ncbi request reprint Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1
    C Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040, Madrid, Spain
    Neuroscience 102:329-39. 2001
    ..They also indicate that cell adhesion molecules might play a role in the structural remodelling that occurs in the hippocampus as a consequence of chronic stress exposure...
  13. doi request reprint Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule
    Erika Borcel
    Department of Psychobiology, National University of Distance Education UNED, Juan del Rosal 10, Madrid, Spain
    Behav Pharmacol 19:41-9. 2008
    ..These findings suggest that the development of new drugs that mimic neural cell adhesion molecule activity might be of therapeutic relevance to treat stress-induced cognitive impairment...
  14. ncbi request reprint Spatial learning impairment induced by chronic stress is related to individual differences in novelty reactivity: search for neurobiological correlates
    K Touyarot
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Psychoneuroendocrinology 29:290-305. 2004
    ..In addition, it provides a model to further search for the neurobiological substrate(s) involved in the differential susceptibility to develop stress-induced cognitive impairments...
  15. ncbi request reprint Chronic stress induces opposite changes in the mRNA expression of the cell adhesion molecules NCAM and L1
    C Venero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040, Madrid, Spain
    Neuroscience 115:1211-9. 2002
    ..Furthermore, they suggest that these effects might be involved in the mechanisms by which stress induces structural and functional alterations in the central nervous system and, particularly, in the hippocampus...
  16. doi request reprint Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors
    L Conboy
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Mol Psychiatry 16:533-47. 2011
    ..These findings underscore MIF as a potentially relevant molecular target for the development of treatments linked to deficits in neurogenesis, as well as to problems related to anxiety, depression, and cognition...
  17. ncbi request reprint Water maze learning and forebrain mRNA expression of the neural cell adhesion molecule L1
    Cesar Venero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Madrid, Spain
    J Neurosci Res 75:172-81. 2004
    ....
  18. pmc Evidence for biological roots in the transgenerational transmission of intimate partner violence
    M I Cordero
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Geneva, CH, Switzerland
    Transl Psychiatry 2:e106. 2012
    ....
  19. ncbi request reprint Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory
    Cesar Venero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Juan del Rosal 10, Madrid, Spain
    Eur J Neurosci 23:1585-95. 2006
    ..Therefore, our findings highlight NCAM as a learning-modulated molecule critically involved in the hippocampal remodeling processes underlying spatial memory formation...
  20. doi request reprint Learning under stress: a role for the neural cell adhesion molecule NCAM
    Reto Bisaz
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Neurobiol Learn Mem 91:333-42. 2009
    ....
  21. ncbi request reprint Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation
    Miguel A Lopez-Fernandez
    Brain Mind Institute, Swiss Federal Institute of Technology, CH 1015 Lausanne, Switzerland
    J Neurosci 27:4552-61. 2007
    ....
  22. pmc Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression
    C Marquez
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Transl Psychiatry 3:e216. 2013
    ..Our data emphasize the impact of biological factors triggered by peripubertal adverse experiences on the emergence of violent behaviors...
  23. ncbi request reprint Selective learning and memory impairments in mice deficient for polysialylated NCAM in adulthood
    K Markram
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Station 15, CH 1015 Lausanne, Switzerland
    Neuroscience 144:788-96. 2007
    ....
  24. doi request reprint The role of NCAM in auditory fear conditioning and its modulation by stress: a focus on the amygdala
    R Bisaz
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Genes Brain Behav 9:353-64. 2010
    ....
  25. ncbi request reprint Individual differences in anxiety trait are related to spatial learning abilities and hippocampal expression of mineralocorticoid receptors
    Ana I Herrero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Juan del Rosal 10, 28040 Madrid, Spain
    Neurobiol Learn Mem 86:150-9. 2006
    ..Taken together, this study has generated evidence of a close interaction between the anxiety trait, hippocampal MR expression and the learning abilities of individuals in stressful spatial orientation tasks...
  26. doi request reprint KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress
    Johan Jakobsson
    School of Life Sciences, National Center of Competence in Research, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Neuron 60:818-31. 2008
    ..We propose a model in which the tethering of KAP1-associated chromatin remodeling factors via KRAB-ZFPs epigenetically controls gene expression in the hippocampus, thereby conditioning responses to behavioral stress...
  27. ncbi request reprint Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction
    Kamila Markram
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Switzerland
    Neurobiol Learn Mem 87:573-82. 2007
    ..These findings point out PSA-NCAM as a potential target for the treatment of psychopathologies that involve impairment in fear extinction...
  28. doi request reprint Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression
    L Calandreau
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Genes Brain Behav 9:958-67. 2010
    ..They also underscore STX KO mice as an interesting animal model that combines a behavioral profile of violence and hyperactivity with reduced anxiety-like behavior...
  29. ncbi request reprint A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation
    Karine Cambon
    Psychobiology Department, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria Sin Numero, 28040 Madrid, Spain
    J Neurosci 24:4197-204. 2004
    ..They suggest that increased efficacy of synaptic transmission and formation of new synapses probably mediate the cognition-enhancing properties displayed by the peptide...
  30. pmc The role and mechanisms of action of glucocorticoid involvement in memory storage
    C Sandi
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria, Madrid, Spain
    Neural Plast 6:41-52. 1998
    ....
  31. ncbi request reprint Glucocorticoid involvement in memory formation in a rat model for traumatic memory
    M Isabel Cordero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Stress 5:73-9. 2002
    ..In addition to further supporting a facilitating role of glucocorticoids in memory consolidation, these findings suggest a critical involvement of these hormones in the formation of traumatic memories...
  32. ncbi request reprint Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats. Evidence for a role of corticosterone
    M Isabel Cordero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Horm Behav 44:338-45. 2003
    ....
  33. ncbi request reprint Rapid reversal of stress induced loss of synapses in CA3 of rat hippocampus following water maze training
    Carmen Sandi
    Dept of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Eur J Neurosci 17:2447-56. 2003
    ..e. stress as a suppressor and learning as a promoter of synaptic plasticity...
  34. ncbi request reprint Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule
    M I Cordero
    Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
    Neuroscience 133:903-10. 2005
    ..Furthermore, these finding provide the first clear evidence that life experiences can regulate the expression of polysialylated neural cell adhesion molecule in the amygdaloid complex...
  35. pmc Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action
    Lisa Conboy
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuropsychopharmacology 35:674-85. 2010
    ..Evidence for the involvement of the neural cell adhesion molecule N-cadherin in interaction with GluA2 is also provided. These findings underscore a new mechanism whereby stress can improve memory function...
  36. ncbi request reprint Abnormal fear conditioning and amygdala processing in an animal model of autism
    Kamila Markram
    Brain Mind Institute, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Neuropsychopharmacology 33:901-12. 2008
    ..We hypothesize an 'aversive world' syndrome that could, even if not a primary cause of the disorder itself, underlie some core symptoms in autism, such as impairments in social interactions and resistance to rehabilitation...
  37. ncbi request reprint Modulation of contextual fear conditioning by chronic stress in rats is related to individual differences in behavioral reactivity to novelty
    M Isabel Cordero
    Department of Psychobiology, Universidad Nacional de Educacion a Distancia, Ciudad Universitaria s n, 28040 Madrid, Spain
    Brain Res 970:242-5. 2003
    ..The results suggest that individuals that display low reactivity to novelty are more susceptible to be influenced by stress exposure to subsequently exhibit potentiated contextual fear conditioning...
  38. doi request reprint The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats
    Lisa Conboy
    Laboratory of Behavioural Genetics, Brain Mind Institute, EPFL, Lausanne, Switzerland
    Int J Neuropsychopharmacol 12:329-41. 2009
    ..This work provides novel observations which indicate that agomelatine blocks the adverse effects of stress on hippocampus-dependent memory and activates molecular mechanisms of memory storage in response to a learning experience...
  39. pmc Stress and memory: behavioral effects and neurobiological mechanisms
    Carmen Sandi
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Neural Plast 2007:78970. 2007
    ..Among the brain regions implicated, the hippocampus, amygdala, and prefrontal cortex were highlighted as critical for the mediation of stress effects...
  40. pmc Role of the amygdala in antidepressant effects on hippocampal cell proliferation and survival and on depression-like behavior in the rat
    Jorge E Castro
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    PLoS ONE 5:e8618. 2010
    ..Our findings underscore the amygdala as a potential target to modulate antidepressants' action in hippocampal neurogenesis and in their link to depression-like behaviors...
  41. doi request reprint Stress, genotype and norepinephrine in the prediction of mouse behavior using reinforcement learning
    Gediminas Luksys
    Laboratory of Computational Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Nat Neurosci 12:1180-6. 2009
    ....
  42. pmc Female vulnerability to the development of depression-like behavior in a rat model of intimate partner violence is related to anxious temperament, coping responses, and amygdala vasopressin receptor 1a expression
    G L Poirier
    Laboratory of Behavioral Genetics, Ecole Polytechnique Federale de Lausanne, Brain Mind Institute Lausanne, Switzerland
    Front Behav Neurosci 7:35. 2013
    ..Furthermore, these results provide potential therapeutic targets of interest in the amygdala and the lateral septum to help improve post-stress behavioral pathology and increase resilience to social adversity...
  43. pmc Stress before puberty exerts a sex- and age-related impact on auditory and contextual fear conditioning in the rat
    Maria Toledo-Rodriguez
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neural Plast 2007:71203. 2007
    ..These results indicate that stress experienced prior to puberty can exert a sex-related differential impact on fear-related behaviors displayed by individuals during late adolescence and early adulthood...
  44. ncbi request reprint Exposure to retrieval cues improves retention performance and induces changes in ACTH and corticosterone release
    Pascale Gisquet-Verrier
    Laboratoire de Neurobiologie de l Apprentissage et de la Mémoire et de la Communication, UMR CNRS 8620, Universite Paris Sud, 91405 Orsay Cedex, France
    Psychoneuroendocrinology 29:529-56. 2004
    ..The present results strengthen the notion that emotion can interact with retrieval processes...
  45. pmc A facilitative role for corticosterone in the acquisition of a spatial task under moderate stress
    Irit Akirav
    Department of Psychology and The Brain and Behavior Research Center, University of Haifa, Haifa 31905, Israel
    Learn Mem 11:188-95. 2004
    ..These two mirror experiments of corticosterone blockade and enhancement strongly suggest that corticosterone is instrumental in the acquisition and retention of the spatial learning task...
  46. ncbi request reprint Olfactory learning-related NCAM expression is state, time, and location specific and is correlated with individual learning capabilities
    Shira Knafo
    Faculty of Health Sciences and Zlotowski Centre for Neuroscience, Ben Gurion University, Beersheva, Israel
    Hippocampus 15:316-25. 2005
    ..We therefore suggest that early synaptic NCAM expression may be one of the factors determining the capability of rats to learn...
  47. ncbi request reprint Dynamics of olfactory learning-induced up-regulation of L1 in the piriform cortex and hippocampus
    Shira Knafo
    Faculty of Health Sciences and Zlotowski Centre for Neuroscience, Ben Gurion University, Beersheva, Israel
    Eur J Neurosci 21:581-6. 2005
    ..We suggest that the dynamics of L1 up-regulation may reflect the functional role of these brain regions in olfactory rule learning...