Aaron P Russell

Summary

Country: Switzerland

Publications

  1. ncbi Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    FASEB J 19:986-8. 2005
  2. ncbi PGC-1alpha and exercise: important partners in combating insulin resistance
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    Curr Diabetes Rev 1:175-81. 2005
  3. ncbi COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    J Cardiopulm Rehabil 24:332-9. 2004
  4. ncbi Lipotoxicity: the obese and endurance-trained paradox
    A P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    Int J Obes Relat Metab Disord 28:S66-71. 2004
  5. ncbi Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3
    Aaron P Russell
    Department of Medical Biochemistry, University of Geneva Medical Center, 1206 Geneva, Switzerland
    J Clin Endocrinol Metab 88:5921-6. 2003
  6. ncbi Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    Aaron P Russell
    Clinique romande de réadaptation, Suva, Sion, Switzerland Endocrine Unit, University Hospital Geneva, Geneva, Switzerland
    Diabetes 52:2874-81. 2003
  7. ncbi Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Case postale 352, 1951 Sion, Switzerland
    FEBS Lett 551:104-6. 2003
  8. ncbi UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects
    A P Russell
    Department of Medical Biochemistry, University of Geneva, CMU, Switzerland
    Pflugers Arch 445:563-9. 2003
  9. pmc UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    J Physiol 550:855-61. 2003
  10. doi Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients
    Bertrand Leger
    Institut de Recherche en Réadaptation Réinsertion, Sion, Switzerland
    Muscle Nerve 40:69-78. 2009

Collaborators

Detail Information

Publications23

  1. ncbi Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    FASEB J 19:986-8. 2005
    ....
  2. ncbi PGC-1alpha and exercise: important partners in combating insulin resistance
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    Curr Diabetes Rev 1:175-81. 2005
    ..Because of the important role of PGC-1alpha in the control of energy metabolism and insulin sensitivity, it is seen as a candidate factor in the etiology of type 2 diabetes and a drug target for its therapeutic treatment...
  3. ncbi COPD results in a reduction in UCP3 long mRNA and UCP3 protein content in types I and IIa skeletal muscle fibers
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    J Cardiopulm Rehabil 24:332-9. 2004
    ....
  4. ncbi Lipotoxicity: the obese and endurance-trained paradox
    A P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    Int J Obes Relat Metab Disord 28:S66-71. 2004
    ..These may be important players in the development of insulin resistance and understanding their activation and expression in both obese and ETr humans should assist in understanding how and why IMTGs become lipotoxic...
  5. ncbi Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3
    Aaron P Russell
    Department of Medical Biochemistry, University of Geneva Medical Center, 1206 Geneva, Switzerland
    J Clin Endocrinol Metab 88:5921-6. 2003
    ....
  6. ncbi Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    Aaron P Russell
    Clinique romande de réadaptation, Suva, Sion, Switzerland Endocrine Unit, University Hospital Geneva, Geneva, Switzerland
    Diabetes 52:2874-81. 2003
    ..001). The increases in PGC-1 and PPAR-alpha levels reported in this study may play an important role in the changes in muscle mitochondria content, oxidative phenotype, and sensitivity to insulin known to be induced by endurance training...
  7. ncbi Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Case postale 352, 1951 Sion, Switzerland
    FEBS Lett 551:104-6. 2003
    ..Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance...
  8. ncbi UCP3 protein expression is lower in type I, IIa and IIx muscle fiber types of endurance-trained compared to untrained subjects
    A P Russell
    Department of Medical Biochemistry, University of Geneva, CMU, Switzerland
    Pflugers Arch 445:563-9. 2003
    ....
  9. pmc UCP3 protein regulation in human skeletal muscle fibre types I, IIa and IIx is dependent on exercise intensity
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    J Physiol 550:855-61. 2003
    ..In addition, the more a fibre type depends on fatty acid beta oxidation and oxidative phosphorylation, the more it responds to ETr by a decrease in its UCP3 content...
  10. doi Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients
    Bertrand Leger
    Institut de Recherche en Réadaptation Réinsertion, Sion, Switzerland
    Muscle Nerve 40:69-78. 2009
    ..The downregulation of signaling proteins that regulate anabolism, such as IGF, GSK-3beta, and 4E-BP1, would reduce the ability to increase protein synthesis rates...
  11. pmc Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy
    Severine Lamon
    Clinique Romande de réadaptation SUVA Care, Sion 1951, Switzerland
    J Physiol 587:1795-803. 2009
    ..Our results show that the STARS signalling pathway is responsive to changes in skeletal muscle loading and appears to play a role in both human skeletal muscle hypertrophy and atrophy...
  12. pmc Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise
    Romain Cartoni
    Clinique romande de réadaptation, SuvaCare, 1951 Sion, Switzerland
    J Physiol 567:349-58. 2005
    ..Our results provide evidence that PGC-1alpha not only mediates the increased expression of oxidative phosphorylation genes but also mediates alterations in mitochondrial architecture in response to aerobic exercise in humans...
  13. doi Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation
    Bertrand Leger
    Clinique Romande de Réadaptation SuvaCare, Sion, Switzerland
    Rejuvenation Res 11:163-175B. 2008
    ..Human sarcopenia may be linked to a reduction in the activity or sensitivity of anabolic signaling proteins such as GHR, IGF-1, and Akt. TNFalpha, SOCS-3, and myostatin are potential candidates influencing this anabolic perturbation...
  14. ncbi Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1
    Bertrand Leger
    Clinique romande de réadaptation, SuvaCare, Sion, Switzerland
    FASEB J 20:583-5. 2006
    ..The transcriptional regulation of human atrogin-1 may be controlled by an Akt-mediated transcription factor other than FKHR or via another signaling pathway...
  15. ncbi Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome
    Philippe Cettour-Rose
    Department of Internal Medicine, Faculty of Medicine, University of Geneva, Switzerland
    Diabetes 54:751-6. 2005
    ....
  16. ncbi Old and new determinants in the regulation of energy expenditure
    A P Russell
    Department of Medical Biochemistry, University Medical Center, Geneva, Switzerland
    J Endocrinol Invest 25:862-6. 2002
    ..The components of energy expenditure are basal metabolism, exercise induced thermogenesis and adaptive thermogenesis. In this short review we shall discuss the main determinants of adaptive thermogenesis...
  17. ncbi Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes
    Anthony E Civitarese
    Dept of Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 289:E1023-9. 2005
    ..05). In conclusion, glucose ingestion during exercise decreases the expression of genes involved in lipid metabolism rather than increasing genes involved in carbohydrate metabolism...
  18. ncbi Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1520-5. 2006
    ..Recent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes...
  19. ncbi A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis
    Davide Mainieri
    Division of Physiology, Department of Medicine, Faculty of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    FASEB J 20:1751-3. 2006
    ....
  20. ncbi Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants
    Lodovica Vergani
    c o Venetian Institute of Molecular Medicine, Via Orus, 2 35129 Padova, Italy E mail
    Brain 130:2715-24. 2007
    ....
  21. ncbi Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease
    Mariève Doucet
    Centre de Recherche de l Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Laval, Quebec, Canada
    Am J Respir Crit Care Med 176:261-9. 2007
    ..The molecular mechanisms of muscle atrophy in chronic obstructive pulmonary disease (COPD) are poorly understood. In wasted animals, muscle mass is regulated by several AKT-related signaling pathways...
  22. pmc Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy
    Bertrand Leger
    School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway 3125, Australia
    J Physiol 576:923-33. 2006
    ..We demonstrate, for the first time in human skeletal muscle, that the regulation of Akt and its downstream signalling pathways GSK-3beta, mTOR and Foxo1 are associated with both the skeletal muscle hypertrophy and atrophy processes...
  23. ncbi Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting
    Maria Jimenez
    Departement de Biochimie Medicale, Centre Medical Universitaire, 1, rue Michel Servet, 1211 Geneve 4, Switzerland
    FEBS Lett 530:37-40. 2002
    ..Hence, beta-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting...