- Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolismMathieu Renouf
Nestle Research Center, Nestec Limited, Vers chez les Blanc, Lausanne, Switzerland
Mol Nutr Food Res 54:760-6. 2010..This study confirms that the small intestine is a significant site for absorption of PA, but shows for the first time that the colon/microflora play the major role in absorption and metabolism of CGAs and PA from coffee...
- Plasma appearance and correlation between coffee and green tea metabolites in human subjectsMathieu Renouf
Nestle Research Center, Nestec Limited, Lausanne, Switzerland
Br J Nutr 104:1635-40. 2010..This implies that the mechanisms of absorption for these two classes of compounds are different, and that a high absorber of phenolic acids is not necessarily a high absorber of catechins...
- Dose-response plasma appearance of green tea catechins in adultsMathieu Renouf
Nestle Research Center, Nestec Ltd, Lausanne, Switzerland
Mol Nutr Food Res 57:833-9. 2013..The most prevalent bioactive compounds in green tea are catechins (C), which are of great interest for their potential health-promoting effects. However, metabolism and bioavailability of C are not fully understood...
- Plasma pharmacokinetics of catechin metabolite 4'-O-Me-EGC in healthy humansMathieu Renouf
Nestle Research Center, Nestec Ltd, Vers chez les Blanc, 1000, Lausanne 26, Switzerland
Eur J Nutr 50:575-80. 2011....
- Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasmaMathieu Renouf
Nestle Research Center, Vers chez les Blancs, 1000 Lausanne 26, Switzerland
J Nutr 140:259-63. 2010..As a conclusion, adding whole milk did not alter the overall bioavailability of coffee phenolic acids, whereas sugar and nondairy creamer affected the T(max) and C(max) but not the appearance of coffee phenolics in plasma...
- Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometryPhilippe A Guy
Nestle Research Center, Nestec Ltd, P O Box 44, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
J Chromatogr B Analyt Technol Biomed Life Sci 877:3965-74. 2009..Using this method, we determined plasma levels in humans and measured the efficiency of deconjugation using our enzymatic cocktail...
- Identification of novel circulating coffee metabolites in human plasma by liquid chromatography-mass spectrometryKarine Redeuil
Metabolomics and Biomarkers Group, Nestle Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne, Switzerland
J Chromatogr A 1218:4678-88. 2011..In future, this analytical method will give more confidence in compound identification to provide a more comprehensive assessment of coffee polyphenol bioavailability studies in humans...
- First identification of dimethoxycinnamic acids in human plasma after coffee intake by liquid chromatography-mass spectrometryKornél Nagy
Metabonomics and Biomarkers Group BioAnalytical Science Department, Nestle Research Center, Nestec Ltd, Lausanne, Switzerland
J Chromatogr A 1218:491-7. 2011....
- Bioavailability of bioactive food compounds: a challenging journey to bioefficacyMaarit J Rein
Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
Br J Clin Pharmacol 75:588-602. 2013..This review focuses on some of the major factors affecting the bioavailability of the aforementioned bioactive food compounds...
- Quantification of phenolic acids and their methylates, glucuronides, sulfates and lactones metabolites in human plasma by LC-MS/MS after oral ingestion of soluble coffeeCynthia Marmet
Nestle Research Center, Vers chez les Blanc, 1000 Lausanne 26, Switzerland Electronic address
J Pharm Biomed Anal 88:617-25. 2014..In conclusion, the developed and validated method is proved to be very sensitive, accurate and precise for the quantification of these possible dietary phenols. ..