Freddy Radtke

Summary

Country: Switzerland

Publications

  1. pmc Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
    Alexis Dumortier
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, Lausanne, Switzerland
    PLoS ONE 5:e9258. 2010
  2. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
  3. doi request reprint Regulation of innate and adaptive immunity by Notch
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Nat Rev Immunol 13:427-37. 2013
  4. doi request reprint Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
  5. doi request reprint Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
  6. pmc Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation
    Valerie Besseyrias
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    J Exp Med 204:331-43. 2007
  7. doi request reprint Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies
    Emma Fiorini
    Ludwig Institute for Cancer Research Ltd, Lausanne Branch, 1066 Epalinges, Switzerland
    J Immunol 183:7212-22. 2009
  8. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
  9. doi request reprint Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting
    Matteo Di Piazza
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Cancer Cell 22:479-93. 2012
  10. doi request reprint Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010

Collaborators

Detail Information

Publications33

  1. pmc Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
    Alexis Dumortier
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, Lausanne, Switzerland
    PLoS ONE 5:e9258. 2010
    ..Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth...
  2. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
    ..Moreover, they strongly suggest that N1-expressing thymic progenitors interact with DL4-expressing TECs to suppress B lineage potential and to induce the first steps of intrathymic T cell development...
  3. doi request reprint Regulation of innate and adaptive immunity by Notch
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Nat Rev Immunol 13:427-37. 2013
    ..A better understanding of Notch function in both innate and adaptive immunity will hopefully provide multiple avenues for therapeutic intervention in disease...
  4. doi request reprint Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
    ..The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments...
  5. doi request reprint Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
    ..In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia...
  6. pmc Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation
    Valerie Besseyrias
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    J Exp Med 204:331-43. 2007
    ..Collectively, our results establish a hierarchy of Notch-Delta interactions in which N1-DL4 exhibits the greatest capacity to induce and support T cell development...
  7. doi request reprint Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies
    Emma Fiorini
    Ludwig Institute for Cancer Research Ltd, Lausanne Branch, 1066 Epalinges, Switzerland
    J Immunol 183:7212-22. 2009
    ..Furthermore they provide an important resource for future analysis of Notch receptors in various tissues including the hematopoietic system...
  8. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4)...
  9. doi request reprint Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting
    Matteo Di Piazza
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Cancer Cell 22:479-93. 2012
    ..Epithelial specific ablation of β-catenin prevents both carcinogenesis and the accumulation of CD11b(+)Gr1(+) myeloid cells, suggesting tumor cells initiate a feed-forward loop that induces protumorigenic inflammation...
  10. doi request reprint Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010
    ..Collectively, our studies identify Hes1 as a critical but context-dependent mediator of canonical Notch signaling in the hematopoietic system...
  11. ncbi request reprint Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
    Stephane J C Mancini
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Blood 105:2340-2. 2005
    ..In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis...
  12. ncbi request reprint Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    ..These results exclude an essential role for canonical Wnt signaling (as mediated by beta- and/or gamma-catenin) during hematopoiesis and lymphopoiesis...
  13. ncbi request reprint Notch regulation of lymphocyte development and function
    Freddy Radtke
    The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nat Immunol 5:247-53. 2004
    ....
  14. pmc Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
    Orbicia Riccio
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges 1066, Switzerland
    EMBO Rep 9:377-83. 2008
    ..Thus, our results indicate that Notch-mediated Hes1 expression contributes to the maintenance of the proliferative crypt compartment of the small intestine by transcriptionally repressing two CDK inhibitors...
  15. ncbi request reprint Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
    Sophie Vauclair
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Dev Cell 13:242-53. 2007
    ..Accordingly, we found that Notch1 signaling is linked to vitamin A metabolism by regulating the expression of cellular retinol binding protein 1 (CRBP1), required to generate a pool of intracellular retinol...
  16. ncbi request reprint Notch signaling in T- and B-cell development
    Freddy Radtke
    The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Curr Opin Immunol 16:174-9. 2004
    ....
  17. doi request reprint Chromosomal number aberrations and transformation in adult mouse retinal stem cells in vitro
    Meta Djojosubroto
    Unit of Gene Therapy and Stem Cell Biology, Department of Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland
    Invest Ophthalmol Vis Sci 50:5975-87. 2009
    ..However, as cells in prolonged cultivation may be unstable and thus have a risk of transformation, it is important to assess the stability of these cells...
  18. pmc Control of the adaptive response of the heart to stress via the Notch1 receptor pathway
    Adrien Croquelois
    Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland
    J Exp Med 205:3173-85. 2008
    ..In cardiac precursors, Notch prevents cardiogenic differentiation, favors proliferation, and may facilitate the expansion of a transient amplifying cell compartment...
  19. ncbi request reprint Notch1 functions as a tumor suppressor in mouse skin
    Michael Nicolas
    Ludwig Institute for Cancer Research, Lausanne Branch, University Lausanne, 1066 Epalinges, Switzerland
    Nat Genet 33:416-21. 2003
    ..This leads to a reduction in the signaling-competent pool of beta-catenin, indicating that Notch1 can inhibit beta-catenin-mediated signaling. Our results indicate that Notch1 functions as a tumor-suppressor gene in mammalian skin...
  20. doi request reprint Mechanisms of T cell development and transformation
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland
    Annu Rev Cell Dev Biol 27:539-62. 2011
    ..This review examines the processes and pathways involved in the highly orchestrated development of T cell fate specification under physiological as well as pathological conditions...
  21. ncbi request reprint Notch1 is essential for postnatal hair follicle development and homeostasis
    Sophie Vauclair
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Dev Biol 284:184-93. 2005
    ..These data show that Notch1 is essential for late stages of hair follicle development during embryogenesis as well as for post-natal hair follicle development and hair homeostasis...
  22. ncbi request reprint Multiple functions of Notch signaling in self-renewing organs and cancer
    Anne Wilson
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    FEBS Lett 580:2860-8. 2006
    ..We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis...
  23. ncbi request reprint The role of Notch in tumorigenesis: oncogene or tumour suppressor?
    Freddy Radtke
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nat Rev Cancer 3:756-67. 2003
    ..However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor...
  24. doi request reprint Notch in T-ALL: new players in a complex disease
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Trends Immunol 32:434-42. 2011
    ..In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling...
  25. pmc The Notch 'gospel'
    Freddy Radtke
    The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    EMBO Rep 6:1120-5. 2005
  26. ncbi request reprint From gut homeostasis to cancer
    Freddy Radtke
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Curr Mol Med 6:275-89. 2006
    ....
  27. ncbi request reprint Haematopoietic stem cell niche in Drosophila
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Fédárale de Lausanne EPFL, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Bioessays 29:713-6. 2007
    ..The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment...
  28. doi request reprint Generation and characterization of a Notch1 signaling-specific reporter mouse line
    Emma Smith
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Genesis 50:700-10. 2012
    ..Thus, this novel reporter mouse line provides a unique tool to specifically investigate the spatial and temporal aspects of Notch1 signaling in vivo...
  29. ncbi request reprint Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation
    Bhushan Sarode
    School of Life Science, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland Swiss Institute for Experimental Cancer Research ISREC, Lausanne, Switzerland
    Pigment Cell Melanoma Res 27:580-9. 2014
    ..Collectively, these data indicate that Notch signaling promotes ciliary body development at the expense of iris formation and reveals novel animal models of human ocular pathologies. ..
  30. doi request reprint Notch signaling in solid tumors
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Lausanne, Switzerland
    Curr Top Dev Biol 92:411-55. 2010
    ....
  31. doi request reprint BCL6 and BCoR gang up on Notch to regulate left-right patterning
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Station 19, 1015 Lausanne, Switzerland
    Dev Cell 18:338-40. 2010
    ..describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning...
  32. ncbi request reprint The role of Notch signaling during hematopoietic lineage commitment
    Freddy Radtke
    The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Immunol Rev 187:65-74. 2002
    ..In this review we will summarize recent findings and controversies regarding the role of Notch signaling in the myeloid and lymphoid systems...
  33. doi request reprint Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
    Mitko Dimitrov
    Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015 Lausanne, Switzerland
    Nat Commun 4:2246. 2013
    ..Molecular simulations suggest that familial Alzheimer's disease mutations modulate the flexibility of the APP transmembrane domain and the presentation of its γ-site, modifying at the same time, the solvation of the ε-site. ..