Freddy Radtke

Summary

Country: Switzerland

Publications

  1. doi request reprint Regulation of innate and adaptive immunity by Notch
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Nat Rev Immunol 13:427-37. 2013
  2. doi request reprint Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
  3. doi request reprint Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
  4. doi request reprint Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting
    Matteo Di Piazza
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Cancer Cell 22:479-93. 2012
  5. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
  6. doi request reprint Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010
  7. pmc Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
    Alexis Dumortier
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, Lausanne, Switzerland
    PLoS ONE 5:e9258. 2010
  8. doi request reprint Chromosomal number aberrations and transformation in adult mouse retinal stem cells in vitro
    Meta Djojosubroto
    Unit of Gene Therapy and Stem Cell Biology, Department of Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland
    Invest Ophthalmol Vis Sci 50:5975-87. 2009
  9. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
  10. doi request reprint Mechanisms of T cell development and transformation
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland
    Annu Rev Cell Dev Biol 27:539-62. 2011

Collaborators

  • H Robson MacDonald
  • Yann Barrandon
  • Ishrut Hussain
  • Lluis Espinosa
  • Hans Clevers
  • Rui Benedito
  • Karin Schuster-Gossler
  • Thierry Pedrazzini
  • Lucio Miele
  • Nancy R Manley
  • Julian Lewis
  • Shadmehr Demehri
  • Tasuku Honjo
  • Fabienne Tacchini-Cottier
  • Ute Koch
  • Luca Pellegrinet
  • Rajwinder Lehal
  • Matteo Di Piazza
  • André Dante Durham
  • Sophie Vauclair
  • Mitko Dimitrov
  • Emma Smith
  • Raphael Kopan
  • Agnieszka A Wendorff
  • Alexis Dumortier
  • Meta Djojosubroto
  • Orbicia Riccio
  • Adrien Croquelois
  • Dirk Beher
  • Jean Rene Alattia
  • Andrzej Fligier
  • Patrick C Fraering
  • Jemila Houacine
  • Matteo Dal Peraro
  • Thomas Lemmin
  • Stéphanie Claudinot
  • Craig S Nowell
  • Veronica Rodilla
  • Shuang Chen
  • Zhenyi Liu
  • Klaus H Kaestner
  • Warren J Leonard
  • Christelle Dubey
  • Daniela Finke
  • F Thomas Wunderlich
  • Andrew G Farr
  • Silvia Wirth
  • Isabel Ferrero
  • Jens C Bruning
  • Gisèle Ferrand
  • Daniel Hohl
  • Lynda Li Song
  • Yvan Arsenijevic
  • Pratyaksha Wirapati
  • Frederic Bollotte
  • Ivan Stamenkovic
  • Lothar J Strobl
  • Emma Fiorini
  • April C Bezdek
  • Valerie Besseyrias
  • Ursula Zimber-Strobl
  • Rolf Kemler
  • Andrea A Domenighetti
  • Mario Lepore
  • Antonio Duarte
  • Nathalie Rosenblatt-Velin
  • Johan H van Es
  • Marielle E van Gijn
  • Mohamed Nemir
  • Anne Wilson
  • Monica Cobas
  • Michel Pierres
  • Norbert B Ghyselinck
  • Francois Majo

Detail Information

Publications20

  1. doi request reprint Regulation of innate and adaptive immunity by Notch
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Nat Rev Immunol 13:427-37. 2013
    ..A better understanding of Notch function in both innate and adaptive immunity will hopefully provide multiple avenues for therapeutic intervention in disease...
  2. doi request reprint Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
    ..The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments...
  3. doi request reprint Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
    ..In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia...
  4. doi request reprint Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting
    Matteo Di Piazza
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, Lausanne, Vaud 1015, Switzerland
    Cancer Cell 22:479-93. 2012
    ..Epithelial specific ablation of β-catenin prevents both carcinogenesis and the accumulation of CD11b(+)Gr1(+) myeloid cells, suggesting tumor cells initiate a feed-forward loop that induces protumorigenic inflammation...
  5. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4)...
  6. doi request reprint Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010
    ..Collectively, our studies identify Hes1 as a critical but context-dependent mediator of canonical Notch signaling in the hematopoietic system...
  7. pmc Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
    Alexis Dumortier
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, Lausanne, Switzerland
    PLoS ONE 5:e9258. 2010
    ..Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth...
  8. doi request reprint Chromosomal number aberrations and transformation in adult mouse retinal stem cells in vitro
    Meta Djojosubroto
    Unit of Gene Therapy and Stem Cell Biology, Department of Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland
    Invest Ophthalmol Vis Sci 50:5975-87. 2009
    ..However, as cells in prolonged cultivation may be unstable and thus have a risk of transformation, it is important to assess the stability of these cells...
  9. pmc Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
    ..Moreover, they strongly suggest that N1-expressing thymic progenitors interact with DL4-expressing TECs to suppress B lineage potential and to induce the first steps of intrathymic T cell development...
  10. doi request reprint Mechanisms of T cell development and transformation
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland
    Annu Rev Cell Dev Biol 27:539-62. 2011
    ..This review examines the processes and pathways involved in the highly orchestrated development of T cell fate specification under physiological as well as pathological conditions...
  11. ncbi request reprint Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    ..These results exclude an essential role for canonical Wnt signaling (as mediated by beta- and/or gamma-catenin) during hematopoiesis and lymphopoiesis...
  12. pmc Control of the adaptive response of the heart to stress via the Notch1 receptor pathway
    Adrien Croquelois
    Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland
    J Exp Med 205:3173-85. 2008
    ..In cardiac precursors, Notch prevents cardiogenic differentiation, favors proliferation, and may facilitate the expansion of a transient amplifying cell compartment...
  13. pmc Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
    Orbicia Riccio
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges 1066, Switzerland
    EMBO Rep 9:377-83. 2008
    ..Thus, our results indicate that Notch-mediated Hes1 expression contributes to the maintenance of the proliferative crypt compartment of the small intestine by transcriptionally repressing two CDK inhibitors...
  14. doi request reprint Generation and characterization of a Notch1 signaling-specific reporter mouse line
    Emma Smith
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Genesis 50:700-10. 2012
    ..Thus, this novel reporter mouse line provides a unique tool to specifically investigate the spatial and temporal aspects of Notch1 signaling in vivo...
  15. doi request reprint Notch in T-ALL: new players in a complex disease
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Trends Immunol 32:434-42. 2011
    ..In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling...
  16. ncbi request reprint Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
    Sophie Vauclair
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Dev Cell 13:242-53. 2007
    ..Accordingly, we found that Notch1 signaling is linked to vitamin A metabolism by regulating the expression of cellular retinol binding protein 1 (CRBP1), required to generate a pool of intracellular retinol...
  17. doi request reprint Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
    Mitko Dimitrov
    Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH1015 Lausanne, Switzerland
    Nat Commun 4:2246. 2013
    ..Molecular simulations suggest that familial Alzheimer's disease mutations modulate the flexibility of the APP transmembrane domain and the presentation of its γ-site, modifying at the same time, the solvation of the ε-site. ..
  18. ncbi request reprint Haematopoietic stem cell niche in Drosophila
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Fédárale de Lausanne EPFL, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Bioessays 29:713-6. 2007
    ..The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment...
  19. doi request reprint BCL6 and BCoR gang up on Notch to regulate left-right patterning
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Station 19, 1015 Lausanne, Switzerland
    Dev Cell 18:338-40. 2010
    ..describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning...
  20. doi request reprint Notch signaling in solid tumors
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Lausanne, Switzerland
    Curr Top Dev Biol 92:411-55. 2010
    ....