Freddy Radtke

Summary

Country: Switzerland

Publications

  1. ncbi Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
  2. ncbi Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
  3. ncbi Mechanisms of T cell development and transformation
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland
    Annu Rev Cell Dev Biol 27:539-62. 2011
  4. ncbi Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
  5. ncbi Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010
  6. ncbi Notch in T-ALL: new players in a complex disease
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Trends Immunol 32:434-42. 2011
  7. ncbi Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
    Sophie Vauclair
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Dev Cell 13:242-53. 2007
  8. ncbi Generation and characterization of a Notch1 signaling-specific reporter mouse line
    Emma Smith
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Genesis 50:700-10. 2012
  9. ncbi Haematopoietic stem cell niche in Drosophila
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Fédárale de Lausanne EPFL, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Bioessays 29:713-6. 2007
  10. ncbi Notch signaling in solid tumors
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Lausanne, Switzerland
    Curr Top Dev Biol 92:411-55. 2010

Collaborators

  • H Robson MacDonald
  • Yann Barrandon
  • Tasuku Honjo
  • Ute Koch
  • Rajwinder Lehal
  • Emma Smith
  • Luca Pellegrinet
  • Agnieszka A Wendorff
  • Orbicia Riccio
  • Sophie Vauclair
  • Stéphanie Claudinot
  • Jens C Bruning
  • F Thomas Wunderlich
  • Christelle Dubey
  • Silvia Wirth
  • April C Bezdek
  • Rui Benedito
  • Monica Cobas
  • Michel Pierres
  • Antonio Duarte
  • Karin Schuster-Gossler
  • Anne Wilson
  • Emma Fiorini
  • Valerie Besseyrias
  • Rolf Kemler
  • Johan H van Es
  • Marielle E van Gijn
  • Lothar J Strobl
  • Nancy R Manley
  • Hans Clevers
  • Ursula Zimber-Strobl
  • André Dante Durham
  • Francois Majo
  • Norbert B Ghyselinck

Detail Information

Publications13

  1. ncbi Stem cells living with a Notch
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, School of Life Science, SwissInstitute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Development 140:689-704. 2013
    ..The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments...
  2. ncbi Notch signaling in the immune system
    Freddy Radtke
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 32:14-27. 2010
    ..In this review, we discuss Notch signaling in hematopoiesis, lymphocyte development, and function as well as in T cell acute lymphoblastic leukemia...
  3. ncbi Mechanisms of T cell development and transformation
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1015 Lausanne, Switzerland
    Annu Rev Cell Dev Biol 27:539-62. 2011
    ..This review examines the processes and pathways involved in the highly orchestrated development of T cell fate specification under physiological as well as pathological conditions...
  4. ncbi Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    ..These results exclude an essential role for canonical Wnt signaling (as mediated by beta- and/or gamma-catenin) during hematopoiesis and lymphopoiesis...
  5. ncbi Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation
    Agnieszka A Wendorff
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Immunity 33:671-84. 2010
    ..Collectively, our studies identify Hes1 as a critical but context-dependent mediator of canonical Notch signaling in the hematopoietic system...
  6. ncbi Notch in T-ALL: new players in a complex disease
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research ISREC, Station 19, 1015 Lausanne, Switzerland
    Trends Immunol 32:434-42. 2011
    ..In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling...
  7. ncbi Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
    Sophie Vauclair
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Dev Cell 13:242-53. 2007
    ..Accordingly, we found that Notch1 signaling is linked to vitamin A metabolism by regulating the expression of cellular retinol binding protein 1 (CRBP1), required to generate a pool of intracellular retinol...
  8. ncbi Generation and characterization of a Notch1 signaling-specific reporter mouse line
    Emma Smith
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Genesis 50:700-10. 2012
    ..Thus, this novel reporter mouse line provides a unique tool to specifically investigate the spatial and temporal aspects of Notch1 signaling in vivo...
  9. ncbi Haematopoietic stem cell niche in Drosophila
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Fédárale de Lausanne EPFL, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Bioessays 29:713-6. 2007
    ..The findings of both papers shed new light on the specific interactions between haematopoietic progenitors and their microenvironment...
  10. ncbi Notch signaling in solid tumors
    Ute Koch
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Lausanne, Switzerland
    Curr Top Dev Biol 92:411-55. 2010
    ....
  11. ncbi BCL6 and BCoR gang up on Notch to regulate left-right patterning
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Station 19, 1015 Lausanne, Switzerland
    Dev Cell 18:338-40. 2010
    ..describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning...
  12. ncbi Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment
    Ute Koch
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, 1066 Epalinges, Switzerland
    J Exp Med 205:2515-23. 2008
    ..Moreover, they strongly suggest that N1-expressing thymic progenitors interact with DL4-expressing TECs to suppress B lineage potential and to induce the first steps of intrathymic T cell development...
  13. ncbi Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
    Orbicia Riccio
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, Epalinges 1066, Switzerland
    EMBO Rep 9:377-83. 2008
    ..Thus, our results indicate that Notch-mediated Hes1 expression contributes to the maintenance of the proliferative crypt compartment of the small intestine by transcriptionally repressing two CDK inhibitors...