Michael Soyka

Summary

Affiliation: Psychiatric Hospital
Country: Switzerland

Publications

  1. ncbi request reprint [Pharmacotherapy of alcohol dependence]
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen
    MMW Fortschr Med 150:22-4. 2008
  2. ncbi request reprint One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
  3. ncbi request reprint Clinical correlates of later violence and criminal offences in schizophrenia
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 94:89-98. 2007
  4. ncbi request reprint [Psychotherapeutic interventions of general practitioners in patients with alcohol problems]
    Michael Soyka
    Psychiatrische Klinik der Universität München, Privatklinik Meiringen, Schweiz
    MMW Fortschr Med 150:33-5. 2008
  5. doi request reprint Alcohol and the risk of overdose death from heroin
    Michael Soyka
    Private Hospital Meiringen PO Box 612, 3860 Meiringen, Switzerland
    Addiction 103:1064-5; discussion 1067-8. 2008
  6. ncbi request reprint New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
  7. doi request reprint Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 11:641-53. 2008
  8. doi request reprint Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:699-703. 2008
  9. ncbi request reprint Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
  10. ncbi request reprint Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Clin Psychopharmacol 25:490-3. 2005

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint [Pharmacotherapy of alcohol dependence]
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen
    MMW Fortschr Med 150:22-4. 2008
  2. ncbi request reprint One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
    ..Taking into account the high comorbidity of opioid dependent patients and the severity of dependence, the mortality rate of approximately 1% confirms that maintenance treatment could be regarded as a fairly safe treatment...
  3. ncbi request reprint Clinical correlates of later violence and criminal offences in schizophrenia
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 94:89-98. 2007
    ..Violence and criminality in patients with schizophrenia has been described in several studies but prediction of later criminal behavior is difficult...
  4. ncbi request reprint [Psychotherapeutic interventions of general practitioners in patients with alcohol problems]
    Michael Soyka
    Psychiatrische Klinik der Universität München, Privatklinik Meiringen, Schweiz
    MMW Fortschr Med 150:33-5. 2008
  5. doi request reprint Alcohol and the risk of overdose death from heroin
    Michael Soyka
    Private Hospital Meiringen PO Box 612, 3860 Meiringen, Switzerland
    Addiction 103:1064-5; discussion 1067-8. 2008
  6. ncbi request reprint New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
    ..Tricyclics have been found to be more effective than serotonin reuptake inhibitors in improving depressive symptoms in these patients...
  7. doi request reprint Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 11:641-53. 2008
    ..The intensity of withdrawal symptoms showed the strongest correlation with drop-out. Future studies are warranted to further address patient profiles and outcome under different substitution regimens...
  8. doi request reprint Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:699-703. 2008
    ..Selective attention improved in both patient groups during treatment. We propose that the improvement of attention may facilitate rehabilitation of drug-dependent patients...
  9. ncbi request reprint Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
    ..Future studies on the role of different subtypes of alcoholics according to their genetic or psychological profile to explain or even predict the effects of opioid antagonists in the treatment of alcohol dependence are needed...
  10. ncbi request reprint Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Clin Psychopharmacol 25:490-3. 2005
    ..We assessed whether patients under buprenorphine, a partial mu-opioid agonist, perform better in cognitive tests measuring psychomotor performance as described in previous nonrandomized studies...
  11. doi request reprint Cognitive function in short- and long-term substitution treatment: are there differences?
    Michael Soyka
    Private Hospital Meiringen, Willigen, Meiringen, Switzerland
    World J Biol Psychiatry 11:400-8. 2010
    ..More longitudinal research and studies controlling for the effects of dosage and duration of opioid addiction are necessary to examine whether cognitive ability may improve under long-term MMT...
  12. ncbi request reprint Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses
    Susanne Karch
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 42:734-45. 2008
    ..This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients...
  13. doi request reprint Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms
    Gabriele Koller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 36:1230-6. 2012
    ..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
  14. doi request reprint No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms
    Gabriele Koller
    Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany
    Addict Biol 14:506-8. 2009
    ..048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis...
  15. ncbi request reprint A comparison of cognitive function in patients under maintenance treatment with heroin, methadone, or buprenorphine and healthy controls: an open pilot study
    Michael Soyka
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Am J Drug Alcohol Abuse 37:497-508. 2011
    ..Cognitive impairment has been reported in drug-dependent patients under opioid maintenance treatment...
  16. ncbi request reprint Outpatient alcohol detoxification: implementation efficacy and outcome effectiveness of a model project
    Michael Soyka
    Psychiatric Hospital, University Munich, Munich, Germany
    Eur Addict Res 10:180-7. 2004
    ..The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach...
  17. ncbi request reprint Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  18. ncbi request reprint Outpatient alcoholism treatment: predictors of outcome after 3 years
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstr 7, 80336 Munich, Germany
    Drug Alcohol Depend 80:83-9. 2005
    ..This prospective study investigated predictors for relapse 3 years after completion of an intensive outpatient treatment programme for alcoholism...
  19. ncbi request reprint OCDS craving scores predict 24-month outcome in alcoholic outpatients
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Am J Addict 19:264-9. 2010
    ..OCDS scores were higher in patients with a less favorable outcome. In line with previous findings, our results showed that the intensity of craving as measured by the OCDS may predict outcome in outpatient alcoholics...
  20. ncbi request reprint Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilians University of Munich, Naussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 39:101-8. 2005
    ..Among patients with risperidone, seven patients (35%) passed all test parameters without major failures. Clinical implications of these findings are discussed...
  21. ncbi request reprint Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Addict Res 11:132-7. 2005
    ..In summary, results of this study indicate a favorable outcome of socially stable alcohol-dependent patients and patients with a lower degree of depression, anxiety and craving in an intensive outpatient rehabilitation program...
  22. doi request reprint Criminal behaviour and violent crimes in former inpatients with affective disorder
    Christian Graz
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Affect Disord 117:98-103. 2009
    ..Several studies have reported criminal and violent behaviour in people with schizophrenia but few have investigated the association between affective disorders and violent behaviour...
  23. doi request reprint The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 12:160-87. 2011
    ..To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence...
  24. ncbi request reprint Delinquency and criminal offenses in former schizophrenic inpatients 7-12 years following discharge
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:289-94. 2004
    ..Previously, we reported a high prevalence of aggression in a large sample of schizophrenic patients treated between 1990-1995 in the psychiatric hospital of the University of Munich...
  25. doi request reprint Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study
    Ulrich W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University, Halle Wittenberg, Julius Kühn Str 7, D 06112 Halle, Germany
    Addict Biol 16:323-33. 2011
    ....
  26. doi request reprint Pharmacological challenge with naloxone and cue exposure in alcohol dependence: results of a randomized, double-blind placebo-controlled trial
    Martin Lieb
    Department of Psychiatry, Bezirksklinikum Regensburg, Regensburg, Germany
    World J Biol Psychiatry 14:539-46. 2013
    ..Altered cortisol response to opioid receptor blockade not only in alcohol dependent persons, but also in persons with a family history of alcohol dependency was reported...
  27. ncbi request reprint Co-consumption of benzodiazepines in heroin users, methadone-substituted and codeine-substituted patients
    Markus Backmund
    Kolner Platz 1, Munchen, 80804, Germany
    J Addict Dis 24:17-29. 2005
    ..05) were associated with concomitant daily consumption of BZDs in opioid dependent subjects. These finding underline the need to further explore the causes, interactions and consequences of concomitant BZD and opiate use...
  28. doi request reprint Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
    ..Maintenance therapy is effective in the reduction in both narcotics-related and acquisition crime...
  29. ncbi request reprint Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine: results of a pooled analysis in 540 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, , Germany
    Eur Arch Psychiatry Clin Neurosci 256:395-401. 2006
    ..In line with previous research, the results from this study give further evidence that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for alcohol withdrawal treatment...
  30. ncbi request reprint Suicidal behavior in alcohol-dependent subjects: the role of personality disorders
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Alcohol Clin Exp Res 30:866-77. 2006
    ....
  31. ncbi request reprint Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    World J Biol Psychiatry 10:217-24. 2009
    ..2 to 39.8%. Withdrawal symptoms, craving and compliance improved significantly after transfer to (R)-methadone. We conclude that transfer from racemic to (R)-methadone is a safe and practical procedure...
  32. ncbi request reprint Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
    Susanne Rösner
    IFT, Institut für Therapieforschung, Munich, Germany
    J Psychopharmacol 22:11-23. 2008
    ..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
  33. ncbi request reprint Influence of anxiety on electrophysiological correlates of response inhibition capacities in alcoholism
    Susanne Karch
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:89-95. 2007
    ..The results emphasize the importance of monitoring trait anxiety in studies regarding cognitive functions in subjects with alcohol use disorder...
  34. doi request reprint Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
    ..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
  35. ncbi request reprint Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study
    Michael Soyka
    Psychiatric Hospital University of Munich, Munich, Germany
    Eur Addict Res 9:65-72. 2003
    ..Although the efficacy of flupenthixol as an anti-craving drug in dual diagnosis patients has to be explored in further studies, the drug may be considered a promising medication for these patients...
  36. doi request reprint High rehospitalization rate in alcohol-induced psychotic disorder
    Michael Soyka
    Private Hospital Meiringen, Willigen, 3860 Meiringen, Switzerland
    Eur Arch Psychiatry Clin Neurosci 263:309-13. 2013
    ..More follow-up studies are needed to elucidate this syndrome...
  37. ncbi request reprint Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Drugs R D 3:1-12. 2002
    ..To determine abstinence rates and to obtain safety data during the use of integrated therapy with acamprosate and the main established psychotherapeutic intervention programmes in the treatment of alcohol dependence...
  38. ncbi request reprint Association for methodology and documentation in psychiatry profiles predict later risk for criminal behavior and violent crimes in former inpatients with affective disorder
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 55:655-9. 2010
    ..As previously demonstrated in another sample of schizophrenic patients, the AMDP syndromes mania (and hostility) is associated with a higher risk of later criminal behavior...
  39. pmc Outpatient alcoholism treatment--24-month outcome and predictors of outcome
    Michael Soyka
    Private Hospital Meiringen, PO Box 612, CH 3860 Meiringen, Switzerland
    Subst Abuse Treat Prev Policy 4:15. 2009
    ..To study the value of demographic and alcohol-related variables for predicting 24-month treatment outcome in an outpatient setting...
  40. ncbi request reprint Association of personality disorders with Type A and Type B alcoholics
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:55-61. 2006
    ..The impact of other personality disorders does not play a substantial role in subtyping alcoholics...
  41. pmc Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study
    Peggy Schmidt
    Psychiatric Hospital, Ludwig Maximilians University, Nussbaumstr, 7, 80336 Munich, Germany
    Subst Abuse Treat Prev Policy 6:14. 2011
    ..The present study examined whether craving as measured by the obsessive-compulsive drinking scale (OCDS) predict long-term outcome in alcohol-dependent inpatients...
  42. ncbi request reprint [The relationship between self-efficacy and abstinence from alcohol after outpatient and inpatient treatment--a two year follow-up]
    Christina Zingg
    Privatklinik Meiringen, Meiringen, Schweiz
    Psychother Psychosom Med Psychol 59:307-13. 2009
    ..The strongest relationship between AASE and treatment outcome could be found for subjects in short-term inpatient treatment. The impact of the results for clinical practice is discussed...
  43. ncbi request reprint Emerging drugs to treat alcoholism
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7 80336 Munich, Germany
    Expert Opin Emerg Drugs 15:695-711. 2010
    ..Alcoholism is a widespread disorder with substantial mortality and negative treatment outcomes. To date, few medications have been found to reduce relapse rates or drinking in alcohol-dependent patients...
  44. ncbi request reprint Hyponatremia-induced seizure during carbamazepine treatment
    Bettina Holtschmidt-Taschner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 8:51-3. 2007
    ..CCT and ECG were normal. To our knowledge, this is the first description of a seizure related to hyponatremia in an adult carbamazepine-treated patient...
  45. ncbi request reprint A combination of carbamazepine/tiapride in outpatient alcohol detoxification. Results from an open clinical study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:197-200. 2002
    ..Results from this study suggest that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for outpatient alcohol detoxification in patients with moderate severity of withdrawal syndrome...
  46. ncbi request reprint Effects of irritability on craving before and after cue exposure in abstinent alcoholic inpatients: experimental data on subjective response and heart rate
    Sonnig S W Chiang
    Psychiatric Hospital of Munich University, Munich, Germany
    Neuropsychobiology 46:150-60. 2002
    ..Irritability is often linked with problem drinking. The aim of this study is to examine the possible influence of irritability on craving induced by a cue-exposure paradigm...
  47. doi request reprint Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:317-24. 2008
    ..Taking the substantial numbers of animal studies suggesting a possible role of CB1 antagonists for the treatment of alcohol dependence into account, it seems worthwhile to further test cannabinoid blockers in the treatment of alcoholism...
  48. ncbi request reprint Buprenorphine and buprenorphine/naloxone intoxication in children - how strong is the risk?
    Michael Soyka
    Department of Psychiatry, University of Munich, Germany
    Curr Drug Abuse Rev 6:63-70. 2013
    ..Although exposure to buprenorphine and other opioids remains a significant concern in children, the drug seems rather to be safe with respect to severe outcomes, in particular death. ..
  49. doi request reprint Nalmefene for treatment of alcohol dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7, D 80336 Munich, Germany
    Expert Opin Investig Drugs 19:1451-9. 2010
    ..Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge...
  50. ncbi request reprint SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
    ..Further analysis are needed to confirm these results...
  51. ncbi request reprint Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
    Hepatology 37:443-51. 2003
    ..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting...
  52. doi request reprint Prevalence of delusional jealousy in psychiatric disorders
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 56:450-2. 2011
    ..We conclude that delusional jealousy is a comparatively rare phenomenon that is most frequent in schizophrenia and related psychoses. Quite a number of affected patients are aggressive, which may indicate a risk of future violence...
  53. ncbi request reprint Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Am J Addict 12:S69-80. 2003
    ..Some centers suggest naltrexone not only for patients aiming for abstinence but also for patients for whom continued drinking is a therapeutic possibility or a clinical inevitability...
  54. ncbi request reprint Impact of craving on alcohol relapse during, and 12 months following, outpatient treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Alcohol Alcohol 39:357-61. 2004
    ..1995) and relapse during and after completion of an intensive outpatient treatment programme...
  55. pmc PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany Department of Psychiatry, Martin Luther University, Halle Wittenberg, Germany
    PLoS ONE 8:e78688. 2013
    ..The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach...
  56. ncbi request reprint Impact of different personality dimensions (NEO Five-Factor Inventory) on the outcome of alcohol-dependent patients 6 and 12 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 136:61-7. 2005
    ..These results are in line with prior research on this topic...
  57. pmc Neurobiology of aggression and violence in schizophrenia
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Schizophr Bull 37:913-20. 2011
    ..Neuroimaging studies may well help further elucidate the interrelationship between neurocognitive functioning, personality traits, and antisocial and violent behavior...
  58. ncbi request reprint Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  59. doi request reprint Buprenorphine and buprenorphine/naloxone soluble-film for treatment of opioid dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7 Munich Munich, Germany
    Expert Opin Drug Deliv 9:1409-17. 2012
    ..A novel buprenorphine/naloxone film has been developed with improved pharmacokinetics and a hopefully lower risk of diversion and accidental intoxications...
  60. ncbi request reprint Opioid antagonists for alcohol dependence
    Susanne Rösner
    Psychiatric Hospital, University of Munich, Nußbaumstr 7, Munich, Germany, 80336
    Cochrane Database Syst Rev 12:CD001867. 2010
    ..Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene...
  61. ncbi request reprint Effects of haloperidol and atypical neuroleptics on psychomotor performance and driving ability in schizophrenic patients. Results from an experimental study
    Sabine Kagerer
    Psychiatric Hospital, Dtstion C4, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 47:212-8. 2003
    ..Only 1 (5%) subject passed all subtests without major failures and could be regarded as competent to drive. Among patients with atypical neuroleptics, 7 patients (24%) passed all test parameters without major failures...
  62. ncbi request reprint Role of aggressivity on reactivity and craving before and after cue exposure in recently detoxified alcoholics: results from an experimental study
    S S Chiang
    Psychiatric Hospital of Munich University, Munich, Germany
    Eur Addict Res 7:184-92. 2001
    ..007. The results were discussed in the context of the Classical, Operant Conditioning Theory, the Cognitive Craving Theory of Tiffany, Gilbert's STAR Model, and the Self-Medication Hypothesis...
  63. ncbi request reprint Hypothalamic-pituitary-adrenal system regulation in recently detoxified alcoholics is not altered by one week of treatment with acamprosate
    U Zimmerman
    Max Planck Institute of Psychiatry, Munich, Germany
    Pharmacopsychiatry 37:98-102. 2004
    ..We therefore investigated whether acamprosate normalizes HPA hyperactivity in alcoholics within the first 3 weeks of abstinence, employing a combined dexamethasone/corticotropin-releasing hormone (Dex-CRH)-test...
  64. ncbi request reprint Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence
    M Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Pharmacopsychiatry 39:30-4. 2006
    ..Few medications have been tested for outpatient alcohol detoxification. Previously we had shown a combination of carbamazepine and tiapride to be effective in an open study. This database is an extension of our previous work...
  65. doi request reprint Buprenorphine use in pregnant opioid users: a critical review
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, Munich, Germany
    CNS Drugs 27:653-62. 2013
    ..These novel findings indicate that buprenorphine is emerging as a first-line treatment for pregnant opioid users...
  66. ncbi request reprint Thalamic hypofunction in alcohol hallucinosis: FDG PET findings
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 139:259-62. 2005
    ..When the second patient was retested after clinical recovery, FDG PET findings were normalized, suggesting the probable thalamic dysfunction to be a functional rather than a structural abnormality...
  67. doi request reprint Why should addiction medicine be an attractive field for young physicians?
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Addiction 104:169-72. 2009
    ..Yet, we believe that the medical specialties of addiction medicine/psychiatry are not attracting the interest and enthusiasm of young physicians. What can be done?..
  68. ncbi request reprint [Combined outpatient alcoholism therapy and occupational rehabilitation on welfare recipients--results of a pilot study]
    M Horak
    Klinik und Poliklinik für Psychiatrie und Psychotherapi, Munchen, Germany
    Fortschr Neurol Psychiatr 70:429-37. 2002
    ..We consider this pilot project a successful starting point for further development of treatment approaches targeted more specifically at this group of patients...
  69. ncbi request reprint Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism
    M Soyka
    Psychiatrische Klinik der Universität München, Munchen, Germany
    Eur Addict Res 6:57-63. 2000
    ..Our findings question the hypothesis of reduced platelet MAO activity to be a possible vulnerability marker for alcoholism...
  70. ncbi request reprint [Glutamatergic mechanisms in alcohol dependence--genetic, molecular-biological and neuropharmacological findings]
    M Soyka
    Psychiatrische Klinik der Universität München, Munich
    Fortschr Neurol Psychiatr 71:S45-50. 2003
    ..A better understanding of the glutamatergic mechanisms in alcohol dependence may therefore also be of relevance for the development of new anti-craving-drugs and therapy-research...
  71. ncbi request reprint Effects of cue exposure on the subjective perception of alcohol dependents with different types of cue reactivity
    S S W Chiang
    Psychiatric Hospital, Munich University, Munich, Germany
    J Neural Transm 112:1275-8. 2005
    ....
  72. pmc Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severity
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle Wittenberg, E 06097 Halle Saale, Germany
    Eur Addict Res 15:188-95. 2009
    ..The majority of alcohol-dependent individuals had one or more comorbid axis II disorders. Univariate and multivariate analyses indicate that different PDs are related to age at first dinking and alcoholism severity...
  73. ncbi request reprint No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Munich, Germany
    Addict Biol 9:73-9. 2004
    ..The possible implications of these findings are discussed...
  74. ncbi request reprint No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Alcohol Alcohol 37:174-8. 2002
    ..The negative results in this study question the role of these polymorphisms in the pathogenesis of alcohol withdrawal-induced seizures and delirium tremens...
  75. ncbi request reprint Association between suicide attempts and 5-HTTLPR-S-allele in alcohol-dependent and control subjects: further evidence from a German alcohol-dependent inpatient sample
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Biol Psychiatry 50:636-9. 2001
    ..A significant association between suicide attempts and the 5-HTT promoter polymorphisms (5-HTTLPR) S-allele has been reported in a sample of French alcohol-dependent subjects, and this paper evaluates this phenomenon in a German sample...
  76. ncbi request reprint Elevated serum levels of S-100B reflect the extent of brain injury in alcohol intoxicated patients after mild head trauma
    P Biberthaler
    Chirurgische Klinik, Klinikum Innenstadt, , , Munich, Germany
    Shock 16:97-101. 2001
    ..Alcohol intoxication did not elevate S-100B levels in group 3 or 4 subjects. Our data indicate for the first time that alcohol intoxication does not influence the diagnostic value of S-100B measurements in patients after MHT...
  77. ncbi request reprint Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoh
    B Hock
    Psychiatric Clinic of Ludwig Maximilian University, Munich, Germany
    Addiction 100:1477-86. 2005
    ....
  78. ncbi request reprint [Is the European Addiction Severity Index a useful tool in the diagnostic routines of alcohol dependence?]
    P Schmidt
    Psychiatrische Klinik der Ludwig Maximilians Universität München, Nussbaumstrasse 7, 80336 Munich, Germany
    Fortschr Neurol Psychiatr 75:541-8. 2007
    ..To study the validity of the EuropASI in the patient allocation context and to measure the alcohol severity changes with treatment...
  79. ncbi request reprint Alcoholism-related phenotypes and genetic variants of the CB1 receptor
    U W Preuss
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universität Muenchen, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 253:275-80. 2003
    ..The aim of this study is to test the potential influence of a bi-allelic cannabinoid receptor gene (CNR1) polymorphism (G1359A) on severe alcohol withdrawal syndromes...
  80. ncbi request reprint Phytohemagglutinin-stimulated calcium signal in lymphocytes of alcoholics before, during and after detoxification
    B Bondy
    Psychiatric Clinic, University of Munich, Munchen, Germany
    Psychiatry Res 81:157-62. 1998
    ..05), and especially for the sustained influx at the end of the observation period (P = 0.001). The detailed mechanisms of this disturbed calcium homeostasis need further investigation...
  81. ncbi request reprint [Cannabinoids and mental health]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen, Nussbaumstr 7, 80336 Munich
    Schmerz 17:268-73. 2003
    ..Chronic pain is only rarely mentioned as reasons for cannabis use, psychological or social reasons prevail. Psychiatric complications in cannabis consumers and its relevance for mental health are discussed...
  82. ncbi request reprint Serotonin transporter gene regulatory region polymorphism (5-HTTLPR), [3H]paroxetine binding in healthy control subjects and alcohol-dependent patients and their relationships to impulsivity
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munchen, Germany
    Psychiatry Res 96:51-61. 2000
    ..K(D) might be influenced by duration of alcohol dependence, but not sufficiently to yield differences between alcohol-dependent and control subjects...
  83. ncbi request reprint Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Neuropsychobiology 43:186-91. 2001
    ..Alcohol dependents were investigated because these personality disorders and impulsive behavior are very frequent in alcohol dependence anf of clinical relevance...
  84. ncbi request reprint Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:232-8. 2001
    ..Implications for the self-medication hypothesis for substance use in schizophrenia and future research in this area are discussed...
  85. ncbi request reprint Late auditory evoked potentials (P300) do not discriminate between subgroups of alcohol-dependent patients defined by family history and antisocial personality traits
    U W Preuss
    Dept of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur J Med Res 4:114-20. 1999
    ..In conclusion, auditory P300 had a low discriminative power with regards to subgroups of inpatient alcoholics defined by family history and antisocial personality traits. Reasons for the negative findings in this study are discussed...
  86. ncbi request reprint Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
    M Soyka
    Psychiatric Hospital University of Munich, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur Neuropsychopharmacol 10:325-32. 2000
    ..Future studies should focus on dosing issues, the differentiation between short- and long-term effects and the identification of subgroups of patients with particular psychopathology...
  87. doi request reprint No association of alcohol dependence with HOMER 1 and 2 genetic variants
    U W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Halle Wittenberg, Halle Saale, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1102-9. 2010
    ..In conclusion, our results suggest that single SNPs, respectively, haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of AD...
  88. ncbi request reprint Association of 5-HT1B receptor gene and antisocial behavior in alcoholism
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Neural Transm 111:101-9. 2004
    ..Adult antisocial personality occurred more often in males than females. Possible implications of these findings are discussed...
  89. ncbi request reprint PET and SPECT findings in alcohol hallucinosis: case report and super-brief review of the pathophysiology of this syndrome
    M Soyka
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 1:215-8. 2000
    ..Current IBZM SPECT data do not support a dopamine receptor dysfunction in alcohol hallucinosis but TRODAT SPECT showed reduced dopamine transporter binding. Possible implications of these findings are discussed...
  90. ncbi request reprint Chronological relationship between antisocial personality disorder and alcohol dependence
    M Bahlmann
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Eur Addict Res 8:195-200. 2002
    ..This finding suggests that in patients with ASPD, alcohol dependence might be a secondary syndrome as suggested by previous research...
  91. ncbi request reprint Fatal poisoning in methadone and buprenorphine treated patients -- are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Pharmacopsychiatry 39:85-7. 2006
    ..Some recent studies have suggested a lower risk of fatal intoxications in drug-dependent patients under buprenorphine compared to methadone treatment...
  92. ncbi request reprint Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
    M Soyka
    Psychiatric Hospital of Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    J Psychiatr Res 36:429-35. 2002
    ..These findings are in line with a number of more recent studies questioning the association between novelty-seeking and DRD4 dopamine receptor gene polymorphism. Possible implications of these findings are discussed...
  93. ncbi request reprint Impulsivity and aggression as predictors of suicide attempts in alcoholics
    G Koller
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:155-60. 2002
    ..Furthermore, the potential influence of concurrent personality disorders and depressive conditions were assessed...
  94. ncbi request reprint Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
    U W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Pharmacogenomics J 6:34-41. 2006
    ..Although this result is suggestive for a significant role of this polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals, further investigation and confirmation are warranted...
  95. ncbi request reprint Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral results
    W M Wong
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 41:72-8. 2008
    ..Furthermore we wanted to know whether functional polymorphisms (5-HTTLPR and 5HT2C Ser23Cys), have any influence on this responsivity...
  96. ncbi request reprint Prevalence of alcohol and drug abuse in schizophrenic inpatients
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 242:362-72. 1993
    ..Dual diagnosis" schizophrenics had a significantly higher rate of suicide attempts and were less likely to be married. Possible clinical implications of these findings are discussed...
  97. ncbi request reprint GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal
    D Rujescu
    Department of Psychiatry, University of Munich, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 133:85-7. 2005
    ..These findings support the hypothesis that the GRIN1 locus may modify the susceptibility to seizures during alcohol withdrawal. This novel finding warrants replication...
  98. ncbi request reprint Buprenorphine and methadone in the treatment of opioid dependence: methods and design of the COBRA study
    Hans Ulrich Wittchen
    Institut für Klinische Psychologie und Psychotherapie, TU Dresden, Germany
    Int J Methods Psychiatr Res 14:14-28. 2005
    ..The COBRA study provides a unique comprehensive database, informing about the natural allocation and intervention processes in routine care and about the course and outcome of patients treated with buprenorphine or methadone...
  99. ncbi request reprint Polymorphisms in the NMDA subunit 2B are not associated with alcohol dependence and alcohol withdrawal-induced seizures and delirium tremens
    Andre Tadic
    Dept of Psychiatry, University of Mainz, 55131 Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 255:129-35. 2005
    ..Moreover, we hypothesized that another genetic variation within GRIN2B (rs1806191) may have an effect in the etiology of alcoholism or withdrawal-related traits...
  100. ncbi request reprint The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    Rainer Spanagel
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Nat Med 11:35-42. 2005
    ..Collectively, these data establish glutamate as a link between dysfunction of the circadian clock gene Per2 and enhanced alcohol intake...
  101. ncbi request reprint Alcohol consumption in heroin users, methadone-substituted and codeine-substituted patients--frequency and correlates of use
    Markus Backmund
    Addiction Medicine, General Hospital Munich Schwabing, Germany
    Eur Addict Res 9:45-50. 2003
    ..Alcohol consumption by opioid-addicted patients treated with methadone or DHC presents a serious medical problem. Co-abuse of alcohol will receive more attention...