Egemen Savaskan

Summary

Affiliation: Psychiatric University Clinics
Country: Switzerland

Publications

  1. ncbi Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    Egemen Savaskan
    Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
    Int J Neuropsychopharmacol 9:507-16. 2006
  2. ncbi The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
  3. ncbi Distribution of melatonin MT1 receptor immunoreactivity in human retina
    Egemen Savaskan
    Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    J Histochem Cytochem 50:519-26. 2002
  4. ncbi Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    J Pineal Res 38:10-6. 2005
  5. ncbi Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
  6. ncbi Humour therapy in patients with late-life depression or Alzheimer's disease: a pilot study
    Marc Walter
    Psychiatric University Clinics, University of Basel, Basel, Switzerland
    Int J Geriatr Psychiatry 22:77-83. 2007
  7. ncbi Orexins and their receptors in the human retina
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Pathobiology 71:211-6. 2004
  8. ncbi Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
    Appl Immunohistochem Mol Morphol 13:190-3. 2005
  9. ncbi Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Basel, Switzerland
    Gerontology 49:380-3. 2003
  10. ncbi Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004

Collaborators

Detail Information

Publications17

  1. ncbi Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine
    Egemen Savaskan
    Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
    Int J Neuropsychopharmacol 9:507-16. 2006
    ..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol...
  2. ncbi The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  3. ncbi Distribution of melatonin MT1 receptor immunoreactivity in human retina
    Egemen Savaskan
    Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    J Histochem Cytochem 50:519-26. 2002
    ..In AD cases photoreceptor cells were degenerated and showed low MT1 expression...
  4. ncbi Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    J Pineal Res 38:10-6. 2005
    ..The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD...
  5. ncbi Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly
    Paola Fontana Gasio
    Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
    Exp Gerontol 38:207-16. 2003
    ..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so...
  6. ncbi Humour therapy in patients with late-life depression or Alzheimer's disease: a pilot study
    Marc Walter
    Psychiatric University Clinics, University of Basel, Basel, Switzerland
    Int J Geriatr Psychiatry 22:77-83. 2007
    ..Therefore non-pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD...
  7. ncbi Orexins and their receptors in the human retina
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Pathobiology 71:211-6. 2004
    ..In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained...
  8. ncbi Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampus
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
    Appl Immunohistochem Mol Morphol 13:190-3. 2005
    ..Rather, these data may indicate a general role for FAP-1 in neuronal death both in adult CNS and during the course of neurodegenerative disorders...
  9. ncbi Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity
    Egemen Savaskan
    Psychiatric Clinic, University of Basel, Basel, Switzerland
    Gerontology 49:380-3. 2003
    ..Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol...
  10. ncbi Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissues
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    Ophthalmic Res 36:312-20. 2004
    ..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis...
  11. doi The circadian rest-activity cycle in Korsakoff psychosis
    Anna Wirz-Justice
    Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
    Am J Geriatr Psychiatry 18:33-41. 2010
    ..This pilot study investigated the rest-activity cycle of KP to see whether there were sleep-wake cycle disturbances similar to those that the authors had observed in patients with AD...
  12. ncbi Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    J Pineal Res 32:59-62. 2002
    ..There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects...
  13. ncbi The role of the brain renin-angiotensin system in neurodegenerative disorders
    Egemen Savaskan
    Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
    Curr Alzheimer Res 2:29-35. 2005
    ..The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders...
  14. ncbi Skill learning in patients with moderate Alzheimer's disease: a prospective pilot-study of waltz-lessons
    Alexander Rösler
    Department of Neurology, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
    Int J Geriatr Psychiatry 17:1155-6. 2002
    ..Patients with AD showed a significant effect in procedural learning whereas depressed patients did not. These findings suggest potential implications for therapeutic interventions in patients with moderate AD...
  15. ncbi Colour vision deficiencies in Alzheimer's disease
    Mona Pache
    University Eye Clinic, Mittlere Strasse 91, CH 4012 Basel, Switzerland
    Age Ageing 32:422-6. 2003
    ..In this study, colour vision of Alzheimer's disease patients was tested using the Ishihara test and the PV-16 choice test. The latter test, primarily designed for children, was chosen in order to avoid problems due to cognitive decline...
  16. ncbi Decline in long-term circadian rest-activity cycle organization in a patient with dementia
    Esther Werth
    Centre for Chronobiology and Alzheimer s Research Group, Psychiatric University Clinic Basel, Switzerland
    J Geriatr Psychiatry Neurol 15:55-9. 2002
    ..Pacing, a nonphotic zeitgeber strengthening, led to improved synchronization of the rest-activity cycle...
  17. ncbi Antidepressive therapy with escitalopram improves mood, cognitive symptoms, and identity memory for angry faces in elderly depressed patients
    Egemen Savaskan
    Division of Psychiatry Research and Psychogeriatric Medicine, Zurich, Switzerland
    Int J Neuropsychopharmacol 11:381-8. 2008
    ..In conclusion, escitalopram, even after a relatively short treatment period, was effective in treating depression in the elderly and may help improve cognitive performance for social stimuli...