Research Topics
Species | Egemen SavaskanSummaryAffiliation: Psychiatric University Clinics Country: Switzerland Publications
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Detail Information
Publications
Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapineEgemen Savaskan
Geriatric Psychiatry, University Psychiatric Hospitals, CH 4025 Basel, Switzerland
Int J Neuropsychopharmacol 9:507-16. 2006..The study provides evidence that quetiapine at a moderate dose may be efficacious in treating behavioural disturbances in AD, with better tolerability than haloperidol...- The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's diseaseEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
Curr Alzheimer Res 4:47-51. 2007..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder... - Distribution of melatonin MT1 receptor immunoreactivity in human retinaEgemen Savaskan
Department of Gerontopsychiatry, Psychiatric University Clinic, University of Basel, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
J Histochem Cytochem 50:519-26. 2002..In AD cases photoreceptor cells were degenerated and showed low MT1 expression... - Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's diseaseEgemen Savaskan
Psychiatric University Clinic, University of Basel, Basel, Switzerland
J Pineal Res 38:10-6. 2005..The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD... - Humour therapy in patients with late-life depression or Alzheimer's disease: a pilot studyMarc Walter
Psychiatric University Clinics, University of Basel, Basel, Switzerland
Int J Geriatr Psychiatry 22:77-83. 2007..Therefore non-pharmacological treatment strategies are of great importance. The aim of the present study was to investigate the impact of humour therapy on quality of life in patients with depression or AD... - Orexins and their receptors in the human retinaEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
Pathobiology 71:211-6. 2004..In the human retina, however, immunohistochemical localization of orexins and their receptors, OX-R1 and OX-R2, has not been ascertained... - Immunohistochemical Localization of Fas-associated phosphatase-1 (FAP-1) in Alzheimer disease hippocampusEgemen Savaskan
Psychiatric Clinic, University of Basel, Wilhelm Klein Str 27, Basel, Switzerland
Appl Immunohistochem Mol Morphol 13:190-3. 2005..Rather, these data may indicate a general role for FAP-1 in neuronal death both in adult CNS and during the course of neurodegenerative disorders... - Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderlyPaola Fontana Gasio
Centre for Chronobiology, Psychiatric University Clinic, Basel, Switzerland
Exp Gerontol 38:207-16. 2003..Increasing zeitgeber strength is an important strategy for improving sleep quality and timing in dementia, and DDS light therapy may provide one of the appropriate means to do so... - Red wine ingredient resveratrol protects from beta-amyloid neurotoxicityEgemen Savaskan
Psychiatric Clinic, University of Basel, Basel, Switzerland
Gerontology 49:380-3. 2003..Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol... - Immunohistochemical localization of angiotensin-converting enzyme, angiotensin II and AT1 receptor in human ocular tissuesEgemen Savaskan
Psychiatric University Clinic, University of Basel, Basel, Switzerland
Ophthalmic Res 36:312-20. 2004..The manifold localization sites of the observed antigens point to rather generalized functions of the RAS in human ocular tissues, such as regulatory effects on neuronal cells, vessels and vitreous humor homeostasis... - Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patientsEgemen Savaskan
Psychiatric University Clinic, Basel, Switzerland
J Pineal Res 32:59-62. 2002..There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects... 
The circadian rest-activity cycle in Korsakoff psychosisAnna Wirz-Justice
Centre for Chronobiology, Psychiatric Hospital of University Basel, Basel, Switzerland
Am J Geriatr Psychiatry 18:33-41. 2010..This pilot study investigated the rest-activity cycle of KP to see whether there were sleep-wake cycle disturbances similar to those that the authors had observed in patients with AD...- The role of the brain renin-angiotensin system in neurodegenerative disordersEgemen Savaskan
Psychiatric University Clinic, Wilhelm Klein Str 27, CH 4025 Basel, Switzerland
Curr Alzheimer Res 2:29-35. 2005..The aim of this brief review is to summarize the current state of research in this field with emphasis on RAS-related alterations during the course of neurodegenerative disorders... - Skill learning in patients with moderate Alzheimer's disease: a prospective pilot-study of waltz-lessonsAlexander Rösler
Department of Neurology, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt, Germany
Int J Geriatr Psychiatry 17:1155-6. 2002..Patients with AD showed a significant effect in procedural learning whereas depressed patients did not. These findings suggest potential implications for therapeutic interventions in patients with moderate AD... - Colour vision deficiencies in Alzheimer's diseaseMona Pache
University Eye Clinic, Mittlere Strasse 91, CH-4012 Basel, Switzerland
Age Ageing 32:422-6. 2003..0008) than the controls. No relation between test performance and severity of Alzheimer's disease was found. CONCLUSIONS: Alzheimer's disease patients have an unspecific colour vision deficiency independent of the severity of the disease... - Decline in long-term circadian rest-activity cycle organization in a patient with dementiaEsther Werth
Centre for Chronobiology and Alzheimer's Research Group, Psychiatric University Clinic Basel, Switzerland
J Geriatr Psychiatry Neurol 15:55-9. 2002..Pacing, a nonphotic zeitgeber strengthening, led to improved synchronization of the rest-activity cycle... - Antidepressive therapy with escitalopram improves mood, cognitive symptoms, and identity memory for angry faces in elderly depressed patientsEgemen Savaskan
Division of Psychiatry Research and Psychogeriatric Medicine, Zurich, Switzerland
Int J Neuropsychopharmacol 11:381-8. 2008..In conclusion, escitalopram, even after a relatively short treatment period, was effective in treating depression in the elderly and may help improve cognitive performance for social stimuli...