Lawrence Rajendran

Summary

Affiliation: Psychiatric University Hospital
Country: Switzerland

Publications

  1. pmc Cellular basis of Alzheimer's disease
    Jitin Bali
    Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    Ann Indian Acad Neurol 13:S89-93. 2010
  2. doi Membrane trafficking pathways in Alzheimer's disease
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, August Forel Str 1, Zurich 8008, Switzerland
    Traffic 13:759-70. 2012
  3. doi Lipid-anchored drugs for delivery into subcellular compartments
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Trends Pharmacol Sci 33:215-22. 2012
  4. pmc Flotillins are involved in the polarization of primitive and mature hematopoietic cells
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Department of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e8290. 2009
  5. doi Subcellular targeting strategies for drug design and delivery
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Rev Drug Discov 9:29-42. 2010
  6. pmc Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides
    Jitin Bali
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:15307-11. 2012
  7. ncbi Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    Zoe V Goodger
    Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Cell Sci 122:3703-14. 2009
  8. doi Retromers in Alzheimer's disease
    Barbara M Siegenthaler
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 10:116-21. 2012
  9. doi Membrane anchored and lipid raft targeted β-secretase inhibitors for Alzheimer's disease therapy
    Saoussen Ben Halima
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Alzheimers Dis 24:143-52. 2011
  10. pmc A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production
    Vinod Udayar
    Systems and Cell Biology of Neurodegeneration, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Division of Psychiatry Research, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Graduate Program of the Zurich Neuroscience Center, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Erasmus Mundus Joint Doctorate Program, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland
    Cell Rep 5:1536-51. 2013

Collaborators

Detail Information

Publications10

  1. pmc Cellular basis of Alzheimer's disease
    Jitin Bali
    Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    Ann Indian Acad Neurol 13:S89-93. 2010
    ..In this review, we summarize the key cellular events that lead to the progression of AD...
  2. doi Membrane trafficking pathways in Alzheimer's disease
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, August Forel Str 1, Zurich 8008, Switzerland
    Traffic 13:759-70. 2012
    ..Here, we discuss an update of our current appraisal on how membrane trafficking may play an important role in the pathogenesis of the disease and how this could be exploited for effective therapy...
  3. doi Lipid-anchored drugs for delivery into subcellular compartments
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Trends Pharmacol Sci 33:215-22. 2012
    ..In this review, we focus on the importance of subcellular targeting of drugs, in particular, the mechanism of lipid-anchoring as a novel strategy and its potential application for the treatment of several diseases...
  4. pmc Flotillins are involved in the polarization of primitive and mature hematopoietic cells
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Department of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e8290. 2009
    ..Many molecules implicated in migratory polarity show uniform cellular distribution under non-activated conditions, but acquire a polarized localization upon exposure to migratory cues...
  5. doi Subcellular targeting strategies for drug design and delivery
    Lawrence Rajendran
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Rev Drug Discov 9:29-42. 2010
    ..In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery...
  6. pmc Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides
    Jitin Bali
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:15307-11. 2012
    ..However, unlike the genes underlying familial AD, late onset AD-susceptibility genes do not specifically alter the Aβ42/40 ratios and suggest that these genes probably contribute to AD through distinct mechanisms...
  7. ncbi Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    Zoe V Goodger
    Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Cell Sci 122:3703-14. 2009
    ..This suggests that amyloidogenic cleavage, despite representing the minor cleavage pathway of APP, is predominantly responsible for AICD-mediated nuclear signaling...
  8. doi Retromers in Alzheimer's disease
    Barbara M Siegenthaler
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 10:116-21. 2012
    ..Misregulation of retromers or retromer-associated proteins influences endosomal localization of APP/BACE1. Here we review the role of retromers in the amyloidogenic processing of APP and their pathogenic role in AD...
  9. doi Membrane anchored and lipid raft targeted β-secretase inhibitors for Alzheimer's disease therapy
    Saoussen Ben Halima
    Systems and Cell Biology of Neurodegeneration, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Alzheimers Dis 24:143-52. 2011
    ..Not only for β-secretase, this strategy could be applied for many membrane targets that are localized either at the plasma membrane or in the endocytic compartments...
  10. pmc A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production
    Vinod Udayar
    Systems and Cell Biology of Neurodegeneration, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Division of Psychiatry Research, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Graduate Program of the Zurich Neuroscience Center, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland Erasmus Mundus Joint Doctorate Program, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland
    Cell Rep 5:1536-51. 2013
    ..Our results reveal trafficking pathways that regulate Aβ levels and show how systems biology approaches can unravel the molecular complexity underlying AD...