Boris B Quednow

Summary

Affiliation: Psychiatric University Hospital
Country: Switzerland

Publications

  1. doi Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [18F]altanserin positron emission tomography
    Boris B Quednow
    Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, Zurich, Switzerland
    Neuroimage 59:3922-32. 2012
  2. pmc Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism
    Boris B Quednow
    University Hospital of Psychiatry, University of Zurich, Lenggstrasse31, CH 8032 Zurich, Switzerland
    Schizophr Bull 36:341-6. 2010
  3. doi Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
  4. doi Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
  5. doi Sensorimotor gating and attentional set-shifting are improved by the mu-opioid receptor agonist morphine in healthy human volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Experimental Psychopathology and Brain Imaging, University of Zurich, Switzerland
    Int J Neuropsychopharmacol 11:655-69. 2008
  6. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
  7. doi The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Division of Experimental and Clinical Pharmacopsychology, University of Zurich, CH 8032 Zurich, Switzerland
    J Neurosci 31:6684-91. 2011
  8. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
  9. doi Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010

Detail Information

Publications40

  1. doi Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [18F]altanserin positron emission tomography
    Boris B Quednow
    Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, Zurich, Switzerland
    Neuroimage 59:3922-32. 2012
    ....
  2. pmc Sensorimotor gating of schizophrenia patients depends on Catechol O-methyltransferase Val158Met polymorphism
    Boris B Quednow
    University Hospital of Psychiatry, University of Zurich, Lenggstrasse31, CH 8032 Zurich, Switzerland
    Schizophr Bull 36:341-6. 2010
    ..These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia as well. In concert with other findings, our data suggest that PPI is a polygenic trait...
  3. doi Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  4. doi Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  5. doi Sensorimotor gating and attentional set-shifting are improved by the mu-opioid receptor agonist morphine in healthy human volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Experimental Psychopathology and Brain Imaging, University of Zurich, Switzerland
    Int J Neuropsychopharmacol 11:655-69. 2008
    ....
  6. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
    ..Therefore, we aimed to replicate these results and investigated the impact of the related polymorphisms on PPI in healthy human volunteers...
  7. doi The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Division of Experimental and Clinical Pharmacopsychology, University of Zurich, CH 8032 Zurich, Switzerland
    J Neurosci 31:6684-91. 2011
    ..Sensorimotor gating is modulated by TCF4 genotype, indicating an influential role of TCF4 gene variations in the development of early information-processing deficits in schizophrenia...
  8. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  9. doi Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
    ..Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters...
  10. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  11. doi Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  12. ncbi Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
    ..Thus, we compared the effects of a combined 5-HT2A/D2 and a pure D2/D3 antagonist on PPI and habituation of ASR in patients with schizophrenia...
  13. doi The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  14. doi Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  15. doi The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  16. doi Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  17. ncbi Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs...
  18. doi Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  19. ncbi Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 175:399-406. 2004
    ..Studies with rodents suggest that an increase or decrease in serotonin level in the brain alters several modalities of the ASR. So far, little is known about serotonergic and noradrenergic startle modulation in humans...
  20. doi From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  21. ncbi Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 92:299-303. 2006
    ..Thus, we investigated PPI and habituation of ASR in suicidal patients with depressive disorders as potential biological markers for suicidal behavior...
  22. doi Startle cue-reactivity differentiates between light and heavy smokers
    Anne K Rehme
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Addiction 104:1757-64. 2009
    ..The goal of the present study was to investigate (i) whether smoking scenes induce appetitive cue effects in smokers, and (ii) whether smoking intensity is related to cue-reactivity...
  23. ncbi Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy")
    Boris B Quednow
    Department of Psychiatry, University of Zurich, Lenggstrasse 31, CH 8008, Zurich, Switzerland
    Psychopharmacology (Berl) 189:517-30. 2007
    ..In fact, MDMA users have shown elevated impulsivity in two studies, but little is known about decision making in drug-free MDMA consumers...
  24. ncbi Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 257:389-95. 2007
    ..The role of impulsivity/orbitofrontal associated executive functioning in remitted depression has not yet been examined...
  25. doi On the influence of baseline startle reactivity on the indexation of prepulse inhibition
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Behav Neurosci 122:885-900. 2008
    ....
  26. pmc Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers
    Boris B Quednow
    Neuropsychopharmacology and Brain Imaging, Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, Heffter Research Center, Zurich, Switzerland
    Neuropsychopharmacology 37:630-40. 2012
    ..Sensorimotor gating and attentional control deficits of schizophrenia patients might be due to changes within the 5-HT(2A)R system...
  27. ncbi Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Psychopharmacol 20:373-84. 2006
    ..These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex...
  28. ncbi Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Biol Psychol 71:256-63. 2006
    ..Nevertheless, PPI was reliable across three test sessions, indicating that the significant attenuation of PPI over time was a consistent phenomenon. These results suggest that PPI exhibits short- and long-term attenuation...
  29. doi Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 221:27-38. 2012
    ..The response to acute nicotine is heterogeneous across subjects and samples; however, only a few reliable predictors of response have been identified...
  30. doi Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013
    ..Instead, the findings likely represent genuine nicotine-induced enhancement of cognitive performance. ..
  31. ncbi The monotonic dependency of prepulse inhibition of the acoustic startle reflex on the intensity of the startle-eliciting stimulus
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Behav Brain Res 174:143-50. 2006
    ....
  32. ncbi The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval
    Franz X Vollenweider
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Neuropsychopharmacology 32:1876-87. 2007
    ....
  33. ncbi Prepulse inhibition and habituation of acoustic startle response in male MDMA ('ecstasy') users, cannabis users, and healthy controls
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Neuropsychopharmacology 29:982-90. 2004
    ..Use of cannabis does not lead to alterations of amplitude, habituation, or PPI of ASR...
  34. doi The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Psychopharmacology (Berl) 229:31-40. 2013
    ..Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence...
  35. pmc Verbal Memory Deficits Are Correlated with Prefrontal Hypometabolism in (18)FDG PET of Recreational MDMA Users
    Oliver G Bosch
    Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry, Zurich, Switzerland
    PLoS ONE 8:e61234. 2013
    ..Thus, we investigated the relation of verbal memory deficits with alterations of regional cerebral brain glucose metabolism (rMRGlu) in recreational MDMA users...
  36. ncbi Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder
    Klaus Hoenig
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 57:1153-8. 2005
    ..However, there is only preliminary evidence about impaired PPI in OCD so far...
  37. doi Cognitive dysfunctions in recreational and dependent cocaine users: role of attention-deficit hyperactivity disorder, craving and early age at onset
    Matthias Vonmoos
    University Hospital of Psychiatry, Clinical and Experimental Pharmacopsychology, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Br J Psychiatry 203:35-43. 2013
    ..Dependent cocaine users consistently display cognitive deficits but cognitive performance of recreational cocaine users has rarely been investigated...
  38. doi Increased sensorimotor gating in recreational and dependent cocaine users is modulated by craving and attention-deficit/hyperactivity disorder symptoms
    Katrin H Preller
    Experimental and Clinical Pharmacopsychology, Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, Zurich, Switzerland
    Biol Psychiatry 73:225-34. 2013
    ..Moreover, the influences of methylenedioxymethamphetamine and cannabis co-use, craving, and attention-deficit/hyperactivity disorder (ADHD) symptoms on startle measures were examined...
  39. ncbi Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  40. doi Reconsidering GHB: orphan drug or new model antidepressant?
    Oliver G Bosch
    Clinic of Affective Disorders and General Psychiatry, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland
    J Psychopharmacol 26:618-28. 2012
    ..This article discusses the unique neurobiological effects of GHB, its misuse potential and possible role as a model substance for the development of novel pharmacological treatment strategies in depressive disorders...