Roger M Nitsch

Summary

Affiliation: Psychiatric University Hospital
Country: Switzerland

Publications

  1. pmc Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Susann Cattepoel
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e18296. 2011
  2. doi request reprint Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
  3. ncbi request reprint Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit
    Raphael Poirier
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
    Neurobiol Dis 24:475-83. 2006
  4. doi request reprint Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
  5. ncbi request reprint A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
  6. ncbi request reprint Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
  7. ncbi request reprint Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
  8. ncbi request reprint Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
  9. pmc The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
    Arames Crameri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    EMBO J 25:432-43. 2006
  10. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009

Collaborators

Detail Information

Publications66

  1. pmc Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Susann Cattepoel
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e18296. 2011
    ..Additionally, our observations support the possibility that Aβ-directed immunotherapy can reduce Aβ deposition in brain vessels in transgenic mice...
  2. doi request reprint Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy
    Roger M Nitsch
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurotherapeutics 5:415-20. 2008
    ....
  3. ncbi request reprint Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit
    Raphael Poirier
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
    Neurobiol Dis 24:475-83. 2006
    ....
  4. doi request reprint Prion protein M129V polymorphism affects retrieval-related brain activity
    Andreas Buchmann
    Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
    Neuropsychologia 46:2389-402. 2008
    ..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours...
  5. ncbi request reprint A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    J Clin Psychiatry 66:940-7. 2005
    ..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease...
  6. ncbi request reprint Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
    ..Further studies are required to determine whether modifications of our protocol could affect the Abeta42-mediated induction of NFT formation...
  7. ncbi request reprint Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ....
  8. ncbi request reprint Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
    ..This protocol may prove useful for the rapid validation of the activity of antibodies designed to be used in immune therapy of AD...
  9. pmc The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
    Arames Crameri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    EMBO J 25:432-43. 2006
    ..Pharmacological enhancement of seladin-1 activity may be a novel Abeta-lowering approach for the treatment of AD...
  10. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
    ..These data indicate that desmosterol can replace cholesterol in membrane-related functions in the DHCR24(-/-) mouse...
  11. ncbi request reprint Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...
  12. ncbi request reprint Active immunization of mice with an Abeta-Hsp70 vaccine
    Michael F Koller
    Institute of Biochemistry, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:20-8. 2004
    ..These data emphasize the need for anti-Abeta antibodies that remove Abeta peptides from the central nervous system without negative side effects...
  13. ncbi request reprint Glucocorticoid-related genetic susceptibility for Alzheimer's disease
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 13:47-52. 2004
    ..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease...
  14. ncbi request reprint Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo
    Rime Madani
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    J Neurosci Res 84:1871-8. 2006
    ....
  15. pmc Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories
    Uwe Konietzko
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008 Zurich, Switzerland
    Neurobiol Aging 31:58-73. 2010
    ..Fe65 and Tip60 also co-localized with APP in the neurites of primary neurons. Pre-assembled AFT complexes may serve to assist fast nuclear signaling upon endoproteolytic APP cleavage...
  16. ncbi request reprint Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Neuroreport 16:839-42. 2005
    ..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory...
  17. ncbi request reprint Effects of memory consolidation on human hippocampal activity during retrieval
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Cortex 41:486-98. 2005
    ..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h...
  18. ncbi request reprint Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers
    Christian R A Mondadori
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Cereb Cortex 17:1934-47. 2007
    ..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans...
  19. ncbi request reprint No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005
    ..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low...
  20. ncbi request reprint Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42
    Alessia Maddalena
    Division of Psychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:1202-6. 2003
    ....
  21. ncbi request reprint Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms
    Marlen Knobloch
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Neurosci 27:7648-53. 2007
    ..Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology...
  22. ncbi request reprint Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
    Marlen Knobloch
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 28:1297-306. 2007
    ..The co-incidence of intracellular Abeta deposits with behavioral deficits support an early role of intracellular Abeta in the pathophysiological cascade leading to beta-amyloid formation and functional impairment...
  23. doi request reprint Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice
    Samira Kocherhans
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Neurosci 30:9228-40. 2010
    ....
  24. ncbi request reprint One month of human memory consolidation enhances retrieval-related hippocampal activity
    Simone Bosshardt
    Division of Psychiatry Research, University of Zurich, Switzerland
    Hippocampus 15:1026-40. 2005
    ....
  25. doi request reprint RAGE does not affect amyloid pathology in transgenic ArcAbeta mice
    Ivana Vodopivec
    Division of Psychiatry Research, University of Zurich, Ch 8008 Zurich, Switzerland ivana vodopivec bli uzh ch
    Neurodegener Dis 6:270-80. 2009
    ..While numerous experiments addressed Abeta toxicity, the mechanisms are still not fully understood. The receptor for advanced glycation end products (RAGE) binds Abeta and was suggested to be involved in the pathological processes of AD...
  26. ncbi request reprint Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 32:1827-38. 2011
    ..These results suggest an age-dependent mutual reinforcement of the tau pathology and mitochondrial dysfunction in vivo, which may contribute to neurodegeneration in patients suffering from AD and other age-related tauopathies...
  27. ncbi request reprint Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's disease
    Jan G Schiltz
    Institute if Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
    J Mol Med (Berl) 82:706-14. 2004
    ..The monoclonal antibodies are applicable for passive immunization studies and may lead to a therapy of AD...
  28. ncbi request reprint A functional genetic variation of the 5-HT2a receptor affects human memory
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Nat Neurosci 6:1141-2. 2003
    ..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant...
  29. ncbi request reprint Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology
    Alessia S Maddalena
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:231-5. 2004
    ..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies...
  30. ncbi request reprint Genetic association study on colony-stimulating factor 1 in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 3:334-7. 2006
    ..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD...
  31. ncbi request reprint ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
    Neurobiol Aging 24:421-6. 2003
    ..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis...
  32. ncbi request reprint Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway
    Zoe V Goodger
    Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Cell Sci 122:3703-14. 2009
    ..This suggests that amyloidogenic cleavage, despite representing the minor cleavage pathway of APP, is predominantly responsible for AICD-mediated nuclear signaling...
  33. ncbi request reprint Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Neuron 38:547-54. 2003
    ..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease...
  34. ncbi request reprint The prion gene is associated with human long-term memory
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
    Hum Mol Genet 14:2241-6. 2005
    ..These results suggest a role for the prion protein in the formation of long-term memory in humans...
  35. ncbi request reprint Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomy
    Katharina Henke
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuroreport 14:1197-202. 2003
    ..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL...
  36. ncbi request reprint Clinical observations with AN-1792 using TAPIR analyses
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:273-6. 2005
    ..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease...
  37. doi request reprint Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice
    Barbara Biscaro
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Neurosci 29:14108-19. 2009
    ....
  38. ncbi request reprint Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 562:16-21. 2004
    ..Therefore, we suggest that the potential of NEP for AD therapy is age-dependent and most effective early in the course of AD pathophysiology...
  39. ncbi request reprint The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease
    Ruth C von Rotz
    Division of Psychiatry Research, University of Zurich, Switzerland
    Eur J Neurosci 21:1289-98. 2005
    ..However, the up-regulation of dactylidin in highly vulnerable brain tissues of AD patients was confirmed by a quantitative PCR approach, suggesting that dactylidin may function early in the progression of neurodegenerative diseases...
  40. ncbi request reprint Implicit associative learning engages the hippocampus and interacts with explicit associative learning
    Nadia Degonda
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neuron 46:505-20. 2005
    ..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory...
  41. ncbi request reprint Low-dose cortisol for symptoms of posttraumatic stress disorder
    Amanda Aerni
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Am J Psychiatry 161:1488-90. 2004
    ....
  42. pmc Turnover of amyloid precursor protein family members determines their nuclear signaling capability
    Manuel T Gersbacher
    Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e69363. 2013
    ....
  43. ncbi request reprint Association study of cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurogenetics 8:179-88. 2007
    ..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples...
  44. doi request reprint Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease
    Barbara Biscaro
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 9:187-98. 2012
    ..Microglia are known to modulate adult hippocampal neurogenesis...
  45. ncbi request reprint Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo
    Meret N M Gaugler
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 579:753-6. 2005
    ....
  46. ncbi request reprint Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobe
    Dominique J F de Quervain
    Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
    Eur J Neurosci 17:1296-302. 2003
    ....
  47. doi request reprint Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice
    Jan Klohs
    Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 32:1705-13. 2012
    ..The study demonstrated that remodeling of the cerebrovasculature can be monitored noninvasively with CE-μMRA in mice...
  48. ncbi request reprint Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neurons
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Switzerland
    Neurobiol Dis 12:174-81. 2003
    ..Our data suggest that normal spatial learning and memory can be achieved without the full number of hippocampal pyramidal neurons in partially lesioned hippocampus...
  49. ncbi request reprint Immunotherapy of Alzheimer disease
    Roger M Nitsch
    University of Zurich, Division of Psychiatry Research, Zurich, Switzerland
    Alzheimer Dis Assoc Disord 18:185-9. 2004
    ..Despite vivid antagonism that was rapidly voiced by many concerned experts, there are actually several excellent reasons why brain beta-amyloid plaques are attractive immunotherapeutic targets for the treatment and prevention of AD...
  50. ncbi request reprint Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:35460-5. 2002
    ..In addition, astrogliosis normally associated with amyloidosis was significantly reduced. Our results suggest that up-regulation of neprilysin in brain may represent an opportunity to reduce or prevent amyloid plaque formation in vivo...
  51. ncbi request reprint Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Nat Med 8:1270-5. 2002
    ..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time...
  52. ncbi request reprint Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...
  53. pmc Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
    Stefan Kins
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    Am J Pathol 163:833-43. 2003
    ..Our findings imply that PP2A is a negative regulator of the ERK and JNK signaling pathways in vivo, suggesting that in AD, tau hyperphosphorylation may be caused in part by PP2A dysfunction...
  54. ncbi request reprint Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
    Luis Pennanen
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    Neurobiol Dis 15:500-9. 2004
    ..We conclude that already aggregation of tau proteins not yet accompanied by massive formation of neurofibrillary tangles causes selective behavioral deficits...
  55. ncbi request reprint beta-Amyloid induces paired helical filament-like tau filaments in tissue culture
    Alessandra Ferrari
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich
    J Biol Chem 278:40162-8. 2003
    ..Further adaptation of the system may allow the screening and validation of compounds designed to prevent PHF formation...
  56. pmc Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis
    Jan Klohs
    Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland
    J Cereb Blood Flow Metab 31:2282-92. 2011
    ..Therefore, QSM may become an important tool for diagnosing CMBs in neurological diseases...
  57. ncbi request reprint Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease
    Christoph Hock
    Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Amyloid 10:1-6. 2003
    ..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD...
  58. ncbi request reprint Laboratory animal welfare: cage enrichment and mouse behaviour
    David P Wolfer
    Division of Neuroanatomy and Behaviour, Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland
    Nature 432:821-2. 2004
    ..Our findings indicate that the housing conditions of laboratory mice can be markedly improved without affecting the standardization of results...
  59. pmc Visualization and Quantification of APP Intracellular Domain-Mediated Nuclear Signaling by Bimolecular Fluorescence Complementation
    Florian Riese
    Division of Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e76094. 2013
    ..Together with the adaptor protein Fe65 and the histone acetyltransferase Tip60, AICD forms nuclear multiprotein complexes (AFT complexes) that function in transcriptional regulation...
  60. doi request reprint Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury
    Remo D Spescha
    Cardiovascular Research, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur Heart J 34:96-103. 2013
    ..Hence, we hypothesized that p66(Shc) may be involved in ischaemia/reperfusion brain damage. To this end, we investigated whether genetic deletion of p66(Shc) protects from ischaemia/reperfusion brain injury...
  61. ncbi request reprint The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor
    Ruth C von Rotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    J Cell Sci 117:4435-48. 2004
    ..These data establish a role for APP in nuclear signaling, and they suggest that therapeutic strategies designed to modulate the cleavage of APP affect AICD-dependent signaling...
  62. ncbi request reprint An alternative sampling algorithm for use in liquid chromatography/tandem mass spectrometry experiments
    Bernhard M Kohli
    Division of Psychiatry Research, August Forel Strasse 1, 8008 Zurich, Switzerland
    Rapid Commun Mass Spectrom 19:589-96. 2005
    ..Further validation of the algorithm will require its incorporation by equipment manufacturers into the instrument control programs...
  63. pmc Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice
    Mario Merlini
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008, Zurich, Switzerland
    Acta Neuropathol 122:293-311. 2011
    ....
  64. ncbi request reprint Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
    J Biol Chem 277:33012-7. 2002
    ....
  65. ncbi request reprint Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Psychiatr Genet 12:155-60. 2002
    ..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD...
  66. ncbi request reprint Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobe
    Katharina Henke
    Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Neuropsychologia 41:863-76. 2003
    ....