Research Topics
Genomes and Genes
| Roger M NitschSummaryAffiliation: Psychiatric University Hospital Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's diseaseSusann Cattepoel
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
PLoS ONE 6:e18296. 2011..Additionally, our observations support the possibility that Aβ-directed immunotherapy can reduce Aβ deposition in brain vessels in transgenic mice...
Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapyRoger M Nitsch
Division of Psychiatry Research, University of Zurich, Switzerland
Neurotherapeutics 5:415-20. 2008....
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficitRaphael Poirier
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, Zurich 8008, Switzerland
Neurobiol Dis 24:475-83. 2006....- Prion protein M129V polymorphism affects retrieval-related brain activityAndreas Buchmann
Division of Psychiatry Research and Hospital for Psychogeriatric Medicine, University of Zurich, Minervastrasse 145, 8032 Zurich, Switzerland
Neuropsychologia 46:2389-402. 2008..Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours... - A cluster of cholesterol-related genes confers susceptibility for Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
J Clin Psychiatry 66:940-7. 2005..Polygenic diseases are related to the complex interplay of genetic variations. We evaluated whether clusters of cholesterol- and lipid-related genetic variations are associated with Alzheimer's disease... - Active immunization trial in Abeta42-injected P301L tau transgenic miceLuka Kulic
Division of Psychiatry Research, , August Forel Str. 1, , Switzerland
Neurobiol Dis 22:50-6. 2006..Further studies are required to determine whether modifications of our protocol could affect the Abeta42-mediated induction of NFT formation... - Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivoM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 1:160-7. 2004..This protocol may prove useful for the rapid validation of the activity of antibodies designed to be used in immune therapy of AD... - Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- miceKatrin Kuehnle
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurochem Res 34:1167-82. 2009..These data indicate that desmosterol can replace cholesterol in membrane-related functions in the DHCR24(-/-) mouse... - The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivoArames Crameri
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
EMBO J 25:432-43. 2006..Pharmacological enhancement of seladin-1 activity may be a novel Abeta-lowering approach for the treatment of AD... - Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's diseaseAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:233-41. 2005.... - Active immunization of mice with an Abeta-Hsp70 vaccineMichael F Koller
Institute of Biochemistry, Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 1:20-8. 2004..These data emphasize the need for anti-Abeta antibodies that remove Abeta peptides from the central nervous system without negative side effects... - Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivoRime Madani
Institute of Anatomy, University of Zurich, Zurich, Switzerland
J Neurosci Res 84:1871-8. 2006.... - Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease... - Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factoriesUwe Konietzko
Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008 Zurich, Switzerland
Neurobiol Aging 31:58-73. 2010..Fe65 and Tip60 also co-localized with APP in the neurites of primary neurons. Pre-assembled AFT complexes may serve to assist fast nuclear signaling upon endoproteolytic APP cleavage... - Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Neuroreport 16:839-42. 2005..In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory... - Effects of memory consolidation on human hippocampal activity during retrievalSimone Bosshardt
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Cortex 41:486-98. 2005..These fMRI results in the human hippocampal formation may correspond to the neurobiological results in the animal hippocampal formation of a strengthening and growth of synaptic connections within 24 h... - Better memory and neural efficiency in young apolipoprotein E epsilon4 carriersChristian R A Mondadori
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Cereb Cortex 17:1934-47. 2007..We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans... - Glucocorticoid-related genetic susceptibility for Alzheimer's diseaseDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Hum Mol Genet 13:47-52. 2004..Our results indicate that a functional variation in the glucocorticoid system increases the risk for AD, which may have important implications for the diagnosis and treatment of this disease... - Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42Alessia Maddalena
Division of Psychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:1202-6. 2003..CONCLUSION: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia... - RAGE does not affect amyloid pathology in transgenic ArcAbeta miceIvana Vodopivec
Division of Psychiatry Research, University of Zurich, Ch 8008 Zurich, Switzerland ivana vodopivec bli uzh ch
Neurodegener Dis 6:270-80. 2009..While numerous experiments addressed Abeta toxicity, the mechanisms are still not fully understood. The receptor for advanced glycation end products (RAGE) binds Abeta and was suggested to be involved in the pathological processes of AD... - Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta miceMarlen Knobloch
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neurobiol Aging 28:1297-306. 2007..The co-incidence of intracellular Abeta deposits with behavioral deficits support an early role of intracellular Abeta in the pathophysiological cascade leading to beta-amyloid formation and functional impairment... - One month of human memory consolidation enhances retrieval-related hippocampal activitySimone Bosshardt
Division of Psychiatry Research, University of Zurich, Switzerland
Hippocampus 15:1026-40. 2005.... - Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease miceSamira Kocherhans
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
J Neurosci 30:9228-40. 2010.... - Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanismsMarlen Knobloch
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Neurosci 27:7648-53. 2007..Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology... - Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer's diseaseJan G Schiltz
Institute if Medical Virology, University of Zurich, Gloriastrasse 30, 8028 Zurich, Switzerland
J Mol Med 82:706-14. 2004..The monoclonal antibodies are applicable for passive immunization studies and may lead to a therapy of AD... - A functional genetic variation of the 5-HT2a receptor affects human memoryDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Nat Neurosci 6:1141-2. 2003..Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant... - No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traitsAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, Lengstrasse 31, 8029 Zurich, Switzerland
Am J Med Genet B Neuropsychiatr Genet 132:21-3. 2005..Although PLAU may be pathophysiologially related to AD, the contribution of common genetic variants of this gene to the risk for developing AD is likely to be low... - Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegenerationLuka Kulic
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neurobiol Aging 32:1827-38. 2011..These results suggest an age-dependent mutual reinforcement of the tau pathology and mitochondrial dysfunction in vivo, which may contribute to neurodegeneration in patients suffering from AD and other age-related tauopathies... - ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Street 1, 8008, Zurich, Switzerland
Neurobiol Aging 24:421-6. 2003..We conclude that genetic variability of ABCA1 influences the development of AD, possibly by interfering with CNS cholesterol homeostasis... - Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technologyAlessia S Maddalena
Division of Psychiatry Research, , , Switzerland
Neurodegener Dis 1:231-5. 2004..Quantitation revealed that CSF levels of Abeta1-38 were significantly decreased in AD as compared to CTR subjects. The CSF profile of Abeta peptides may be used for diagnostic and therapeutic purposes in clinical studies... - Genetic association study on colony-stimulating factor 1 in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 3:334-7. 2006..The human CSF1 gene maps to chromosome 1p21-p13, a region previously linked to Alzheimer's disease (AD). Thus, CSF1 is a functional and positional candidate gene for AD... - Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathwayZoe V Goodger
Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
J Cell Sci 122:3703-14. 2009..This suggests that amyloidogenic cleavage, despite representing the minor cleavage pathway of APP, is predominantly responsible for AICD-mediated nuclear signaling... - Antibodies against beta-amyloid slow cognitive decline in Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Neuron 38:547-54. 2003..Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease... - The prion gene is associated with human long-term memoryAndreas Papassotiropoulos
Division of Psychiatry Research, University of Zurich, 8032 Zurich, Switzerland
Hum Mol Genet 14:2241-6. 2005..These results suggest a role for the prion protein in the formation of long-term memory in humans... - Low-dose cortisol for symptoms of posttraumatic stress disorderAmanda Aerni
Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland
Am J Psychiatry 161:1488-90. 2004..CONCLUSIONS: The results of this pilot study indicate that low-dose cortisol treatment reduces the cardinal symptoms of PTSD... - Clinical observations with AN-1792 using TAPIR analysesChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 2:273-6. 2005..We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease... - Functional neuroimaging predicts individual memory outcome after amygdalohippocampectomyKatharina Henke
Division of Psychiatry Research, University of Zurich, Switzerland
Neuroreport 14:1197-202. 2003..There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL... - The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's diseaseRuth C von Rotz
Division of Psychiatry Research, University of Zurich, Switzerland
Eur J Neurosci 21:1289-98. 2005..However, the up-regulation of dactylidin in highly vulnerable brain tissues of AD patients was confirmed by a quantitative PCR approach, suggesting that dactylidin may function early in the progression of neurodegenerative diseases... - Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 miceBarbara Biscaro
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
J Neurosci 29:14108-19. 2009.... - Implicit associative learning engages the hippocampus and interacts with explicit associative learningNadia Degonda
Division of Psychiatry Research, University of Zurich, Switzerland
Neuron 46:505-20. 2005..These findings suggest that implicit semantic associative learning engages the hippocampus and influences explicit memory... - Association study of cholesterol-related genes in Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
Neurogenetics 8:179-88. 2007..004). We conclude that genetic variants investigated in this study may be associated with a moderate modification of the risk for AD in some samples... - Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's diseaseM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
FEBS Lett 562:16-21. 2004..Therefore, we suggest that the potential of NEP for AD therapy is age-dependent and most effective early in the course of AD pathophysiology... - Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's diseaseBarbara Biscaro
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Neurodegener Dis 9:187-98. 2012..Microglia are known to modulate adult hippocampal neurogenesis... - Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivoMeret N M Gaugler
Division of Psychiatry Research, University of Zurich, August Forel Str. 1, 8008 Zurich, Switzerland
FEBS Lett 579:753-6. 2005.... - Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ miceJan Klohs
Institute for Biomedical Engineering, Swiss Federal Institute of Technology and University of Zurich, CH 8093 Zurich, Switzerland
J Neurosci 32:1705-13. 2012..The study demonstrated that remodeling of the cerebrovasculature can be monitored noninvasively with CE-μMRA in mice... - Intact spatial memory in mice with seizure-induced partial loss of hippocampal pyramidal neuronsM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, Switzerland
Neurobiol Dis 12:174-81. 2003..Our data suggest that normal spatial learning and memory can be achieved without the full number of hippocampal pyramidal neurons in partially lesioned hippocampus... - Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivoM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
J Biol Chem 277:35460-5. 2002..In addition, astrogliosis normally associated with amyloidosis was significantly reduced. Our results suggest that up-regulation of neprilysin in brain may represent an opportunity to reduce or prevent amyloid plaque formation in vivo... - Immunotherapy of Alzheimer diseaseRoger M Nitsch
University of Zurich, Division of Psychiatry Research, Zurich, Switzerland
Alzheimer Dis Assoc Disord 18:185-9. 2004..Despite vivid antagonism that was rapidly voiced by many concerned experts, there are actually several excellent reasons why brain beta-amyloid plaques are attractive immunotherapeutic targets for the treatment and prevention of AD... - Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphismAndreas Papassotiropoulos
Division of Pychiatry Research, University of Zurich, Switzerland
Arch Neurol 60:29-35. 2003..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain... - Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
Nat Med 8:1270-5. 2002..Whether vaccination to produce antibodies against beta-amyloid will halt the cognitive decline in AD will depend upon clinical assessments over time... - Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Eur J Neurosci 17:1296-302. 2003.... - Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosisJan Klohs
Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland
J Cereb Blood Flow Metab 31:2282-92. 2011..Therefore, QSM may become an important tool for diagnosing CMBs in neurological diseases... - Laboratory animal welfare: cage enrichment and mouse behaviourDavid P Wolfer
Division of Neuroanatomy and Behaviour, Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland
Nature 432:821-2. 2004..Our findings indicate that the housing conditions of laboratory mice can be markedly improved without affecting the standardization of results... - Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's diseaseChristoph Hock
Division of Psychiatry Research, University of Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
Amyloid 10:1-6. 2003..967 ng/ml, respectively; p < 0.05). These data show that treatment with the m1 agonist talsaclidine reduced A beta peptides, and particularly A beta 42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD... - Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic miceStefan Kins
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
Am J Pathol 163:833-43. 2003..Our findings imply that PP2A is a negative regulator of the ERK and JNK signaling pathways in vivo, suggesting that in AD, tau hyperphosphorylation may be caused in part by PP2A dysfunction... - An alternative sampling algorithm for use in liquid chromatography/tandem mass spectrometry experimentsBernhard M Kohli
Division of Psychiatry Research, August Forel Strasse 1, 8008 Zurich, Switzerland
Rapid Commun Mass Spectrom 19:589-96. 2005..Further validation of the algorithm will require its incorporation by equipment manufacturers into the instrument control programs... - The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursorRuth C von Rotz
Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
J Cell Sci 117:4435-48. 2004..These data establish a role for APP in nuclear signaling, and they suggest that therapeutic strategies designed to modulate the cleavage of APP affect AICD-dependent signaling... - Accelerated extinction of conditioned taste aversion in P301L tau transgenic miceLuis Pennanen
Division of Psychiatry Research, , , Switzerland
Neurobiol Dis 15:500-9. 2004..We conclude that already aggregation of tau proteins not yet accompanied by massive formation of neurofibrillary tangles causes selective behavioral deficits... - Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ miceMario Merlini
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008, Zurich, Switzerland
Acta Neuropathol 122:293-311. 2011.... - Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutationM Hasan Mohajeri
Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland
J Biol Chem 277:33012-7. 2002.... - Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's diseaseM Axel Wollmer
Division of Psychiatry Research, University of Zurich, Switzerland
Psychiatr Genet 12:155-60. 2002..In addition, no significant differences were observed after stratification for TIMP 1 genotypes. Our data show that neither genetic variability nor protein levels of TIMP-1 are associated with AD... - Nonconscious formation and reactivation of semantic associations by way of the medial temporal lobeKatharina Henke
Division of Psychiatry Research, Psychiatric University Hospital, University of Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
Neuropsychologia 41:863-76. 2003....