Jochen Mutschler

Summary

Affiliation: Psychiatric University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Ann Nutr Metab 62:271-6. 2013
  2. doi request reprint Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Nicotine Tob Res 15:1322-7. 2013
  3. doi request reprint [Mechanism of action of disulfiram and treatment optimization in prevention of recurrent alcoholism]
    Jochen Mutschler
    Klinik für Soziale Psychiatrie und Allgemeinpsychiatrie, Psychiatrische Universitätsklinik Zürich und Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Praxis (Bern 1994) 102:139-46. 2013
  4. doi request reprint Functional social support within a medical supervised outpatient treatment program
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Drug Alcohol Abuse 39:44-9. 2013
  5. ncbi request reprint Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 18:246-52. 2012
  6. ncbi request reprint Application of electronic diaries in patients with schizophrenia and bipolar disorders
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Militarstrasse 8, P O Box 1930, CH 8021 Zurich, Switzerland
    Psychiatr Danub 24:206-10. 2012
  7. doi request reprint Safety and efficacy of long-term disulfiram aftercare
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 34:195-8. 2011
  8. doi request reprint The natriuretic peptide system as a possible therapeutic target for stress-induced obesity
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Militarstrasse 8, P O Box 1930, 8021 Zurich, Switzerland
    Med Hypotheses 76:388-90. 2011
  9. ncbi request reprint Urinary ethylglucuronide assessment in patients treated with disulfiram: a tool to improve verification of abstention and safety
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 33:285-7. 2010
  10. pmc Dextromethorphan withdrawal and dependence syndrome
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg
    Dtsch Arztebl Int 107:537-40. 2010

Detail Information

Publications22

  1. ncbi request reprint Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Ann Nutr Metab 62:271-6. 2013
    ..The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution...
  2. doi request reprint Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Nicotine Tob Res 15:1322-7. 2013
    ....
  3. doi request reprint [Mechanism of action of disulfiram and treatment optimization in prevention of recurrent alcoholism]
    Jochen Mutschler
    Klinik für Soziale Psychiatrie und Allgemeinpsychiatrie, Psychiatrische Universitätsklinik Zürich und Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Praxis (Bern 1994) 102:139-46. 2013
    ..Given the high prevalence of alcohol dependence in our view disulfiram is used very little, although the use of disulfiram in the context of structured, multi-modal outpatient treatment programs are considered to be safe...
  4. doi request reprint Functional social support within a medical supervised outpatient treatment program
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Am J Drug Alcohol Abuse 39:44-9. 2013
    ..This study examined functional social support (FSS) and its impact on treatment outcome in alcohol-dependent outpatients treated with supervised disulfiram...
  5. ncbi request reprint Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 18:246-52. 2012
    ..The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking...
  6. ncbi request reprint Application of electronic diaries in patients with schizophrenia and bipolar disorders
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Militarstrasse 8, P O Box 1930, CH 8021 Zurich, Switzerland
    Psychiatr Danub 24:206-10. 2012
    ..The primary aim of the current study was to assess the tolerability, validity and feasibility of the pocket-sized electronic diary Medicus®...
  7. doi request reprint Safety and efficacy of long-term disulfiram aftercare
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 34:195-8. 2011
    ..Also, it is not clear if supervised long-term disulfiram treatment is safe and sufficiently efficient in the long run...
  8. doi request reprint The natriuretic peptide system as a possible therapeutic target for stress-induced obesity
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Militarstrasse 8, P O Box 1930, 8021 Zurich, Switzerland
    Med Hypotheses 76:388-90. 2011
    ....
  9. ncbi request reprint Urinary ethylglucuronide assessment in patients treated with disulfiram: a tool to improve verification of abstention and safety
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 33:285-7. 2010
    ..Therefore, the use of an alcohol marker monitoring retrospective alcohol use is tested in this study...
  10. pmc Dextromethorphan withdrawal and dependence syndrome
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Universitat Heidelberg
    Dtsch Arztebl Int 107:537-40. 2010
    ..Dextromethorphan is avidly taken, mainly by young people, as a psychoactive drug. The currently available data yield incomplete information about the extent of the problem and its significance for addiction medicine in Germany...
  11. ncbi request reprint Quetiapine-induced hyperventilation and dyspnea
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 33:214. 2010
    ..Quetiapine is an atypical antipsychotic with favorable properties in the treatment of bipolar disorder, but it has recently been associated with respiratory dysfunction...
  12. ncbi request reprint [Impact of functional social support for abstinence after inpatient detoxification]
    Jochen Mutschler
    Klinik für Soziale Psychiatrie und Allgemeinpsychiatrie, ZH West, Psychiatrische Universitätsklinik Zürich
    Neuropsychiatr 24:118-24. 2010
    ..In this prospective study, we examined the impact of fss on different alcohol-dependence related variables in 132 alcohol-dependent patients...
  13. doi request reprint Supervised disulfiram in relapse prevention in alcohol-dependent patients suffering from comorbid borderline personality disorder--a case series
    Jochen Mutschler
    1Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg, J5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:146-50. 2010
    ..We examined the safety and efficacy in relapse prevention of a series of alcoholics with borderline personality disorder (BPD)...
  14. doi request reprint Disulfiram, an option for the treatment of pathological gambling?
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Square J 5 68159 Mannheim, Germany
    Alcohol Alcohol 45:214-6. 2010
    ..Because there may be common neurochemical substrates and neuronal circuits for pathological gambling and addiction, we wished to explore the effect of disulfiram in gambling...
  15. doi request reprint Experienced acetaldehyde reaction does not improve treatment response in outpatients treated with supervised disulfiram
    Jochen Mutschler
    Department of General and Social Psychiatry, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Clin Neuropharmacol 34:161-5. 2011
    ..Therefore, in this study, we test the hypothesis if an experienced acetaldehyde reaction during the therapy with disulfiram predicts better treatment outcome in alcohol-dependent patients...
  16. ncbi request reprint [Recent results in relaps prevention of alcoholism with Disulfiram]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:243-51. 2008
    ..It acts as a psychological deterrence of a possible disulfiram-alcohol reaction. This paper describes the current clinical impact and possible future of disulfiram...
  17. doi request reprint Association of leptin with food cue-induced activation in human reward pathways
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5 68159 Mannheim, Germany
    Arch Gen Psychiatry 69:529-37. 2012
    ..Whereas the hypothalamic regulation of energy homeostasis by endocrine feedback signals has been widely investigated, its interplay with mesolimbic reward-associated pathways represents a rich field of future research...
  18. doi request reprint Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors
    Jochen Mutschler
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, J 5, 68159 Mannheim, Germany
    Alcohol Alcohol 45:13-6. 2010
    ..We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor...
  19. ncbi request reprint [A new pharmacological treatment option for alcohol dependence discovered in transnational study: neurokinin-1 receptor antagonist as a possible therapy for alcoholism?]
    Jochen Mutschler
    Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut fur Seelische Gesundheit, Mannheim
    Neuropsychiatr 22:283-5. 2008
    ..They could demonstrate that either the blockade of the receptor, or the lack of the receptors leds to a decreased alcohol intake as well as reduced alcohol tolerance and craving concomitantly accompanied by improved general well-beeing...
  20. ncbi request reprint Pregabalin abuse among opiate addicted patients
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg Medical Faculty Mannheim, J5 68159, Mannheim, Germany
    Eur J Clin Pharmacol 69:2021-5. 2013
    ..Thus, we hypothesized that pregabalin might be abused by patients who were undergoing an opiate replacement therapy and never had an indication for taking pregabalin on medical grounds...
  21. doi request reprint Reduced affective symptoms during tobacco dependence treatment with varenicline
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Addiction 104:859-61. 2009
    ....
  22. doi request reprint Agomelatine is effective in reducing insomnia in abstinent alcohol-dependent patients
    Martin Grosshans
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg Medical Faculty, Mannheim, Germany and Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland
    Clin Neuropharmacol 37:6-8. 2014
    ..The melatonin-agonist agomelatine has been shown to improve overall sleep quality without daytime sedation...