Luka Kulic

Summary

Affiliation: Psychiatric University Hospital
Country: Switzerland

Publications

  1. pmc Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation
    L Kulic
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Transl Psychiatry 2:e183. 2012
  2. doi Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 32:1827-38. 2011
  3. doi Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?
    Melinda Farkas
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Alzheimers Dis 33:1097-104. 2013
  4. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
  5. pmc Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Susann Cattepoel
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e18296. 2011
  6. ncbi Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
  7. doi S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 7:373-8. 2010

Detail Information

Publications7

  1. pmc Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation
    L Kulic
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Transl Psychiatry 2:e183. 2012
    ..These results provide a possible explanation for the recessive trait of inheritance of the Osaka APP mutation and the apparent lack of amyloid deposition in E693Δ mutation carriers...
  2. doi Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 32:1827-38. 2011
    ..These results suggest an age-dependent mutual reinforcement of the tau pathology and mitochondrial dysfunction in vivo, which may contribute to neurodegeneration in patients suffering from AD and other age-related tauopathies...
  3. doi Hyperhomocysteinemia in Alzheimer's disease: the hen and the egg?
    Melinda Farkas
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Alzheimers Dis 33:1097-104. 2013
    ..e., represent both a cause and a consequence of neurodegeneration. Such a vicious cycle may be breakable by dietary or supplementation strategies increasing the availability of 5-MTHF...
  4. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
    ..These data indicate that desmosterol can replace cholesterol in membrane-related functions in the DHCR24(-/-) mouse...
  5. pmc Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    Susann Cattepoel
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 6:e18296. 2011
    ..Additionally, our observations support the possibility that Aβ-directed immunotherapy can reduce Aβ deposition in brain vessels in transgenic mice...
  6. ncbi Active immunization trial in Abeta42-injected P301L tau transgenic mice
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Dis 22:50-6. 2006
    ..Further studies are required to determine whether modifications of our protocol could affect the Abeta42-mediated induction of NFT formation...
  7. doi S-adenosylmethionine is decreased in the cerebrospinal fluid of patients with Alzheimer's disease
    Michael Linnebank
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Neurodegener Dis 7:373-8. 2010
    ..Increased plasma homocysteine levels have been described as an independent risk factor for Alzheimer's disease (AD), but the underlying pathophysiology is unclear...