Anne Eckert

Summary

Affiliation: Psychiatric University Clinics
Country: Switzerland

Publications

  1. ncbi Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761
    Anne Eckert
    Department of Pharmacology, Biocenter, University of Frankfurt, Germany
    Ann N Y Acad Sci 1056:474-85. 2005
  2. pmc Piracetam improves mitochondrial dysfunction following oxidative stress
    Uta Keil
    Department of Pharmacology, Biocenter, N260, University of Frankfurt, Marie Curie Strasse 9, 60439 Frankfurt, Germany
    Br J Pharmacol 147:199-208. 2006
  3. doi Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice
    Anne Eckert
    Neurobiology Research Laboratory, Psychiatric University Clinics, Basel, Switzerland
    Neurodegener Dis 5:157-9. 2008
  4. doi [Clinically relevant drug interactions with new generation antidepressants and antipsychotics]
    Anne Eckert
    Neurobiologisches Labor für Brain Aging and Mental Health, Universitäre Psychiatrische Kliniken Basel, Basel
    Ther Umsch 66:485-92. 2009
  5. pmc Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship
    Amandine Grimm
    Neurobiology Laboratory for Brain Ageing and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012 Basel, Switzerland
    Mol Neurobiol 46:151-60. 2012
  6. pmc Amyloid-Beta interaction with mitochondria
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Wilhelm Klein Straße 27, 4012 Basel, Switzerland
    Int J Alzheimers Dis 2011:925050. 2011
  7. pmc The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Basel, Switzerland
    PLoS ONE 5:e13376. 2010
  8. doi Mitochondrial effects of Ginkgo biloba extract
    Anne Eckert
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, Basel, Switzerland
    Int Psychogeriatr 24:S18-20. 2012
  9. ncbi Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice
    Anne Eckert
    Neurobiology Laboratory, Psychiatric University Clinic Basel, Wilhelm Klein Strasse 27, 4025, Basel, Switzerland
    J Mol Med (Berl) 86:1255-67. 2008
  10. pmc Convergence of amyloid-beta and tau pathologies on mitochondria in vivo
    Anne Eckert
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025, Basel, Switzerland
    Mol Neurobiol 41:107-14. 2010

Collaborators

Detail Information

Publications49

  1. ncbi Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761
    Anne Eckert
    Department of Pharmacology, Biocenter, University of Frankfurt, Germany
    Ann N Y Acad Sci 1056:474-85. 2005
    ..Taken together, our findings clearly show stabilization and protection of mitochondrial function as a specific and very sensitive property of EGb 761 at therapeutically relevant doses...
  2. pmc Piracetam improves mitochondrial dysfunction following oxidative stress
    Uta Keil
    Department of Pharmacology, Biocenter, N260, University of Frankfurt, Marie Curie Strasse 9, 60439 Frankfurt, Germany
    Br J Pharmacol 147:199-208. 2006
    ..Mitochondrial stabilization and protection might be an important mechanism to explain many of piracetam's beneficial effects in elderly patients...
  3. doi Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice
    Anne Eckert
    Neurobiology Research Laboratory, Psychiatric University Clinics, Basel, Switzerland
    Neurodegener Dis 5:157-9. 2008
    ....
  4. doi [Clinically relevant drug interactions with new generation antidepressants and antipsychotics]
    Anne Eckert
    Neurobiologisches Labor für Brain Aging and Mental Health, Universitäre Psychiatrische Kliniken Basel, Basel
    Ther Umsch 66:485-92. 2009
    ....
  5. pmc Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship
    Amandine Grimm
    Neurobiology Laboratory for Brain Ageing and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012 Basel, Switzerland
    Mol Neurobiol 46:151-60. 2012
    ....
  6. pmc Amyloid-Beta interaction with mitochondria
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Wilhelm Klein Straße 27, 4012 Basel, Switzerland
    Int J Alzheimers Dis 2011:925050. 2011
    ..Thus, this paper establishes a modified model of the Alzheimer cascade mitochondrial hypothesis...
  7. pmc The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Basel, Switzerland
    PLoS ONE 5:e13376. 2010
    ..We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior...
  8. doi Mitochondrial effects of Ginkgo biloba extract
    Anne Eckert
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, Basel, Switzerland
    Int Psychogeriatr 24:S18-20. 2012
    ....
  9. ncbi Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice
    Anne Eckert
    Neurobiology Laboratory, Psychiatric University Clinic Basel, Wilhelm Klein Strasse 27, 4025, Basel, Switzerland
    J Mol Med (Berl) 86:1255-67. 2008
    ..Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric A beta 42 damage indicating that oligomeric and fibrillar A beta 42 are both toxic, but exert different degrees of toxicity...
  10. pmc Convergence of amyloid-beta and tau pathologies on mitochondria in vivo
    Anne Eckert
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025, Basel, Switzerland
    Mol Neurobiol 41:107-14. 2010
    ..This review highlights the convergence of Abeta and tau on mitochondria and establishes a molecular link in AD pathology in vivo...
  11. ncbi [The importance of nimodipine in treatment of dementia]
    Anne Eckert
    Neurobiologisches Forschungslabor, Psychiatrische Universitätsklinik Basel
    Pharm Unserer Zeit 34:392-8. 2005
  12. pmc Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity
    Anne Eckert
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012, Basel, Switzerland
    Alzheimers Res Ther 3:15. 2011
    ..A vicious cycle as well as several vicious circles within the cycle, each accelerating the other, can be drawn, emphasizing the synergistic deterioration of mitochondria by tau and Aβ...
  13. ncbi Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice
    Katrin Schuessel
    Department of Pharmacology, Biocentre, University of Frankfurt, Germany
    Free Radic Biol Med 40:850-62. 2006
    ..Hence, oxidative stress caused by the combined effects of aging and PS1 mutations may be causative for triggering neurodegenerative events in FAD patients...
  14. ncbi Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761)
    Reham Abdel-Kader
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Pharmacol Res 56:493-502. 2007
    ..The single components of EGb 761 showed in both cell models protection of the mitochondrial membrane potential indicating that a complementary action of the components is responsible for the versatile actions of EGb 761...
  15. pmc Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure
    Virginie Rhein
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e12359. 2010
    ..Therefore, the aim of the present study was to investigate whether standardized Ginkgo biloba extract LI 1370 (GBE) is able to rescue Abeta-induced defects in energy metabolism...
  16. ncbi Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway
    Celio A Marques
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 278:28294-302. 2003
    ....
  17. ncbi Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Biol Chem 279:50310-20. 2004
    ..We suggest a hypothetical sequence of pathogenic steps linking mutant APP expression and amyloid production with enhanced NO production and mitochondrial dysfunction finally leading to cell death...
  18. ncbi Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice
    Katrin Schuessel
    Department of Pharmacology, Biocentre, J W Goethe University of Frankfurt, Germany
    Neurobiol Dis 18:89-99. 2005
    ..Our results demonstrate that impaired Cu/Zn-SOD activity contributes to oxidative damage in Thy1-APP751(SL) transgenic mice, and these findings are closely linked to increased beta-amyloidogenic cleavage of APP...
  19. ncbi Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
    Susanne Hauptmann
    Department of Pharmacology Biocentrs, University of Frankfurt, 60439 Frankfurt, Germany
    Exp Gerontol 41:668-73. 2006
    ....
  20. ncbi Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations
    Uta Keil
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt, Germany
    J Alzheimers Dis 9:139-46. 2006
    ..Thus, both Alzheimer relevant protein alterations seem to have synergistic actions probably at the level of mitochondria leading to synaptic dysfunction and apoptotic cell death...
  21. pmc Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
    Virginie Rhein
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
    Proc Natl Acad Sci U S A 106:20057-62. 2009
    ..Our study establishes a molecular link between Abeta and tau protein in AD pathology in vivo, illustrating the potential of quantitative proteomics...
  22. ncbi Impact of aging: sporadic, and genetic risk factors on vulnerability to apoptosis in Alzheimer's disease
    Katharina Schindowski
    Department of Pharmacology, Biocenter, J W Goethe University of Frankfurt, Marie Curie Str 9, D 60439 Frankfurt am Main, Germany
    Neuromolecular Med 4:161-78. 2003
    ..In contrast, normal aging results in an increased susceptibility to apoptosis of both, CD4+ and CD8+ T cells...
  23. ncbi Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?
    Kristina Leuner
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, Germany
    Antioxid Redox Signal 9:1659-75. 2007
    ..Herein, the authors suggest that mitochondrial protection and subsequent reduction of oxidative stress are important components of the neuroprotective activity of Ginkgo biloba extract...
  24. ncbi Insights into mitochondrial dysfunction: aging, amyloid-β, and tau-A deleterious trio
    Karen Schmitt
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Basel, Switzerland
    Antioxid Redox Signal 16:1456-66. 2012
    ..The pathology of AD is characterized by amyloid plaques (aggregates of amyloid-β [Aβ]) and neurofibrillary tangles (aggregates of tau), but the mechanisms underlying this dysfunction are still partially unclear...
  25. ncbi Increased apoptotic cell death in sporadic and genetic Alzheimer's disease
    Anne Eckert
    Department of Pharmacology, Biocenter, University of Frankfurt, 60439 Frankfurt am Main, Germany
    Ann N Y Acad Sci 1010:604-9. 2003
    ..Finally, we propose a hypothetical sequence of the pathogenic steps linking sporadic AD, FAD, Abeta production, mitochondrial dysfunction with caspase pathway, and neuronal loss...
  26. ncbi Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects
    Walter E Muller
    Department of Pharmacology, Biocenter, University of Frankfurt, Max von Laue Strasse 9, 60438, Frankfurt, Germany
    Mol Neurobiol 41:159-71. 2010
    ..We suggest that mitochondrial protection and subsequent reduction of oxidative stress are important targets for prevention and long-term treatment of early stages of AD...
  27. ncbi Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease
    Anne Eckert
    Department of Pharmacology, Biocenter, J W Goethe University of Frankfurt, Marie Curie Str 9, D 60439 Frankfurt am Main, Germany
    Biochem Pharmacol 66:1627-34. 2003
    ..Finally, we emphasize a hypothetical sequence of the pathogenic steps linking sporadic AD, FAD, and Abeta production with mitochondrial dysfunction, caspase pathway, and neuronal loss...
  28. doi A new link to mitochondrial impairment in tauopathies
    Kathrin L Schulz
    Department of Pharmacology, ZAFES, Biocenter, University of Frankfurt, 60438 Frankfurt, Germany
    Mol Neurobiol 46:205-16. 2012
    ..Our findings clearly link tau bidirectional to mitochondrial function and dynamics, identifying a novel aspect of the physiological role of tau and the pathomechanism of tauopathies...
  29. pmc Serum factors in older individuals change cellular clock properties
    Lucia Pagani
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, CH 4012 Basel, Switzerland
    Proc Natl Acad Sci U S A 108:7218-23. 2011
    ..Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable...
  30. ncbi The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, Basel, Switzerland
    Curr Alzheimer Res 4:47-51. 2007
    ..Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder...
  31. ncbi Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death
    Steffen Leutz
    Department of Pharmacology, Biocenter, University of Frankfurt, Germany
    J Mol Neurosci 18:189-201. 2002
    ..Our study further emphasizes the pathogenic role of mutant APP and may provide new insights in the mechanisms underlying the massive neurodegeneration in brain from patients bearing the APPsw mutation...
  32. ncbi Effects of Alzheimer's amyloid-beta and tau protein on mitochondrial function -- role of glucose metabolism and insulin signalling
    Virginie Rhein
    Neurobiology Laboratory, Psychiatric University Clinics Basel, Basel, Switzerland
    Arch Physiol Biochem 113:131-41. 2007
    ..Thus, this review addresses also the question if mitochondrial dysfunction may represent a link between diabetes and AD...
  33. ncbi Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
    Egemen Savaskan
    Psychiatric University Clinic, University of Basel, Basel, Switzerland
    J Pineal Res 38:10-6. 2005
    ..The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD...
  34. ncbi March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease
    Anne Eckert
    Neurobiology Laboratory, Psychiatric University Clinics Basel, University of Basel, Switzerland
    Biochim Biophys Acta 1842:1258-66. 2014
    ....
  35. ncbi High baseline BDNF serum levels and early psychopathological improvement are predictive of treatment outcome in major depression
    Thorsten Mikoteit
    Center for Affective, Stress and Sleep Disorders ZASS, Psychiatric Clinics of the University of Basel, Wilhelm Klein Strasse 27, 4012, Basel, Switzerland
    Psychopharmacology (Berl) 231:2955-65. 2014
    ..Although sBDNF levels tend to normalize following psychopathological improvement with antidepressant treatment, it is unclear how closely sBDNF changes are associated with treatment outcome...
  36. pmc The interplay of stress and sleep impacts BDNF level
    Maria Giese
    Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics, University of Basel, Basel, Switzerland Transfaculty Research Platform, Molecular and Cognitive Neuroscience, Univ of Basel, Basel, Switzerland
    PLoS ONE 8:e76050. 2013
    ..In accordance with the paradigm indicating a link between sleep and BDNF, we aimed to investigate if the stress system influences the association between sleep and BDNF...
  37. ncbi Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets
    Katharina Schindowski
    Department of Pharmacology, Johann Wolfgang Goethe University Biocenter, Marie Curie Strasse 9, 60439 Frankfurt Main, Germany
    Mech Ageing Dev 123:375-90. 2002
    ..The results will be discussed in relation to their relevance in neurodegenerative and psychiatric disorders...
  38. ncbi Modulation of neurosteroid production in human neuroblastoma cells by Alzheimer's disease key proteins
    Veronique Schaeffer
    Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique Université Louis Pasteur, Strasbourg, France
    J Neurobiol 66:868-81. 2006
    ..The data suggest that pathogenic factors may induce neurodegeneration in humans through the reduction of the synthesis of endogenous neuroprotective neurosteroids in nerve cells...
  39. pmc Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice
    Thomas A Bayer
    Department of Psychiatry, Division of Neurobiology, University of the Saarland Medical Center, D 66421 Homburg, Germany
    Proc Natl Acad Sci U S A 100:14187-92. 2003
    ..Cu treatment lowered endogenous CNS Abeta before a detectable reduction of amyloid plaques. Thus, APP23 mice reveal APP-induced alterations linked to Cu homeostasis, which can be reversed by addition of dietary Cu...
  40. ncbi Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
    Della C David
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 280:23802-14. 2005
    ..Taken together, we conclude that tau pathology involves a mitochondrial and oxidative stress disorder possibly distinct from that caused by Abeta...
  41. ncbi The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion
    Ekaterini Copanaki
    Department of Neurosurgery, Johann Wolfgang Goethe University Clinics, D 60590 Frankfurt, Germany
    Biochim Biophys Acta 1773:157-65. 2007
    ..Our data demonstrate that APP significantly modulates Ca(2+) store depletion-induced cell death in a SOC- and CHOP-dependent manner, but independent of the UPR...
  42. ncbi Amyloid beta enhances cytosolic phospholipase A2 level and arachidonic acid release via nitric oxide in APP-transfected PC12 cells
    Małgorzata Chalimoniuk
    Medical Research Center, Department of Cellular Signaling, Polish Academy of Sciences, Warszawa, Poland
    Acta Biochim Pol 54:611-23. 2007
    ..These results indicate that Abeta peptides enhance the protein level and phosphorylation of cPLA2 and AA release by the NO signaling pathway...
  43. ncbi Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death
    Julia Leschik
    Department of Neurobiology, University of Osnabruck, Osnabruck, Germany
    J Neurochem 101:1303-15. 2007
    ..Suppression of tau expression or inhibition of tau phosphorylation at disease-relevant sites may provide an effective therapeutic strategy to prevent neurodegeneration in Alzheimer's disease...
  44. ncbi Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy
    Katharina Schindowski
    Institute of Pharmacology, Biocenter building N260, Johann Wolfgang Goethe University, Max von Laue Strasse 9, 60438 Frankfurt am Main, Germany
    Neuromolecular Med 9:340-54. 2007
    ..Our data implicate the generation of reactive memory T-cell in AD and of anergic memory T-cells in transgenic mice and should be taken into concern when designing immunotherapy...
  45. doi Dose-dependent and sequence-sensitive effects of amyloid-beta peptide on neurosteroidogenesis in human neuroblastoma cells
    Veronique Schaeffer
    Equipe Stéroïdes et Système Nociceptif, Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique Université Louis Pasteur, 21 rue René Descartes, 67084 Strasbourg Cedex, France
    Neurochem Int 52:948-55. 2008
    ....
  46. ncbi Age-related alteration of activity and gene expression of endothelial nitric oxide synthase in different parts of the brain in rats
    Joanna B Strosznajder
    Department of Cellular Signaling, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, PL 02106 Warsaw, Poland
    Neurosci Lett 370:175-9. 2004
    ..It is also possible that a post-translational modification of the enzyme occurs in the aged rat brain. The lower eNOS activity in aged brain may significantly affects the signal transduction processes on the pathway NO/cGMP/PKG...
  47. ncbi The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis
    Donat Kogel
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, University Münster Clinics, Munster, Germany
    J Neurochem 87:248-56. 2003
    ..Our data indicate that APP plays an important physiological role in protecting neurons from the consequences of prolonged ER stress, and that APP mutations associated with familial Alzheimer's disease may impair this protective activity...
  48. ncbi [From the Frankfurter Institute for the Insane and Epileptics. Alois Alzheimer and Alzheimer disease]
    Anne Eckert
    Pharmakologisches Institut für Naturwissenschaftler Marie Curie Str 9, 60439 Frankfurt
    Pharm Unserer Zeit 31:356-60. 2002