Michael Honer

Summary

Affiliation: Paul Scherrer Institute
Country: Switzerland

Publications

  1. pmc Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PET
    Michael Honer
    Center for Radiopharmaceutical Science, Eidgenoessische Technische Hochschule, Zurich, Switzerland
    Transl Oncol 3:264-75. 2010
  2. ncbi request reprint Dynamic imaging of striatal D2 receptors in mice using quad-HIDAC PET
    Michael Honer
    Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen, Switzerland
    J Nucl Med 45:464-70. 2004
  3. ncbi request reprint Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis
    Karin Knogler
    Center for Radiopharmaceutical Science, ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
    Clin Cancer Res 13:603-11. 2007
  4. ncbi request reprint In vivo evaluation of 177Lu- and 67/64Cu-labeled recombinant fragments of antibody chCE7 for radioimmunotherapy and PET imaging of L1-CAM-positive tumors
    Jürgen Grünberg
    Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, Villigen, Switzerland
    Clin Cancer Res 11:5112-20. 2005
  5. ncbi request reprint Targeting of renal carcinoma with 67/64Cu-labeled anti-L1-CAM antibody chCE7: selection of copper ligands and PET imaging
    Kurt Zimmermann
    Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
    Nucl Med Biol 30:417-27. 2003
  6. ncbi request reprint NanoPET imaging of [(18)F]fluoromisonidazole uptake in experimental mouse tumours
    Matthias T Wyss
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    Eur J Nucl Med Mol Imaging 33:311-8. 2006
  7. ncbi request reprint Imaging of renal carcinoma xenografts with 64Cu-labelled anti-L1-CAM antibody chCE7
    Ilse Novak-Hofer
    Center for Radiopharmaceutical Sciences ETH PSI USZ, Paul Scherrer Institute, 5232, Villigen, Switzerland
    Eur J Nucl Med Mol Imaging 30:1066. 2003
  8. ncbi request reprint Performance evaluation of the 16-module quad-HIDAC small animal PET camera
    John Missimer
    Biomolecular Research and Center for Radiopharmaceutical Science of PSI, ETH and USZ, Life Sciences Division, Paul Scherrer Institute, 5232 Villigen, Switzerland
    Phys Med Biol 49:2069-81. 2004
  9. ncbi request reprint Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors
    Andrea Bettio
    Department of Chemistry and Applied Biosciences of ETH, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Zurich, Switzerland
    J Nucl Med 47:1153-60. 2006
  10. ncbi request reprint Influence of ceftriaxone treatment on FDG uptake--an in vivo [18F]-fluorodeoxyglucose imaging study in soft tissue infections in rats
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Nucl Med Biol 31:875-82. 2004

Collaborators

Detail Information

Publications20

  1. pmc Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PET
    Michael Honer
    Center for Radiopharmaceutical Science, Eidgenoessische Technische Hochschule, Zurich, Switzerland
    Transl Oncol 3:264-75. 2010
    ..These conclusions warrant clinical testing...
  2. ncbi request reprint Dynamic imaging of striatal D2 receptors in mice using quad-HIDAC PET
    Michael Honer
    Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen, Switzerland
    J Nucl Med 45:464-70. 2004
    ..The aim of this study was to establish the tomograph's utility in a biologic application and to demonstrate the feasibility of rapid dynamic neuroreceptor imaging in mice...
  3. ncbi request reprint Copper-67 radioimmunotherapy and growth inhibition by anti-L1-cell adhesion molecule monoclonal antibodies in a therapy model of ovarian cancer metastasis
    Karin Knogler
    Center for Radiopharmaceutical Science, ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
    Clin Cancer Res 13:603-11. 2007
    ..We examined the tumor-targeting and therapeutic effects of (67)Cu-labeled single amino acid mutant forms of anti-L1 monoclonal antibody chCE7 in nude mice with orthotopically implanted SKOV3ip human ovarian carcinoma cells...
  4. ncbi request reprint In vivo evaluation of 177Lu- and 67/64Cu-labeled recombinant fragments of antibody chCE7 for radioimmunotherapy and PET imaging of L1-CAM-positive tumors
    Jürgen Grünberg
    Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, Villigen, Switzerland
    Clin Cancer Res 11:5112-20. 2005
    ....
  5. ncbi request reprint Targeting of renal carcinoma with 67/64Cu-labeled anti-L1-CAM antibody chCE7: selection of copper ligands and PET imaging
    Kurt Zimmermann
    Center for Radiopharmaceutical Science ETH PSI USZ, Paul Scherrer Institute, CH 5232 Villigen, Switzerland
    Nucl Med Biol 30:417-27. 2003
    ..High resolution PET imaging with (64)Cu-CPTA-labeled MAb chCE7 showed uptake in lymph nodes and heterogeneous distribution in tumor xenografts...
  6. ncbi request reprint NanoPET imaging of [(18)F]fluoromisonidazole uptake in experimental mouse tumours
    Matthias T Wyss
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Paul Scherrer Institute, Villigen, Switzerland
    Eur J Nucl Med Mol Imaging 33:311-8. 2006
    ..The purpose of this study was to assess the potential and utility of ultra-high-resolution hypoxia imaging in various murine tumour models using the established hypoxia PET tracer [(18)F]fluoromisonidazole ([(18)F]FMISO)...
  7. ncbi request reprint Imaging of renal carcinoma xenografts with 64Cu-labelled anti-L1-CAM antibody chCE7
    Ilse Novak-Hofer
    Center for Radiopharmaceutical Sciences ETH PSI USZ, Paul Scherrer Institute, 5232, Villigen, Switzerland
    Eur J Nucl Med Mol Imaging 30:1066. 2003
  8. ncbi request reprint Performance evaluation of the 16-module quad-HIDAC small animal PET camera
    John Missimer
    Biomolecular Research and Center for Radiopharmaceutical Science of PSI, ETH and USZ, Life Sciences Division, Paul Scherrer Institute, 5232 Villigen, Switzerland
    Phys Med Biol 49:2069-81. 2004
    ..Reconstruction of a point source yields a resolution of 1.1 mm FWHM for all three components. The performance of the camera demonstrates its excellent suitability for the functional imaging of small animals...
  9. ncbi request reprint Synthesis and preclinical evaluation of a folic acid derivative labeled with 18F for PET imaging of folate receptor-positive tumors
    Andrea Bettio
    Department of Chemistry and Applied Biosciences of ETH, Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Zurich, Switzerland
    J Nucl Med 47:1153-60. 2006
    ..The 18F-labeled alpha/gamma-FBA-folate counterpart was examined for in vivo tumor targeting efficiency in nude mice bearing folate receptor-positive tumor cells...
  10. ncbi request reprint Influence of ceftriaxone treatment on FDG uptake--an in vivo [18F]-fluorodeoxyglucose imaging study in soft tissue infections in rats
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Nucl Med Biol 31:875-82. 2004
    ..The change of FDG uptake over time in treated and untreated infections is complex and further in vivo experiments have to be initiated to investigate the potential value of clinical FDG PET in therapy monitoring of infection...
  11. ncbi request reprint Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5
    Michael Honer
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
    Nucl Med Biol 34:973-80. 2007
    ..FE-DABP688 was radiolabeled with fluorine-18 and characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5)...
  12. ncbi request reprint Radiosynthesis and preclinical evaluation of 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ and Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    J Nucl Med 47:698-705. 2006
    ....
  13. ncbi request reprint 18F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 31:312-6. 2004
    ..Future studies are now needed to determine the degree of this limitation in human cancer patients...
  14. doi request reprint Molecular imaging with PET
    Simon M Ametamey
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences of ETH, CH 8093 Zurich, Switzerland
    Chem Rev 108:1501-16. 2008
  15. ncbi request reprint Comparison of [18F]FDOPA, [18F]FMT and [18F]FECNT for imaging dopaminergic neurotransmission in mice
    Michael Honer
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, CH 8093 Zurich, Switzerland
    Nucl Med Biol 33:607-14. 2006
    ..This study describes our efforts to adopt the methodology of human Parkinson's disease (PD) PET studies to mice...
  16. ncbi request reprint Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study
    Karl Dimiter Bissig
    Department of Clinical Pharmacology, University of Berne, 3010 Berne, Switzerland
    Biometals 18:83-8. 2005
    ..This trapping does however limit the utility of PET to measure whole animal copper flux...
  17. ncbi request reprint Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment
    Oliver Riesterer
    Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland
    Clin Cancer Res 12:3518-24. 2006
    ..To directly assess this still controversial issue, we analyzed treatment-dependent alterations of tumor oxygenation in response to inhibition of angiogenesis alone, ionizing radiation, and combined treatment...
  18. ncbi request reprint Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment
    Matthias J E Arlt
    Klinikum rechts der Isar der Technischen Universitat Munchen, Institut für Experimentelle Onkologie und Therapieforschung, Ismaninger Strasse 22, D 81675 Munich, Germany
    Cancer Res 66:936-43. 2006
    ....
  19. ncbi request reprint A-186253, a specific antagonist of the alpha 4 beta 2 nAChRs: its properties and potential to study brain nicotinic acetylcholine receptors
    Valerie Itier
    Department of Physiology, Medical Faculty, CMU, University of Geneva, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Neuropharmacology 47:538-57. 2004
    ..While the A-186253 can be valuable to discriminate receptor subtypes, improvements of this molecule must be brought for in vivo measurements...
  20. ncbi request reprint Synthesis and in vitro and in vivo evaluation of [11C]methyl-BIII277CL for imaging the PCP-binding site of the NMDA receptor by pet
    Marko Kokic
    Center for Radiopharmaceutical Science of the ETH, Paul Scherrer Institute and Division of Nuclear Medicine, University Hospital Zurich, CH 5232 Villigen PSI, Switzerland
    J Recept Signal Transduct Res 22:123-39. 2002
    ..36 mL/mL(tissue)/min and k2 = 0.37min(-1)) in pig cortex. [11C]methyl-BIII277CL, due to the lack of specificity in vivo, may not be a candidate for imaging the PCP-binding site of the NMDA receptor...