Greg Elson

Summary

Affiliation: NovImmune SA
Country: Switzerland

Publications

  1. ncbi Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
    Greg Elson
    NovImmune SA, Geneva, Switzerland
    Blood 109:1574-83. 2007
  2. ncbi TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock
    Bruno Daubeuf
    NovImmune SA, Geneva, Switzerland
    J Immunol 179:6107-14. 2007
  3. ncbi Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
    Alexandre Garin
    NovImmune SA, 14 Chemin des Aulx, 1228 Plan les Ouates, Switzerland
    Immunity 33:84-95. 2010
  4. ncbi Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
    Irene Dunn-Siegrist
    NovImmune SA, 1228 Plan les Ouates, Switzerland
    J Biol Chem 282:34817-27. 2007
  5. ncbi Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    Stefan Rose-John
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Leukoc Biol 80:227-36. 2006
  6. ncbi Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia
    Osamu Kajikawa
    Pulmonary Research Laboratories at the Seattle Department of Veterans Affairs Medical Center, University of Washington School of Medicine, 151L 1660 South Columbian Way, Seattle, WA 98108, USA
    Gene 344:193-202. 2005
  7. ncbi Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
    Jerome Pugin
    Laboratory of the Division of Intensive Care, Department of Internal Medicine, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Blood 104:4071-9. 2004
  8. ncbi Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
    Pierre Tissieres
    Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Switzerland
    Blood 111:2122-31. 2008
  9. ncbi Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin
    Lincoln S Smith
    Division of Pediatric Critical Care, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Exp Lung Res 34:225-43. 2008
  10. ncbi Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines
    David Perret
    INSERM U564, CHU d Angers, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Biol Chem 279:43961-70. 2004

Collaborators

  • Jerome Pugin
  • Marc Thilo Figge
  • Michael Meyer-Hermann
  • Marie H Kosco-Vilbois
  • Richard Ulevitch
  • Matthias Gunzer
  • Hermann Wagner
  • Bruno Daubeuf
  • Irene Dunn-Siegrist
  • Osamu Kajikawa
  • Alexandre Garin
  • Pierre Tissieres
  • Lincoln S Smith
  • Suzanne Herren
  • Charles W Frevert
  • Thomas R Martin
  • Stefan Rose-John
  • David Perret
  • Kai Michael Toellner
  • Mathias Contie
  • Vanessa Buatois
  • Vandack Nobre
  • Steve Mongovin
  • Rachel Comte
  • Michela Schappi
  • Merry Wick
  • Yann Dean
  • Stephan Spiller
  • Olivier Leger
  • Yves Poitevin
  • Carsten J Kirschning
  • Fabien Dépis
  • John Mathison
  • Stephanie Hugues
  • Walter Ferlin
  • Jürgen Scheller
  • Simon A Jones
  • Shu-Min Lin
  • Kim Ballman
  • Steve M Mongovin
  • Venus Wong
  • Shu Min Lin
  • Richard B Goodman
  • Catherine Guillet
  • Josy Froger
  • Hugues Gascan
  • Francois Rousseau
  • Helene Plun-Favreau
  • Marie Chabbert
  • Jean Francois Gauchat

Detail Information

Publications10

  1. ncbi Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
    Greg Elson
    NovImmune SA, Geneva, Switzerland
    Blood 109:1574-83. 2007
    ..This study identifies dominant TLRs involved in responses to whole bacteria. It also validates the concept that host cell activation by bacterial pathogens can be therapeutically reduced by anti-TLR4, -TLR2, and -CD14 mAbs...
  2. ncbi TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock
    Bruno Daubeuf
    NovImmune SA, Geneva, Switzerland
    J Immunol 179:6107-14. 2007
    ..These results demonstrate that neutralizing TLR4/MD-2 is highly efficacious in protecting against bacterial infection-induced toxemia and offers TLR4/MD-2 mAb treatment as a potential therapy for numerous clinical indications...
  3. ncbi Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation
    Alexandre Garin
    NovImmune SA, 14 Chemin des Aulx, 1228 Plan les Ouates, Switzerland
    Immunity 33:84-95. 2010
    ..Thus, our data place TLR4 in the heart of adaptive humoral immunity, providing further insight into mechanisms driving GCs arising in both health and disease...
  4. ncbi Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
    Irene Dunn-Siegrist
    NovImmune SA, 1228 Plan les Ouates, Switzerland
    J Biol Chem 282:34817-27. 2007
    ....
  5. ncbi Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    Stefan Rose-John
    Biochemisches Institut, Christian Albrechts Universitat zu Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    J Leukoc Biol 80:227-36. 2006
    ..The pathophysiological mechanisms by which the IL-6/sIL-6R complex regulates the inflammatory state are discussed...
  6. ncbi Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia
    Osamu Kajikawa
    Pulmonary Research Laboratories at the Seattle Department of Veterans Affairs Medical Center, University of Washington School of Medicine, 151L 1660 South Columbian Way, Seattle, WA 98108, USA
    Gene 344:193-202. 2005
    ..In contrast, the increased gene expression of TLR2, TLR4, and MD2 in organs distant to the primary site of infection may contribute to the deleterious systemic inflammatory response observed in patients with sepsis...
  7. ncbi Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
    Jerome Pugin
    Laboratory of the Division of Intensive Care, Department of Internal Medicine, University Hospital of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Blood 104:4071-9. 2004
    ..We therefore propose that soluble MD-2 is an important mediator of organ inflammation during sepsis...
  8. ncbi Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria
    Pierre Tissieres
    Intensive Care, Department of Anesthesiology, Pharmacology and Intensive Care, University Hospitals of Geneva, Switzerland
    Blood 111:2122-31. 2008
    ..This suggests that sMD-2 plays a key role in the host innate immune response to Gram-negative infections...
  9. ncbi Effect of Toll-like receptor 4 blockade on pulmonary inflammation caused by mechanical ventilation and bacterial endotoxin
    Lincoln S Smith
    Division of Pediatric Critical Care, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA
    Exp Lung Res 34:225-43. 2008
    ..In contrast, blockade of CD14 did not significantly decrease the number of neutrophils or the amount of CXCL8. These data show that TLR4 blockade reduces pulmonary inflammation caused by the combination of LPS and Mechanical ventilation...
  10. ncbi Two different contact sites are recruited by cardiotrophin-like cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha composite cytokines
    David Perret
    INSERM U564, CHU d Angers, 4 rue Larrey, 49033 Angers Cedex 01, France
    J Biol Chem 279:43961-70. 2004
    ..This study establishes the molecular details of the interaction of CLC with CLF, CNTFRalpha, and LIFRbeta and helps to define the precise role of each protein in this functional receptor complex...