Thierry Delatour

Summary

Affiliation: Nestlé Research Center
Country: Switzerland

Publications

  1. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
    Maricel Marin Kuan
    Nestlé Research Center, Quality and Safety, PO Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Toxicon 52:195-202
  2. A comparative study of proteolysis methods for the measurement of 3-nitrotyrosine residues: enzymatic digestion versus hydrochloric acid-mediated hydrolysis
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 851:268-76
  3. Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole
    Ans Punt
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Chem Res Toxicol 20:991-8
  4. Limits of suspicion, recognition and confirmation as concepts that account for the confirmation transitions at the detection limit for quantification by liquid chromatography-tandem mass spectrometry
    Thierry Delatour
    Nestlé Research Centre, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr A 1169:103-10
  5. N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response
    Timo M Buetler
    Nestlé Research Center, Lausanne, Switzerland
    Mol Nutr Food Res 52:370-8
  6. Absence of 2'-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS
    Thierry Delatour
    Institut für Toxikologie, Universität Würzburg, Würzburg, Germany
    Mol Nutr Food Res 52:472-82
  7. Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
    Suzanne M F Jeurissen
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Food Chem Toxicol 46:2296-302
  8. Dicarbonyls stimulate cellular protection systems in primary rat hepatocytes and show anti-inflammatory properties
    Timo M Buetler
    Nestlé Research Center, Lausanne 26, Switzerland
    Ann N Y Acad Sci 1126:113-7
  9. Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity
    Christophe Cavin
    Quality and Safety Department, Nestlé Research Center, CH 1000 Lausanne 26, Switzerland
    Toxicol Sci 96:30-9
  10. Simultaneous determination of 3-nitrotyrosine and tyrosine in plasma proteins of rats and assessment of artifactual tyrosine nitration
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 779:189-99

Detail Information

Publications23

  1. Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
    Maricel Marin Kuan
    Nestlé Research Center, Quality and Safety, PO Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Toxicon 52:195-202
    ..From a risk assessment perspective, it has to be noted that the mechanisms proposed above depend mainly upon gene expression and enzyme activation, and are, therefore, likely to be thresholded...
  2. A comparative study of proteolysis methods for the measurement of 3-nitrotyrosine residues: enzymatic digestion versus hydrochloric acid-mediated hydrolysis
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 851:268-76
    ..We additionally show that the enzyme efficacy is not altered when the digestion is carried out in the presence of BSA with a high content of NY...
  3. Tandem mass spectrometry analysis of N2-(trans-Isoestragol-3'-yl)-2'-deoxyguanosine as a strategy to study species differences in sulfotransferase conversion of the proximate carcinogen 1'-hydroxyestragole
    Ans Punt
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Chem Res Toxicol 20:991-8
    ....
  4. Limits of suspicion, recognition and confirmation as concepts that account for the confirmation transitions at the detection limit for quantification by liquid chromatography-tandem mass spectrometry
    Thierry Delatour
    Nestlé Research Centre, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr A 1169:103-10
    ..For these three limits, applications and drawbacks are shown, while determination methods are proposed...
  5. N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response
    Timo M Buetler
    Nestlé Research Center, Lausanne, Switzerland
    Mol Nutr Food Res 52:370-8
    ..Thus, CML probably does not form the necessary structure(s) to interact with RAGE and activate an inflammatory signaling cascade in RAGE-expressing cells...
  6. Absence of 2'-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS
    Thierry Delatour
    Institut für Toxikologie, Universität Würzburg, Würzburg, Germany
    Mol Nutr Food Res 52:472-82
    ..5 dGuoOTA/10(9) nucleotides. These data are consistent with previous results showing lack of DNA adduct formation by OTA and demonstrate that dGuoOTA is not formed in biologically relevant amounts under physiological conditions in vivo...
  7. Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
    Suzanne M F Jeurissen
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    Food Chem Toxicol 46:2296-302
    ....
  8. Dicarbonyls stimulate cellular protection systems in primary rat hepatocytes and show anti-inflammatory properties
    Timo M Buetler
    Nestlé Research Center, Lausanne 26, Switzerland
    Ann N Y Acad Sci 1126:113-7
    ..In addition, we demonstrate that dicarbonyls can attenuate the inflammatory signaling induced by tumor necrosis factor-alpha in a reporter cell system...
  9. Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity
    Christophe Cavin
    Quality and Safety Department, Nestlé Research Center, CH 1000 Lausanne 26, Switzerland
    Toxicol Sci 96:30-9
    ..Our data suggest that reduction of cellular defense against oxidative stress by Nrf2 inhibition may be a plausible mechanism of OTA nephrotoxicity and carcinogenicity...
  10. Simultaneous determination of 3-nitrotyrosine and tyrosine in plasma proteins of rats and assessment of artifactual tyrosine nitration
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 779:189-99
    ..Tyrosine and 3-nitrotyrosine fractions are mixed in an appropriate ratio prior to the analysis. The method was applied to animals exposed to ferric nitrilotriacetate to induce oxidative stress...
  11. Artifactual nitration controlled measurement of protein-bound 3-nitro-L-tyrosine in biological fluids and tissues by isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    Chem Res Toxicol 15:1209-17
    ..Reliable detection of NTyr in proteins may allow insight into the role of nitric oxide-derived oxidants under various pathological conditions...
  12. Preparation of stable isotope-labeled 2-nitrobenzaldehyde derivatives of four metabolites of nitrofuran antibiotics and their comprehensive characterization by UV, MS, and NMR techniques
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Agric Food Chem 51:6371-9
    ..A major advantage of the described procedure is that it can be extended to the preparation of other carbon-13-labeled derivatives of metabolites of nitrofuran antibiotics...
  13. Performance of quantitative analyses by liquid chromatography-electrospray ionisation tandem mass spectrometry: from external calibration to isotopomer-based exact matching
    Thierry Delatour
    Nestlé Research Centre, Nestec Ltd, Vers chez les Blanc, 1000, Lausanne 26, Switzerland
    Anal Bioanal Chem 380:515-23
    ..We compare external and internal calibrations, isotope dilution and isotopomer-based exact matching. The role of both sample preparation and multiple transitions monitoring is particularly addressed...
  14. Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography-electrospray ionisation-tandem mass spectrometry
    Pascal Mottier
    Department of Quality and Safety Assurance, Nestle Research Centre, Nestec Ltd, Vers chez les Blanc, 1000 Lausanne 26, Switzerland
    J Chromatogr A 1067:85-91
    ..The method is robust and suitable for routine quality control operations, and more than 200 sample injections were performed without excessive pollution of the mass spectrometer or loss of LC column performance...
  15. Synthesis, tandem MS- and NMR-based characterization, and quantification of the carbon 13-labeled advanced glycation endproduct, 6-N-carboxymethyllysine
    T Delatour
    Department of Quality and Safety, Nestlé Research Centre, Lausanne, Switzerland
    Amino Acids 30:25-34
    ..Finally, the standards of CML and carbon-13 labeled CML were accurately quantified based on (1)H-NMR and tandem MS using lysine as an internal reference...
  16. Analysis of matrix-bound nitrofuran residues in worldwide-originated honeys by isotope dilution high-performance liquid chromatography-tandem mass spectrometry
    Seu-Ping Khong
    Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland
    J Agric Food Chem 52:5309-15
    ..12-0.56 microg/kg. The method has been successfully applied in a survey of honeys of various geographical origins, showing that furazolidone is the main nitrofuran antibiotic administered to treat bacterial diseases of bees...
  17. Improved sample preparation to determine acrylamide in difficult matrixes such as chocolate powder, cocoa, and coffee by liquid chromatography tandem mass spectroscopy
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, P.O. Box 44, CH - 1000 Lausanne 26, Switzerland
    J Agric Food Chem 52:4625-31
    ..Furthermore, the accuracy of the method is demonstrated by the results obtained in three inter-laboratory proficiency tests...
  18. A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
    Ans Punt
    Division of Toxicology, Wageningen University, Tuinlaan 5, 6703HE Wageningen, The Netherlands
    Toxicol Appl Pharmacol 231:248-59
    ..These results indicate that the relative importance of different metabolic pathways of estragole may vary in a dose-dependent way, leading to a relative increase in bioactiviation of estragole at higher doses...
  19. 3-Nitrotyrosine butyl ester: a novel derivative to assess tyrosine nitration in rat plasma by liquid chromatography-tandem mass spectrometry detection
    Thierry Delatour
    Nestlé Research Center, Nestec Ltd, Vers-chez-les-Blanc, Lausanne 26, 1000, Switzerland
    Anal Biochem 302:10-8
    ..In this context, analysis of eight rat plasma samples showed quantifiable levels in only four of the samples of the order of 1.4-1.5 nM...