Henry Markram

Summary

Country: Switzerland

Publications

  1. doi request reprint Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments
    Luca Gambazzi
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Pharmacol Exp Ther 335:13-22. 2010
  2. ncbi request reprint Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  3. ncbi request reprint The blue brain project
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Switzerland
    Nat Rev Neurosci 7:153-60. 2006
  4. ncbi request reprint Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex
    Jean Vincent Le Bé
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cereb Cortex 17:2204-13. 2007
  5. ncbi request reprint Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid
    Tania Rinaldi
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Switzerland
    Cereb Cortex 18:763-70. 2008
  6. ncbi request reprint Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
  7. pmc Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections
    Srikanth Ramaswamy
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    J Physiol 590:737-52. 2012
  8. pmc Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
    Thomas K Berger
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, Switzerland
    J Physiol 587:5411-25. 2009
  9. pmc Neuropeptide and calcium-binding protein gene expression profiles predict neuronal anatomical type in the juvenile rat
    Maria Toledo-Rodriguez
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Physiol 567:401-13. 2005
  10. pmc Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
    Sean L Hill
    Blue Brain Project, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 109:E2885-94. 2012

Collaborators

Detail Information

Publications49

  1. doi request reprint Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments
    Luca Gambazzi
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Pharmacol Exp Ther 335:13-22. 2010
    ..Moreover, the novel model paradigm established here is well suited to further mechanistic and drug screening research applications...
  2. ncbi request reprint Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  3. ncbi request reprint The blue brain project
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Switzerland
    Nat Rev Neurosci 7:153-60. 2006
    ....
  4. ncbi request reprint Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex
    Jean Vincent Le Bé
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cereb Cortex 17:2204-13. 2007
    ..The study shows that layer V pyramidal neurons projecting to different targets form subnetworks with specialized connectivity profiles, in addition to the specialized morphological and electrophysiological intrinsic properties...
  5. ncbi request reprint Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid
    Tania Rinaldi
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne 1015, Switzerland
    Cereb Cortex 18:763-70. 2008
    ..This could underlie some of the core symptoms observed in humans prenatally exposed to valproic acid...
  6. ncbi request reprint Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..We describe this feedback pathway and propose it as a central mechanism for regulation of cortical activity...
  7. pmc Intrinsic morphological diversity of thick-tufted layer 5 pyramidal neurons ensures robust and invariant properties of in silico synaptic connections
    Srikanth Ramaswamy
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    J Physiol 590:737-52. 2012
    ..Finally, we show that the average physiological properties of the TTL5 microcircuit are surprisingly robust to anatomical and physiological perturbations also partly due to the intrinsic diversity of pyramidal neuron morphology...
  8. pmc Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
    Thomas K Berger
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne EPFL, Switzerland
    J Physiol 587:5411-25. 2009
    ..Our results suggest that the basic construction of neocortical synaptic pathways follows principles that are independent of modality or hierarchical order within the neocortex...
  9. pmc Neuropeptide and calcium-binding protein gene expression profiles predict neuronal anatomical type in the juvenile rat
    Maria Toledo-Rodriguez
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Physiol 567:401-13. 2005
    ..We reveal here, for the first time, a strong relationship between specific combinations of NP and CaBP gene expressions and the anatomical class of neocortical neurones...
  10. pmc Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
    Sean L Hill
    Blue Brain Project, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 109:E2885-94. 2012
    ..This finding suggests that random alignment of axonal and dendritic arbors provides a sufficient foundation for specific functional connectivity to emerge in local neural microcircuits...
  11. pmc Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid
    Tania Rinaldi
    Laboratory of Neural Microcircuits, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 104:13501-6. 2007
    ..Enhanced plasticity introduces a surprising perspective to the potential molecular and synaptic mechanisms involved in children prenatally exposed to VPA...
  12. ncbi request reprint Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis
    Corrado Calì
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    J Comput Neurosci 24:330-45. 2008
    ..We validate our method through computer simulations, theoretical and numerical methods and electrophysiological paired recordings...
  13. pmc Combinatorial expression rules of ion channel genes in juvenile rat (Rattus norvegicus) neocortical neurons
    Georges Khazen
    Blue Brain Project, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e34786. 2012
    ..This novel strategy can be used for predictive reverse engineering combinatorial expression rules from single-cell data and could help identify candidate transcription regulatory processes...
  14. pmc Spontaneous and evoked synaptic rewiring in the neonatal neocortex
    Jean Vincent Le Bé
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:13214-9. 2006
    ..We speculate that this form of microcircuit plasticity enables an evolution of the microcircuit connectivity by natural selection as a function of experience...
  15. ncbi request reprint Short-term synaptic plasticity orchestrates the response of pyramidal cells and interneurons to population bursts
    Magnus J E Richardson
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Computational Neuroscience, School of Computer and Communication Sciences and Brain Mind Institute, CH 1015 Lausanne, Switzerland
    J Comput Neurosci 18:323-31. 2005
    ..The functional role of such delays in the temporal organisation of activity in the cortical microcircuit is discussed...
  16. pmc Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit
    Gilad Silberberg
    Brain Mind Institute, EPFL, Lausanne CH 1015, Switzerland
    J Physiol 556:19-27. 2004
    ..We propose that synaptic dynamics choreograph neuronal activity within the neocortical microcircuit in a context-dependent manner...
  17. pmc A synaptic organizing principle for cortical neuronal groups
    Rodrigo Perin
    Blue Brain Project, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 108:5419-24. 2011
    ..We speculate that these elementary neuronal groups are prescribed Lego-like building blocks of perception and that acquired memory relies more on combining these elementary assemblies into higher-order constructs...
  18. ncbi request reprint Abnormal fear conditioning and amygdala processing in an animal model of autism
    Kamila Markram
    Brain Mind Institute, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Neuropsychopharmacology 33:901-12. 2008
    ..We hypothesize an 'aversive world' syndrome that could, even if not a primary cause of the disorder itself, underlie some core symptoms in autism, such as impairments in social interactions and resistance to rehabilitation...
  19. ncbi request reprint Correlation maps allow neuronal electrical properties to be predicted from single-cell gene expression profiles in rat neocortex
    Maria Toledo-Rodriguez
    Brain and Mind Institute, EPFL, Lausanne 1015, Switzerland
    Cereb Cortex 14:1310-27. 2004
    ..This is the first report of a consistent relationship between the co-expression of a large profile of ion channel and calcium binding protein genes and the electrical phenotype of individual neocortical neurons...
  20. doi request reprint A neuron membrane mesh representation for visualization of electrophysiological simulations
    Sébastien Lasserre
    EPFL Blue Brain Project, AAB 201 station 15, Lausanne 1015, Switzerland
    IEEE Trans Vis Comput Graph 18:214-27. 2012
    ..We compare the new mesh representation with the state of the art and present a series of use cases and applications of this technique to visualize simulations of single neurons and networks of multiple neurons...
  21. pmc Enhanced long-term microcircuit plasticity in the valproic Acid animal model of autism
    Guilherme Testa Silva
    Laboratory of Neural Microcircuitry, Brain and Mind Institute, EPFL Lausanne, Switzerland
    Front Synaptic Neurosci 1:1. 2009
    ..This study provides further evidence to support the notion that the neocortex is highly plastic in response to new experiences in this animal model of autism...
  22. pmc A Component-Based Extension Framework for Large-Scale Parallel Simulations in NEURON
    James G King
    Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Neuroinform 3:10. 2009
    ....
  23. doi request reprint Matched pre- and post-synaptic changes underlie synaptic plasticity over long time scales
    Alex Loebel
    Faculty of Biology, Ludwig Maxmilians Universität München, and Bernstein Center for Computational Neuroscience, D 82152 Munich, Germany
    J Neurosci 33:6257-66. 2013
    ..These findings suggest that ongoing synaptic plasticity results in matched presynaptic and postsynaptic modifications, in which elementary modules that span the synaptic cleft are added or removed as a function of experience...
  24. pmc Computing the size and number of neuronal clusters in local circuits
    Rodrigo Perin
    Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Neuroanat 7:1. 2013
    ..We find that cluster sizes do not grow indefinitely as network parameters increase, but tend to characteristic limiting values...
  25. pmc Channelpedia: an integrative and interactive database for ion channels
    Rajnish Ranjan
    Blue Brain Project, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Neuroinform 5:36. 2011
    ..It is web based, freely accessible and currently contains 187 annotated ion channels with 45 Hodgkin-Huxley models...
  26. pmc A history of spike-timing-dependent plasticity
    Henry Markram
    Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Synaptic Neurosci 3:4. 2011
    ....
  27. pmc The intense world theory - a unifying theory of the neurobiology of autism
    Kamila Markram
    Laboratory of Neural Microcircuits, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Hum Neurosci 4:224. 2010
    ..The theory also makes further predictions from the molecular to the behavioral levels, provides a treatment strategy and presents its own falsifying hypothesis...
  28. ncbi request reprint NEOBASE: databasing the neocortical microcircuit
    Asif Jan Muhammad
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Switzerland
    Stud Health Technol Inform 112:167-77. 2005
    ..The database will be available to local as well as remote users using Grid based tools and technologies...
  29. pmc Hyper-connectivity and hyper-plasticity in the medial prefrontal cortex in the valproic Acid animal model of autism
    Tania Rinaldi
    Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland
    Front Neural Circuits 2:4. 2008
    ..We propose that a number of deficits in autism such as sociability, attention, multi-tasking and repetitive behaviours, should be re-interpreted in the light of a hyper-functional prefrontal cortex...
  30. ncbi request reprint Spike frequency adaptation and neocortical rhythms
    Galit Fuhrmann
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurophysiol 88:761-70. 2002
    ..Adaptation could therefore be one of the crucial factors in setting the frequency of population rhythms in the neocortex...
  31. ncbi request reprint Input prediction and autonomous movement analysis in recurrent circuits of spiking neurons
    Robert Legenstein
    Institute for Theoretical Computer Science, Technische Universitaet Graz, Graz, Austria
    Rev Neurosci 14:5-19. 2003
    ....
  32. ncbi request reprint Deriving physical connectivity from neuronal morphology
    Nir Kalisman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Biol Cybern 88:210-8. 2003
    ..The model could be useful for studying microcircuit connectivity and for designing artificial neural networks...
  33. ncbi request reprint Anatomical, physiological, molecular and circuit properties of nest basket cells in the developing somatosensory cortex
    Yun Wang
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Cereb Cortex 12:395-410. 2002
    ..These data provide multiparametric distinguishing features of three major subclasses of basket cells and indicate that NBCs are powerful interneurons that provide most of the (peri-)somatic inhibition in the supragranular layers...
  34. pmc Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat
    Yun Wang
    Division of Neurology Research, St Elizabeth s Medical Center, Tufts University, Boston, MA 02135, USA
    J Physiol 561:65-90. 2004
    ..It is proposed that MCs are crucial interneurones for feedback inhibition in and between neocortical layers and columns...
  35. ncbi request reprint Real-time computing without stable states: a new framework for neural computation based on perturbations
    Wolfgang Maass
    Institute for Theoretical Computer Science, Technische Universitat Graz, A 8010 Graz, Austria
    Neural Comput 14:2531-60. 2002
    ..Our approach provides new perspectives for the interpretation of neural coding, the design of experiments and data analysis in neurophysiology, and the solution of problems in robotics and neurotechnology...
  36. ncbi request reprint Coding of temporal information by activity-dependent synapses
    Galit Fuhrmann
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Jerusalem 91904, Israel
    J Neurophysiol 87:140-8. 2002
    ..Facilitating synapses, however, are optimized to code information at higher presynaptic rates of 9-70 Hz and can represent the timing of over eight presynaptic spikes...
  37. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  38. ncbi request reprint Heterogeneity in the pyramidal network of the medial prefrontal cortex
    Yun Wang
    Division of Neurology Research, Caritas St Elizabeth s Medical Center, Tufts University, Boston, Massachusetts 02135, USA
    Nat Neurosci 9:534-42. 2006
    ..These cellular, synaptic and network properties could amplify recurrent interactions between pyramidal neurons and support persistent activity in the prefrontal cortex...
  39. ncbi request reprint [A new mechanism for memory: neuronal networks rewiring in the young rat neocortex]
    Jean Vincent Le Bé
    Med Sci (Paris) 22:1031-3. 2006
  40. ncbi request reprint Bioinformatics: industrializing neuroscience
    Henry Markram
    Nature 445:160-1. 2007
  41. ncbi request reprint Fading memory and kernel properties of generic cortical microcircuit models
    Wolfgang Maass
    Institute for Theoretical Computer Science, Technische Universitaet Graz, Austria
    J Physiol Paris 98:315-30. 2004
    ..This article also provides detailed data on the fading memory property of generic neural microcircuit models, and a quick review of other new results on the computational power of such circuits of spiking neurons...
  42. ncbi request reprint Microcircuits in action--from CPGs to neocortex
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Trends Neurosci 28:525-33. 2005
    ..The long-term goal is to identify the components of a molecular and synaptic tool kit for the design of different microcircuits...
  43. ncbi request reprint Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits
    Andrea Mazzatenta
    Physiology and Pathology Department, B R A I N, University of Trieste, I 34127, Trieste, Italy
    J Neurosci 27:6931-6. 2007
    ..Our experimental results, supported by mathematical models to describe the electrical interactions occurring in SWNT-neuron hybrid systems, clearly indicate that SWNTs can directly stimulate brain circuit activity...
  44. ncbi request reprint Synaptic pathways in neural microcircuits
    Gilad Silberberg
    Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Trends Neurosci 28:541-51. 2005
    ....
  45. pmc The neocortical microcircuit as a tabula rasa
    Nir Kalisman
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 102:880-5. 2005
    ..These data also indicate that the local neocortical microcircuit has the potential to be differently rewired without the need for remodeling axonal or dendritic arbors...
  46. pmc Parallel network simulations with NEURON
    M Migliore
    Institute of Biophysics, National Research Council, via U La Malfa 153, 90146, Palermo, Italy
    J Comput Neurosci 21:119-29. 2006
    ..8 seconds and communication time of 1.3 seconds. The potential for speed-ups of several orders of magnitude makes practical the running of large network simulations that could otherwise not be explored...
  47. ncbi request reprint Synapses as dynamic memory buffers
    Wolfgang Maass
    Institute for Theoretical Computer Science, Technische Universitat Graz, Austria
    Neural Netw 15:155-61. 2002
    ..We show that the relatively large number of synaptic release sites that make up a GABAergic synaptic connection makes these connections suitable for such complex information transmission processes...
  48. ncbi request reprint Stereotypy in neocortical microcircuits
    Gilad Silberberg
    Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Trends Neurosci 25:227-30. 2002
    ..Stereotypy is an appealing concept because it provides strong support for determinism in the formation of neuronal microcircuits and in the relationship between their specific structure and function...
  49. ncbi request reprint Interneuron Diversity series: Molecular and genetic tools to study GABAergic interneuron diversity and function
    Hannah Monyer
    IZN, Department of Clinical Neurobiology, University of Heidelberg, Heidelberg, Germany
    Trends Neurosci 27:90-7. 2004
    ..This article reviews literature regarding molecular tools that have been used, or that appear promising for future attempts, to classify GABAergic interneurons. Some important limitations will also be indicated...