Matthias Lutolf

Summary

Country: Switzerland

Publications

  1. pmc Designing materials to direct stem-cell fate
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 462:433-41. 2009
  2. pmc Hydrogel microfluidics for the patterning of pluripotent stem cells
    S Cosson
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Sci Rep 4:4462. 2014
  3. doi request reprint Patterning of cell-instructive hydrogels by hydrodynamic flow focusing
    Steffen Cosson
    Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Station 15, Bldg AI 1109, CH 1015 Lausanne, Switzerland
    Lab Chip 13:2099-105. 2013
  4. doi request reprint Automated analysis of single stem cells in microfluidic traps
    Stefan A Kobel
    Laboratory of Stem Cell Bioengineering LSCB, Institute of Bioengineering and School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    Lab Chip 12:2843-9. 2012
  5. doi request reprint Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells
    Colette A Bichsel
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Lab Chip 12:2313-6. 2012
  6. doi request reprint High-throughput clonal analysis of neural stem cells in microarrayed artificial niches
    Marta Roccio
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Integr Biol (Camb) 4:391-400. 2012
  7. pmc Artificial stem cell niches
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Switzerland
    Adv Mater 21:3255-68. 2009
  8. doi request reprint Integration column: artificial ECM: expanding the cell biology toolbox in 3D
    Matthias P Lutolf
    Laboratory of Stem Cell Bioengineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Integr Biol (Camb) 1:235-41. 2009
  9. doi request reprint Programmable microfluidic patterning of protein gradients on hydrogels
    Simone Allazetta
    Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne Station 15 Bldg AI 1109, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 47:191-3. 2011
  10. pmc Artificial three-dimensional niches deconstruct pancreas development in vitro
    Chiara Greggio
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, CH 1015 Lausanne, Switzerland
    Development 140:4452-62. 2013

Collaborators

  • Anne Grapin-Botton
  • Henrik Semb
  • Steffen Cosson
  • Samy Gobaa
  • Simone Allazetta
  • Stefan Kobel
  • S Cosson
  • Chiara Greggio
  • Colette A Bichsel
  • Marta Roccio
  • Stefan A Kobel
  • Manuel Figueiredo-Larsen
  • Filippo De Franceschi
  • Adrian Ranga
  • Olivier Burri
  • Chiara Secondini
  • Arne Seitz
  • George N Thalmann
  • Mukul Girotra
  • Marco G Cecchini
  • Alexandra Griffa

Detail Information

Publications11

  1. pmc Designing materials to direct stem-cell fate
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Nature 462:433-41. 2009
    ..Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration...
  2. pmc Hydrogel microfluidics for the patterning of pluripotent stem cells
    S Cosson
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Sci Rep 4:4462. 2014
    ..This technique should be useful for testing the effect of dose and timing of biomolecules, singly or in combination, on stem cell fate. ..
  3. doi request reprint Patterning of cell-instructive hydrogels by hydrodynamic flow focusing
    Steffen Cosson
    Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Station 15, Bldg AI 1109, CH 1015 Lausanne, Switzerland
    Lab Chip 13:2099-105. 2013
    ..Our concept should be broadly applicable to probe how complex signaling microenvironments influence stem cell fate in culture...
  4. doi request reprint Automated analysis of single stem cells in microfluidic traps
    Stefan A Kobel
    Laboratory of Stem Cell Bioengineering LSCB, Institute of Bioengineering and School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015, Lausanne, Switzerland
    Lab Chip 12:2843-9. 2012
    ..This approach should be applicable to automatically track single live cells in a wealth of microfluidic systems...
  5. doi request reprint Diagnostic microchip to assay 3D colony-growth potential of captured circulating tumor cells
    Colette A Bichsel
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Lab Chip 12:2313-6. 2012
    ....
  6. doi request reprint High-throughput clonal analysis of neural stem cells in microarrayed artificial niches
    Marta Roccio
    School of Life Sciences, Institute of Bioengineering and Laboratory of Stem Cell Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Integr Biol (Camb) 4:391-400. 2012
    ..We believe that the bioengineering of such in vitro niche analogues is a powerful approach to elucidate single stem cell fate regulation in a well-controlled fashion...
  7. pmc Artificial stem cell niches
    Matthias P Lutolf
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Switzerland
    Adv Mater 21:3255-68. 2009
    ..Such "artificial niches" constitute potent tools for elucidating stem cell regulatory mechanisms with the capacity to directly impact the development of novel therapeutic strategies for tissue regeneration...
  8. doi request reprint Integration column: artificial ECM: expanding the cell biology toolbox in 3D
    Matthias P Lutolf
    Laboratory of Stem Cell Bioengineering and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Integr Biol (Camb) 1:235-41. 2009
    ..Here I will discuss emerging approaches in aECM design, hopefully inspiring cell biologists to apply these systems to address their specific biological question...
  9. doi request reprint Programmable microfluidic patterning of protein gradients on hydrogels
    Simone Allazetta
    Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne Station 15 Bldg AI 1109, CH 1015 Lausanne, Switzerland
    Chem Commun (Camb) 47:191-3. 2011
    ..Computer-controlled hydrodynamic flow focusing was utilized to generate tethered protein gradients of any user-defined shape on the surface of soft synthetic hydrogels...
  10. pmc Artificial three-dimensional niches deconstruct pancreas development in vitro
    Chiara Greggio
    Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, CH 1015 Lausanne, Switzerland
    Development 140:4452-62. 2013
    ..Finally, growth conditions in chemically defined biomaterials pave the way for testing the biophysical and biochemical properties of the niche that sustains pancreatic progenitors. ..
  11. doi request reprint High-throughput methods to define complex stem cell niches
    Stefan Kobel
    Laboratory of Stem Cell Bioengineering LSCB and Institute of Bioengineering IBI, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Biotechniques 48:ix-xxii. 2010
    ..Increased merging of microfabrication with advanced biomaterials technologies may ultimately result in functional artificial niches capable of recapitulating extrinsic stem cell regulation in vitro and on a single-cell level...