Genomes and Genes
- SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisRuth Luthi-Carter
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Proc Natl Acad Sci U S A 107:7927-32. 2010..Furthermore, the ascertainment of SIRT2's role in regulating cellular metabolism demonstrates a central function shared with other sirtuin proteins...
- Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulationTamara Seredenina
Laboratory of Functional Neurogenomics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
PLoS ONE 6:e22231. 2011..Here we test whether individual changes in striatal gene expression are capable of mitigating HD-related neurotoxicity...
- Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activationOzgun Gokce
Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
PLoS ONE 4:e5292. 2009..Moreover, reduction of BDNF delivery to the striatum has been implicated in the pathophysiology of Huntington's disease. Nevertheless, many essential aspects of BDNF responses in striatal neurons remain to be elucidated...
- Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression dataLesley Jones
Depts of Psychological Medicine and Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK
BMC Bioinformatics 7:211. 2006..We conducted an experiment hybridising RNA from human brain to 117 U133A Affymetrix GeneChips and used these data to explore the relationship between 4 pre-chip variables and 22 post-chip outcomes and quality control measures...
- Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'Alexandre Kuhn
Swiss Institute of Bioinformatics SIB, CH 1015 Lausanne, Switzerland
BMC Bioinformatics 9:26. 2008..e. flat file databases. This common flat database format thus provides a simple and robust solution to flexibly integrate various sources of information and a basis for the combined analysis of heterogeneous gene expression profiles...
- Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragmentsLuca Gambazzi
Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
J Pharmacol Exp Ther 335:13-22. 2010..Moreover, the novel model paradigm established here is well suited to further mechanistic and drug screening research applications...
- Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitryHeike Runne
Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Switzerland
J Neurosci 28:9723-31. 2008....
- Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's diseaseValérie Perrin
Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Lausanne, Switzerland
Mol Ther 15:903-11. 2007..Finally, hsp104 induced the production of endogenous hsp27. These data demonstrate the protective effects of chaperones in mammalian models of HD...
- Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypesAna Jovicic
Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
J Neurosci 33:5127-37. 2013....
- Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosageAlexandre Kuhn
Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
Hum Mol Genet 16:1845-61. 2007....
- Synchrotron infrared microspectroscopy detecting the evolution of Huntington's disease neuropathology and suggesting unique correlates of dysfunction in white versus gray brain matterMarkus Bonda
Laboratory of Complex Matter Physics, Ecole Polytechnique Fédéralede Lausanne EPFL, Lausanne, Switzerland
Anal Chem 83:7712-20. 2011..Parallel studies in cultured neurons expressing the same htt fragments showed similar changes...
- MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanismsAna Jovicic
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland
PLoS ONE 8:e54222. 2013..A new therapeutic approach to have emerged recently is the engagement of microRNAs (miRNAs), which affords the opportunity to target multiple cellular pathways simultaneously using a single sequence...
- Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neuronsNikita Rudinskiy
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
J Neurochem 111:460-72. 2009..These results indicate that diminished hippocalcin expression does not contribute to HD-related neurodegeneration...
- Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral bloodHeike Runne
Laboratory of Functional Neurogenomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:14424-9. 2007..2005) Proc Natl Acad Sci USA 102:11023-11028]. The present results may nonetheless inform the future design and testing of HD biomarker strategies...
- MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibitionDavid M Taylor
Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
J Neurosci 33:2313-25. 2013....
- Developmental expression of Synaptotagmin isoforms in single calyx of Held-generating neuronsLe Xiao
Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
Mol Cell Neurosci 44:374-85. 2010..Our study sheds light on the molecular properties of putative calyx of Held-generating neurons and shows the developmental regulation of the Syt-isoform expression profile in a single neuron type...
- A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylaseDavid M Taylor
Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
ACS Chem Biol 6:540-6. 2011..The outcome of this study provides a clear opportunity for lead optimization and drug development, targeting metabolic dysfunctions in CNS disorders where abnormal cholesterol homeostasis is implicated...
- What have we learned from gene expression profiles in Huntington's disease?Tamara Seredenina
Laboratory of Functional Neurogenomics, Ecole Polytechnique Federale de Lausanne, Station 15, 1015 Lausanne, Switzerland
Neurobiol Dis 45:83-98. 2012..An exciting new arm of this research also demonstrates the power of pharmacogenomics to detect (and rule out) important neuroprotective gene expression effects...
- Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1Fang Wu
Laboratory of Molecular and Cellular Biology of Alzheimer s Disease, Brain Mind Institute and School of Life Sciences, Swiss Federal Institute of Technology, Lausanne, Switzerland
FASEB J 24:2464-74. 2010..Our results suggest that the flexible PS1-CTF (381)LGLG(384) loop comprises a substrate-docking site capable of recognizing specifically different gamma-secretase substrates...
- The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicityAsad Jan
Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
J Biol Chem 283:28176-89. 2008....
- Population-specific expression analysis (PSEA) reveals molecular changes in diseased brainAlexandre Kuhn
Laboratory of Functional Neurogenomics, Ecole Polytechnique Federale de Lausanne, Switzerland
Nat Methods 8:945-7. 2011..PSEA of brains from individuals with Huntington's disease revealed myelin-related abnormalities that were undetected using standard differential expression analysis...
- Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegenerationNikita Rudinskiy
Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Station 15, Lausanne CH1015, Switzerland
J Biol Chem 284:12447-58. 2009....
- Comprehensive spatiotemporal transcriptomic analyses of the ganglionic eminences demonstrate the uniqueness of its caudal subdivisionSusan Willi-Monnerat
School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Mol Cell Neurosci 37:845-56. 2008..These GE profiles reveal new candidate regulators of spatiotemporally governed GABAergic neuronogenesis...