Dennis F Lawler

Summary

Country: Switzerland

Publications

  1. ncbi Diet restriction and ageing in the dog: major observations over two decades
    Dennis F Lawler
    2 Research South, Nestle Research Center St Louis NRC STL, Checkerboard Square, St Louis, MO 63164, USA
    Br J Nutr 99:793-805. 2008
  2. ncbi Effects of diet restriction on life span and age-related changes in dogs
    Richard D Kealy
    Pet Nutrition Research Department, Nestle Purina Pet Care Co, St Louis, MO 63164, USA
    J Am Vet Med Assoc 220:1315-20. 2002
  3. ncbi Influence of lifetime food restriction on causes, time, and predictors of death in dogs
    Dennis F Lawler
    Nestle Purina PetCare Research, 835 S 8th St, St Louis, MO 63164, USA
    J Am Vet Med Assoc 226:225-31. 2005
  4. ncbi Influence of lifetime food restriction on physiological variables in Labrador retriever dogs
    Dennis F Lawler
    The Nestle Research Center St Louis, St Louis, MO 63164, USA
    Exp Gerontol 42:204-14. 2007
  5. ncbi The aging feline kidney: a model mortality antagonist?
    Dennis F Lawler
    Nestle Research Center St Louis, Nestle Purina PetCare Company, 2 Research South, St Louis, MO 63164, USA
    J Feline Med Surg 8:363-71. 2006
  6. ncbi Heritable components of feline hematology, clinical chemistry, and acid-base profiles
    Dennis F Lawler
    Nutrition Research Center, Nestle Purina Company, Checkerboard Square, St Louis, MO 63164, USA
    J Hered 97:549-54. 2006
  7. ncbi Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs
    Brian T Larson
    Nestle Purina PetCare Research, St Louis, MO 63164, USA
    J Nutr 133:2887-92. 2003
  8. ncbi Antioxidant status of pair-fed labrador retrievers is affected by diet restriction and aging
    Howard D Stowe
    Nestle Purina PetCare Company, St Louis, MO 63164, USA
    J Nutr 136:1844-8. 2006
  9. doi The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder
    Jeffrey J Runge
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 37:102-7. 2008
  10. ncbi Modulation of canine immunosenescence by life-long caloric restriction
    Elizabeth H Greeley
    Department of Pathobiology, University of Illinois, Urbana, IL 61802, USA
    Vet Immunol Immunopathol 111:287-99. 2006

Collaborators

Detail Information

Publications16

  1. ncbi Diet restriction and ageing in the dog: major observations over two decades
    Dennis F Lawler
    2 Research South, Nestle Research Center St Louis NRC STL, Checkerboard Square, St Louis, MO 63164, USA
    Br J Nutr 99:793-805. 2008
    ..When diet group was taken into account, PWM responses and cell counts and percentages remained predictive of earlier death...
  2. ncbi Effects of diet restriction on life span and age-related changes in dogs
    Richard D Kealy
    Pet Nutrition Research Department, Nestle Purina Pet Care Co, St Louis, MO 63164, USA
    J Am Vet Med Assoc 220:1315-20. 2002
    ..To evaluate the effects of 25% diet restriction on life span of dogs and on markers of aging...
  3. ncbi Influence of lifetime food restriction on causes, time, and predictors of death in dogs
    Dennis F Lawler
    Nestle Purina PetCare Research, 835 S 8th St, St Louis, MO 63164, USA
    J Am Vet Med Assoc 226:225-31. 2005
    ..To describe effects of lifetime food restriction on causes of death and the association between body-mass characteristics and time of death in dogs...
  4. ncbi Influence of lifetime food restriction on physiological variables in Labrador retriever dogs
    Dennis F Lawler
    The Nestle Research Center St Louis, St Louis, MO 63164, USA
    Exp Gerontol 42:204-14. 2007
    ..Other clinical chemistry and thyroid variables, parathyroid variables, and acid-base variables were not strongly influenced by diet restriction but revealed age-related effects...
  5. ncbi The aging feline kidney: a model mortality antagonist?
    Dennis F Lawler
    Nestle Research Center St Louis, Nestle Purina PetCare Company, 2 Research South, St Louis, MO 63164, USA
    J Feline Med Surg 8:363-71. 2006
    ..Emerging molecular technology offers the future potential to further evaluate and refine these observations. At present, the existence of plastic and adaptive aging programming is suggested by these findings...
  6. ncbi Heritable components of feline hematology, clinical chemistry, and acid-base profiles
    Dennis F Lawler
    Nutrition Research Center, Nestle Purina Company, Checkerboard Square, St Louis, MO 63164, USA
    J Hered 97:549-54. 2006
    ..59, and from 0.41 to 0.69 (P < 0.05). This result indicates that serum variability has a genetic basis and is segregating in this feline population. These findings may have important implications in both research and clinical medicine...
  7. ncbi Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs
    Brian T Larson
    Nestle Purina PetCare Research, St Louis, MO 63164, USA
    J Nutr 133:2887-92. 2003
    ..05), but diet restriction explained most of this relationship's variation. Glucose disposal efficiency and insulin response were associated with increased quality and length of life in diet-restricted dogs...
  8. ncbi Antioxidant status of pair-fed labrador retrievers is affected by diet restriction and aging
    Howard D Stowe
    Nestle Purina PetCare Company, St Louis, MO 63164, USA
    J Nutr 136:1844-8. 2006
    ....
  9. doi The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder
    Jeffrey J Runge
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 37:102-7. 2008
    ..To report effects of age and lifetime food restriction on development and progression of shoulder joint osteoarthritis (OA) in Labrador retriever dogs...
  10. ncbi Modulation of canine immunosenescence by life-long caloric restriction
    Elizabeth H Greeley
    Department of Pathobiology, University of Illinois, Urbana, IL 61802, USA
    Vet Immunol Immunopathol 111:287-99. 2006
    ....
  11. ncbi Evaluation of a circumferential femoral head osteophyte as an early indicator of osteoarthritis characteristic of canine hip dysplasia in dogs
    Stephanie D Szabo
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 231:889-92. 2007
    ....
  12. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs...
  13. pmc Bilaterally asymmetric effects of quantitative trait loci (QTLs): QTLs that affect laxity in the right versus left coxofemoral (hip) joints of the dog (Canis familiaris)
    Kevin Chase
    Department of Biology, University of Utah, Salt Lake City, Utah 84102, USA
    Am J Med Genet A 124:239-47. 2004
    ..The other, associated with FH2598, was significant for the right but not the left hip. For both QTLs, some extreme phenotypes were best explained by specific interactions between haplotypes...
  14. pmc Genetic regulation of osteoarthritis: A QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris)
    Kevin Chase
    Am J Med Genet A 135:334-5. 2005
  15. ncbi Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs
    Gail K Smith
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104 6010, USA
    J Am Vet Med Assoc 229:690-3. 2006
    ..To evaluate the effects of diet restriction on development of radiographic evidence of hip joint osteoarthritis in dogs...
  16. pmc Exploring human/animal intersections: converging lines of evidence in comparative models of aging
    John Q Trojanowski
    School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:1-5. 2008
    ..Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research...