Katrin Kuehnle

Summary

Country: Switzerland

Publications

  1. pmc Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress
    Katrin Kuehnle
    Swiss Academy of Medical Sciences, Petersplatz 13, 4051 Basel, Switzerland
    Mol Cell Biol 28:539-50. 2008
  2. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
  3. ncbi Swiss national MD-PhD-program: an outcome analysis
    Katrin Kuehnle
    Swiss Academy of Medical Sciences, Basel, Switzerland
    Swiss Med Wkly 139:540-6. 2009
  4. pmc The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
    Arames Crameri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    EMBO J 25:432-43. 2006
  5. ncbi Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
  6. ncbi Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 32:1827-38. 2011
  7. ncbi Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 562:16-21. 2004

Detail Information

Publications8

  1. pmc Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress
    Katrin Kuehnle
    Swiss Academy of Medical Sciences, Petersplatz 13, 4051 Basel, Switzerland
    Mol Cell Biol 28:539-50. 2008
    ..Our findings reveal a dual capacity of DHCR24/seladin-1, which appears to be involved in two mechanistically independent prosurvival effects, exerting an acute response and a chronic response to oxidative stress...
  2. pmc Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice
    Katrin Kuehnle
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurochem Res 34:1167-82. 2009
    ..These data indicate that desmosterol can replace cholesterol in membrane-related functions in the DHCR24(-/-) mouse...
  3. ncbi Swiss national MD-PhD-program: an outcome analysis
    Katrin Kuehnle
    Swiss Academy of Medical Sciences, Basel, Switzerland
    Swiss Med Wkly 139:540-6. 2009
    ..This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years...
  4. pmc The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo
    Arames Crameri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    EMBO J 25:432-43. 2006
    ..Pharmacological enhancement of seladin-1 activity may be a novel Abeta-lowering approach for the treatment of AD...
  5. ncbi Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 1:160-7. 2004
    ..This protocol may prove useful for the rapid validation of the activity of antibodies designed to be used in immune therapy of AD...
  6. ncbi Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration
    Luka Kulic
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Neurobiol Aging 32:1827-38. 2011
    ..These results suggest an age-dependent mutual reinforcement of the tau pathology and mitochondrial dysfunction in vivo, which may contribute to neurodegeneration in patients suffering from AD and other age-related tauopathies...
  7. ncbi Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease
    M Hasan Mohajeri
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    FEBS Lett 562:16-21. 2004
    ..Therefore, we suggest that the potential of NEP for AD therapy is age-dependent and most effective early in the course of AD pathophysiology...