Research Topics
Species | Felix KesslerSummaryCountry: Switzerland Publications
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Publications
Tocopherol cyclase (VTE1) localization and vitamin E accumulation in chloroplast plastoglobule lipoprotein particlesPierre-Alexandre Vidi
Institute of Botany, , Emile Argand 11, , Switzerland
J Biol Chem 281:11225-34. 2006..Thus, in addition to their lipid storage function, we propose that plastoglobules are metabolically active, taking part in tocopherol synthesis and likely other pathways...
A novel method for prenylquinone profiling in plant tissues by ultra-high pressure liquid chromatography-mass spectrometryJacopo Martinis
Chemical Analytical Service of the Swiss Plant Science Web, University of Neuchatel, 2000 Neuchatel, Switzerland
Plant Methods 7:23. 2011..abstract:..- Plastoglobule lipid bodies: their functions in chloroplasts and their potential for applicationsFelix Kessler
Institute of Botany, University of Neuchatel, Emile Argand 11, CP158, 2009, Neuchatel, Switzerland
Adv Biochem Eng Biotechnol 107:153-72. 2007..On the basis of similarities between plastoglobules and seed oleosomes, the potential of plastoglobules for bioengineering applications is discussed... - Chloroplast protein import: solve the GTPase riddle for entryFelix Kessler
Laboratoire de Physiologie Vegetale, Institute de Botanique, Universite de Neuchatel, Rue Emile Argand 11, 2007 Neuchatel, Switzerland
Trends Cell Biol 14:334-8. 2004..Recent studies of protein targeting to chloroplasts suggest a novel mechanism in which GTP-dependent substrate recognition is coupled to a GTP-driven motor that initiates the translocation of proteins into the organelle... - The function and diversity of plastid protein import pathways: a multilane GTPase highway into plastidsFelix Kessler
Laboratoire de Physiologie Vegetale, Institut de Botanique, Universite de Neuchatel, Rue Emile Argand 11, 2007 Neuchatel, Switzerland
Traffic 7:248-57. 2006..These different import pathways appear to be necessary to balance the essential physiological role of plastids in cellular metabolism with the demands of cellular differentiation and plant development... - The acidic A-domain of Arabidopsis TOC159 occurs as a hyperphosphorylated proteinBirgit Agne
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, CH 2009 Neuchatel, Switzerland
Plant Physiol 153:1016-30. 2010..However, the physiological relevance of this process is unclear. The data show that the A-domain of Toc159 as well as those of its homologs Toc132 and Toc120 are targets of a casein kinase 2-like activity... 
In vivo interaction between atToc33 and atToc159 GTP-binding domains demonstrated in a plant split-ubiquitin systemGwendoline Rahim
Laboratoire de Physiologie Vegetale, Institut de Biologie, Universite de Neuchatel, Rue Emile Argand 11, CH 2009 Neuchatel, Switzerland
J Exp Bot 60:257-67. 2009..Using the same method, the self-interaction of the peroxisomal membrane protein atPex11e is demonstrated. The finding suggests a more general suitability of the split-ubiquitin system as a plant in vivo interaction assay...- The chloroplast import receptor Toc90 partially restores the accumulation of Toc159 client proteins in the Arabidopsis thaliana ppi2 mutantSibylle Infanger
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Rue Emile Argand 11, 2000 Neuchatel, Switzerland
Mol Plant 4:252-63. 2011..Several lines of evidence including proteome profiling demonstrate the import and accumulation of proteins essential for chloroplast biogenesis and functionality... - Plastid lipid droplets at the crossroads of prenylquinone metabolismLucia Eugeni Piller
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, 2000 Neuchatel, Switzerland
J Exp Bot 63:1609-18. 2012..In this review the function of PGs and their associated enzymes in prenylquinone metabolism will be discussed... - A toc159 import receptor mutant, defective in hydrolysis of GTP, supports preprotein import into chloroplastsBirgit Agne
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Rue Emile Argand 11, 2007 Neuchatel, Switzerland
J Biol Chem 284:8670-9. 2009..The data also indicate that preprotein import requires at least one additional GTPase other than Toc159... - The TOC complex: preprotein gateway to the chloroplastCharles Andres
Institut de Biologie, Universite de Neuchatel, CH 2009 Neuchatel, Switzerland
Biochim Biophys Acta 1803:715-23. 2010..In this review we will describe the current state of knowledge regarding the composition and function of the TOC complex... - Protein transport in organelles: The Toc complex way of preprotein importBirgit Agne
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Switzerland
FEBS J 276:1156-65. 2009..This minireview describes the components of the Toc complex and their function during the initial steps of preprotein translocation across the chloroplast envelope... - Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulationLucia Eugeni Piller
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, 2000 Neuchatel, Switzerland
Proc Natl Acad Sci U S A 108:14354-9. 2011..Finally, NDC1 is required for normal plastochromanol-8 accumulation and is essential for vitamin K(1) production... 
Plastoglobules: a new address for targeting recombinant proteins in the chloroplastPierre Alexandre Vidi
Institute of Botany, University of Neuchatel, Rue Emile Argand 11, CP158, CH 2009 Neuchatel, Switzerland
BMC Biotechnol 7:4. 2007..Extraction and purification of recombinant proteins from leaf material contribute to a large extent to the production costs. Developing new strategies facilitating these processes is therefore necessary...- Chloroplast biogenesis: diversity and regulation of the protein import apparatusFelix Kessler
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Neuchatel, Switzerland
Curr Opin Cell Biol 21:494-500. 2009..Recent studies also have revealed new components that could represent additional levels of control on the import process... - Plastoglobules: versatile lipoprotein particles in plastidsClaire Bréhélin
Laboratoire de Physiologie Vegetale, Institut de Biologie, Universite de Neuchatel, Neuchatel, Switzerland
Trends Plant Sci 12:260-6. 2007..Understanding the function of plastoglobules should provide a foundation for improving the nutritional value and yield of plants... - Preparation of multiprotein complexes from Arabidopsis chloroplasts using tandem affinity purificationCharles Andres
Plant Physiology Laboratory, University of Neuchatel, Neuchatel, Switzerland
Methods Mol Biol 775:31-49. 2011..PLoS ONE 4:e6685, 2009). Here, we describe a TAP tag purification method for the purification of protein complexes from total Arabidopsis extracts, that we employed successfully using a TAP-tagged chloroplast outer envelope protein... - The plastoglobule: a bag full of lipid biochemistry tricksClaire Bréhélin
Laboratoire de Physiologie Vegetale, Universite de Neuchatel, Neuchatel, Switzerland
Photochem Photobiol 84:1388-94. 2008..This review will give a summary of research, past and present, attempting to elucidate the role of plastoglobules in the context of plastid function... - Dimerization of Toc-GTPases at the chloroplast protein import machineryPetra Weibel
Laboratoire de Physiologie Vegetale, Institut de Botanique, Universite de Neuchatel, Rue Emile Argand 11, 2007 Neuchatel, Switzerland
J Biol Chem 278:37321-9. 2003..Independent regulation of GTPase activity may serve to coordinate the interactions of the GTPases during the import of proteins into the chloroplast... - Essential role of the G-domain in targeting of the protein import receptor atToc159 to the chloroplast outer membraneJörg Bauer
Plant Physiology and Biochemistry Group, Institute of Plant Sciences, ETH Zurich, CH 8092 Zurich, Switzerland
J Cell Biol 159:845-54. 2002..Thus, the function of atToc159 in chloroplast biogenesis is dependent on an intrinsic GTP-regulated switch that controls localization of the receptor to the chloroplast envelope... - The targeting of the atToc159 preprotein receptor to the chloroplast outer membrane is mediated by its GTPase domain and is regulated by GTPMatthew D Smith
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA
J Cell Biol 159:833-43. 2002..Our findings demonstrate a role for the coordinate action of the Toc GTPases in assembly of the functional Toc complex at the chloroplast outer envelope membrane... - atTic110 functions as a scaffold for coordinating the stromal events of protein import into chloroplastsTakehito Inaba
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Biol Chem 278:38617-27. 2003..These data support the hypothesis that the bulk of Tic110 extends into the chloroplast stroma and suggest that the domain forms a docking site for preproteins as they emerge from the Tic translocon... - A GTPase gate for protein import into chloroplastsFelix Kessler
Nat Struct Biol 9:81-3. 2002 - Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastidsTakehito Inaba
Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
Plant Cell 17:1482-96. 2005..Together, these data suggest that Tic110 plays a general role in the import of nuclear-encoded preproteins as a common component of Tic complexes... - Plastoglobules are lipoprotein subcompartments of the chloroplast that are permanently coupled to thylakoid membranes and contain biosynthetic enzymesJotham R Austin
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
Plant Cell 18:1693-703. 2006.... - Nitrogen deficiency in Arabidopsis affects galactolipid composition and gene expression and results in accumulation of fatty acid phytyl estersNicole Gaude
Department of Molecular Physiology, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
Plant J 49:729-39. 2007..Therefore N deficiency in higher plants results in a co-ordinated breakdown of galactolipids and chlorophyll with deposition of specific fatty acid phytyl esters in thylakoids and plastoglobules of chloroplasts... - AtToc90, a new GTP-binding component of the Arabidopsis chloroplast protein import machineryAndreas Hiltbrunner
, , , D-79104 Freiburg, Germany
Plant Mol Biol 54:427-40. 2004..As both proteins specifically contribute to the accumulation of photosynthetic proteins in chloroplasts they may be components of the same import pathway...