D Jegger

Summary

Country: Switzerland

Publications

  1. ncbi request reprint Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter
    David Jegger
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 290:H1540-8. 2006
  2. ncbi request reprint Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine
    David Jegger
    Ecole Polytechnique Federale de Lausanne, Laboratory of Hemodynamics and Cardiovascular Technology, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 291:H1942-51. 2006
  3. ncbi request reprint The effect of a myocardial infarction on the normalized time-varying elastance curve
    David Jegger
    Laboratory of Haemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Appl Physiol 102:1123-9. 2007
  4. ncbi request reprint Effects of an aging vascular model on healthy and diseased hearts
    David Jegger
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Haemodynamics and Cardiovascular Technology, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 293:H1334-43. 2007
  5. ncbi request reprint Using computational fluid dynamics to evaluate a novel venous cannula (Smart canula) for use in cardiopulmonary bypass operating procedures
    D Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Perfusion 22:257-65. 2007
  6. ncbi request reprint Optimization of the pump driven venous return for minimally invasive open heart surgery
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital, Lausanne, Switzerland
    Int J Artif Organs 22:684-9. 1999
  7. ncbi request reprint Ex vivo testing of the Quart arterial line filter
    X M Mueller
    Clinic for Cardiovascular Surgery, Centre Hospitalier Universitaire, Lausanne, Switzerland
    Perfusion 14:481-7. 1999
  8. ncbi request reprint Assembly of the Heparin Removal Device for patients with suspected adverse reaction to protamine sulphate
    D Jegger
    Department of Cardiovascular Surgery, University Hospital, Lausanne
    Perfusion 15:453-6. 2000
  9. ncbi request reprint Heparin removal after cardiopulmonary bypass in a patient with adverse reaction to protamine
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital, Lausanne, Switzerland
    Thorac Cardiovasc Surg 46:303-4. 1998
  10. ncbi request reprint A cardiopulmonary bypass score system to assess quality of perfusion performance
    D Jegger
    Department of Cardiovascular Surgery, CHUV, Lausanne, Switzerland
    Perfusion 16:183-8. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter
    David Jegger
    Laboratory of Hemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 290:H1540-8. 2006
    ..These findings support the use of these two new noninvasive indexes for long-term analysis of the post-MI LV remodeling...
  2. ncbi request reprint Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine
    David Jegger
    Ecole Polytechnique Federale de Lausanne, Laboratory of Hemodynamics and Cardiovascular Technology, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 291:H1942-51. 2006
    ....
  3. ncbi request reprint The effect of a myocardial infarction on the normalized time-varying elastance curve
    David Jegger
    Laboratory of Haemodynamics and Cardiovascular Technology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Appl Physiol 102:1123-9. 2007
    ..We conclude that the E(n)(t(n)) differs quantitatively in all phases of the heart cycle, between normal and hearts post-MI. This should be considered when utilizing the single-beat concept...
  4. ncbi request reprint Effects of an aging vascular model on healthy and diseased hearts
    David Jegger
    Ecole Polytechnique Federale de Lausanne EPFL, Laboratory of Haemodynamics and Cardiovascular Technology, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 293:H1334-43. 2007
    ..05). The combination of ISH due to this aging model and MI demonstrates significant alterations in cardiac function. This model mimics several clinical phenomena of cardiovascular aging and may thus serve to further study novel therapies...
  5. ncbi request reprint Using computational fluid dynamics to evaluate a novel venous cannula (Smart canula) for use in cardiopulmonary bypass operating procedures
    D Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Perfusion 22:257-65. 2007
    ..This is also advocated by a better pressure gradient and higher average velocities. By reducing cannula-tip surface area or increasing hole surface area, greater flow rates are achieved...
  6. ncbi request reprint Optimization of the pump driven venous return for minimally invasive open heart surgery
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital, Lausanne, Switzerland
    Int J Artif Organs 22:684-9. 1999
    ..The size and type of cannula also significantly affected blood drainage. Active drainage was best with the percutaneous 28F cannula. This cannula was specially attractive at low CVP conditions...
  7. ncbi request reprint Ex vivo testing of the Quart arterial line filter
    X M Mueller
    Clinic for Cardiovascular Surgery, Centre Hospitalier Universitaire, Lausanne, Switzerland
    Perfusion 14:481-7. 1999
    ..Moreover, it offers a venting function and an integrated bypass system...
  8. ncbi request reprint Assembly of the Heparin Removal Device for patients with suspected adverse reaction to protamine sulphate
    D Jegger
    Department of Cardiovascular Surgery, University Hospital, Lausanne
    Perfusion 15:453-6. 2000
    ..The HRD presents an alternative to protamine sulphate when this drug is contraindicated for a certain patient population who might have a suspected, known or emergency adverse reaction...
  9. ncbi request reprint Heparin removal after cardiopulmonary bypass in a patient with adverse reaction to protamine
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital, Lausanne, Switzerland
    Thorac Cardiovasc Surg 46:303-4. 1998
    ..In 35 minutes ACT decreased from 480 sec to 180 sec and clots appeared in the operating field. This system provides an excellent alternative to protamine in patients with an adverse reaction to protamine...
  10. ncbi request reprint A cardiopulmonary bypass score system to assess quality of perfusion performance
    D Jegger
    Department of Cardiovascular Surgery, CHUV, Lausanne, Switzerland
    Perfusion 16:183-8. 2001
    ..This is another step towards our goal of total quality management...
  11. ncbi request reprint Performance of a new implantable cardiac assist centrifugal pump
    H T Tevaearai
    Clinic for Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Artif Organs 25:67-9. 2001
    ..In addition to the advantage of its particular design, the AB-180 can be considered as an efficient left ventricular assist device (LVAD). It significantly unloads the left heart cavities and ensures efficient systemic AP and blood flow...
  12. ncbi request reprint Impact of a remote pump head on neonatal priming volumes
    J Horisberger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Perfusion 14:351-6. 1999
    ..This reduction in priming volume is clinically significant as it lowers the ratio of priming volume to patient blood volume and reduces homologous blood requirements...
  13. ncbi request reprint Venous drainage with a single peripheral bicaval cannula for less invasive atrial septal defect repair
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital CHUV, Lausanne, Switzerland
    Ann Thorac Surg 72:1772-3. 2001
    ..6% +/- 11.7% of theoretical cardiac output. Drainage was augmented to 93.4% +/- 8.6% of theoretical cardiac output by means of a centrifugal pump...
  14. ncbi request reprint Are standard human coagulation tests suitable in pigs and calves during extracorporeal circulation?
    X M Mueller
    Clinic for Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Artif Organs 25:579-84. 2001
    ..The pig model is a better model in which both coagulation pathways could be activated with standard human coagulation tests...
  15. ncbi request reprint Atrial, ventricular, or both cannulation sites to optimize left ventricular assistance?
    H T Tevaearai
    Department of Cardiovascular Surgery, University Hospital CHUV, Lausanne, Switzerland
    ASAIO J 47:261-5. 2001
    ..However, in severe heart failure, blood drainage through the LV cannula decreases and the LA cannulation site is superior...
  16. ncbi request reprint Poly2-methoxyethylacrylate (PMEA) coated oxygenator: an ex vivo study
    X M Mueller
    Department of Cardio Vascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Int J Artif Organs 25:223-9. 2002
    ..This study compares thrombus resistance, blood path resistance, thrombocyte profile, and blood trauma of the PMEA coated Capiox membrane oxygenator (Terumo, Japan) vs. an uncoated version...
  17. ncbi request reprint A new expandable cannula to increase venous return during peripheral access cardiopulmonary bypass surgery
    D Jegger
    Department of Cardio Vascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Int J Artif Organs 25:136-40. 2002
    ..0001) and 14% under AVD conditions (p=0.0002). The new cannula outperforms the classical percutaneous venous cannulae during all of the four conditions tested in vitro...
  18. ncbi request reprint Establishing an association between a peri-operative perfusion score system (PerfSCORE) and post-operative patient morbidity/mortality during CPB cardiac surgery
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Perfusion 22:311-6. 2007
    ..The purpose was to create a new method for evaluating the quality of care the perfusionist provides during CPB procedures and to deduce whether it predicts patient morbidity and mortality...
  19. ncbi request reprint Antithrombotic properties of trillium coated connectors
    Xavier M Mueller
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    ASAIO J 48:483-6. 2002
    ..3 +/- 2.8 for controls; p = 0.03). Therefore, Trillium coating exhibits significant antithrombotic properties that outperform standards for connectors used in clinical perfusion...
  20. ncbi request reprint Infarct-remodeled myocardium is receptive to protection by isoflurane postconditioning: role of protein kinase B/Akt signaling
    Jianhua Feng
    Institute of Anesthesiology, University Hospital Zurich, Switzerland
    Anesthesiology 104:1004-14. 2006
    ..Postinfarct remodeled myocardium exhibits numerous structural and biochemical alterations. So far, it is unknown whether postconditioning elicited by volatile anesthetics can also provide protection in the remodeled myocardium...
  21. ncbi request reprint Flow dynamic comparison of peripheral venous cannulas used with centrifugal pump assistance in vitro
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Artif Organs 26:390-2. 2002
    ..7 mm) with a total hole area of 586 mm2 also allowed a similar flow of 5.03 +/- 0.12 L/min. Therefore, the total hole area appears to be a critical factor in designing peripheral cannulas used in restricted chambers such as vena cavae...
  22. ncbi request reprint A new concept of integrated cardiopulmonary bypass circuit
    Xavier M Mueller
    Department of Cardio Vascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, CH 1011 Lausanne, Switzerland
    Eur J Cardiothorac Surg 21:840-6. 2002
    ..Santa Clara, CA, USA). The impact of this system on gas exchange capacity, blood elements and hemolysis is compared to that of a conventional circuit in a model of prolonged perfusion...
  23. ncbi request reprint Comparing oxygen transfer performance between three membrane oxygenators: effect of temperature changes during cardiopulmonary bypass
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Artif Organs 31:290-300. 2007
    ..Using this parameter, we demonstrated significant differences among commercially available oxygenators. However, all three oxygenators are considered to meet the oxygen needs of the patients...
  24. ncbi request reprint A novel device for reducing hemolysis provoked by cardiotomy suction during open heart cardiopulmonary bypass surgery: a randomized prospective study
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Artif Organs 31:23-30. 2007
    ..05). This novel SS device evokes significantly lowered blood PFH and LDH values peri- and post CPB compared with the CTRL blood using a CS system. The SS may be a valuable alternative compared to traditional CS techniques...
  25. ncbi request reprint Miniaturization in cardiopulmonary bypass
    Ludwig K von Segesser
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, CHUV, Lausanne, Switzerland
    Perfusion 18:219-24. 2003
    ..This report provides an update of already commercially available low prime perfusion devices (e.g., the CORx integrated pump-oxygenator) as well as promising prototypes like the smart suction system and the smartcanula...
  26. ncbi request reprint A novel technique using echocardiography to evaluate venous cannula performance perioperatively in CPB cardiac surgery
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Eur J Cardiothorac Surg 29:525-9. 2006
    ..Also, little progress has been made in venous cannula design in order to optimise venous return to the heart lung machine. We designed a self-expandable Smartcanula (SC) and analysed its performance capability using echocardiography...
  27. ncbi request reprint Air filtering capacity of an integrated cardiopulmonary bypass unit
    Xavier M Mueller
    Department of Cardio Vascular Surgery, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
    ASAIO J 49:365-9. 2003
    ..Its integrated concept offers a simplification of the circuit with fewer devices and connections, which further reduces the risk of accidental air introduction...
  28. ncbi request reprint The Smartcanula: a new tool for remote access perfusion in limited access cardiac surgery
    Ludwig K von Segesser
    Department of Cardio Vascular Surgery, Centre Hospitalier Universitaire Vaudois, CHUV, Lausanne, Switzerland
    Heart Surg Forum 8:E241-5. 2005
    ..The benefits of smart cannulation are obvious in remote cannulation for limited access cardiac surgery, but there are many other cannula applications where space is an issue, and that is where smart cannulation is most effective...
  29. ncbi request reprint Vascular access for cardiopulmonary bypass procedures
    David Jegger
    Department of Cardiovascular Surgery, Center Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon, Lausanne, Switzerland
    Artif Organs 28:649-54. 2004
    ..An example is presented with the development of the Smartcanula which maximizes hole surface area and minimizes the wall thickness in order to optimize flow rate and vascular access to the patient...
  30. ncbi request reprint Limitations using the vacuum-assist venous drainage technique during cardiopulmonary bypass procedures
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    J Extra Corpor Technol 35:207-11. 2003
    ..Therefore, VAVD is a safe technique as long as the perfusionist stops the vacuum when the arterial pump is no longer in use...
  31. ncbi request reprint A prototype paediatric venous cannula with shape change in situ
    David Jegger
    Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Perfusion 18:61-5. 2003
    ..26 +/- 0.05 L/min) by 24% (p < 0.001). This new cannula design provides superior flow characteristics, under all test conditions, compared to the classic single-stage venous cannulae used for paediatric CPB surgery...