Shiva K Tyagarajan
Affiliation: Institute of Pharmacology and Toxicology
Tyagarajan S, Ghosh H, Yevenes G, Nikonenko I, Ebeling C, Schwerdel C, et al
. Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin. Proc Natl Acad Sci U S A. 2011;108:379-84 pubmed publisher
..Together, these findings identify gephyrin as synaptogenic molecule regulating GABAergic synaptic plasticity, likely contributing to the therapeutic action of lithium. ..
Tyagarajan S, Ghosh H, Harvey K, Fritschy J. Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J Cell Sci. 2011;124:2786-96 pubmed publisher
..Taken together, our results identify CB and Cdc42 as major regulators of GABAergic postsynaptic densities. ..
Tyagarajan S, Ghosh H, Yevenes G, Imanishi S, Zeilhofer H, Gerrits B, et al
. Extracellular signal-regulated kinase and glycogen synthase kinase 3? regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem. 2013;288:9634-47 pubmed publisher
..We unravel novel mechanisms for activity- and ERK-dependent calpain action on gephyrin, which are likely relevant in the context of cellular signaling affecting GABAergic transmission and homeostatic synaptic plasticity in pathology. ..
Maffei A, Charrier C, Caiati M, Barberis A, Mahadevan V, Woodin M, et al
. Emerging Mechanisms Underlying Dynamics of GABAergic Synapses. J Neurosci. 2017;37:10792-10799 pubmed publisher
..Together, the selection of topics demonstrates how developmental and activity-dependent mechanisms coordinate inhibition in relation to the excitatory inputs and vice versa. ..
Fritschy J, Tyagarajan S. GABAergic Synaptogenesis: A Case for Cooperation. Neuron. 2017;96:709-711 pubmed publisher
..In this issue of Neuron, Li et al. (2017) report cooperativity between Neuroligin2 and Slitrk3, exerting distinct effects on GABAergic synapse formation in immature and mature neurons...