Federica Sallusto

Summary

Affiliation: Institute for Research in Biomedicine
Country: Switzerland

Publications

  1. ncbi request reprint Origin and migratory properties of dendritic cells in the skin
    F Sallusto
    Institute for Reseach in Biomedicine, Bellinzona, Switzerland
    Curr Opin Allergy Clin Immunol 1:441-8. 2001
  2. ncbi request reprint Chemoattractants and their receptors in homeostasis and inflammation
    Federica Sallusto
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Immunol 16:724-31. 2004
  3. pmc From vaccines to memory and back
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Immunity 33:451-63. 2010
  4. pmc Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    Claudia R Ruprecht
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 201:1793-803. 2005
  5. pmc Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
    Rebekka Geiger
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 206:1525-34. 2009
  6. doi request reprint Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:2076-82. 2009
  7. doi request reprint Human Th17 cells in infection and autoimmunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Microbes Infect 11:620-4. 2009
  8. ncbi request reprint Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
  9. ncbi request reprint Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
    F Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 177:134-40. 2000
  10. ncbi request reprint The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
    Laura Lozza
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 38:30-9. 2008

Detail Information

Publications75

  1. ncbi request reprint Origin and migratory properties of dendritic cells in the skin
    F Sallusto
    Institute for Reseach in Biomedicine, Bellinzona, Switzerland
    Curr Opin Allergy Clin Immunol 1:441-8. 2001
    ..Therefore dendritic cells within the skin are the key regulators of both quantitative and qualitative aspects of immune responses to local antigenic challenge...
  2. ncbi request reprint Chemoattractants and their receptors in homeostasis and inflammation
    Federica Sallusto
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Immunol 16:724-31. 2004
    ..Finally, antagonists (or agonists) of chemoattractant receptors and their signalling pathways represent the most attractive strategy for the treatment of a wide range of inflammatory diseases, including allergy...
  3. pmc From vaccines to memory and back
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Immunity 33:451-63. 2010
    ..Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back...
  4. pmc Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    Claudia R Ruprecht
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 201:1793-803. 2005
    ....
  5. pmc Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
    Rebekka Geiger
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 206:1525-34. 2009
    ....
  6. doi request reprint Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:2076-82. 2009
    ..Here, we review our current understanding of CD4(+) T-cell lineage heterogeneity and flexibility, with emphasis on the human system, and propose an organization of effector and memory T cells based on distinct functional modules...
  7. doi request reprint Human Th17 cells in infection and autoimmunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Microbes Infect 11:620-4. 2009
    ..Since their discovery, efforts have been made in characterizing human Th17 cells and the factors involved in their differentiation and in understanding the role these cells play in protective immunity and autoimmune diseases...
  8. ncbi request reprint Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  9. ncbi request reprint Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
    F Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 177:134-40. 2000
    ..These studies provide insights into the mechanisms that control T-cell priming as well as memory and effector immune responses...
  10. ncbi request reprint The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
    Laura Lozza
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 38:30-9. 2008
    ..These results show that the strength of stimulation determines properties of activated IL-7R(hi) T cells, and suggest that memory T cell subsets could be derived from CCR7(+) precursors that received different strengths of stimulation...
  11. doi request reprint Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  12. pmc CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Exp Med 205:2561-74. 2008
    ..These results show that T(EM) cells can behave as endogenous adjuvants and suggest a mechanistic link between lymphocyte traffic in lymph nodes and induction of autoimmunity...
  13. ncbi request reprint Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells
    Anja Langenkamp
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 33:474-82. 2003
    ..These results indicate a complex chemokine receptor regulation dependent on both T cell activation and differentiation state. In addition, they reveal the existence of DC-specific cues for the regulation of T cell migratory capacity...
  14. pmc Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells
    Laura Rivino
    Institute for Research in Biomedicine, Via Vela 6, 6500 Bellinzona, Switzerland
    J Exp Med 200:725-35. 2004
    ..Our results also explain how the quality of primary T cell responses could be maintained by T(CM) cells in the absence of antigen...
  15. ncbi request reprint Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ....
  16. doi request reprint Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1301-12. 2009
    ....
  17. doi request reprint C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    Andrea Reboldi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:514-23. 2009
    ..Our results identify distinct molecular requirements and ports of lymphocyte entry into uninflamed versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS...
  18. ncbi request reprint Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses...
  19. pmc Clonal dissection of the human memory B-cell repertoire following infection and vaccination
    Debora Pinna
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1260-70. 2009
    ..These results reveal novel aspects of memory B-cell kinetics and provide a powerful tool to monitor immune responses following infection and vaccination...
  20. ncbi request reprint L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
    Greta Guarda
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:743-52. 2007
    ..The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses...
  21. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
  22. ncbi request reprint Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  23. doi request reprint Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β
    Christina E Zielinski
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Nature 484:514-8. 2012
    ..albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase...
  24. pmc CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
    Laura Rivino
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Exp Med 207:565-77. 2010
    ....
  25. ncbi request reprint Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
    Jens Geginat
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 101:4260-6. 2003
    ..Furthermore, they suggest that TEMRA cells are generated from a TCM subset upon homeostatic proliferation in the absence of antigen...
  26. ncbi request reprint Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
    Dirk Baumjohann
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
    Immunity 38:596-605. 2013
    ....
  27. pmc MiR-146a and NF-κB1 regulate mast cell survival and T lymphocyte differentiation
    Nicole Rusca
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Mol Cell Biol 32:4432-44. 2012
    ....
  28. doi request reprint T-cell trafficking in the central nervous system
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 248:216-27. 2012
    ..In particular, we elaborate on the role of CCR6/CCL20 axis in migration through the choroid plexus and the involvement of this pathway in immune surveillance of and autoimmunity in the CNS...
  29. pmc Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Clin Invest 120:1663-73. 2010
    ..These findings reveal that seasonal influenza vaccination can induce polyclonal heterosubtypic neutralizing antibodies that cross-react with the swine-origin pandemic H1N1 influenza virus and with the highly pathogenic H5N1 virus...
  30. ncbi request reprint TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
    Jens Geginat
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Adv Exp Med Biol 512:107-12. 2002
    ..Thus human naïve and memory T cell pools can be maintained with homeostatic cytokines in the absence of TCR stimulation...
  31. ncbi request reprint Duration, combination and timing: the signal integration model of dendritic cell activation
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Trends Immunol 28:227-33. 2007
    ....
  32. pmc Rational engineering of a human anti-dengue antibody through experimentally validated computational docking
    Luca Simonelli
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 8:e55561. 2013
    ....
  33. doi request reprint A functional BCR in human IgA and IgM plasma cells
    Dora Pinto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 121:4110-4. 2013
    ..These findings demonstrate a significant difference between human IgG, IgM, and IgA PCs and suggest that the IgA PC repertoire may be modulated by specific antigens with implications for the regulation of the mucosal immune system...
  34. ncbi request reprint Understanding and making use of human memory B cells
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 211:303-9. 2006
    ..This method can be exploited for the production of neutralizing antibodies for serotherapy and for "analytic vaccinology"...
  35. ncbi request reprint A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
    Davide Corti
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Science 333:850-6. 2011
    ..This antibody may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency...
  36. pmc The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
    Martina Beltramello
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    Cell Host Microbe 8:271-83. 2010
    ..Our findings reveal an unexpected degree of cross-reactivity in human antibodies against DENV and illustrate the potential for an antibody-based therapy to control severe dengue...
  37. pmc A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
    Annalisa Macagno
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:1481-92. 2006
    ..Collectively, these results indicate that CyP is a potent competitive inhibitor of LPS in vitro and in vivo and reveal the requirement of sustained TLR4 stimulation for induction of cytokine genes in human DCs...
  38. ncbi request reprint T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
    Anja Langenkamp
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 32:2046-54. 2002
    ....
  39. ncbi request reprint Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    Mara Messi
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 4:78-86. 2003
    ..Thus, most human CD4+ T cells retain both memory and flexibility of cytokine gene expression...
  40. ncbi request reprint Chemokines and leukocyte traffic
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 9:949-52. 2008
    ....
  41. pmc Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Virol 84:1005-13. 2010
    ....
  42. pmc Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection
    Daniele Lilleri
    Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    PLoS ONE 8:e59863. 2013
    ..Taken together, these findings indicate that the HCMV pentamer complex is a major target of the antibody-mediated maternal immunity...
  43. pmc Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
    ....
  44. doi request reprint Dissecting the human immunologic memory for pathogens
    Christina E Zielinski
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 240:40-51. 2011
    ..We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as 'analytic vaccinology'...
  45. ncbi request reprint Progressive differentiation and selection of the fittest in the immune response
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Rev Immunol 2:982-7. 2002
    ....
  46. ncbi request reprint T cell fitness determined by signal strength
    Amanda V Gett
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 4:355-60. 2003
    ..Our results are consistent with the concept that signal strength drives progressive T cell differentiation and the acquisition of fitness...
  47. pmc Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:615-21. 2003
    ..These results indicate that DC number and tissue inflammation are critical parameters for DC-based vaccination...
  48. doi request reprint Human B cell memory
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Curr Opin Immunol 21:298-304. 2009
    ..These findings offer new insights into the human B cell response, which are relevant for vaccination and therapeutic intervention...
  49. ncbi request reprint Understanding the generation and function of memory T cell subsets
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Immunol 17:326-32. 2005
    ..Collectively these data point to a critical role of central memory T cells in conferring long-term immunity...
  50. ncbi request reprint Human Th17 subsets
    Federica Sallusto
    Institute for Research in Biomedicine, Cellular Immunology, Bellinzona, Switzerland
    Eur J Immunol 42:2215-20. 2012
    ..In this review, we discuss recent studies addressing the heterogeneity of human Th17 cells, their differentiation requirements, their migratory capacities, and their role in defense against fungi and extracellular bacteria...
  51. ncbi request reprint Human monoclonal antibodies by immortalization of memory B cells
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Biotechnol 18:523-8. 2007
    ....
  52. ncbi request reprint Toll-like receptors and innate immunity in B-cell activation and antibody responses
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, Bellinzona, Switzerland
    Curr Opin Immunol 19:268-74. 2007
    ..However, the scientific fecundity in this rapidly evolving field will probably give rise to discoveries that could be translated into more effective vaccines and immunotherapies...
  53. ncbi request reprint Antigen decoding by T lymphocytes: from synapses to fate determination
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 2:487-92. 2001
    ..The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance...
  54. ncbi request reprint Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Science 290:92-7. 2000
    ..This results in the generation of both terminally differentiated effector cells and intermediates that play distinctive roles in protection, immunoregulation, and immunological memory...
  55. ncbi request reprint From synapses to immunological memory: the role of sustained T cell stimulation
    A Lanzavecchia
    Institute of Research in Biomedicine, Bellinzona, CH 6500, Switzerland
    Curr Opin Immunol 12:92-8. 2000
    ..These findings explain the unique capacity of the immune system to discriminate between antigens from infectious and noninfectious agents...
  56. ncbi request reprint The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500, Bellinzona, Switzerland
    Curr Opin Immunol 13:291-8. 2001
    ....
  57. ncbi request reprint Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells
    J Geginat
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500, Bellinzona, Suisse
    Pathol Biol (Paris) 51:64-6. 2003
    ....
  58. pmc Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
    J Geginat
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    J Exp Med 194:1711-9. 2001
    ..The sustained antigen-independent generation of T(EM) from a pool of T(CM) cells provides a plausible mechanism for the maintenance of a polyclonal and functionally diverse repertoire of human CD4(+) memory T cells...
  59. doi request reprint High throughput cellular screens to interrogate the human T and B cell repertoires
    Davide Corti
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Immunol 23:430-5. 2011
    ....
  60. pmc The instructive role of dendritic cells on T-cell responses
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Arthritis Res 4:S127-32. 2002
    ..We discuss how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of the T-cell response...
  61. doi request reprint CD4+ CD25+ Treg regulate the contribution of CD8+ T-cell subsets in repopulation of the lymphopenic environment
    Afonso R M Almeida
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 40:3478-88. 2010
    ..CD4(+) CD25(+) Treg suppress these responses and lead to controlled repopulation, contributing decisively to the maintenance of recovered T(CM) and T(EM) fractions, and leading to repopulation of each pool with progeny of its own kind...
  62. doi request reprint Negative regulators take center stage
    Silvia Monticelli
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 13:719-20. 2012
    ..This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset...
  63. ncbi request reprint Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    D Jarrossay
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 31:3388-93. 2001
    ..These results reveal a remarkable specialization and complementarity in microbial molecule recognition as well as a flexibility in effector function among myeloid and plasmacytoid DC...
  64. ncbi request reprint Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets
    Tatyana Chtanova
    Garvan Institute of Medical Research, Darlinghurst, Australia
    J Immunol 175:7837-47. 2005
    ....
  65. ncbi request reprint Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    Ata Ur Rasheed
    Department of Tumor Genetics and Immunogenetics, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    Eur J Immunol 36:1892-903. 2006
    ....
  66. ncbi request reprint Lead and follow: the dance of the dendritic cell and T cell
    Antonio Lanzavecchia
    Nat Immunol 5:1201-2. 2004
  67. ncbi request reprint Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22
    Paolo Ghia
    Department of Oncological Sciences, University of Torino, University Division of Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I, Torino, Italy
    Eur J Immunol 32:1403-13. 2002
    ....
  68. doi request reprint Intrasplenic trafficking of natural killer cells is redirected by chemokines upon inflammation
    Claude Gregoire
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    Eur J Immunol 38:2076-84. 2008
    ..This phenomenon ensures the segregation of NK cells outside of the white pulp and might contribute to the control of immunopathology...
  69. ncbi request reprint Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate
    Steven L Reiner
    Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 317:622-5. 2007
    ....
  70. ncbi request reprint A new role for CCR5 in innate immunity--binding to bacterial heat shock protein 70
    Charles R Mackay
    Immunology and Inflammation Department, Garvan Institute of Medical Research, Darlinghurst, Australia
    Eur J Immunol 36:2293-5. 2006
    ..These findings imply a role for CCR5 in innate immunity, in addition to its more established role as a chemoattractant receptor for adaptive immune responses...
  71. pmc Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Med 4:e178. 2007
    ..We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection...
  72. ncbi request reprint Effects of the adjuvant cholera toxin on dendritic cells: stimulatory and inhibitory signals that result in the amplification of immune responses
    M Cristina Gagliardi
    Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, Italy
    Int J Med Microbiol 291:571-5. 2002
    ..CT has immunomodulatory effects on different cell types, however, the interaction of CT with dendritic cells (DCs), which have a primary role in the priming of immune responses, may be crucial for its adjuvant activity...
  73. pmc Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
    Lea Barfod
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Mol Microbiol 63:335-47. 2007
    ....
  74. ncbi request reprint Sliding doors in the immune response
    Federica Sallusto
    Nat Immunol 6:10-2. 2005
  75. ncbi request reprint Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
    Silvia Casati
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 33:47-62. 2005