Markus G Manz

Summary

Affiliation: Institute for Research in Biomedicine
Country: Switzerland

Publications

  1. pmc Prospective isolation of human clonogenic common myeloid progenitors
    Markus G Manz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11872-7. 2002
  2. ncbi request reprint Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
  3. ncbi request reprint Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:1207-16. 2007
  4. pmc Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:227-38. 2006
  5. pmc Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations
    Laurie Chicha
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 200:1519-24. 2004
  6. ncbi request reprint Human-hemato-lymphoid-system mice: opportunities and challenges
    Markus G Manz
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Immunity 26:537-41. 2007
  7. ncbi request reprint The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    Dior Kingston
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 114:835-43. 2009
  8. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
  9. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
  10. ncbi request reprint Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity
    Roxane Tussiwand
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Immunol 175:3674-80. 2005

Collaborators

Detail Information

Publications23

  1. pmc Prospective isolation of human clonogenic common myeloid progenitors
    Markus G Manz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:11872-7. 2002
    ..The isolation of highly purified hematopoietic intermediates provides tools to better understand developmental programs underlying normal and leukemic hematopoiesis...
  2. ncbi request reprint Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  3. ncbi request reprint Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:1207-16. 2007
    ..These clonogenic common DC progenitors thus define a cytokine-regulated DC developmental pathway that ensures the supply of various DC populations...
  4. pmc Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:227-38. 2006
    ..1-mediated IPC and DC differentiation program in Flt3+ hematopoietic progenitor cells...
  5. pmc Clonal type I interferon-producing and dendritic cell precursors are contained in both human lymphoid and myeloid progenitor populations
    Laurie Chicha
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 200:1519-24. 2004
    ..This would fit with natural interferon type I-producing cell and dendritic cell activity in innate immunity, the evolutionary older arm of the cellular immune system...
  6. ncbi request reprint Human-hemato-lymphoid-system mice: opportunities and challenges
    Markus G Manz
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Immunity 26:537-41. 2007
    ....
  7. ncbi request reprint The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis
    Dior Kingston
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 114:835-43. 2009
    ..These data thus show the concerted action of GM-CSF and Flt3-ligand on DC homeostasis in vivo...
  8. pmc Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo
    Holger Karsunky
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:305-13. 2003
    ....
  9. ncbi request reprint Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Med 10:510-7. 2004
    ....
  10. ncbi request reprint Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity
    Roxane Tussiwand
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Immunol 175:3674-80. 2005
    ....
  11. ncbi request reprint Flt3 in regulation of type I interferon-producing cell and dendritic cell development
    Nobuyuki Onai
    Institute for Research in Biomedicine IRB, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Ann N Y Acad Sci 1106:253-61. 2007
    ..1-mediated IPC and DC differentiation program in Flt3(+)-hematopoietic progenitor cells...
  12. ncbi request reprint Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors
    Holger Karsunky
    Department of Pathology, Stanford University School of Medicine, Stanford, Calif, USA
    Exp Hematol 33:173-81. 2005
    ....
  13. doi request reprint Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Blood 118:4829-40. 2011
    ..This mechanism likely developed to support DC homeostasis on specific need at sites of inflammation...
  14. ncbi request reprint Early defect prethymic in bone marrow T cell progenitors in athymic nu/nu mice
    Devavani Chatterjea-Matthes
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Immunol 171:1207-15. 2003
    ..We show that defects in bone marrow prethymic T cell development can also contribute to T cell deficiency in nu/nu mice...
  15. doi request reprint Instructive cytokine signals in dendritic cell lineage commitment
    Michael A Schmid
    Institute for Research in Biomedicine IRB, Bellinzona, Switzerland
    Immunol Rev 234:32-44. 2010
    ..Along this line, we emphasize the role that diverse microenvironments have in influencing the generation of DC subsets with specific functions throughout the body...
  16. ncbi request reprint Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells
    Steffen Boettcher
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Immunol 188:5824-8. 2012
    ..Collectively, our findings reveal a key and nonredundant role for nonhematopoietic compartment pathogen sensing that is subsequently translated into cytokine release for enhanced, demand-adapted myeloid cell production...
  17. pmc Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
    Hitoshi Takizawa
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Exp Med 208:273-84. 2011
    ..These findings suggest a model in which all HSCs undergo dynamic and demand-adapted entry into and exit out of the cell cycle over time. This may facilitate a similar degree of turnover of the entire HSC pool at the end of life...
  18. ncbi request reprint Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    Catriona H M Jamieson
    Division of Hematology, Stanford University School of Medicine, Stanford, Calif 94305 5323, USA
    N Engl J Med 351:657-67. 2004
    ..In normal mouse hematopoietic stem cells, the process of self-renewal involves the beta-catenin-signaling pathway. We investigated whether leukemic stem cells in CML also use the beta-catenin pathway for self-renewal...
  19. ncbi request reprint Langerhans cells renew in the skin throughout life under steady-state conditions
    Miriam Merad
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Nat Immunol 3:1135-41. 2002
    ..These data indicate that under steady-state conditions, LCs are maintained locally, but inflammatory changes in the skin result in their replacement by blood-borne LC progenitors...
  20. doi request reprint The STATs on dendritic cell development
    Nobuyuki Onai
    Department of Immunology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Immunity 28:490-2. 2008
    ..In this issue of Immunity, Esashi et al. (2008) demonstrate how cytokine-receptor-regulated downstream transcription factors direct dendritic cell subpopulation differentiation from hematopoietic progenitor cells...
  21. pmc CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection
    Mario Cocco
    Department of Human Pathology and Oncology, Division of Pathological Anatomy, University of Siena, Siena, Italy
    Am J Pathol 173:1369-78. 2008
    ..Future experiments might allow understanding of the mechanisms responsible for persistent EBV infection and provide targets for more highly tailored therapeutic interventions...
  22. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
    ....
  23. ncbi request reprint Human adaptive immune system Rag2-/-gamma(c)-/- mice
    Laurie Chicha
    Department of Medicine II, Eberhard Karls University Medical School, Otfried Mueller Str 10, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1044:236-43. 2005
    ....