A Lanzavecchia

Summary

Affiliation: Institute for Research in Biomedicine
Country: Switzerland

Publications

  1. ncbi request reprint Understanding and making use of human memory B cells
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 211:303-9. 2006
  2. pmc Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
  3. pmc The instructive role of dendritic cells on T-cell responses
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Arthritis Res 4:S127-32. 2002
  4. pmc Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein
    Daniel Voss
    Institute of Virology, Philipps University Marburg, Marburg, Germany
    Virol J 6:79. 2009
  5. pmc Migration and function of antigen-primed nonpolarized T lymphocytes in vivo
    G Iezzi
    Basel Institute for Immunology, CH-4005 Basel, Switzerland
    J Exp Med 193:987-93. 2001
  6. ncbi request reprint Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Science 290:92-7. 2000
  7. ncbi request reprint From synapses to immunological memory: the role of sustained T cell stimulation
    A Lanzavecchia
    Institute of Research in Biomedicine, Bellinzona, CH 6500, Switzerland
    Curr Opin Immunol 12:92-8. 2000
  8. ncbi request reprint The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500, Bellinzona, Switzerland
    Curr Opin Immunol 13:291-8. 2001
  9. doi request reprint Human B cell memory
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Curr Opin Immunol 21:298-304. 2009
  10. ncbi request reprint Antigen decoding by T lymphocytes: from synapses to fate determination
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 2:487-92. 2001

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Understanding and making use of human memory B cells
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 211:303-9. 2006
    ..This method can be exploited for the production of neutralizing antibodies for serotherapy and for "analytic vaccinology"...
  2. pmc Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    PLoS ONE 5:e8805. 2010
    ....
  3. pmc The instructive role of dendritic cells on T-cell responses
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Arthritis Res 4:S127-32. 2002
    ..We discuss how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of the T-cell response...
  4. pmc Studies on membrane topology, N-glycosylation and functionality of SARS-CoV membrane protein
    Daniel Voss
    Institute of Virology, Philipps University Marburg, Marburg, Germany
    Virol J 6:79. 2009
    ....
  5. pmc Migration and function of antigen-primed nonpolarized T lymphocytes in vivo
    G Iezzi
    Basel Institute for Immunology, CH-4005 Basel, Switzerland
    J Exp Med 193:987-93. 2001
    ..These results suggest that nonpolarized T cells are in an intermediate state of differentiation characterized by lymph node homing capacity and increased responsiveness that allows them to mount a prompt and effective secondary response...
  6. ncbi request reprint Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Science 290:92-7. 2000
    ..This results in the generation of both terminally differentiated effector cells and intermediates that play distinctive roles in protection, immunoregulation, and immunological memory...
  7. ncbi request reprint From synapses to immunological memory: the role of sustained T cell stimulation
    A Lanzavecchia
    Institute of Research in Biomedicine, Bellinzona, CH 6500, Switzerland
    Curr Opin Immunol 12:92-8. 2000
    ..These findings explain the unique capacity of the immune system to discriminate between antigens from infectious and noninfectious agents...
  8. ncbi request reprint The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500, Bellinzona, Switzerland
    Curr Opin Immunol 13:291-8. 2001
    ....
  9. doi request reprint Human B cell memory
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Curr Opin Immunol 21:298-304. 2009
    ..These findings offer new insights into the human B cell response, which are relevant for vaccination and therapeutic intervention...
  10. ncbi request reprint Antigen decoding by T lymphocytes: from synapses to fate determination
    A Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 2:487-92. 2001
    ..The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance...
  11. ncbi request reprint Understanding the generation and function of memory T cell subsets
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Immunol 17:326-32. 2005
    ..Collectively these data point to a critical role of central memory T cells in conferring long-term immunity...
  12. ncbi request reprint A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 101:4500-4. 2003
    ..Thus, in human B cells TLRs are downstream of BCR and play a role both in the primary response and in the memory phase...
  13. ncbi request reprint Toll-like receptors and innate immunity in B-cell activation and antibody responses
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, Bellinzona, Switzerland
    Curr Opin Immunol 19:268-74. 2007
    ..However, the scientific fecundity in this rapidly evolving field will probably give rise to discoveries that could be translated into more effective vaccines and immunotherapies...
  14. ncbi request reprint Human monoclonal antibodies by immortalization of memory B cells
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Curr Opin Biotechnol 18:523-8. 2007
    ....
  15. pmc Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
    F Sallusto
    Basel Institute for Immunology, CH 4005, Basel, Switzerland
    J Exp Med 187:875-83. 1998
    ..These results demonstrate that chemokine receptors are markers of naive and polarized T cell subsets and suggest that flexible programs of chemokine receptor gene expression may control tissue-specific migration of effector T cells...
  16. ncbi request reprint Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:2037-45. 1999
    ..As a result, T cells that are activated in tissues may either recirculate to draining lymph nodes or migrate to nearby sites of organized ectopic lymphoid tissues...
  17. ncbi request reprint Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Nature 401:708-12. 1999
    ....
  18. ncbi request reprint Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells
    Anja Langenkamp
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 33:474-82. 2003
    ..These results indicate a complex chemokine receptor regulation dependent on both T cell activation and differentiation state. In addition, they reveal the existence of DC-specific cues for the regulation of T cell migratory capacity...
  19. ncbi request reprint Maintenance of serological memory by polyclonal activation of human memory B cells
    Nadia L Bernasconi
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Science 298:2199-202. 2002
    ..Although antigen boosting leads to a transient increase in specific antibody levels, ongoing polyclonal activation of memory B cells offers a means to maintain serological memory for a human lifetime...
  20. pmc Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:821-9. 1999
    ....
  21. pmc Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering
    A Viola
    Basel Institute for Immunology, Switzerland
    J Exp Med 186:1775-9. 1997
    ..In the latter case the coreceptor increases the efficiency of TCR triggering without changing the activation threshold or the quality of the T cell response...
  22. ncbi request reprint Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:2760-9. 1998
    ..These different patterns of chemokine receptors are consistent with "inflammatory" and "primary response" phases of DC function...
  23. doi request reprint Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    Thomas Duhen
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:857-63. 2009
    ..Our findings delineate a previously unknown subset of human CD4(+) effector T cells dedicated to skin pathophysiology...
  24. ncbi request reprint Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    D Jarrossay
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 31:3388-93. 2001
    ..These results reveal a remarkable specialization and complementarity in microbial molecule recognition as well as a flexibility in effector function among myeloid and plasmacytoid DC...
  25. pmc Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells
    J Geginat
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    J Exp Med 194:1711-9. 2001
    ..The sustained antigen-independent generation of T(EM) from a pool of T(CM) cells provides a plausible mechanism for the maintenance of a polyclonal and functionally diverse repertoire of human CD4(+) memory T cells...
  26. ncbi request reprint Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
    M Cella
    Basel Institute for Immunology, Switzerland
    Nature 388:782-7. 1997
    ..The capacity of dendritic cells to load many antigenic peptides over a short period of initial exposure to inflammatory stimuli could favour presentation of infectious antigens...
  27. ncbi request reprint The interplay between the duration of TCR and cytokine signaling determines T cell polarization
    G Iezzi
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 29:4092-101. 1999
    ..Thus, the duration of TCR stimulation represents a crucial parameter that influences the response to polarizing cytokines and the acquisition of T cell effector functions...
  28. ncbi request reprint A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies
    A Viola
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:3080-3. 1997
    ..These results indicate that TCR antagonists inhibit T cell responses by interfering with the ongoing process of serial triggering, rather than by delivering an inhibitory signal to T cells...
  29. pmc A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    M Cella
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 185:1743-51. 1997
    ..Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake...
  30. ncbi request reprint L-selectin-negative CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
    Greta Guarda
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:743-52. 2007
    ..The inducible recruitment of blood-borne effector and memory T cells to lymph nodes may represent a mechanism for terminating primary and limiting secondary immune responses...
  31. ncbi request reprint The strength of T cell stimulation determines IL-7 responsiveness, secondary expansion, and lineage commitment of primed human CD4+IL-7Rhi T cells
    Laura Lozza
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 38:30-9. 2008
    ..These results show that the strength of stimulation determines properties of activated IL-7R(hi) T cells, and suggest that memory T cell subsets could be derived from CCR7(+) precursors that received different strengths of stimulation...
  32. ncbi request reprint Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses...
  33. ncbi request reprint Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation
    M Salio
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 27:1769-73. 1997
    ..These results demonstrate that TCR down-regulation is induced by early events which follow specific engagement by an agonist and can be dissociated from those required for full T cell activation...
  34. ncbi request reprint Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells
    E Scotet
    Basel Institute for Immunology, Basel, Switzerland
    Blood 98:2568-70. 2001
    ..These results suggest that in Th2 cells both cytokine production and migratory capacity are regulated through a similar mechanism involving chromatin remodeling...
  35. ncbi request reprint Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells
    J Geginat
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500, Bellinzona, Suisse
    Pathol Biol (Paris) 51:64-6. 2003
    ....
  36. ncbi request reprint T lymphocyte costimulation mediated by reorganization of membrane microdomains
    A Viola
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Science 283:680-2. 1999
    ..These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains...
  37. pmc Clonal dissection of the human memory B-cell repertoire following infection and vaccination
    Debora Pinna
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1260-70. 2009
    ..These results reveal novel aspects of memory B-cell kinetics and provide a powerful tool to monitor immune responses following infection and vaccination...
  38. ncbi request reprint An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
    Elisabetta Traggiai
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Belllinzona, Switzerland
    Nat Med 10:871-5. 2004
    ..These results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection...
  39. pmc CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    J Exp Med 205:2561-74. 2008
    ..These results show that T(EM) cells can behave as endogenous adjuvants and suggest a mechanistic link between lymphocyte traffic in lymph nodes and induction of autoimmunity...
  40. ncbi request reprint Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    Mara Messi
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 4:78-86. 2003
    ..Thus, most human CD4+ T cells retain both memory and flexibility of cytokine gene expression...
  41. pmc The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
    Martina Beltramello
    Institute for Research in Biomedicine, Bellinzona 6500, Switzerland
    Cell Host Microbe 8:271-83. 2010
    ..Our findings reveal an unexpected degree of cross-reactivity in human antibodies against DENV and illustrate the potential for an antibody-based therapy to control severe dengue...
  42. pmc Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells
    Laura Rivino
    Institute for Research in Biomedicine, Via Vela 6, 6500 Bellinzona, Switzerland
    J Exp Med 200:725-35. 2004
    ..Our results also explain how the quality of primary T cell responses could be maintained by T(CM) cells in the absence of antigen...
  43. ncbi request reprint Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  44. pmc Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    M Cella
    Basel Institute for Immunology, Switzerland
    J Exp Med 184:747-52. 1996
    ..These findings reveal a new role for CD40-CD40L interaction in regulating DC function and are relevant to design therapeutic strategies using cultured DCs...
  45. ncbi request reprint Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Science 277:2005-7. 1997
    ..The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils...
  46. ncbi request reprint Mouse pre-immunocytes as non-proliferating multipotent precursors of macrophages, interferon-producing cells, CD8alpha(+) and CD8alpha(-) dendritic cells
    L Bruno
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 31:3403-12. 2001
    ..These cells are defined as "pre-immunocytes" to underline the fact that they serve in a flexible fashion multiple, and often divergent, functions required for the immune response to pathogens...
  47. ncbi request reprint The role of chemokine receptors in primary, effector, and memory immune responses
    F Sallusto
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    Annu Rev Immunol 18:593-620. 2000
    ....
  48. ncbi request reprint Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression
    F Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Immunol Rev 177:134-40. 2000
    ..These studies provide insights into the mechanisms that control T-cell priming as well as memory and effector immune responses...
  49. ncbi request reprint Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    Claudia R Ruprecht
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 36:810-6. 2006
    ..The coupling of BCR stimulation to TLR expression endows the human system with a high degree of specificity since it allows focusing of innate signals only on antigen-stimulated B cells...
  50. ncbi request reprint TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines
    Jens Geginat
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Adv Exp Med Biol 512:107-12. 2002
    ..Thus human naïve and memory T cell pools can be maintained with homeostatic cytokines in the absence of TCR stimulation...
  51. ncbi request reprint T cell priming by dendritic cells: thresholds for proliferation, differentiation and death and intraclonal functional diversification
    Anja Langenkamp
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 32:2046-54. 2002
    ....
  52. doi request reprint C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    Andrea Reboldi
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Nat Immunol 10:514-23. 2009
    ..Our results identify distinct molecular requirements and ports of lymphocyte entry into uninflamed versus inflamed CNS and suggest that the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS...
  53. pmc Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    F Sallusto
    Basel Institute for Immunology, Switzerland
    J Exp Med 179:1109-18. 1994
    ....
  54. ncbi request reprint Distinct patterns and kinetics of chemokine production regulate dendritic cell function
    F Sallusto
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1617-25. 1999
    ..The time-ordered production of inflammatory and constitutive chemokines provides DC with the capacity to self-regulate their migratory behavior as well as to recruit other cells for the afferent and efferent limb of the immune response...
  55. pmc Regulation of peripheral T cell activation by calreticulin
    Simona Porcellini
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:461-71. 2006
    ..These observations support the hypothesis that CRT-dependent shaping of Ca2+ signaling critically contributes to the modulation of the T cell adaptive immune response...
  56. ncbi request reprint Duration, combination and timing: the signal integration model of dendritic cell activation
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    Trends Immunol 28:227-33. 2007
    ....
  57. pmc A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression
    Annalisa Macagno
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:1481-92. 2006
    ..Collectively, these results indicate that CyP is a potent competitive inhibitor of LPS in vitro and in vivo and reveal the requirement of sustained TLR4 stimulation for induction of cytokine genes in human DCs...
  58. pmc From vaccines to memory and back
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Immunity 33:451-63. 2010
    ..Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back...
  59. ncbi request reprint Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ....
  60. pmc CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function
    Laura Rivino
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Exp Med 207:565-77. 2010
    ....
  61. doi request reprint Human Th17 cells in infection and autoimmunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Microbes Infect 11:620-4. 2009
    ..Since their discovery, efforts have been made in characterizing human Th17 cells and the factors involved in their differentiation and in understanding the role these cells play in protective immunity and autoimmune diseases...
  62. doi request reprint Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1301-12. 2009
    ....
  63. doi request reprint Heterogeneity of CD4+ memory T cells: functional modules for tailored immunity
    Federica Sallusto
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:2076-82. 2009
    ..Here, we review our current understanding of CD4(+) T-cell lineage heterogeneity and flexibility, with emphasis on the human system, and propose an organization of effector and memory T cells based on distinct functional modules...
  64. pmc Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex
    Annalisa Macagno
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Virol 84:1005-13. 2010
    ....
  65. ncbi request reprint Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines
    Jens Geginat
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Blood 101:4260-6. 2003
    ..Furthermore, they suggest that TEMRA cells are generated from a TCM subset upon homeostatic proliferation in the absence of antigen...
  66. ncbi request reprint Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  67. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
  68. ncbi request reprint ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells
    Stefan Wirths
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 35:3433-41. 2005
    ....
  69. pmc Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    Claudia R Ruprecht
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 201:1793-803. 2005
    ....
  70. pmc Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:615-21. 2003
    ..These results indicate that DC number and tissue inflammation are critical parameters for DC-based vaccination...
  71. ncbi request reprint Progressive differentiation and selection of the fittest in the immune response
    Antonio Lanzavecchia
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Rev Immunol 2:982-7. 2002
    ....
  72. ncbi request reprint Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
    M Salio
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 30:705-8. 2000
    ..Our results reveal that DC are able to sense mycoplasma infection and mature as they do in response to most viruses and bacteria. In contrast, apoptotic or necrotic cells fail to induce DC maturation...
  73. ncbi request reprint Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes
    C Giachino
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 28:3506-13. 1998
    ..Taken together, these data suggest that secondary Ig gene rearrangements leading to replacement may occur in human GC and may contribute to the peripheral B cell repertoire...
  74. ncbi request reprint Mechanisms of antigen uptake for presentation
    A Lanzavecchia
    Basel Institute for Immunology, Switzerland
    Curr Opin Immunol 8:348-54. 1996
    ..These findings provide new insights into antigen presentation in vivo and will be instrumental in designing better methods of vaccination...
  75. ncbi request reprint T cell fitness determined by signal strength
    Amanda V Gett
    Institute for Research in Biomedicine, Via Vela 6, CH 6500 Bellinzona, Switzerland
    Nat Immunol 4:355-60. 2003
    ..Our results are consistent with the concept that signal strength drives progressive T cell differentiation and the acquisition of fitness...
  76. pmc Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development
    Nobuyuki Onai
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 203:227-38. 2006
    ..1-mediated IPC and DC differentiation program in Flt3+ hematopoietic progenitor cells...
  77. ncbi request reprint Antigen dependent and independent mechanisms that sustain serum antibody levels
    Elisabetta Traggiai
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Vaccine 21:S35-7. 2003
    ..Antigenic boost sustains high levels of serum antibodies only for a few months, while polyclonal activation sustains low levels of protective antibodies for a human lifetime...
  78. pmc Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells
    Rebekka Geiger
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 206:1525-34. 2009
    ....
  79. pmc Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
    Davide Corti
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    J Clin Invest 120:1663-73. 2010
    ..These findings reveal that seasonal influenza vaccination can induce polyclonal heterosubtypic neutralizing antibodies that cross-react with the swine-origin pandemic H1N1 influenza virus and with the highly pathogenic H5N1 virus...
  80. pmc Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes
    Hiroyuki Yoneyama
    Department of Molecular Preventive Medicine, School of Medicine and Core Research and Evolutional Science and Technology CREST, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 195:1257-66. 2002
    ..Thus, mature DC-derived CXCL10 is pivotal to retain Th1 lymphocytes within T cell areas of draining LNs and optimize the Th1-mediated immune responses...
  81. ncbi request reprint The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  82. ncbi request reprint Lack of fair play in the T cell response
    Antonio Lanzavecchia
    Nat Immunol 3:9-10. 2002
  83. ncbi request reprint Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation
    Giorgio Napolitani
    Chiron Vaccines, Siena, Italy
    Eur J Immunol 33:2832-41. 2003
    ..Thus, src-kinases control cytokine production in LPS-induced DC maturation through a timely formation of AP-1...
  84. doi request reprint Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    J Cell Physiol 215:276-82. 2008
    ..Taken together this data suggests an active role for the Cdk9/Cyclin T1 complex during lymphoid differentiation through germinal center reaction...
  85. pmc Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge
    Barry Rockx
    Department of Epidemiology, 2107 McGavran Greenberg, CB 7435, University of North Carolina, Chapel Hill, NC 27699 7435, USA
    J Virol 82:3220-35. 2008
    ....
  86. ncbi request reprint A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, PO Box 12000, Jerusalem, 91120, Israel
    Trends Immunol 23:592-5. 2002
    ..Several phenomena related to T-cell behavior and self-nonself discrimination are discussed...
  87. ncbi request reprint Simvastatin inhibits the MHC class II pathway of antigen presentation by impairing Ras superfamily GTPases
    Raffaella Ghittoni
    Department of Evolutionary Biology, University of Siena, Siena, Italy
    Eur J Immunol 36:2885-93. 2006
    ..In addition, simvastatin was found to preferentially affect the invariant chain-dependent MHC class II pathway, thereby identifying this route of antigen processing and presentation as a selective target of statins...
  88. pmc Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA
    Lea Barfod
    Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital Rigshospitalet and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark
    Mol Microbiol 63:335-47. 2007
    ....
  89. ncbi request reprint T cell costimulation by chemokine receptors
    Barbara Molon
    Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, 35100 Padua, Italy
    Nat Immunol 6:465-71. 2005
    ....
  90. ncbi request reprint Immune subversion by Helicobacter pylori
    Cosima T Baldari
    Department of Evolutionary Biology, University of Siena, Via A Moro 2, I 53100 Siena, Italy
    Trends Immunol 26:199-207. 2005
    ..Several mechanisms and the bacterial factors involved in immune subversion have, in recent years, been elucidated, thus opening the possibility of a better understanding of the pathogenicity of this microorganism...
  91. pmc Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
    Zhongyu Zhu
    Protein Interactions Group, Center for Cancer Research Nanobiology Program, SAIC Frederick, Inc, National Cancer Institute Frederick, National Institutes of Health, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 104:12123-8. 2007
    ..These antibodies exhibit cross-reactivity against isolates from the two SARS outbreaks and palm civets and could have potential applications for diagnosis, prophylaxis, and treatment of SARS-CoV infections...
  92. ncbi request reprint Lead and follow: the dance of the dendritic cell and T cell
    Antonio Lanzavecchia
    Nat Immunol 5:1201-2. 2004
  93. pmc Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    Cameron P Simmons
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
    PLoS Med 4:e178. 2007
    ..We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection...
  94. ncbi request reprint Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate
    Steven L Reiner
    Abramson Family Cancer Research Institute of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 317:622-5. 2007
    ....
  95. ncbi request reprint Pillars article: Antigen-specific interaction between T and B cells. 1985
    Antonio Lanzavecchia
    J Immunol 179:7206-8. 2007
  96. ncbi request reprint Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  97. ncbi request reprint Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells
    Nicola Bortoletto
    IRIS, Chiron S p A, Siena, Italy
    Eur J Immunol 32:3102-7. 2002
    ..These results are consistent with the TCR serial triggering model and suggest that BscAb with extremely low affinity for the TCR-CD3 complex could be exploited therapeutically because of their preferential localization to tumor cells...
  98. ncbi request reprint Characterization of severe acute respiratory syndrome coronavirus membrane protein
    Daniel Voss
    Institute for Virology, Philipps University Marburg, Robert Koch str 17, 35037 Marburg, Germany
    FEBS Lett 580:968-73. 2006
    ..In SARS-CoV infected cells and in purified virions, however, N-glycosylation of M remained endoglycosidase H-sensitive suggesting that trimming of the N-linked sugar side chain is inhibited...
  99. ncbi request reprint Human adaptive immune system Rag2-/-gamma(c)-/- mice
    Laurie Chicha
    Department of Medicine II, Eberhard Karls University Medical School, Otfried Mueller Str 10, 72076 Tubingen, Germany
    Ann N Y Acad Sci 1044:236-43. 2005
    ....
  100. pmc CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection
    Mario Cocco
    Department of Human Pathology and Oncology, Division of Pathological Anatomy, University of Siena, Siena, Italy
    Am J Pathol 173:1369-78. 2008
    ..Future experiments might allow understanding of the mechanisms responsible for persistent EBV infection and provide targets for more highly tailored therapeutic interventions...
  101. ncbi request reprint Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice
    Sonia Feau
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milan, Italy
    Blood 105:697-702. 2005
    ..Our results indicate that DC-produced IL-2 is tightly coregulated with the expression of IL-15...