I Knuesel

Summary

Affiliation: Institute of Pharmacology and Toxicology
Country: Switzerland

Publications

  1. ncbi request reprint Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients
    Tina Notter
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Acta Neuropathol Commun 1:27. 2013
  2. pmc Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators
    Dimitrije Krstic
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e47793. 2012
  3. pmc Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
    Dimitrije Krstic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Neuroinflammation 9:151. 2012
  4. doi request reprint Characterization and turnover of CD73/IP(3)R3-positive microvillar cells in the adult mouse olfactory epithelium
    SANDRA PFISTER
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Chem Senses 37:859-68. 2012
  5. doi request reprint [Prenatal infection as driving force of aging-associated neurodegenerative diseases]
    I Knuesel
    Institut fur Pharmakologie und Toxikologie, Universitat Zurich
    Praxis (Bern 1994) 100:299-304. 2011
  6. doi request reprint Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Prog Neurobiol 91:257-74. 2010
  7. ncbi request reprint Age-related accumulation of Reelin in amyloid-like deposits
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Neurobiol Aging 30:697-716. 2009
  8. ncbi request reprint Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy
    I Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr. 190, CH-8057 Zurich, Switzerland
    Eur J Neurosci 13:1113-24. 2001
  9. doi request reprint Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice
    Samira Kocherhans
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Neurosci 30:9228-40. 2010
  10. doi request reprint Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging
    Amrita Madhusudan
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Eur J Neurosci 30:1064-76. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients
    Tina Notter
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, CH 8057, Switzerland
    Acta Neuropathol Commun 1:27. 2013
    ..Here, we aimed to investigate whether a similar Reelin-associated neuropathology is observed in the aged human hippocampus and whether it correlated with dementia status...
  2. pmc Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators
    Dimitrije Krstic
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    PLoS ONE 7:e47793. 2012
    ..While this pattern remained stable during normal aging, changes in their protein levels coincided with accelerated Reelin aggregation in a mouse model of AD...
  3. pmc Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
    Dimitrije Krstic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Neuroinflammation 9:151. 2012
    ..However, there is no experimental evidence for a causal link between systemic inflammation or neuroinflammation and the onset of the disease...
  4. doi request reprint Characterization and turnover of CD73/IP(3)R3-positive microvillar cells in the adult mouse olfactory epithelium
    SANDRA PFISTER
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Chem Senses 37:859-68. 2012
    ..These combined properties are unique among olfactory cells, in line with the possibility that they might regulate cellular homeostasis driven by extracellular ATP and adenosine...
  5. doi request reprint [Prenatal infection as driving force of aging-associated neurodegenerative diseases]
    I Knuesel
    Institut fur Pharmakologie und Toxikologie, Universitat Zurich
    Praxis (Bern 1994) 100:299-304. 2011
    ....
  6. doi request reprint Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Prog Neurobiol 91:257-74. 2010
    ..Thus, the findings presented in this review suggest that schizophrenia can indeed be described as a form of accelerated aging or "dementia praecox" as first described by Emil Kraepelin in 1906...
  7. ncbi request reprint Age-related accumulation of Reelin in amyloid-like deposits
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Neurobiol Aging 30:697-716. 2009
    ..Our findings suggest that elevated Reelin plaque load creates a precursor condition for senile plaque deposition and may represent a critical risk factor for sporadic AD...
  8. ncbi request reprint Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy
    I Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstr. 190, CH-8057 Zurich, Switzerland
    Eur J Neurosci 13:1113-24. 2001
    ..These results suggest that utrophin provides structural support of neuronal membranes, whereas dystrophin is a component of GABAergic synapses...
  9. doi request reprint Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice
    Samira Kocherhans
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Neurosci 30:9228-40. 2010
    ....
  10. doi request reprint Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging
    Amrita Madhusudan
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    Eur J Neurosci 30:1064-76. 2009
    ....
  11. doi request reprint Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice
    Jana Doehner
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Alzheimers Dis 19:1339-57. 2010
    ..Our results suggest that Reelin itself aggregates into abnormal oligomeric or protofibrillary deposits during aging, potentially creating a precursor condition for fibrillary amyloid-beta plaque formation...
  12. doi request reprint Decisive role of Reelin signaling during early stages of Alzheimer's disease
    D Krstic
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Switzerland
    Neuroscience 246:108-16. 2013
    ....
  13. ncbi request reprint Identification and characterisation of transcript and protein of a new short N-terminal utrophin isoform
    R A Zuellig
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    J Cell Biochem 77:418-31. 2000
    ..It is assumed that it co-localises via the two spectrin-like repeats with the full-length utrophin at the cell membrane...
  14. ncbi request reprint GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin
    Ina Brünig
    Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 22:4805-13. 2002
    ..We suggest that selective signaling from GABAergic terminals contributes to postsynaptic clustering of dystrophin...
  15. ncbi request reprint Short communication: altered synaptic clustering of GABAA receptors in mice lacking dystrophin (mdx mice)
    I Knuesel
    Institute of Pharmacology, University of Zurich, Switzerland
    Eur J Neurosci 11:4457-62. 1999
    ..These deficits may underlie the cognitive impairment seen in Duchenne patients...
  16. ncbi request reprint Increased vulnerability to kainate-induced seizures in utrophin-knockout mice
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Eur J Neurosci 15:1474-84. 2002
    ..These findings suggest that utrophin contributes to protect CNS neurons against pathological insults, in particular, stimuli leading to massive neuronal hypertrophy...