Michael O Hottiger

Summary

Country: Switzerland

Publications

  1. pmc Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
    Christine Buerki
    Institute of Veterinary Biochemistry and Molecular Biology, 8057 Zurich, Switzerland
    Nucleic Acids Res 36:1665-80. 2008
  2. pmc Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
    Matthias Altmeyer
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    Aging (Albany NY) 1:458-69. 2009
  3. pmc PARP1 ADP-ribosylates lysine residues of the core histone tails
    Simon Messner
    Institute of Veterinary Biochemistry and Molecular Biology, Life Science Zurich Graduate School, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nucleic Acids Res 38:6350-62. 2010
  4. pmc PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts
    A Bluwstein
    Institute of Veterinary Biochemistry and Molecular Biology IVBMB, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Cell Death Dis 4:e498. 2013
  5. pmc Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
    Ingrid Kassner
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, Zurich, 8057, Switzerland
    Epigenetics Chromatin 6:1. 2013
  6. doi request reprint Toward a unified nomenclature for mammalian ADP-ribosyltransferases
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Biochem Sci 35:208-19. 2010
  7. doi request reprint Progress in the function and regulation of ADP-Ribosylation
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse, Switzerland
    Sci Signal 4:mr5. 2011
  8. doi request reprint ADP-ribosylation of histones by ARTD1: an additional module of the histone code?
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    FEBS Lett 585:1595-9. 2011
  9. ncbi request reprint Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 280:40450-64. 2005
  10. pmc Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
    Marcela Covic
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 24:85-96. 2005

Detail Information

Publications55

  1. pmc Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
    Christine Buerki
    Institute of Veterinary Biochemistry and Molecular Biology, 8057 Zurich, Switzerland
    Nucleic Acids Res 36:1665-80. 2008
    ..These results support the hypothesis that site-specific p300-mediated acetylation of RelA/p65 regulates the specificity of NF-kappaB dependent gene expression...
  2. pmc Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
    Matthias Altmeyer
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    Aging (Albany NY) 1:458-69. 2009
    ..This review summarizes recent findings on PARP1 and puts them in the context of metabolic stress and inflammation in aging...
  3. pmc PARP1 ADP-ribosylates lysine residues of the core histone tails
    Simon Messner
    Institute of Veterinary Biochemistry and Molecular Biology, Life Science Zurich Graduate School, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nucleic Acids Res 38:6350-62. 2010
    ..Taken together, our computational and experimental results provide strong evidence that PARP1 modifies important regulatory lysines of the core histone tails...
  4. pmc PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts
    A Bluwstein
    Institute of Veterinary Biochemistry and Molecular Biology IVBMB, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Cell Death Dis 4:e498. 2013
    ..These findings contribute to the understanding of the cellular and nuclear IR response and may thus eventually improve the efficacy of radiotherapy and help overcome tumor radioresistance...
  5. pmc Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4
    Ingrid Kassner
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, Zurich, 8057, Switzerland
    Epigenetics Chromatin 6:1. 2013
    ..abstract:..
  6. doi request reprint Toward a unified nomenclature for mammalian ADP-ribosyltransferases
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Biochem Sci 35:208-19. 2010
    ..A unified nomenclature would facilitate communication between researchers both inside and outside the ADP-ribosylation field...
  7. doi request reprint Progress in the function and regulation of ADP-Ribosylation
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse, Switzerland
    Sci Signal 4:mr5. 2011
    ....
  8. doi request reprint ADP-ribosylation of histones by ARTD1: an additional module of the histone code?
    Michael O Hottiger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    FEBS Lett 585:1595-9. 2011
    ..The ADP-ribose modification is read by zinc finger motifs or macrodomains, which then regulate chromatin structure and transcription. Thus, histone ADP-ribosylation may be considered an additional component of the histone code...
  9. ncbi request reprint Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 280:40450-64. 2005
    ..Thus, acetylation of PARP-1 by p300/CREB-binding protein plays an important regulatory role in NF-kappaB-dependent gene activation by enhancing its functional interaction with p300 and the Mediator complex...
  10. pmc Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
    Marcela Covic
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 24:85-96. 2005
    ..Our results suggest that the cooperative action between protein arginine methyltransferases and protein lysine acetyltransferases regulates NF-kappaB-dependent gene activation in vivo...
  11. ncbi request reprint Arginine methylation regulates DNA polymerase beta
    Nazim El-Andaloussi
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 22:51-62. 2006
    ..Based on our findings, we propose that PRMT6 plays a role as a regulator of BER...
  12. doi request reprint Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Biol 377:668-78. 2008
    ..These results suggest that the cooperative action between PRMT1 and CARM1 is required for NF-kappaB-dependent gene expression...
  13. doi request reprint Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression
    Michael Elser
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Mol Cancer Res 6:282-90. 2008
    ....
  14. ncbi request reprint Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen
    Nazim El-Andaloussi
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    FASEB J 21:26-34. 2007
    ..Together, our results provide evidence that PRMT1 methylation of pol beta might play a regulatory role in BER by preventing the involvement of pol beta in PCNA-dependent DNA metabolic events...
  15. doi request reprint SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
    Karin M Rothgiesser
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
    J Cell Sci 123:4251-8. 2010
    ..Our work provides evidence that p65 is deacetylated by SIRT2 in the cytoplasm to regulate the expression of specific NF-κB-dependent genes...
  16. ncbi request reprint The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity
    Erica Friedrich-Heineken
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    J Mol Biol 353:980-9. 2005
    ..Finally, acetylation of Fen1 by p300-HAT abolished the stimulatory effect of the 9-1-1 complex but not that of PCNA, suggesting a possible mechanism of regulation of this important repair pathway...
  17. ncbi request reprint MYBBP1a is a novel repressor of NF-kappaB
    Heather R Owen
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Biol 366:725-36. 2007
    ..These results indicate that MYBBP1a is a novel NF-kappaB co-repressor of transcription that competes with p300 and may function to regulate cell type specific genes...
  18. doi request reprint Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
    Sandra S Haenni
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Int J Biochem Cell Biol 40:2274-83. 2008
    ..Together, our results provide evidence that acetylation of PARP-2 is a key post-translational modification that may regulate DNA binding and consequently also the enzymatic activity of PARP-2...
  19. pmc Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
    Matthias Altmeyer
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nucleic Acids Res 37:3723-38. 2009
    ..Together, our findings provide novel mechanistic insights into PAR synthesis with significant relevance for the different biological functions of PARP family members...
  20. ncbi request reprint An epigenetic code for DNA damage repair pathways?
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Switzerland
    Biochem Cell Biol 83:270-85. 2005
    ..We also discuss new technologies and strategies to elucidate the putative epigenetic code for each of the DNA repair processes discussed...
  21. pmc SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress
    Ingrid Kassner
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Open Biol 3:120173. 2013
    ..Together, these results reveal a novel mechanism for the regulation of cellular ARTD1 activity by SET7/9 to assure efficient PAR formation upon cellular stress. ..
  22. ncbi request reprint Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 278:45145-53. 2003
    ..Together, these results indicate that PARP-1 acts synergistically with p300 and plays an essential regulatory role in NF-kappaB-dependent gene expression...
  23. doi request reprint Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
    Simon Messner
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    FASEB J 23:3978-89. 2009
    ....
  24. pmc Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression
    Karin M Rothgiesser
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    BMC Genomics 11:22. 2010
    ..We have earlier reported that p65, a subunit of NF-kappaB, is acetylated in vitro and in vivo at three different lysines (K310, K314 and K315) by the histone acetyltransferase p300...
  25. doi request reprint Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA
    Claudio Guetg
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 45:790-800. 2012
    ..The data unravel a function of PARP1 and ADP-ribosylation that serves to allow for the inheritance of silent chromatin structures, shedding light on how epigenetic marks are transmitted during each cell cycle...
  26. pmc Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
    Sandra S Haenni
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    BMC Cell Biol 9:39. 2008
    ....
  27. ncbi request reprint Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
    Natalie Möckli
    Dualsystems Biotech AG, Zurich, Switzerland
    Biotechniques 42:725-30. 2007
    ..The cytoY2H system extends existing methods for the detection of protein interactions by providing a convenient solution for screening a wide range of transcriptionally active proteins...
  28. doi request reprint ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation
    Suheda Erener
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, Zurich 8057, Switzerland
    FASEB J 26:2631-8. 2012
    ..In summary, we show that ARTD1(-/-) mice fed an HFD display impaired adipogenesis and show exacerbated hepatic steatosis, which can have important implications for nonalcoholic fatty liver disease...
  29. doi request reprint Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes
    Suheda Erener
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 46:200-11. 2012
    ..These findings propose an apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression and provide insight into inflammasome signaling...
  30. doi request reprint Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function
    Suheda Erener
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    Mol Endocrinol 26:79-86. 2012
    ..Together, our study identifies PARP1 as a critical regulator of PPARγ2-dependent gene expression with implications in adipocyte function and obesity-related disease models...
  31. pmc Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
    Isabella M Toller
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:14944-9. 2011
    ..pylori and with its mutagenic properties in vitro and in vivo and may contribute to the genetic instability and frequent chromosomal aberrations that are a hallmark of gastric cancer...
  32. doi request reprint Histone ADP-ribosylation in DNA repair, replication and transcription
    Simon Messner
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Cell Biol 21:534-42. 2011
    ..We discuss here the functional aspects of histone ADP-ribosylation and its influence on DNA repair, replication and transcription...
  33. doi request reprint CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression
    Sandrine Jayne
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    J Mol Biol 394:485-95. 2009
    ..Together, our results confirm the importance of CARM1 as transcriptional cofactor without the involvement of its catalytic activity...
  34. ncbi request reprint Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB)
    Heather R Owen
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    J Proteome Res 4:1381-90. 2005
    ..Analysis by electrophoresis and liquid chromatography tandem mass spectrometry identified several novel putative molecular partners. Some were strongly enriched in the complex formed from the nuclear extracts of specific cell types...
  35. pmc Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
    Matthias Altmeyer
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Infect Immun 78:3420-31. 2010
    ..Consequently, animals lacking PARP1 show impaired infiltration of immune cells into the gut, with severely delayed inflammation...
  36. ncbi request reprint Gene expression in synovial membrane cells after intraarticular delivery of plasmid-linked superparamagnetic iron oxide particles--a preliminary study in sheep
    Larry D Galuppo
    Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    J Nanosci Nanotechnol 6:2841-52. 2006
    ..In addition, the best suited concentration and size of nanoparticles, which will optimize gene delivery and expression, while minimizing intraarticular inflammation, needs to be determined...
  37. ncbi request reprint NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells
    Mirjam Cramer
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Biol Chem 386:865-72. 2005
    ..Furthermore, we found that hypoxic conditions induce nuclear translocation and interaction of MTF-1 and NF-kappaB p65 proteins, suggesting a role for this complex in hypoxia-induced transcription of PlGF...
  38. pmc Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Microbiol Mol Biol Rev 70:789-829. 2006
    ..e., DNA damage response, transcriptional regulation, and insulator function), are described. A potential cross talk between nuclear ADP-ribosylation processes and other NAD(+)-dependent pathways is discussed...
  39. doi request reprint Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
    Isabella M Toller
    Institute of Molecular Cancer Research and Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    Cancer Res 70:5912-22. 2010
    ....
  40. ncbi request reprint PARP1 is required for adhesion molecule expression in atherogenesis
    Tobias von Lukowicz
    Cardiovascular Research, Institute of Physiology, University of Zurich and Cardiology, Cardiovascular Center, University Hospital Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland
    Cardiovasc Res 78:158-66. 2008
    ..However, the key mediators linking recruitment of inflammatory cells to atherogenesis remain poorly defined. Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme, which plays a role in acute inflammatory diseases...
  41. doi request reprint Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction
    Catherine Gebhard
    Cardiovascular Research, Physiology Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Biochem Biophys Res Commun 414:641-6. 2011
    ..Generation of reactive oxygen species (ROS) is a key feature of vascular disease. Activation of the nuclear enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase-1 (PARP-1) is a downstream effector of oxidative stress...
  42. doi request reprint Identification of distinct amino acids as ADP-ribose acceptor sites by mass spectrometry
    Florian Rosenthal
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    Methods Mol Biol 780:57-66. 2011
    ....
  43. pmc The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair
    Magali Toueille
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich Irchel, Wintherturerstrasse 190, CH 8057, Zurich, Switzerland
    Nucleic Acids Res 32:3316-24. 2004
    ..Our data raise the possibility that the 9-1-1 complex might attract DNA polymerase beta to DNA damage sites, thus connecting directly checkpoints and DNA repair...
  44. doi request reprint Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
    Florian Rosenthal
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    Nat Struct Mol Biol 20:502-7. 2013
    ..Our results establish macrodomain-containing proteins as mono-ADP-ribosylhydrolases and define a class of enzymes that renders mono-ADP-ribosylation a reversible modification...
  45. pmc SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
    Sokrates Stein
    Cardiovascular Research, Institute of Physiology, Zurich University and Cardiology, Cardiovascular Center, University Hospital Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Eur Heart J 31:2301-9. 2010
    ..Our aim in this study was to analyse the role of SIRT1, a class III deacetylase with important metabolic functions, in plaque macrophages and atherogenesis...
  46. pmc Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field
    Sarah W Kamau
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Nucleic Acids Res 34:e40. 2006
    ..The highly efficient gene transfer already within 5 min shows that this technique is a powerful tool for future in vivo studies, where rapid gene delivery is required before systemic clearance or filtration of the gene vectors occurs...
  47. doi request reprint Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures
    Sarah W Kamau Chapman
    Institute of Veterinary Biochemistry and Molecular Biology, Vetsuisse Faculty, University of Zurich, Winterthurerstr 190, CH 8057, Zurich, Switzerland
    In Vitro Cell Dev Biol Anim 45:152-62. 2009
    ..This method provided a large number of primary equine melanoma cells that could be used to study new therapeutic approaches for treatment of equine melanomas...
  48. ncbi request reprint Acetylation regulates the DNA end-trimming activity of DNA polymerase beta
    Sameez Hasan
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 10:1213-22. 2002
    ..This was due to an impairment of the dRP-lyase activity of Polbeta. Acetylation of Polbeta thus acts as an intranuclear regulatory mechanism and implies that p300 plays a critical regulatory role in BER...
  49. doi request reprint SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
    Fabienne Niederer
    Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
    Ann Rheum Dis 70:1866-73. 2011
    ..To analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA...
  50. pmc The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
    Claudio Guetg
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 29:2135-46. 2010
    ..These findings point to a role of TIP5 in protecting genome stability and suggest that it can play a role in the cellular transformation process...
  51. ncbi request reprint Localized insulin-like growth factor I delivery to enhance new bone formation
    Lorenz Meinel
    Institute of Pharmaceutical Sciences, Drug Formulation and Delivery Group, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Bone 33:660-72. 2003
    ....
  52. ncbi request reprint Genetic approaches to the identification of interactions between membrane proteins in yeast
    Daniel Auerbach
    DUALSYSTEMS BIOTECH Inc, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Recept Signal Transduct Res 22:471-81. 2002
    ....
  53. pmc ARTD2 activity is stimulated by RNA
    Karolin Léger
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland and Life Science Zurich Graduate School, University of Zurich, 8057 Zurich, Switzerland
    Nucleic Acids Res 42:5072-82. 2014
    ..Thus, our findings identify a new activator of ARTD2-dependent ADP-ribosylation, which has important implications for the future analysis of the biological role of ARTD2 in the nucleus. ..
  54. ncbi request reprint Identification of ADP-ribosylated peptides and ADP-ribose acceptor sites
    Florian Rosenthal
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Switzerland
    Front Biosci (Landmark Ed) 19:1041-56. 2014
    ..Here, we summarize the most recent progress in defining the cellular ADP-ribosylome and the efforts to detect ADP-ribose acceptor sites by enzymatic reactions and mass-spectrometry. ..
  55. ncbi request reprint Histone acetyl transferases: a role in DNA repair and DNA replication
    Sameez Hasan
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Med (Berl) 80:463-74. 2002
    ..This review discusses various aspects of histone acetyl transferases and summarizes recent findings which suggest a role for histone acetyl transferases in DNA repair and DNA replication...