Research Topics
Genomes and Genes | Boris HinzSummaryCountry: Switzerland Publications
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Publications
Formation and function of the myofibroblast during tissue repairBoris Hinz
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
J Invest Dermatol 127:526-37. 2007..Moreover, intervening with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis...
The myofibroblast: one function, multiple originsBoris Hinz
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
Am J Pathol 170:1807-16. 2007....- Myofibroblast development is characterized by specific cell-cell adherens junctionsB Hinz
Laboratory of Cell Biophysics, Swiss Federal Institute of Technology, 1015 Lausanne, Switzerland
Mol Biol Cell 15:4310-20. 2004..Anti-OB-cadherin but not anti-N-cadherin peptides reduce the contraction of myofibroblast-populated collagen gels, suggesting that AJs are instrumental for myofibroblast contractile activity... - Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmissionBoris Hinz
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
Eur J Cell Biol 85:175-81. 2006.... - Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodelingBoris Hinz
Laboratory of Cell Biophysics, Swiss Federal Institute of Technology, Bâtiment SG AA B 143, CH 1015 Lausanne, Switzerland
Thromb Haemost 90:993-1002. 2003.... - Mechanisms of force generation and transmission by myofibroblastsBoris Hinz
Laboratory of Cell Biophysics, Swiss Federal Institute of Technology EPFL, Bâtiment SG AA B 143, CH 1015 Lausanne, Switzerland
Curr Opin Biotechnol 14:538-46. 2003..Regulation of these phenomena will be important for therapeutic strategies aimed at influencing fibrocontractive diseases... - Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblastsBoris Hinz
Department of Pathology, Centre Medical Universitaire, University of Geneva, Switzerland
Mol Biol Cell 14:2508-19. 2003..We conclude that the formation and stability of supermature FAs depends on a high alpha-SMA-mediated contractile activity of myofibroblast stress fibers... 
A new lock-step mechanism of matrix remodelling based on subcellular contractile eventsLysianne Follonier Castella
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
J Cell Sci 123:1751-60. 2010..The joint action of both contraction modes can result in macroscopic tissue contractures of approximately 1 cm per month...- The covalent attachment of adhesion molecules to silicone membranes for cell stretching applicationsPierre Jean Wipff
Ecole Polytechnique Federale de Lausanne, Switzerland
Biomaterials 30:1781-9. 2009..Hence, covalent linkage of adhesive molecules is superior to non-covalent methods in providing a coating that resists large deformations and that fully transmit this stretch to cultured cells... - Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bondsPhilippe Pittet
Laboratory of Cell Biophysics, Institute of Physics of the Complex Matter, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
J Cell Sci 121:877-86. 2008..We propose that this plasticity adapts fibroblast adhesions to the changing mechanical microenvironment of tissue under remodeling... 
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrixPierre Jean Wipff
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
J Cell Biol 179:1311-23. 2007..We propose activation of TGF-beta1 via integrin-mediated myofibroblast contraction as a potential checkpoint in the progression of fibrosis, restricting autocrine generation of myofibroblasts to a stiffened ECM...- Myofibroblasts work best under stressPierre Jean Wipff
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Lausanne, Switzerland
J Bodyw Mov Ther 13:121-7. 2009..From these findings it emerges that the specific matrix adhesion structures of myofibroblasts are promising targets to modulate myofibroblast differentiation and activity... - The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivoBoris Hinz
Department of Pathology, , University of Geneva, 1211 Geneva 4, Switzerland
J Cell Biol 157:657-63. 2002.... - Regulation of myofibroblast activities: calcium pulls some strings behind the sceneLysianne Follonier Castella
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
Exp Cell Res 316:2390-401. 2010.... - Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibersJérôme M Goffin
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, CH 1015, Lausanne, Switzerland
J Cell Biol 172:259-68. 2006..We propose that the different molecular composition and higher phosphorylation of FAs on supermature islets, compared with FAs on classical islets, accounts for higher stress resistance... - The single-molecule mechanics of the latent TGF-β1 complexLara Buscemi
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Curr Biol 21:2046-54. 2011..Latent TGF-β1 mechanical activation is more efficient with higher cell forces and ECM stiffening. However, little is known about the molecular events involved in this mechanical activation mechanism... - Myofibroblast communication is controlled by intercellular mechanical couplingLysianne Follonier
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SG AA B143, Station 15, CH 1015 Lausanne, Switzerland
J Cell Sci 121:3305-16. 2008..This mechanism could improve the remodelling of cell-dense tissue by coordinating the activity of myofibroblasts... - Integrins and the activation of latent transforming growth factor beta1 - an intimate relationshipPierre Jean Wipff
Laboratory of Cell Biophysics, Bâtiment SG AA B143, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Eur J Cell Biol 87:601-15. 2008..Understanding that different integrins use different mechanisms to activate latent TGF-beta1 opens new possibilities to develop cell-specific therapeutic strategies for TGF-beta1-induced pathologies... - A novel method of dynamic culture surface expansion improves mesenchymal stem cell proliferation and phenotypeHicham Majd
Ecole Polytechnique Federale de Lausanne, Switzerland
Stem Cells 27:200-9. 2009..Development of an undesired fibrogenic myofibroblast phenotype was suppressed. Hence, our novel method can rapidly provide the high number of autologous, multipotent, and nonfibrogenic MSC needed for successful regenerative medicine... - Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblastsAdrian C Shieh
Institute of Bioengineering and Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Cancer Res 71:790-800. 2011..This represents a novel mechanism in which interstitial flow causes fibroblast-mediated stromal remodeling that facilitates tumor invasion... - A key role for NOX4 in epithelial cell death during development of lung fibrosisStephanie Carnesecchi
Department of Pediatrics, Medical School, University of Geneva, Geneva, Switzerland
Antioxid Redox Signal 15:607-19. 2011..We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells... - Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiationB Hinz
Department of Pathology, University of Geneva, Geneva, Switzerland
Am J Pathol 159:1009-20. 2001..Our results support the assumption that mechanical tension is crucial for myofibroblast modulation and for the maintenance of their contractile activity... - Immunofluorescence detection of the cytoskeleton and extracellular matrix in tissue and cultured cellsJosiane Smith-Clerc
Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
Methods Mol Biol 611:43-57. 2010..Therefore, it is recommended to test different protocols for a "new" protein or epitope - the results will pay back your investment... - Alpha-smooth muscle actin expression upregulates fibroblast contractile activityB Hinz
Department of Pathology, CMU, University of Geneva, 1211 Geneva 4, Switzerland
Mol Biol Cell 12:2730-41. 2001..This took place in the absence of any change in smooth muscle or nonmuscle myosin heavy-chain expression. Our results indicate that an increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity... - Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)Matthias Geissbuehler
Laboratoire d Optique Biomedicale, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Biophys J 98:339-49. 2010..The proposed method has the potential to become a new tool for investigating oxygen metabolism at the single cell and the subcellular level... - NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expressionBin Li
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
J Innate Immun 1:570-81. 2009.... - Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migrationC Ballestrem
Department of Pathology, Centre Medical Universitaire, Geneva, Switzerland
Mol Biol Cell 11:2999-3012. 2000..In conclusion, we demonstrate that the formation of lamellipodia can occur via actin polymerization independently of microtubules, but that microtubules are required for cell migration, tail retraction, and modulation of cell adhesion... - Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiationIrmgard S Thorey
Institute of Cell Biology, Department of Biology, ETH Zurich, Honggerberg, CH 8093 Zurich, Switzerland
J Biol Chem 279:26674-84. 2004..Furthermore, our data suggested that systemic GH treatment is detrimental for wound healing in healthy individuals... - Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activityJames J Tomasek
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Wound Repair Regen 14:313-20. 2006..These results are consistent with inhibition of myosin light chain phosphatase by the Rho/ROCK signaling pathway, which would account for the long-duration contraction of myofibroblasts necessary for wound closure... - Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitroChee Ping Ng
Department of Chemical and Biological Engineering, Northwestern University, Evanston, 633 Clark Street, Chicago, IL 60208, USA
J Cell Sci 118:4731-9. 2005.... - Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiationThorsten Peters
Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
EMBO J 24:3400-10. 2005..Our data demonstrates that the paracrine secretion of growth factors is essential for cellular differentiation in wound healing... - Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiationMikko J Rönty
Neuroscience Program and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
J Invest Dermatol 126:2387-96. 2006..They also provide for the first time information about the signaling cascades involved in the regulation of palladin expression... - The N-terminal Ac-EEED sequence plays a role in alpha-smooth-muscle actin incorporation into stress fibersSophie Clement
Department of Pathology and Immunology, CMU, Geneva, Switzerland
J Cell Sci 118:1395-404. 2005..Here, we propose a new mechanism of how alpha-smooth-muscle actin is incorporated in stress fibers involving the sequence Ac-EEED... - Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue InvasionLaura Machesky
CRUK Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
EMBO Rep 9:139-43. 2008 - Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytesPierre Shephard
Department of Dermatology, University of Cologne, Germany
Thromb Haemost 92:262-74. 2004..Our results dissect the roles of TGF-beta and ET-1 on mechanical force generation in keratinocyte-fibroblast co-cultures, and identify GM-CSF as an inducer of myofibroblasts acting indirectly... - Myofibroblasts and mechano-regulation of connective tissue remodellingJames J Tomasek
Department of Cell Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
Nat Rev Mol Cell Biol 3:349-63. 2002.... - Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cellsAlexander Link
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Nat Immunol 8:1255-65. 2007..Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors...