Jan Helbing

Summary

Country: Switzerland

Publications

  1. doi request reprint Vibrational circular dichroism signal enhancement using self-heterodyning with elliptically polarized laser pulses
    Jan Helbing
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Chem Phys 131:174507. 2009
  2. doi request reprint Temperature dependence of the heat diffusivity of proteins
    Jan Helbing
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem A 116:2620-8. 2012
  3. pmc Folding and unfolding of a photoswitchable peptide from picoseconds to microseconds
    Janne A Ihalainen
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:5383-8. 2007
  4. ncbi request reprint Coexistence of hydrogen-bonded loop and extended tetrapeptide conformations
    Valentina Cervetto
    Physikalisch Chemisches Institut Universität Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 13:9004-11. 2007
  5. doi request reprint Transient 2D-IR spectroscopy of thiopeptide isomerization
    Valentina Cervetto
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 112:8398-405. 2008
  6. doi request reprint Time-resolved infrared spectroscopy of thiopeptide isomerization and hydrogen-bond breaking
    Valentina Cervetto
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 112:3540-4. 2008
  7. pmc Protein ligand migration mapped by nonequilibrium 2D-IR exchange spectroscopy
    Jens Bredenbeck
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:14243-8. 2007
  8. ncbi request reprint Two-dimensional infrared spectroscopy of photoswitchable peptides
    Peter Hamm
    Physikalisch Chemisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Annu Rev Phys Chem 59:291-317. 2008
  9. ncbi request reprint Intramolecular disulfide bridges as a phototrigger to monitor the dynamics of small cyclic peptides
    Christoph Kolano
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 111:11297-302. 2007
  10. ncbi request reprint Watching hydrogen-bond dynamics in a beta-turn by transient two-dimensional infrared spectroscopy
    Christoph Kolano
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH8057 Zurich, Switzerland or
    Nature 444:469-72. 2006

Collaborators

Detail Information

Publications15

  1. doi request reprint Vibrational circular dichroism signal enhancement using self-heterodyning with elliptically polarized laser pulses
    Jan Helbing
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Chem Phys 131:174507. 2009
    ..An analogous scheme allows for vibrational optical rotary dispersion measurements. The techniques are compared with similar approaches using both a linear response picture and the Jones matrix calculus...
  2. doi request reprint Temperature dependence of the heat diffusivity of proteins
    Jan Helbing
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem A 116:2620-8. 2012
    ..Assuming that this coupling is anharmonic in nature, the observed temperature trend can readily be explained...
  3. pmc Folding and unfolding of a photoswitchable peptide from picoseconds to microseconds
    Janne A Ihalainen
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:5383-8. 2007
    ..We conclude that a rather large spread of rates (k(1) : k(n) approximately 9) is needed to explain the experimentally observed stretched exponential response with stretching factor beta = 0.8 at 279 K...
  4. ncbi request reprint Coexistence of hydrogen-bonded loop and extended tetrapeptide conformations
    Valentina Cervetto
    Physikalisch Chemisches Institut Universität Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 13:9004-11. 2007
    ..The hydrogen bond between the Boc terminal group and the amide proton of Aib can be broken by photoisomerisation of the thioamide bond...
  5. doi request reprint Transient 2D-IR spectroscopy of thiopeptide isomerization
    Valentina Cervetto
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 112:8398-405. 2008
    ..Different types of transient cross-peak signals are observed, and their information content is discussed by comparison with model spectra...
  6. doi request reprint Time-resolved infrared spectroscopy of thiopeptide isomerization and hydrogen-bond breaking
    Valentina Cervetto
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 112:3540-4. 2008
    ....
  7. pmc Protein ligand migration mapped by nonequilibrium 2D-IR exchange spectroscopy
    Jens Bredenbeck
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:14243-8. 2007
    ..Exchange cross-peaks between the bands associated with substates of heme-bound CO and photodissociated CO in the primary docking site reveal the substate connectivity at physiological temperature...
  8. ncbi request reprint Two-dimensional infrared spectroscopy of photoswitchable peptides
    Peter Hamm
    Physikalisch Chemisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Annu Rev Phys Chem 59:291-317. 2008
    ..Several photoswitches have been tested, and we discuss our progress in merging these two pathways of research...
  9. ncbi request reprint Intramolecular disulfide bridges as a phototrigger to monitor the dynamics of small cyclic peptides
    Christoph Kolano
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem B 111:11297-302. 2007
    ..The photocleavable disulfide bridge hence may serve as an intrinsic, naturally occurring phototrigger to study peptide dynamics that opens a wide time-window from a few picoseconds to many hundreds of microseconds...
  10. ncbi request reprint Watching hydrogen-bond dynamics in a beta-turn by transient two-dimensional infrared spectroscopy
    Christoph Kolano
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH8057 Zurich, Switzerland or
    Nature 444:469-72. 2006
    ..We find that the rate of this process is two orders of magnitude faster than the 'folding speed limit' established for contact formation between protein side chains...
  11. doi request reprint Polarization control of ultrashort mid-IR laser pulses for transient vibrational circular dichroism measurements
    Mathias Bonmarin
    Physikalisch Chemisches Institut, Universitat Zurich, Zurich CH 8057, Switzerland
    Chirality 21:E298-306. 2009
    ..Residual static birefringence of the modulator and the sample cell can be largely compensated by carefully controlling the arrival time of the ultrashort probe pulses at the modulator...
  12. ncbi request reprint Time-resolved IR spectroscopy of N-methylthioacetamide: trans-->cis isomerization upon n-pi and pi-pi excitation and cis-->trans photoreaction
    Valentina Cervetto
    Physikalisch Chemisches Institut, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Phys Chem A 110:11473-8. 2006
    ..These results support a mechanism by which isomerization takes place via one common intermediate state independent of electronic excitation energy and initial conformation...
  13. pmc Alpha-helix formation in a photoswitchable peptide tracked from picoseconds to microseconds by time-resolved IR spectroscopy
    Jens Bredenbeck
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 102:2379-84. 2005
    ..We find differing relaxation dynamics at different spectral positions...
  14. ncbi request reprint Restricted rotational motion of CO in a protein internal cavity: evidence for nonseparating correlation functions from IR pump-probe spectroscopy
    Jan Helbing
    Physikalisch Chemisches Institut, Universitat Zurich, Winterthurerstrasse, 190, CH 8057 Zurich, Switzerland
    J Chem Phys 122:124505. 2005
    ....
  15. pmc Time-resolved visible and infrared study of the cyano complexes of myoglobin and of hemoglobin I from Lucina pectinata
    Jan Helbing
    Physikalisch Chemisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Biophys J 87:1881-91. 2004
    ..In addition, the CN-stretch frequency is sensitive to the excitation of low frequency heme modes, and yields independent information about vibrational cooling, which occurs on the same timescale...