Research Topics
| Patrice FrancoisSummaryAffiliation: Genomic Research Laboratory Country: Switzerland Publications
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Detail Information
Publications
Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureusThibaud Koessler
Genomic Research Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, CH-1211 Geneva 14, Switzerland
J Clin Microbiol 44:1040-8. 2006....- Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitisCaroline Le Marechal
INRA, UMR1253 Science et Technologie du Lait et de l Œuf, F 35042 Rennes, France
Vet Res 42:35. 2011..These findings open avenues in S. aureus mastitis studies as some of these proteins, expressed in vivo, are likely to account for the success of S. aureus as a pathogen of the ruminant mammary gland... - Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophageJean Marc Rolain
URMITE CNRS IRD UMR 6236, Faculte de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Biol Direct 4:1. 2009..We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution... - Role of the SaeRS two-component regulatory system in Staphylococcus epidermidis autolysis and biofilm formationQiang Lou
Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology and Institutes of Biomedical Sciences, Shanghai Medical College of Fudan University, 138 Yixueyuan Road, Shanghai, 200032, PR China
BMC Microbiol 11:146. 2011..The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear... - Effect of a glucose impulse on the CcpA regulon in Staphylococcus aureusKati Seidl
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
BMC Microbiol 9:95. 2009..This study is the first CcpA-dependent transcriptome and proteome analysis in Staphylococcus aureus, focussing on short-time effects of glucose under stable pH conditions... - Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistanceMilla Pietiäinen
Antimicrobial Resistance Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, PL 30, 00271 Helsinki, Finland
BMC Genomics 10:429. 2009..Three antimicrobial peptides were used in the analysis, two are derived from frog, temporin L and dermaseptin K4-S4(1-16), and the ovispirin-1 is obtained from sheep... 
Comparison of fluorescence and resonance light scattering for highly sensitive microarray detection of bacterial pathogensPatrice Francois
Genomic Research Laboratory, Division of Infectious Diseases, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
J Microbiol Methods 55:755-62. 2003..Our study reveals that nanoparticle-labeled bacterial RNA generates reproducible resonance light scattering signals that are at least 50 times more intense than state-of-the-art confocal-based fluorescence signals...- Rapid bacterial identification using evanescent-waveguide oligonucleotide microarray classificationPatrice Francois
University Hospitals of Geneva, Genomic Research Laboratory, Service of Infectious Diseases, Switzerland
J Microbiol Methods 65:390-403. 2006..In conclusion, when coupled to optimal signal detection strategy, microarrays provide bacterial identification within a few hours post-sampling, allowing targeted antimicrobial prescription... - Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assayPatrice Francois
Genomic Research Laboratory, University of Geneva Hospitals, Service of Infectious Diseases Genomic Research Laboratory, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 44:1892-5. 2006..aureus agr type. This assay represents a rapid and affordable alternative to sequence-based strategies for assessing relevant epidemiological information... - Comparison of amplification methods for transcriptomic analyses of low abundance prokaryotic RNA sourcesPatrice Francois
Genomic Research Laboratory, Service of Infectious Diseases, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
J Microbiol Methods 68:385-91. 2007.... - Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureusPatrice Francois
Department of Internal Medicine, Service of Infectious Diseases Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 45:2011-3. 2007..Our results suggest that users of orfX-staphylococcal cassette chromosome mec-based assays should repeatedly monitor the local epidemiology to minimize the risks of detection bias and the omission of emerging MRSA clones... - Genome content determination in methicillin-resistant Staphylococcus aureusPatrice Francois
Service of Infectious Diseases, Genomic Research Laboratory, Department of Internal Medicine, Geneva 14, Switzerland
Future Microbiol 2:187-98. 2007..In addition, sequence information is mandatory for the development of molecular tests allowing the rapid identification, genotyping and characterization of clinical isolates... - A novel multiplex real-time PCR assay for rapid typing of major staphylococcal cassette chromosome mec elementsPatrice Francois
Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 42:3309-12. 2004..This novel assay constitutes a valuable tool for evaluating the molecular epidemiology of MRSA and adjusting infection control strategies against MRSA... 
Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiologyPatrice Francois
University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
J Microbiol Methods 72:296-305. 2008..This type of rapid and high-throughput methodology opens the possibility to rapidly assess long-term nosocomial transmission or to characterize infecting strains in the general procedure of routine laboratories, in real-time...- Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005Patrice Francois
University of Geneva Hospitals, Geneva, Switzerland
Emerg Infect Dis 14:304-7. 2008..We demonstrated strain diversity, including clones rarely found in Europe. Local epidemiology of community-associated MRSA is diverse and is evolving by importation and transmission of new strains... - Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolatesPatrice Francois
Genomic Research Laboratory, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 43:3346-55. 2005..All steps of this new procedure were developed to ensure a rapid turnaround time and moderate cost. The results obtained suggest that this rapid approach is a valuable tool for the genotyping of S. aureus isolates in real time... - Induction of fibronectin adhesins in quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin or by sigma B transcription factor activity is mediated by two separate pathwaysDongmei Li
Service of Infectious Diseases, University Hospitals of Geneva, Geneva, Switzerland
Antimicrob Agents Chemother 49:916-24. 2005..aureus occurs via independent pathways whose concerted actions may significantly promote bacterial adhesion and colonization... - A generic approach for the design of whole-genome oligoarrays, validated for genomotyping, deletion mapping and gene expression analysis on Staphylococcus aureusYvan Charbonnier
Genomic Research Laboratory, University Hospitals of Geneva, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
BMC Genomics 6:95. 2005..Relying on parameters shown to affect the hybridization of nucleic acids, we designed freely available software and validated experimentally its performance on the bacterial pathogen Staphylococcus aureus... - Modulation of fibronectin adhesins and other virulence factors in a teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureusAdriana Renzoni
Division of Infectious Diseases, University Hospitals of Geneva, CH-1211 Geneva 14, Switzerland
Antimicrob Agents Chemother 48:2958-65. 2004..These molecular and phenotypic changes may have a profound impact on the bacterial adhesion and colonization properties of such multiresistant organisms... - A global view of Staphylococcus aureus whole genome expression upon internalization in human epithelial cellsChristian Garzoni
Service of Infectious Diseases, University Hospital of Geneva, Department of Internal Medicine, Geneva 14, Switzerland
BMC Genomics 8:171. 2007..Mechanisms contributing to internalization have been partly elucidated, but bacterial processes triggered intracellularly are largely unknown... - Identification by genomic and genetic analysis of two new genes playing a key role in intermediate glycopeptide resistance in Staphylococcus aureusAdriana Renzoni
Service of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland
Antimicrob Agents Chemother 53:903-11. 2009..In conclusion, our study demonstrates the key role of two novel loci in endogenous, low-level glycopeptide resistance in S. aureus whose precise molecular functions warrant further investigation... - Daptomycin resistance mechanisms in clinically derived Staphylococcus aureus strains assessed by a combined transcriptomics and proteomics approachAdrien Fischer
Genomic Research Laboratory, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
J Antimicrob Chemother 66:1696-711. 2011..The development of daptomycin resistance in Staphylococcus aureus is associated with clinical treatment failures. The mechanism(s) of such resistance have not been clearly defined... - Rapid detection of methicillin-resistant Staphylococcus aureus directly from sterile or nonsterile clinical samples by a new molecular assayPatrice Francois
Genomic Research Laboratory, Division of Infectious Diseases, University Hospitals of Geneva, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 41:254-60. 2003..The complete protocol may provide results in less than 6 h (while standard procedure needs 2 to 3 days), thus allowing prompt and cost-effective implementation of contact precautions... - High prevalence of isolates with reduced glycopeptide susceptibility in persistent or recurrent bloodstream infections due to methicillin-resistant Staphylococcus aureusIlker Uckay
Service of Infectious Diseases, Infection Control Program, Geneva University Hospital and Medical School, Geneva, Switzerland
Antimicrob Agents Chemother 56:1258-64. 2012..0001). Detection of elevated teicoplanin MICs may help to predict a poor response to glycopeptide therapy in MRSA bacteremic patients... - Epidemiology and virulence insights from MRSA and MSSA genome analysisVladimir Lazarevic
Genomic Research Laboratory, Geneva University Hospitals, Switzerland
Future Microbiol 6:513-32. 2011..This high resolution approach allows the monitoring micro- and macroevolution of MRSA and identification of specific genomic markers of evolution of invasive or highly virulent phenotypes... - Cartography of methicillin-resistant S. aureus transcripts: detection, orientation and temporal expression during growth phase and stress conditionsMarie Beaume
Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals, Geneva, Switzerland
PLoS ONE 5:e10725. 2010..Most studies evaluating gene content have so far neglected to analyze the so-called intergenic regions as well as potential antisense RNA molecules... - A recA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureusCarmelo Bisognano
Division of Infectious Diseases, University Hospital, CH-1211 Geneva 14, Switzerland
J Biol Chem 279:9064-71. 2004..We conclude that activation of recA and derepression of lexA-regulated genes by CPX may represent a response to drug-induced damage that results in a novel induction of a virulence factor leading to increased bacterial tissue adherence... - Comparative efficacy of daptomycin and vancomycin in the therapy of experimental foreign body infection due to Staphylococcus aureusPierre Vaudaux
Division of Infectious Diseases, Geneva University Hospital, CH 1211 Geneva 14, Switzerland
J Antimicrob Chemother 52:89-95. 2003..aureus. Drug dosage should be adapted to obtain inflammatory fluid levels of daptomycin minimizing emergence of resistant subpopulations... - High-density DNA probe arrays for identification of staphylococci to the species levelSabine Couzinet
Genomic Research Laboratory, University Hospitals of Geneva Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland
J Microbiol Methods 61:201-8. 2005..The total time required for identification of 4 isolates was 5 h. Such a tool represents a powerful method for routine microbiological diagnostic as well as for epidemiological studies... - Increased expression of clumping factor and fibronectin-binding proteins by hemB mutants of Staphylococcus aureus expressing small colony variant phenotypesPierre Vaudaux
Division of Infectious Diseases, University Hospital, CH 1211 Geneva 14, Switzerland
Infect Immun 70:5428-37. 2002..Both agr-positive and agr-lacking hemB mutants were also more efficiently internalized by human embryonic kidney cells than were their isogenic controls, presumably because of increased surface display of their fibronectin adhesins... - Development and validation of a modified broad-range 16S rDNA PCR for diagnostic purposes in clinical microbiologyAbdessalam Cherkaoui
Clinical Microbiology Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, Geneva 14, Switzerland
J Microbiol Methods 79:227-31. 2009..Compared with conventional methods, broad-range PCR with ExoIII pre-treatment of reagents substantially improves the diagnostic yield of bacterial pathogen identification from normally sterile sites... - Lack of biofilm contribution to bacterial colonisation in an experimental model of foreign body infection by Staphylococcus aureus and Staphylococcus epidermidisPatrice Francois
Division of Infectious Diseases, University Hospitals of Geneva, 1211 Geneva 14, Switzerland
FEMS Immunol Med Microbiol 35:135-40. 2003..aureus or S. epidermidis were equivalent to those of their respective ica-negative mutants, in the locally infected fluids and on tissue-cage-inserted plastic coverslips... - Proteomic approaches to study Staphylococcus aureus pathogenesisPatrice Francois
Genomic Research Laboratory, Service of Infectious Diseases, Department of Internal Medicine, Geneva University and Geneva University Hospitals, 1211 Geneva 14, Switzerland
J Proteomics 73:701-8. 2010..This review summarizes the impact of proteomic on our comprehension of S. aureus virulence and pathogenesis... - Impact of oleic acid (cis-9-octadecenoic acid) on bacterial viability and biofilm production in Staphylococcus aureusLudwig Stenz
Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals, Geneva 14, Switzerland
FEMS Microbiol Lett 287:149-55. 2008..Our results suggest a natural protective effect of oleic acid against primary adhesion... - Community-associated methicillin-resistant Staphylococcus aureus, SwitzerlandStephan Harbarth
University of Geneva Hospitals, Geneva, Switzerland
Emerg Infect Dis 11:962-5. 2005..9/1,000 admissions. Although 5 CA-MRSA isolates contained Panton-Valentine leukocidin, only 1 patient had a previous skin infection. No easily modifiable risk factor for CA-MRSA was identified... - Evaluation of a high-density oligonucleotide array for characterization of grlA, grlB, gyrA and gyrB mutations in fluoroquinolone resistant Staphylococcus aureus isolatesSabine Couzinet
Division of Infectious Diseases, University Hospitals of Geneva, CH 1211, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
J Microbiol Methods 60:275-9. 2005..For the two most important genes, gyrA and grlA, correlation with sequencing reached 95.1%. If all genes were considered, correlation was 88.8%... - Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markersAlexander Scherl
Biomedical Proteomics Research Group, Geneva University, Geneva, Switzerland
BMC Genomics 7:296. 2006..Quantitative proteomics performed on membrane extracts showed exquisite inter-experimental reproducibility permitting the identification and relative quantification of >30% of the predicted S. aureus proteome... - Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort studyStephan Harbarth
Infection Control Program, Geneva University Hospitals, Geneva, Switzerland
Crit Care 10:R25. 2006.... - Robustness of a loop-mediated isothermal amplification reaction for diagnostic applicationsPatrice Francois
Genomic Research Laboratory, University Hospitals of Geneva, Service of Infectious Diseases, Geneva, Switzerland
FEMS Immunol Med Microbiol 62:41-8. 2011..Our results demonstrate that LAMP is not only easy to use, but is also a very robust, innovative and powerful molecular diagnostic method for both industrialized and developing countries... - Proteomic approach to investigate MRSAPatrice Francois
Department of Internal Medicine, Service of Infectious Diseases Genomic Research Laboratory, Geneva, Switzerland
Methods Mol Biol 391:179-99. 2007..aureus on the organism level. Coupled with methods analyzing the whole bacterial transcriptome, this approach might contribute to the development of rapid diagnostic tests and to the identification of new drug targets... - New approaches for functional genomic studies in staphylococciMarie Beaume
Genomic Research Laboratory, Service of Infectious Diseases, University of Geneva Hospitals HUG, CH 1211 Geneva 14, Switzerland
Int J Med Microbiol 300:88-97. 2010..Here we review the principles, advantages and disadvantages of recent technical developments in the field of transcriptomics and their potential impact on S. aureus research... - Study of inter- and intra-individual variations in the salivary microbiotaVladimir Lazarevic
Genomic Research Laboratory, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
BMC Genomics 11:523. 2010..Culture-independent approaches provide the best means to assess the diversity of oral bacteria because most of them remain uncultivable... - Development and evaluation of a rapid strategy to determine enterotoxin gene content in Staphylococcus aureusAdrien Fischer
Genomic Research Laboratory, Service of Infectious Diseases, University Hospital of Geneva, University of Geneva, CH 1 211 Geneva 14, Switzerland
J Microbiol Methods 77:184-90. 2009..A combined genotyping method that includes rapid enterotoxin content determination appears informative for various epidemiological survey purposes... - Novel microarray design strategy to study complex bacterial communitiesAntoine Huyghe
Genomic Research Laboratory, Infectious Diseases Service, University of Geneva Hospitals, Micheli du Crest 24, 1211 Geneva 14, Geneva, Switzerland
Appl Environ Microbiol 74:1876-85. 2008..Our results show that this hierarchical approach can reveal minor changes (<or=1%) in gingival flora content when samples collected in individuals from similar geographical origins are compared... - Metagenomic study of the oral microbiota by Illumina high-throughput sequencingVladimir Lazarevic
Genomic Research Laboratory, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
J Microbiol Methods 79:266-71. 2009..Access to large amounts of data is already leading to a better representation of sample diversity at a reasonable cost... - The CodY pleiotropic repressor controls virulence in gram-positive pathogensLudwig Stenz
Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals, Geneva, Switzerland
FEMS Immunol Med Microbiol 62:123-39. 2011..This is true for the anthrax toxins of Bacillus anthracis and the haemolysins of Staphylococcus aureus. The purpose of this review is to illustrate CodY-regulated mechanisms on virulence in major gram-positive pathogens... - Analysis of the salivary microbiome using culture-independent techniquesVladimir Lazarevic
Genomic Research Laboratory, Division of Infectious Diseases, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, CH 1211 Geneva 14, Switzerland
J Clin Bioinforma 2:4. 2012..abstract:.. - Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species levelAbdessalam Cherkaoui
Clinical Microbiology Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, CH 1211 Geneva 14, Switzerland
J Clin Microbiol 48:1169-75. 2010..Our data suggest that implementation of MS as a first test strategy for one-step species identification would improve timeliness and reduce isolate identification costs in clinical bacteriology laboratories now... - Comparison of four chromogenic media for culture-based screening of meticillin-resistant Staphylococcus aureusAbdessalam Cherkaoui
Clinical Microbiology Laboratory, University of Geneva Hospitals HUG, Service of Infectious Diseases, CH 1211 Geneva 14, Switzerland
J Med Microbiol 56:500-3. 2007..aureus are commercially available. However, their respective performances under real conditions of utilization are heterogeneous, underlining the absence of a gold standard medium for MRSA screening... - De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computerDavid Hernandez
Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals and the University of Geneva, CH 1211 Geneva 4, Switzerland
Genome Res 18:802-9. 2008..5- to 3.0-kb fragments. We also provide indications that the broad coverage achieved by high-throughput sequencing might allow for the detection of clonal polymorphisms in the set of DNA molecules being sequenced... - Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureusPierre Vaudaux
Division of Infectious Diseases, Geneva University Hospital, CH 1211 Geneva 14, Switzerland
Antimicrob Agents Chemother 46:1503-9. 2002..The mechanisms explaining the inferior activity of alatrofloxacin compared to the activity of levofloxacin against chronic foreign-body-associated infections by MRSA are unknown... - Screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposisFrédéric Heymans
Rhinology Olfactology Unit, Department of Otorhinolaryngology and ENT Surgery, Geneva University Hospital, Geneva, Switzerland
PLoS ONE 5:e9525. 2010..The aim of this study was to investigate whether the presence of any of the 22 currently known staphylococcal exotoxin genes could be correlated with chronic rhinosinusitis... - Accelerated digestion for high-throughput proteomics analysis of whole bacterial proteomesAli R Vaezzadeh
Biomedical Proteomics Research Group, Department of Structural Biology and Bioinformatics, Geneva University, 1 Michel Servet, Geneva, Switzerland
J Microbiol Methods 80:56-62. 2010..The combination of high-throughput proteomics with accelerated and efficient sample preparation should enhance the practicability of proteomics by reducing the time from sample collection to obtaining the results... - Orientation and expression of methicillin-resistant Staphylococcus aureus small RNAs by direct multiplexed measurements using the nCounter of NanoString technologyMarie Beaume
Genomic Research Laboratory, Service of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland
J Microbiol Methods 84:327-34. 2011..e. during host-pathogen interactions) or when starting from poorly purified RNA or even directly from lysed infected tissues... - Differentiating osteoarticular infections caused by Kingella kingae from those due to typical pathogens in young childrenDimitri Ceroni
Pediatric Orthopedic Service, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
Pediatr Infect Dis J 30:906-9. 2011..kingae osteoarticular infections by using the following 4 variables: body temperature <38°C, serum C-reactive protein <55 mg/L, white blood cell count <14,000/mm, and band forms <150/mm... - Development of a rapid PCR assay for screening of maternal colonization by group B streptococcus and neonatal invasive Escherichia coli during laborBegona Martinez de Tejada
Department of Obstetrics and Gynecology, University Hospitals of Geneva, Geneva, Switzerland
Gynecol Obstet Invest 70:250-5. 2010..To screen for colonization during labor, we developed a real-time PCR assay for the simultaneous detection of GBS and neonatal invasive strains of E. coli... - Ceftazidime-resistant Klebsiella oxytoca producing an OXY-2-type variant from SwitzerlandJosé Manuel Rodríguez-Martínez
Int J Antimicrob Agents 32:278-9. 2008 - In vivo detection of clonally derived methicillin-resistant/methicillin-susceptible Staphylococcus aureus strains is not a rare eventPatrice Francois
J Clin Microbiol 46:1890-1. 2008 - Evidence of an intracellular reservoir in the nasal mucosa of patients with recurrent Staphylococcus aureus rhinosinusitisSophie Clement
Department of Pathology and Immunology, University of Geneva, Switzerland
J Infect Dis 192:1023-8. 2005..Intracellular residence may provide a sanctuary for pathogenic bacteria by protecting them from host defense mechanisms and antibiotic treatment during acute, recurrent S. aureus rhinosinusitis... - Nonredundant mass spectrometry: a strategy to integrate mass spectrometry acquisition and analysisAlexander Scherl
Biomedical Proteomics Research Group, Central Clinical Chemistry Laboratory, Geneva University Hospital, Switzerland
Proteomics 4:917-27. 2004..It was also found that this new workflow significantly increased sequence coverage by identifying unexpected peptides, which can result from post-translational modifications... - Inactivation of a subpopulation of human neutrophils by exposure to ultrahigh-molecular-weight polyethylene wear debrisLouis Bernard
Service of Orthopaedic Surgery, Geneva University Hospital, Switzerland
FEMS Immunol Med Microbiol 49:425-32. 2007..In conclusion, engulfment of UHMWPE wear particles led to inactivation of S. aureus uptake in nearly half of the neutrophil population, which may potentially impair host clearance mechanisms against pyogenic infections...