Yoshikuni Nagamine

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. ncbi request reprint Transcriptional and posttranscriptional regulation of the plasminogen activator system
    Yoshikuni Nagamine
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Thromb Haemost 93:661-75. 2005
  2. pmc Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
    Simon Lattmann
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nucleic Acids Res 38:6219-33. 2010
  3. ncbi request reprint Transcriptional regulation of the plasminogen activator inhibitor type 1--with an emphasis on negative regulation
    Yoshikuni Nagamine
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Thromb Haemost 100:1007-13. 2008
  4. ncbi request reprint Non-redundant role of Shc in Erk activation by cytoskeletal reorganization
    Amir Faisal
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 279:3202-11. 2004
  5. ncbi request reprint Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell 13:101-11. 2004
  6. pmc Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain
    Katerina Chalupníková
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    J Biol Chem 283:35186-98. 2008
  7. ncbi request reprint Regulation of PAI-1 gene expression during adipogenesis
    Joshi Venugopal
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, Basel, Switzerland
    J Cell Biochem 101:369-80. 2007
  8. pmc Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Mol Cell Biol 23:7177-88. 2003
  9. pmc Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes
    Joshi Venugopal
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:17120-5. 2004
  10. ncbi request reprint Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling
    Sandra Kleiner
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    FEBS J 274:227-40. 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Transcriptional and posttranscriptional regulation of the plasminogen activator system
    Yoshikuni Nagamine
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Thromb Haemost 93:661-75. 2005
    ..In this short review, we summarize current understanding of the transcriptional and mRNA-stability regulation of the PA system...
  2. pmc Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU
    Simon Lattmann
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nucleic Acids Res 38:6219-33. 2010
    ..Thus, these results reveal a novel motif in RHAU protein that plays an important role in recognizing and resolving G4-RNA structures, properties unique to RHAU among many known RNA helicases...
  3. ncbi request reprint Transcriptional regulation of the plasminogen activator inhibitor type 1--with an emphasis on negative regulation
    Yoshikuni Nagamine
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Thromb Haemost 100:1007-13. 2008
    ..Furthermore, the engagement of negative factors in these pathways has been shown to be important, adding complexity and versatility to PAI-1 gene regulation...
  4. ncbi request reprint Non-redundant role of Shc in Erk activation by cytoskeletal reorganization
    Amir Faisal
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 279:3202-11. 2004
    ..In summary, we have found a novel, non-redundant role for ShcA in contrast to its redundant role in many other signaling pathways...
  5. ncbi request reprint Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell 13:101-11. 2004
    ..ARE(uPA)-mRNA recognition by RHAU may be mediated through its RNA-dependent interaction with the AUBPs HuR and NFAR1. A model is presented to describe the action of RHAU in ARE(uPA)-directed mRNA turnover...
  6. pmc Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain
    Katerina Chalupníková
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    J Biol Chem 283:35186-98. 2008
    ..Thus, our results show that RHAU is the fourth RNA helicase detected in SGs, after rck/p54, DDX3, and eIF4A, and that its association with SGs is dynamic and mediated by an RHAU-specific RNA-binding domain...
  7. ncbi request reprint Regulation of PAI-1 gene expression during adipogenesis
    Joshi Venugopal
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, Basel, Switzerland
    J Cell Biochem 101:369-80. 2007
    ....
  8. pmc Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Mol Cell Biol 23:7177-88. 2003
    ..These results indicate a role for HuR and MK2 in regulating the expression of uPA and uPAR genes at the posttranscriptional level...
  9. pmc Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes
    Joshi Venugopal
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 101:17120-5. 2004
    ..This study identifies a caveolar-dependent signal pathway that up-regulates PAI-1 in insulin-resistant adipocytes and proposes a previously undescribed pharmacological paradigm of disrupting pRB-E2F interaction to suppress PAI-1 levels...
  10. ncbi request reprint Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling
    Sandra Kleiner
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    FEBS J 274:227-40. 2007
    ....
  11. doi request reprint Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU
    Fumiko Iwamoto
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland
    Exp Cell Res 314:1378-91. 2008
    ..We propose that RHAU has a dual function, being involved in both the synthesis and degradation of mRNA in different subcellular compartments...
  12. ncbi request reprint Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling
    Amir Faisal
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 277:30144-52. 2002
    ....
  13. ncbi request reprint Regulation of protease and protease inhibitor gene expression: the role of the 3'-UTR and lessons from the plasminogen activating system
    Stan Stasinopoulos
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Prog Nucleic Acid Res Mol Biol 80:169-215. 2005
  14. pmc The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme
    Simon Lattmann
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nucleic Acids Res 39:9390-404. 2011
    ..Furthermore, our results suggest the existence of alternatively folded forms of TERC in the fully assembled telomerase holoenyzme...
  15. pmc Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA
    Malgorzata Kisielow
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66 CH 4058 Basel, Switzerland
    Biochem J 363:1-5. 2002
    ..This allowed functional analysis of individual ShcA isoforms and may be more generally applicable for studying genes encoding multiple proteins...
  16. ncbi request reprint AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stability
    Andrea Thiele
    Hubrecht Laboratory, The Netherlands Institute of Developmental Biology, Uppsalalaan 8, NL 3584 CT Utrecht, The Netherlands
    Exp Cell Res 312:2367-78. 2006
    ..These results suggest that alternative splicing and AREs can act together in regulating beta-catenin mRNA stability and thereby provide a step of controlling the cellular beta-catenin concentration...