Research Topics
Genomes and Genes
| Nancy E HynesSummaryAffiliation: Friedrich Miescher Institute Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
The ErbB receptor tyrosine family as signal integratorsN E Hynes
Friedrich Miescher Institute, PO Box 2543, CH 4002 Basel, Switzerland
Endocr Relat Cancer 8:151-9. 2001..Cross-regulation of ErbB RTKs and cytokines receptors represents another mechanism for controlling and enhancing tumor cell proliferation...- ERBB receptors and cancer: the complexity of targeted inhibitorsNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Nat Rev Cancer 5:341-54. 2005..We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response... - Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinaseN E Hynes
Friedrich Miescher Institute, Basel, Switzerland
J Mammary Gland Biol Neoplasia 6:141-50. 2001..Data from our laboratory will be presented showing that deregulated ErbB2 activity strongly stimulates cytoplasmic signaling pathways which in turn impinge on Myc at multiple levels causing its deregulated expression... - Tyrosine kinase signalling in breast cancerN E Hynes
Friedrich Miescher Institute, Basel, Switzerland
Breast Cancer Res 2:154-7. 2000..This topic is the major focus of the thematic review section of this issue of Breast Cancer Research... - Targeting ADAMS and ERBBs in lung cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Cancer Cell 10:7-11. 2006..This minireview will discuss recent findings on possible mechanisms leading to ERBB-targeted therapy resistance and potential means to overcome them... - Prolactin mediated intracellular signaling in mammary epithelial cellsN E Hynes
Friedrich Miescher Institute, Basel, Switzerland
J Mammary Gland Biol Neoplasia 2:19-27. 1997..In this review we discuss the prolactin induced signaling pathways which mediate differentiation of the mammary gland... - ErbB2 activation and signal transduction in normal and malignant mammary cellsN E Hynes
Friedrich Miescher Institute, Basel, Switzerland
J Mammary Gland Biol Neoplasia 1:199-206. 1996..In clinical studies, the ErbB2 protein level has been examined for its utility in predicting patient prognosis and response to treatment. The ErbB2 receptor is also being tested as a target for tumor directed therapies... - ErbB receptors and signaling pathways in cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Curr Opin Cell Biol 21:177-84. 2009..Finally, mechanisms contributing to resistance to ErbB-targeted therapeutics will also be discussed... - The mTOR pathway in breast cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Mammary Gland Biol Neoplasia 11:53-61. 2006.... - Therapeutic targeting of signal transduction pathways and proteins in breast cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
J Mammary Gland Biol Neoplasia 11:1-2. 2006 - Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activityM Wartmann
Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
J Biol Chem 271:31863-8. 1996..This indicates that the MAP kinase pathway does not contribute to lactogenic hormone induction of the beta-casein gene... - Potential for targeting the fibroblast growth factor receptors in breast cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 70:5199-202. 2010..Finally, to improve the chances for success with FGFR signal transduction inhibitors, strategies to choose appropriate breast cancer patients for treatment will be discussed... - Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasisJulien H Dey
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 70:4151-62. 2010..Of interest are the downregulated matrix metalloproteases (MMP), in particular MMP9, which is essential for metastatic spread of 4T1 tumors... - Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migrationMaria Meira
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Cell Sci 122:787-97. 2009..In summary, these data indicate that Memo also regulates actin dynamics by interacting with cofilin and enhancing its function... - WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growthYutaka Matsuda
Friedrich Miescher Institute for Biomedical Research Part of the Novartis Research Foundation, Basel, Switzerland
Breast Cancer Res 11:R32. 2009..Here we examine the role of WNT signaling in breast tumor cell migration and on xenograft outgrowth... - Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivationThomas Schlange
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Breast Cancer Res 9:R63. 2007.... - The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationThomas Holbro
Friedrich Miescher Institute, P O Box 2543, 4002 Basel, Switzerland
Proc Natl Acad Sci U S A 100:8933-8. 2003..Furthermore, we identify ErbB3's role, which is to couple active ErbB2 to the phosphatidylinositol 3-kinase/protein kinase B pathway. Thus, the ErbB2/ErbB3 dimer functions as an oncogenic unit to drive breast tumor cell proliferation... - Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclinsMagdalena Koziczak
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Oncogene 23:3501-8. 2004..In SUM 52 cells, both MAPK and PI3K signaling pathways were suppressed. In conclusion, results shown here describe a mechanism by which FGFR promotes proliferation of breast cancer cells... - Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathwaysIvana Samarzija
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Biochem Biophys Res Commun 386:449-54. 2009..Taken together, our data indicate that Wnt3a induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration... - The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptidesAndrea B Motoyama
Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Cancer Res 62:3151-8. 2002.... - c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary glandTina Stoelzle
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
BMC Biol 7:63. 2009..Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach... - TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activityNicole Schick
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 279:38787-96. 2004..Intriguingly, Stat3 repression did not require TEL DNA binding and appeared to proceed via recruitment of TEL to Stat3. Inhibition of Stat3 activity by TEL represents a novel mechanism regulating the Stat3 signaling pathway... - Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translationMagdalena Koziczak
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
J Biol Chem 279:50004-11. 2004..Thus, we propose a novel mechanism for controlling cyclin D1 expression downstream of combined activity of ErbB2 and FGFR-4 that involves S6K1-mediated translation... - The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expressionBérengère Fayard
Friedrich Miescher Institute for Biological Research, Basel, Switzerland
Cancer Res 69:5690-8. 2009..These results suggest that PN-1 might become a prognostic marker in breast cancer... - Novel c-MYC target genes mediate differential effects on cell proliferation and migrationDavid Cappellen
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
EMBO Rep 8:70-6. 2007..Our combined genomic and phenotypic analysis indicates that c-MYC functions are cellular-context-dependent and that selectively regulated genes are responsible for its differential properties... - PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enoughNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4059 Basel, Switzerland
Cancer Cell 15:353-5. 2009..show that trastuzumab disrupts ligand-independent ErbB2/ErbB3/PI3K complexes and blocks AKT signaling; if PI3K is mutated, complex disruption does not inhibit AKT, which explains why trastuzumab is ineffective in some tumors... - Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cellsN Cella
Friedrich Miescher Institute, Basel, Switzerland
Mol Cell Biol 18:1783-92. 1998..These results suggest that glucocorticoids affect milk protein gene expression via association of the GR with Stat5. Thus, there is a functional coupling between Stat-dependent and nuclear hormone receptor-dependent gene transcription... - Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoliNa Li
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
EMBO J 24:1942-53. 2005..A connection between p21 Cip1 and beta1 integrin as well as FAK was also established in primary mammary cells. These results point to the essential role of beta1 integrin signaling in mammary epithelial cell proliferation... - Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeuticsPatrizia Sini
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 68:1581-92. 2008.... - Mammary gland growth factors: roles in normal development and in cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerestrasse 66, CH 4058 Basel, Switzerland
Cold Spring Harb Perspect Biol 2:a003186. 2010..We will discuss different peptides in the context of normal development and cancer in this review... - Memo mediates ErbB2-driven cell motilityRomina Marone
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Nat Cell Biol 6:515-22. 2004..Our data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton... - The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancerAnne Boulay
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 68:3743-51. 2008..In summary, we showed that Ret is a novel proliferative pathway interacting with ER signaling in vitro. Expression of Ret in primary breast tumors suggests that Ret might be a novel therapeutic target in breast cancer... - Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signalingH A Lane
Friedrich Miescher Institute, Basel, Switzerland
Ann Oncol 12:S21-2. 2001.... - BAD: a good therapeutic target?Andrea B Motoyama
Friedrich Miescher Institute, Basel, Switzerland
Breast Cancer Res 5:27-30. 2003..Furthermore, they showed that the major effector of the EGFR-targeted therapy is BAD, a widely expressed BCL-2 family member. These results are promising in light of the role of the EGFR in breast cancer development... - ErbB receptors: directing key signaling networks throughout lifeThomas Holbro
Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
Annu Rev Pharmacol Toxicol 44:195-217. 2004..In this review, we discuss these data in more detail, illustrating the importance of tightly regulated ErbB signaling throughout life... - Targeting ERBB receptors in cancerNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Recent Results Cancer Res 172:45-57. 2007 - The ErbB receptors and their role in cancer progressionThomas Holbro
Friedrich Miescher Institute, PO Box 2543, 4002, Basel, Switzerland
Exp Cell Res 284:99-110. 2003..e., ErbB1 cooperates with other classes of receptors, and the ligand-less ErbB2 functions as a heterodimer with other ErbBs... - The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockadePatrizia Sini
Novartis Institute for Biomedical Research, Oncology Research, Basel, Switzerland
Clin Cancer Res 11:4521-32. 2005.... - An essential role for Src kinase in ErbB receptor signaling through the MAPK pathwayM A Olayioye
Friedrich Miescher Institute, Basel, CH-4002, Switzerland
Exp Cell Res 267:81-7. 2001..Thus, ErbB signaling requires the engagement of a novel Src-dependent route to MAPK, to trigger its rapid activation and subsequent efficient stimulation of transcription... - Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growthI M Harwerth
Friedrich Miescher Institute, Basel, Switzerland
Br J Cancer 68:1140-5. 1993..The effect of the MAbs on the anchorage-independent growth of erbB-2 transformed cells and on erbB-2 receptor turnover was also measured... - The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cellsK Horsch
Friedrich Miescher Institute, CH 4002 Basel, Switzerland
Mol Endocrinol 15:2182-96. 2001..In support of this model, PTP-PEST-containing lysates from EGF-treated HC11 cells dephosphorylated JAK2 to a greater extent than lysates prepared from control cells... - ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinasesM A Olayioye
Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
J Biol Chem 274:17209-18. 1999..Taken together, the experiments establish two independent roles for Src kinases: (i) key molecules in ErbB receptor-mediated Stat signaling and (ii) potential upstream regulators of Jak kinases... - Copine-III interacts with ErbB2 and promotes tumor cell migrationC Heinrich
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Oncogene 29:1598-610. 2010..Moreover, in an in situ tissue microarray analysis, we detected differential protein expression of Copine-III in normal versus breast, prostate and ovarian tumors, suggesting a more general role for Copine-III in carcinogenesis... - MHO1, an Evolutionarily Conserved Gene, Is Synthetic Lethal with PLC1; Mho1p Has a Role in Invasive GrowthIvan D Schlatter
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS ONE 7:e32501. 2012..Moreover, a role for Memo in cell motility/invasion appears to be conserved across species... - Key signalling nodes in mammary gland development and cancer: MycNancy E Hynes
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Breast Cancer Res 11:210. 2009..This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer... - Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cellsGianluca Civenni
Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
EMBO Rep 4:166-71. 2003..Our finding that Wnts transactivate ErbB1 in addition to stimulating the prototypic beta-catenin/TCF pathway may help to explain why wnt1 is a potent oncogene in the mammary gland... - Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cellsA Badache
Friedrich Miescher Institute, Basel, Switzerland
Cancer Res 61:383-91. 2001..Cooperation between IL-6 and the EGF receptor in T47D breast carcinoma cells illustrates how a combination of multiple stimuli, either exogenous or endogenous, may result in synergistic cellular responses... - ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partnerM A Olayioye
Friedrich Miescher Institute, CH 4002 Basel, Switzerland
Mol Cell Biol 18:5042-51. 1998..Differential receptor phosphorylation may, therefore, be the basis for the differences in the signaling properties observed... - ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependencyH A Lane
Friedrich Miescher Institute, CH 4002 Basel, Switzerland
Mol Cell Biol 20:3210-23. 2000.... - The role of overexpressed HER2 in transformationR M Neve
Friedrich Miescher Institute, Basel, Switzerland
Ann Oncol 12:S9-13. 2001.... - Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4Gertraud Orend
Friedrich Miescher Institute for Biomedical Research, Novartis Forschungsstiftung, PO Box 2543, CH 4002 Basel, Switzerland
Oncogene 22:3917-26. 2003..We therefore propose that syndecan-4 signaling plays a central role in the control of cellular proliferation of anchorage-dependent fibroblasts... - The lysosomal-associated membrane protein LAMP-1 is a novel differentiation marker for HC11 mouse mammary epithelial cellsN Cella
Friedrich Miescher Institute, Basel, Switzerland
Differentiation 61:113-20. 1996..Increase in lysosomal vesicles and their contents might play a role in intra- and extra-cellular remodeling, which is characteristic of cell differentiation... - The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involutionR Neve
Friedrich Miescher Institute, Basel CH 4058, Switzerland
FASEB J 12:1541-50. 1998.... - Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimersLily Yen
Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, Department of Medicine and McGill Centre for Translational Research in Cancer, McGill University, Montreal, Quebec, H3T 1E2, Canada
Mol Biol Cell 13:4029-44. 2002..These results emphasize the biological implications of cell signaling diversity among members of the ErbB receptor family in regulation of the tumor microenvironment... - A new therapeutic antibody masks ErbB2 to its partnersAli Badache
Friedrich Miescher Institute of the Novartis Research Foundation, P.O. Box 2543, CH-4002 Basel, Switzerland
Cancer Cell 5:299-301. 2004..Pertuzumab's novel mode of action might offer additional therapeutic opportunities for treatment of tumors expressing ligand-activated ErbB2... - Targeting of human breast cancer by a bispecific antibody directed against two tumour-associated antigens: ErbB-2 and carcinoembryonic antigenMylène Dorvillius
EMI 0227 INSERM and GDR CNRS 2352, Universite Montpellier I, Cancer Research Centre, Montpellier, France
Tumour Biol 23:337-47. 2002..The results obtained with the BAb in the double-positive tumour-bearing nude mice suggest that targeting two distinct tumour-associated antigens on the same cell could improve tumour localisation... - Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptorStephen Hyland
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, D-co596 Frankfourt an Main, Germany
Oncogene 22:1557-67. 2003..Upon cytoplasmic expression in human tumor cells, scFvs colocalized with EGFR at the plasma membrane demonstrating their functionality in vivo... - ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation eventsDiane E Clark
Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, New Orleans, Louisiana 70112 2669, USA
J Biol Chem 280:24175-80. 2005..Our studies demonstrate that phosphorylation of STAT5A at Ser-127/Ser-128 and Ser-779 are obligatory events regulating ERBB4-mediated activation of STAT5A... - ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002Niels Tørring
Department of Clinical Biochemistry AKH, Aarhus University Hospital, Aarhus C, Denmark
Prostate 56:142-9. 2003..ErbB receptor tyrosine kinases have been implicated in the development of prostate cancer... - Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active siteChen Qiu
Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
J Biol Chem 283:2734-40. 2008..Memo thus represents a new class of phosphotyrosine-binding protein... - Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cellsRichard M Neve
Department of Hematology Oncology, UCSF San Francisco and Buck Institute, Novato, California 94945, USA
Oncogene 21:4567-76. 2002..This suggests that downstream effectors of ErbB receptors represent good therapeutic targets for breast cancer...