Nancy E Hynes

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. pmc BAD: a good therapeutic target?
    Andrea B Motoyama
    Friedrich Miescher Institute, Basel, Switzerland
    Breast Cancer Res 5:27-30. 2003
  2. ncbi request reprint The ErbB receptor tyrosine family as signal integrators
    N E Hynes
    Friedrich Miescher Institute, PO Box 2543, CH 4002 Basel, Switzerland
    Endocr Relat Cancer 8:151-9. 2001
  3. ncbi request reprint ERBB receptors and cancer: the complexity of targeted inhibitors
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Rev Cancer 5:341-54. 2005
  4. ncbi request reprint Targeting ADAMS and ERBBs in lung cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Cancer Cell 10:7-11. 2006
  5. ncbi request reprint The mTOR pathway in breast cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Mammary Gland Biol Neoplasia 11:53-61. 2006
  6. ncbi request reprint Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 6:141-50. 2001
  7. ncbi request reprint Therapeutic targeting of signal transduction pathways and proteins in breast cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 11:1-2. 2006
  8. pmc Tyrosine kinase signalling in breast cancer
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    Breast Cancer Res 2:154-7. 2000
  9. doi request reprint ErbB receptors and signaling pathways in cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Opin Cell Biol 21:177-84. 2009
  10. ncbi request reprint Prolactin mediated intracellular signaling in mammary epithelial cells
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 2:19-27. 1997

Collaborators

Detail Information

Publications65

  1. pmc BAD: a good therapeutic target?
    Andrea B Motoyama
    Friedrich Miescher Institute, Basel, Switzerland
    Breast Cancer Res 5:27-30. 2003
    ..Furthermore, they showed that the major effector of the EGFR-targeted therapy is BAD, a widely expressed BCL-2 family member. These results are promising in light of the role of the EGFR in breast cancer development...
  2. ncbi request reprint The ErbB receptor tyrosine family as signal integrators
    N E Hynes
    Friedrich Miescher Institute, PO Box 2543, CH 4002 Basel, Switzerland
    Endocr Relat Cancer 8:151-9. 2001
    ..Cross-regulation of ErbB RTKs and cytokines receptors represents another mechanism for controlling and enhancing tumor cell proliferation...
  3. ncbi request reprint ERBB receptors and cancer: the complexity of targeted inhibitors
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Rev Cancer 5:341-54. 2005
    ..We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response...
  4. ncbi request reprint Targeting ADAMS and ERBBs in lung cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Cancer Cell 10:7-11. 2006
    ..This minireview will discuss recent findings on possible mechanisms leading to ERBB-targeted therapy resistance and potential means to overcome them...
  5. ncbi request reprint The mTOR pathway in breast cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Mammary Gland Biol Neoplasia 11:53-61. 2006
    ....
  6. ncbi request reprint Myc and mammary cancer: Myc is a downstream effector of the ErbB2 receptor tyrosine kinase
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 6:141-50. 2001
    ..Data from our laboratory will be presented showing that deregulated ErbB2 activity strongly stimulates cytoplasmic signaling pathways which in turn impinge on Myc at multiple levels causing its deregulated expression...
  7. ncbi request reprint Therapeutic targeting of signal transduction pathways and proteins in breast cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 11:1-2. 2006
  8. pmc Tyrosine kinase signalling in breast cancer
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    Breast Cancer Res 2:154-7. 2000
    ..This topic is the major focus of the thematic review section of this issue of Breast Cancer Research...
  9. doi request reprint ErbB receptors and signaling pathways in cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Opin Cell Biol 21:177-84. 2009
    ..Finally, mechanisms contributing to resistance to ErbB-targeted therapeutics will also be discussed...
  10. ncbi request reprint Prolactin mediated intracellular signaling in mammary epithelial cells
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 2:19-27. 1997
    ..In this review we discuss the prolactin induced signaling pathways which mediate differentiation of the mammary gland...
  11. ncbi request reprint ErbB2 activation and signal transduction in normal and malignant mammary cells
    N E Hynes
    Friedrich Miescher Institute, Basel, Switzerland
    J Mammary Gland Biol Neoplasia 1:199-206. 1996
    ..In clinical studies, the ErbB2 protein level has been examined for its utility in predicting patient prognosis and response to treatment. The ErbB2 receptor is also being tested as a target for tumor directed therapies...
  12. ncbi request reprint Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity
    M Wartmann
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Biol Chem 271:31863-8. 1996
    ..This indicates that the MAP kinase pathway does not contribute to lactogenic hormone induction of the beta-casein gene...
  13. doi request reprint Potential for targeting the fibroblast growth factor receptors in breast cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 70:5199-202. 2010
    ..Finally, to improve the chances for success with FGFR signal transduction inhibitors, strategies to choose appropriate breast cancer patients for treatment will be discussed...
  14. doi request reprint Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
    Julien H Dey
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 70:4151-62. 2010
    ..Of interest are the downregulated matrix metalloproteases (MMP), in particular MMP9, which is essential for metastatic spread of 4T1 tumors...
  15. ncbi request reprint Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration
    Maria Meira
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 122:787-97. 2009
    ..In summary, these data indicate that Memo also regulates actin dynamics by interacting with cofilin and enhancing its function...
  16. ncbi request reprint The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides
    Andrea B Motoyama
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Cancer Res 62:3151-8. 2002
    ....
  17. pmc Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
    Thomas Schlange
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Breast Cancer Res 9:R63. 2007
    ....
  18. pmc WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
    Yutaka Matsuda
    Friedrich Miescher Institute for Biomedical Research Part of the Novartis Research Foundation, Basel, Switzerland
    Breast Cancer Res 11:R32. 2009
    ..Here we examine the role of WNT signaling in breast tumor cell migration and on xenograft outgrowth...
  19. pmc The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    Thomas Holbro
    Friedrich Miescher Institute, P O Box 2543, 4002 Basel, Switzerland
    Proc Natl Acad Sci U S A 100:8933-8. 2003
    ..Furthermore, we identify ErbB3's role, which is to couple active ErbB2 to the phosphatidylinositol 3-kinase/protein kinase B pathway. Thus, the ErbB2/ErbB3 dimer functions as an oncogenic unit to drive breast tumor cell proliferation...
  20. doi request reprint Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways
    Ivana Samarzija
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Biochem Biophys Res Commun 386:449-54. 2009
    ..Taken together, our data indicate that Wnt3a induces canonical and non-canonical Wnt signaling in HUVECs, and stimulates their proliferation and migration...
  21. ncbi request reprint Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
    Magdalena Koziczak
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Oncogene 23:3501-8. 2004
    ..In SUM 52 cells, both MAPK and PI3K signaling pathways were suppressed. In conclusion, results shown here describe a mechanism by which FGFR promotes proliferation of breast cancer cells...
  22. pmc c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
    Tina Stoelzle
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    BMC Biol 7:63. 2009
    ..Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach...
  23. ncbi request reprint TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity
    Nicole Schick
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 279:38787-96. 2004
    ..Intriguingly, Stat3 repression did not require TEL DNA binding and appeared to proceed via recruitment of TEL to Stat3. Inhibition of Stat3 activity by TEL represents a novel mechanism regulating the Stat3 signaling pathway...
  24. ncbi request reprint Cooperation between fibroblast growth factor receptor-4 and ErbB2 in regulation of cyclin D1 translation
    Magdalena Koziczak
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    J Biol Chem 279:50004-11. 2004
    ..Thus, we propose a novel mechanism for controlling cyclin D1 expression downstream of combined activity of ErbB2 and FGFR-4 that involves S6K1-mediated translation...
  25. ncbi request reprint Memo mediates ErbB2-driven cell motility
    Romina Marone
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Cell Biol 6:515-22. 2004
    ..Our data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton...
  26. pmc Novel c-MYC target genes mediate differential effects on cell proliferation and migration
    David Cappellen
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    EMBO Rep 8:70-6. 2007
    ..Our combined genomic and phenotypic analysis indicates that c-MYC functions are cellular-context-dependent and that selectively regulated genes are responsible for its differential properties...
  27. doi request reprint The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression
    Bérengère Fayard
    Friedrich Miescher Institute for Biological Research, Basel, Switzerland
    Cancer Res 69:5690-8. 2009
    ..These results suggest that PN-1 might become a prognostic marker in breast cancer...
  28. doi request reprint PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4059 Basel, Switzerland
    Cancer Cell 15:353-5. 2009
    ..show that trastuzumab disrupts ligand-independent ErbB2/ErbB3/PI3K complexes and blocks AKT signaling; if PI3K is mutated, complex disruption does not inhibit AKT, which explains why trastuzumab is ineffective in some tumors...
  29. pmc Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells
    N Cella
    Friedrich Miescher Institute, Basel, Switzerland
    Mol Cell Biol 18:1783-92. 1998
    ..These results suggest that glucocorticoids affect milk protein gene expression via association of the GR with Stat5. Thus, there is a functional coupling between Stat-dependent and nuclear hormone receptor-dependent gene transcription...
  30. doi request reprint The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer
    Anne Boulay
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 68:3743-51. 2008
    ..In summary, we showed that Ret is a novel proliferative pathway interacting with ER signaling in vitro. Expression of Ret in primary breast tumors suggests that Ret might be a novel therapeutic target in breast cancer...
  31. doi request reprint Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeutics
    Patrizia Sini
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 68:1581-92. 2008
    ....
  32. pmc Mammary gland growth factors: roles in normal development and in cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerestrasse 66, CH 4058 Basel, Switzerland
    Cold Spring Harb Perspect Biol 2:a003186. 2010
    ..We will discuss different peptides in the context of normal development and cancer in this review...
  33. pmc Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli
    Na Li
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    EMBO J 24:1942-53. 2005
    ..A connection between p21 Cip1 and beta1 integrin as well as FAK was also established in primary mammary cells. These results point to the essential role of beta1 integrin signaling in mammary epithelial cell proliferation...
  34. ncbi request reprint Modulation of p27/Cdk2 complex formation through 4D5-mediated inhibition of HER2 receptor signaling
    H A Lane
    Friedrich Miescher Institute, Basel, Switzerland
    Ann Oncol 12:S21-2. 2001
    ....
  35. pmc Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells
    Albana Gattelli
    Friedrich Miescher Institute for Biomedical Research FMI, Basel, Switzerland
    EMBO Mol Med 5:1335-50. 2013
    ..Our results suggest that Ret kinase should be considered as a novel therapeutic target in subsets of breast cancer. ..
  36. ncbi request reprint ErbB receptors: directing key signaling networks throughout life
    Thomas Holbro
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Annu Rev Pharmacol Toxicol 44:195-217. 2004
    ..In this review, we discuss these data in more detail, illustrating the importance of tightly regulated ErbB signaling throughout life...
  37. ncbi request reprint The ErbB receptors and their role in cancer progression
    Thomas Holbro
    Friedrich Miescher Institute, PO Box 2543, 4002, Basel, Switzerland
    Exp Cell Res 284:99-110. 2003
    ..e., ErbB1 cooperates with other classes of receptors, and the ligand-less ErbB2 functions as a heterodimer with other ErbBs...
  38. ncbi request reprint Targeting ERBB receptors in cancer
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Recent Results Cancer Res 172:45-57. 2007
  39. ncbi request reprint The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade
    Patrizia Sini
    Novartis Institute for Biomedical Research, Oncology Research, Basel, Switzerland
    Clin Cancer Res 11:4521-32. 2005
    ....
  40. pmc Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth
    I M Harwerth
    Friedrich Miescher Institute, Basel, Switzerland
    Br J Cancer 68:1140-5. 1993
    ..The effect of the MAbs on the anchorage-independent growth of erbB-2 transformed cells and on erbB-2 receptor turnover was also measured...
  41. ncbi request reprint An essential role for Src kinase in ErbB receptor signaling through the MAPK pathway
    M A Olayioye
    Friedrich Miescher Institute, Basel, CH-4002, Switzerland
    Exp Cell Res 267:81-7. 2001
    ..Thus, ErbB signaling requires the engagement of a novel Src-dependent route to MAPK, to trigger its rapid activation and subsequent efficient stimulation of transcription...
  42. doi request reprint Loss of Memo, a novel FGFR regulator, results in reduced lifespan
    Barbara Haenzi
    1Mechanisms of Cancer, Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FASEB J 28:327-36. 2014
    ..In summary, the results from in vivo and in vitro models support the hypothesis that Memo is a novel regulator of FGFR signaling with a role in controlling 1,25(OH)2D production and normal calcium homeostasis...
  43. ncbi request reprint ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases
    M A Olayioye
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Biol Chem 274:17209-18. 1999
    ..Taken together, the experiments establish two independent roles for Src kinases: (i) key molecules in ErbB receptor-mediated Stat signaling and (ii) potential upstream regulators of Jak kinases...
  44. ncbi request reprint The protein tyrosine phosphatase-PEST is implicated in the negative regulation of epidermal growth factor on PRL signaling in mammary epithelial cells
    K Horsch
    Friedrich Miescher Institute, CH 4002 Basel, Switzerland
    Mol Endocrinol 15:2182-96. 2001
    ..In support of this model, PTP-PEST-containing lysates from EGF-treated HC11 cells dephosphorylated JAK2 to a greater extent than lysates prepared from control cells...
  45. doi request reprint Copine-III interacts with ErbB2 and promotes tumor cell migration
    C Heinrich
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Oncogene 29:1598-610. 2010
    ..Moreover, in an in situ tissue microarray analysis, we detected differential protein expression of Copine-III in normal versus breast, prostate and ovarian tumors, suggesting a more general role for Copine-III in carcinogenesis...
  46. ncbi request reprint A new therapeutic antibody masks ErbB2 to its partners
    Ali Badache
    Friedrich Miescher Institute of the Novartis Research Foundation, P O Box 2543, CH 4002 Basel, Switzerland
    Cancer Cell 5:299-301. 2004
    ..Pertuzumab's novel mode of action might offer additional therapeutic opportunities for treatment of tumors expressing ligand-activated ErbB2...
  47. pmc MHO1, an evolutionarily conserved gene, is synthetic lethal with PLC1; Mho1p has a role in invasive growth
    Ivan D Schlatter
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 7:e32501. 2012
    ..Moreover, a role for Memo in cell motility/invasion appears to be conserved across species...
  48. pmc Key signalling nodes in mammary gland development and cancer: Myc
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Breast Cancer Res 11:210. 2009
    ..This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer...
  49. pmc Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells
    Gianluca Civenni
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    EMBO Rep 4:166-71. 2003
    ..Our finding that Wnts transactivate ErbB1 in addition to stimulating the prototypic beta-catenin/TCF pathway may help to explain why wnt1 is a potent oncogene in the mammary gland...
  50. ncbi request reprint Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells
    A Badache
    Friedrich Miescher Institute, Basel, Switzerland
    Cancer Res 61:383-91. 2001
    ..Cooperation between IL-6 and the EGF receptor in T47D breast carcinoma cells illustrates how a combination of multiple stimuli, either exogenous or endogenous, may result in synergistic cellular responses...
  51. pmc ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency
    H A Lane
    Friedrich Miescher Institute, CH 4002 Basel, Switzerland
    Mol Cell Biol 20:3210-23. 2000
    ....
  52. ncbi request reprint The role of overexpressed HER2 in transformation
    R M Neve
    Friedrich Miescher Institute, Basel, Switzerland
    Ann Oncol 12:S9-13. 2001
    ....
  53. pmc ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner
    M A Olayioye
    Friedrich Miescher Institute, CH 4002 Basel, Switzerland
    Mol Cell Biol 18:5042-51. 1998
    ..Differential receptor phosphorylation may, therefore, be the basis for the differences in the signaling properties observed...
  54. ncbi request reprint Memo is a copper-dependent redox protein with an essential role in migration and metastasis
    Gwen MacDonald
    Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland
    Sci Signal 7:ra56. 2014
    ..Memo abundance was increased in >40% of the primary breast tumors tested, was correlated with clinical parameters of aggressive disease, and was an independent prognostic factor of early distant metastasis. ..
  55. ncbi request reprint Tenascin-C blocks cell-cycle progression of anchorage-dependent fibroblasts on fibronectin through inhibition of syndecan-4
    Gertraud Orend
    Friedrich Miescher Institute for Biomedical Research, Novartis Forschungsstiftung, PO Box 2543, CH 4002 Basel, Switzerland
    Oncogene 22:3917-26. 2003
    ..We therefore propose that syndecan-4 signaling plays a central role in the control of cellular proliferation of anchorage-dependent fibroblasts...
  56. ncbi request reprint The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution
    R Neve
    Friedrich Miescher Institute, Basel CH 4058, Switzerland
    FASEB J 12:1541-50. 1998
    ....
  57. ncbi request reprint The lysosomal-associated membrane protein LAMP-1 is a novel differentiation marker for HC11 mouse mammary epithelial cells
    N Cella
    Friedrich Miescher Institute, Basel, Switzerland
    Differentiation 61:113-20. 1996
    ..Increase in lysosomal vesicles and their contents might play a role in intra- and extra-cellular remodeling, which is characteristic of cell differentiation...
  58. pmc Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers
    Lily Yen
    Lady Davis Institute for Medical Research of the Sir Mortimer B Davis Jewish General Hospital, Department of Medicine and McGill Centre for Translational Research in Cancer, McGill University, Montreal, Quebec, H3T 1E2, Canada
    Mol Biol Cell 13:4029-44. 2002
    ..These results emphasize the biological implications of cell signaling diversity among members of the ErbB receptor family in regulation of the tumor microenvironment...
  59. doi request reprint Signalling change: signal transduction through the decades
    Nancy E Hynes
    Friedrich Miescher Institute for Biomedical Research, and University of Basel, Basel, Switzerland
    Nat Rev Mol Cell Biol 14:393-8. 2013
    ..Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades...
  60. ncbi request reprint Targeting of human breast cancer by a bispecific antibody directed against two tumour-associated antigens: ErbB-2 and carcinoembryonic antigen
    Mylène Dorvillius
    EMI 0227 INSERM and GDR CNRS 2352, Universite Montpellier I, Cancer Research Centre, Montpellier, France
    Tumour Biol 23:337-47. 2002
    ..The results obtained with the BAb in the double-positive tumour-bearing nude mice suggest that targeting two distinct tumour-associated antigens on the same cell could improve tumour localisation...
  61. ncbi request reprint Generation and functional characterization of intracellular antibodies interacting with the kinase domain of human EGF receptor
    Stephen Hyland
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, D co596 Frankfourt an Main, Germany
    Oncogene 22:1557-67. 2003
    ..Upon cytoplasmic expression in human tumor cells, scFvs colocalized with EGFR at the plasma membrane demonstrating their functionality in vivo...
  62. ncbi request reprint ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events
    Diane E Clark
    Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, New Orleans, Louisiana 70112 2669, USA
    J Biol Chem 280:24175-80. 2005
    ..Our studies demonstrate that phosphorylation of STAT5A at Ser-127/Ser-128 and Ser-779 are obligatory events regulating ERBB4-mediated activation of STAT5A...
  63. ncbi request reprint Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
    Richard M Neve
    Department of Hematology Oncology, UCSF San Francisco and Buck Institute, Novato, California 94945, USA
    Oncogene 21:4567-76. 2002
    ..This suggests that downstream effectors of ErbB receptors represent good therapeutic targets for breast cancer...
  64. ncbi request reprint ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002
    Niels Tørring
    Department of Clinical Biochemistry AKH, Aarhus University Hospital, Aarhus C, Denmark
    Prostate 56:142-9. 2003
    ..ErbB receptor tyrosine kinases have been implicated in the development of prostate cancer...
  65. ncbi request reprint Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site
    Chen Qiu
    Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 283:2734-40. 2008
    ..Memo thus represents a new class of phosphotyrosine-binding protein...