Thomas Holbro

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. ncbi Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells
    Gianluca Civenni
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    EMBO Rep 4:166-71. 2003
  2. ncbi The ErbB receptors and their role in cancer progression
    Thomas Holbro
    Friedrich Miescher Institute, PO Box 2543, 4002, Basel, Switzerland
    Exp Cell Res 284:99-110. 2003
  3. ncbi ErbB receptors: directing key signaling networks throughout life
    Thomas Holbro
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Annu Rev Pharmacol Toxicol 44:195-217. 2004
  4. ncbi Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
    Magdalena Koziczak
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Oncogene 23:3501-8. 2004
  5. ncbi The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    Thomas Holbro
    Friedrich Miescher Institute, P O Box 2543, 4002 Basel, Switzerland
    Proc Natl Acad Sci U S A 100:8933-8. 2003

Collaborators

Detail Information

Publications5

  1. ncbi Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells
    Gianluca Civenni
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    EMBO Rep 4:166-71. 2003
    ..Our finding that Wnts transactivate ErbB1 in addition to stimulating the prototypic beta-catenin/TCF pathway may help to explain why wnt1 is a potent oncogene in the mammary gland...
  2. ncbi The ErbB receptors and their role in cancer progression
    Thomas Holbro
    Friedrich Miescher Institute, PO Box 2543, 4002, Basel, Switzerland
    Exp Cell Res 284:99-110. 2003
    ..e., ErbB1 cooperates with other classes of receptors, and the ligand-less ErbB2 functions as a heterodimer with other ErbBs...
  3. ncbi ErbB receptors: directing key signaling networks throughout life
    Thomas Holbro
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Annu Rev Pharmacol Toxicol 44:195-217. 2004
    ..In this review, we discuss these data in more detail, illustrating the importance of tightly regulated ErbB signaling throughout life...
  4. ncbi Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
    Magdalena Koziczak
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Oncogene 23:3501-8. 2004
    ..In SUM 52 cells, both MAPK and PI3K signaling pathways were suppressed. In conclusion, results shown here describe a mechanism by which FGFR promotes proliferation of breast cancer cells...
  5. ncbi The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    Thomas Holbro
    Friedrich Miescher Institute, P O Box 2543, 4002 Basel, Switzerland
    Proc Natl Acad Sci U S A 100:8933-8. 2003
    ..Furthermore, we identify ErbB3's role, which is to couple active ErbB2 to the phosphatidylinositol 3-kinase/protein kinase B pathway. Thus, the ErbB2/ErbB3 dimer functions as an oncogenic unit to drive breast tumor cell proliferation...