Alexander Hergovich

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. ncbi Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland
    Biofactors 35:338-45. 2009
  2. ncbi The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Biol 19:1692-702. 2009
  3. ncbi Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases
    Reto S Kohler
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 30:4507-20. 2010
  4. ncbi Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 25:11019-29. 2005
  5. ncbi NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
    Anton Vichalkovski
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Curr Biol 18:1889-95. 2008
  6. ncbi Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 31:1382-95. 2011
  7. ncbi The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochem Biophys Res Commun 345:50-8. 2006
  8. ncbi Centrosome-associated NDR kinase regulates centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell 25:625-34. 2007
  9. ncbi Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Sci Signal 3:ra47. 2010
  10. ncbi Mammalian NDR protein kinases: from regulation to a role in centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biochim Biophys Acta 1784:3-15. 2008

Collaborators

Detail Information

Publications16

  1. ncbi Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland
    Biofactors 35:338-45. 2009
    ..In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation...
  2. ncbi The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Biol 19:1692-702. 2009
    ..We also addressed the regulation of human centrosome duplication by mammalian serine/threonine Ste20-like (MST) kinases, considering that MOB proteins can function together with Ste20-like kinases in eukaryotes...
  3. ncbi Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases
    Reto S Kohler
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 30:4507-20. 2010
    ..In summary, our data indicate that hMOB2 is a negative regulator of human NDR kinases in biochemical and biological settings...
  4. ncbi Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 25:11019-29. 2005
    ..We conclude that activation of NDR is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3, autophosphorylation of Ser281/2, and binding of MOB1A...
  5. ncbi NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
    Anton Vichalkovski
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Curr Biol 18:1889-95. 2008
    ..Our findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade...
  6. ncbi Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 31:1382-95. 2011
    ..These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells...
  7. ncbi The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochem Biophys Res Commun 345:50-8. 2006
    ....
  8. ncbi Centrosome-associated NDR kinase regulates centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell 25:625-34. 2007
    ..Overall, considering that centrosome overduplication is linked to cellular transformation, our observations may also provide a molecular link between mammalian NDR kinases and cancer...
  9. ncbi Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Sci Signal 3:ra47. 2010
    ..Together, our data suggest that a reduction in the abundances of the NDR proteins results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors...
  10. ncbi Mammalian NDR protein kinases: from regulation to a role in centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biochim Biophys Acta 1784:3-15. 2008
    ..How far NDR-driven centrosome overduplication could actually contribute to cellular transformation will also be discussed...
  11. ncbi Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    Alexander Hergovich
    Friedrich Miescher Institut, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    Nat Cell Biol 5:64-70. 2003
    ..Our data identify a role for pVHL in the regulation of microtubule dynamics and potentially provide a link between this function of pVHL and the pathogenesis of haemangioblastoma and phaeochromocytoma in the context of VHL disease...
  12. ncbi NDR kinases regulate essential cell processes from yeast to humans
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Nat Rev Mol Cell Biol 7:253-64. 2006
    ..Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes...
  13. ncbi Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 25:8259-72. 2005
    ..We provide insight into a potential in vivo mechanism of NDR activation through rapid recruitment to the plasma membrane mediated by hMOBs...
  14. ncbi Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cell Cycle 10:1897-904. 2011
    ..Here, we discuss these novel cell cycle functions of NDR kinases in a broader context and elaborate on possible explanations for the opposing functions of NDR kinases in normal and tumor biology...
  15. ncbi Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 279:23806-12. 2004
    ..Further we show a predominant cytoplasmic localization of ectopically expressed NDR2...
  16. ncbi TAZ-mediated crosstalk between Wnt and Hippo signaling
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Dev Cell 18:508-9. 2010
    ..In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades...