Research Topics
Genomes and Genes
| Brian A HemmingsSummaryAffiliation: Friedrich Miescher Institute Country: Switzerland Publications
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Detail Information
Publications
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinaseJianhua Feng
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 279:41189-96. 2004..We conclude that DNA-PK is a long sought after kinase responsible for the Ser-473 phosphorylation step in the activation of PKB...
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylationAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Mol Cell Biol 25:8259-72. 2005..We provide insight into a potential in vivo mechanism of NDR activation through rapid recruitment to the plasma membrane mediated by hMOBs...- Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesBettina Dummler
Friedrich Miescher Institute for Biomedical Research, Basel CH 4058, Switzerland
Mol Cell Biol 26:8042-51. 2006.... - Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3Mario R Stegert
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Mol Cell Biol 25:11019-29. 2005..We conclude that activation of NDR is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3, autophosphorylation of Ser281/2, and binding of MOB1A... - Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinasesReto S Kohler
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Mol Cell Biol 30:4507-20. 2010..In summary, our data indicate that hMOB2 is a negative regulator of human NDR kinases in biochemical and biological settings... - The human tumour suppressor LATS1 is activated by human MOB1 at the membraneAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Biochem Biophys Res Commun 345:50-8. 2006.... - Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 proteinSamuel J Bichsel
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Biol Chem 279:35228-35. 2004..We show that this sequence is autoinhibitory, and our data indicate that the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition... - The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamicsArnaud Parcellier
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS ONE 4:e5471. 2009..They are looked upon as dynamic tubular networks. We showed recently that the Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that may be released into the cytosol under apoptotic conditions... 
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosisAnton Vichalkovski
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Curr Biol 18:1889-95. 2008..Our findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade...- In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesisBanu Surucu
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 283:30025-33. 2008..These findings reveal stimulus-specific regulation of PKB activation by specific upstream kinases and provide genetic evidence of PKB deregulation in DNA-PKcs(-/-) mice... - Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosisArnaud Parcellier
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Cell Signal 21:639-50. 2009..Thus, proper maturation of CTMP is essential for its pro-apoptotic function. Finally, we demonstrate that CTMP delays PKB phosphorylation following cell death induction, suggesting that CTMP regulates apoptosis via inhibition of PKB... - The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylationAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Curr Biol 19:1692-702. 2009..We also addressed the regulation of human centrosome duplication by mammalian serine/threonine Ste20-like (MST) kinases, considering that MOB proteins can function together with Ste20-like kinases in eukaryotes... - DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motifJongsun Park
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 284:6169-74. 2009..Thus, these data define the specificity of DNA-PK action as a Ser-473 kinase for PKB in DNA repair signaling... - PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survivalLana Bozulic
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Mol Cell 30:203-13. 2008..Furthermore, this function is apparently restricted to the PKBalpha isoform... - Mammalian NDR/LATS protein kinases in hippo tumor suppressor signalingAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland
Biofactors 35:338-45. 2009..In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation... - MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastomaMichal Grzmil
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 71:2392-402. 2011..Furthermore, they suggest MNK1-controlled translational pathways in targeted strategies to more effectively treat GBM... - Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stabilityHauke Cornils
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Mol Cell Biol 31:1382-95. 2011..These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells... - Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in miceZhong Zhou Yang
Friedrich Miescher Institute for Biomedical Research, P O Box 2543, Maulbeerstrasse 66, Basel CH 4002, Switzerland
Mol Cell Biol 25:10407-18. 2005..Our results indicate isoform-specific and dosage-dependent effects of Akt on animal survival and development... - Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathwayElisabeth Fayard
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058, Basel, Switzerland
Curr Top Microbiol Immunol 346:31-56. 2010.... - Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphomaHauke Cornils
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Sci Signal 3:ra47. 2010..Together, our data suggest that a reduction in the abundances of the NDR proteins results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors... - Deletion of PKBalpha/Akt1 affects thymic developmentElisabeth Fayard
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS ONE 2:e992. 2007..Defects in single components of this pathway prevent thymocytes from progressing beyond early T cell developmental stages. Protein kinase B (PKB) is the main effector of the PI3K pathway... - Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasisOliver Tschopp
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Development 132:2943-54. 2005..Our results provide novel insights into the physiological role of Pkb(gamma) and suggest a crucial role in postnatal brain development... - Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylationJianhua Feng
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland
J Biol Chem 279:35510-7. 2004..These findings suggest that PKB plays a critical role in controlling of the Mdm2.p53 signaling pathway by regulating Mdm2 stability... - Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinaseRastislav Tamaskovic
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
J Biol Chem 278:6710-8. 2003.... - Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivoDavid F Restuccia
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Dis Model Mech 5:403-11. 2012..Targeted therapeutic augmentation of specific PKBβ signaling could therefore provide a new avenue for the treatment and management of ovarian cysts... - PIKKing on PKB: regulation of PKB activity by phosphorylationLana Bozulic
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Curr Opin Cell Biol 21:256-61. 2009..This present review concerns PKB regulation by mTORC2 and DNA-PK in a stimulus-dependent and context-dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention... - PKBalpha is required for adipose differentiation of mouse embryonic fibroblastsAnne Baudry
Friedrich Miescher Institute for Biomedical Research, Maulbeerstr 66, CH 4058, Basel, Switzerland
J Cell Sci 119:889-97. 2006..The results underscore an essential role for PKBalpha in the transcriptional program required for adipogenesis... - Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding proteinMario R Stegert
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Biol Chem 279:23806-12. 2004..Further we show a predominant cytoplasmic localization of ectopically expressed NDR2... - Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver developmentElena Zhuravleva
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Mol Cell Biol 32:2685-97. 2012..The novel mitochondrial acyl-CoA thioesterase Them5 has a critical and specific role in the cardiolipin remodeling process, connecting it to the development of fatty liver and related conditions... - Centrosome-associated NDR kinase regulates centrosome duplicationAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Mol Cell 25:625-34. 2007..Overall, considering that centrosome overduplication is linked to cellular transformation, our observations may also provide a molecular link between mammalian NDR kinases and cancer... - Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent controlElisabeth Fayard
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Sci Signal 3:re5. 2010.... - Mammalian NDR protein kinases: from regulation to a role in centrosome duplicationAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
Biochim Biophys Acta 1784:3-15. 2008..How far NDR-driven centrosome overduplication could actually contribute to cellular transformation will also be discussed... - Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axesGongda Xue
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Discov 2:248-59. 2012..Our results thus illustrate a direct role of PI3K/Akt signaling in metastatic cancer development and suggest that Twist1 phosphorylation could be a potential therapeutic target in clinical cancer treatment... - Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progressionHauke Cornils
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cell Cycle 10:1897-904. 2011..Here, we discuss these novel cell cycle functions of NDR kinases in a broader context and elaborate on possible explanations for the opposing functions of NDR kinases in normal and tumor biology... - Structure, regulation and function of PKB/AKT--a major therapeutic targetMasahito Hanada
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland
Biochim Biophys Acta 1697:3-16. 2004..Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics... - NDR kinases regulate essential cell processes from yeast to humansAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Nat Rev Mol Cell Biol 7:253-64. 2006..Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes... - NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesisRastislav Tamaskovic
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
FEBS Lett 546:73-80. 2003..melanogaster and C. elegans. In mammalians, the LATS kinase is a tumor suppressor, negatively regulating the cyclin-dependent kinase CDK1, cell proliferation rate, and modulating cell survival... - Protein kinase B alpha/Akt1 regulates placental development and fetal growthZhong Zhou Yang
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
J Biol Chem 278:32124-31. 2003..These data represent the first evidence for the role of PKB alpha and endothelial nitricoxide synthase in regulating placental development and provide an animal model for intrauterine growth retardation... - Translation regulation as a therapeutic target in cancerMichal Grzmil
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Cancer Res 72:3891-900. 2012..This review describes altered mechanisms of protein synthesis in human cancers and discusses therapeutic approaches based on the targeting of translation... - Phosphorylation of basic helix-loop-helix transcription factor Twist in development and diseaseGongda Xue
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Biochem Soc Trans 40:90-3. 2012.... - Deregulated signalling networks in human brain tumoursMichal Grzmil
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Biochim Biophys Acta 1804:476-83. 2010..This review focuses on genetic alterations leading to the activation of key deregulated pathways in human gliomas... - From man to mouse and back again: advances in defining tumor AKTivities in vivoDavid F Restuccia
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Dis Model Mech 3:705-20. 2010..The implications of these findings on the therapeutic targeting of AKT and potential new drug targets are also explored... - Protein kinase B/Akt at a glanceElisabeth Fayard
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
J Cell Sci 118:5675-8. 2005 - PKB binding proteins. Getting in on the AktDerek P Brazil
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Cell 111:293-303. 2002..In this review, we discuss the implications of these data in understanding the multitude of functions predicted for PKB in cells... - Inhibition of protein kinase B/Akt. implications for cancer therapyMichelle M Hill
Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
Pharmacol Ther 93:243-51. 2002..Since inhibition of PKB activity induces apoptosis in a range of mammalian cells, a PKB inhibitor may be effective, in combination with other anticancer drugs, for the treatment of tumors with other mutations... - PromoterPlot: a graphical display of promoter similarities by pattern recognitionAlessandro Di Cara
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
Nucleic Acids Res 33:W423-6. 2005..The results are stored as an interactive SVG web page on our server... - PKB and the mitochondria: AKTing on apoptosisArnaud Parcellier
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Cell Signal 20:21-30. 2008..In this review, we will summarize mechanisms by which PKB mediates its anti-apoptotic activities in cells and survey recent developments in understanding mitochondrial dynamics and their role during apoptosis... - Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1Michelle M Hill
Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
Curr Biol 12:1251-5. 2002..In contrast to previous observations, however, ILK immunoprecipitates did not retain Ser473 kinase activity. Thus, we have identified a novel raft-associated PKB Ser473 kinase, implicating a role for lipid rafts in PKB signaling... - Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in BaselLana Bozulic
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Sci STKE 2007:pe8. 2007..Attendees gained insight into drug development, as well as increased understanding of how normal cellular processes are subverted during oncogenesis, which may lead to new targets for intervention... - TAZ-mediated crosstalk between Wnt and Hippo signalingAlexander Hergovich
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
Dev Cell 18:508-9. 2010..In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades... - Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKBHugo Stocker
Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Science 295:2088-91. 2002..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila... - Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylationJing Yang
Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Mol Cell 9:1227-40. 2002.... - Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localizationDerick G Wansink
Department of Cell Biology, Nijmegen Center for Molecular Life Sciences, University Medical Center, 6500 HB Nijmegen, The Netherlands
Mol Cell Biol 23:5489-501. 2003..Our results suggest that DMPK isoforms have cell-type and location dependent substrate specificities with a role in organellar and cytoarchitectural dynamics... - Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcriptionIvana Galetic
Friedrich Miescher Institute, P. O. Box 2543, CH-4002 Basel, Switzerland
J Biol Chem 278:4416-23. 2003..Therefore, our findings delineate a novel mechanism regulating immediate-early transcription, which may be involved in the initial steps in PKB-induced oncogenic transformation... - Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activationShin Young Na
Institutes of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
J Immunol 171:1285-96. 2003..Thus, our observations clearly indicate a cross-talk between PKB and important signaling molecules downstream of TCR that modulate the thresholds of thymocyte selection and T cell activation... - RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1Dong Wook Kim
Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Daejon, Korea
Mol Endocrinol 17:1382-94. 2003..In conclusion, RET/PTC-induced tyrosine phosphorylation of PDK1 may be one of the mechanisms by which it acts as an oncogenic tyrosine kinase in thyroid carcinogenesis... - Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNPJing Yang
Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK
Nat Struct Biol 9:940-4. 2002..Analysis of the interactions between PKB and the GSK3beta-peptide explains how PKB selects for protein substrates distinct from those of PKA... - Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinaseNelly Marmy Conus
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006 Australia
J Biol Chem 277:38021-8. 2002..Our data identifies a novel regulatory mechanism for this pleiotropic enzyme that may be applicable to the AGC family of protein kinases given the conserved nature of the COOH-terminal hydrophobic motif containing Tyr-474... - Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesionsYoshihiro Taniyama
Department of Medicine, Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Mol Cell Biol 23:8019-29. 2003..These observations identify a novel interaction between PDK1 and Pyk2 that regulates the integrity of focal adhesions, which are major compartments for integrating signals for cell growth, apoptosis, and migration... - Analysis of protein kinase B/AktMichelle M Hill
Friedrich Miescher Institute, CH-4058 Basel, Switzerland
Methods Enzymol 345:448-63. 2002 - Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitorsStephen J Fuller
National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
Cell Signal 20:1564-77. 2008..From a pathological viewpoint, we conclude that activities of NDR1 and NDR2 are responsive to cytotoxic stresses in heart preparations and this may represent a previously-unidentified response to myocardial ischaemia in vivo... - Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain bindingKeum Jin Yang
Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Chungnam National University, 6 Munhwa dong, Jung Gu, Taejeon 301 131, South Korea
J Biol Chem 283:1480-91. 2008..Furthermore, Tyr(9) phosphorylation is critical for the stabilization of both PDK1 and the PDK1/Src complex via Hsp90-mediated protection of PDK1 degradation... - Intramolecular and intermolecular interactions of protein kinase B define its activation in vivoVéronique Calleja
Cell Biophysics Laboratory, Lincoln s Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom
PLoS Biol 5:e95. 2007..This has important implications not only in extending our understanding of this oncogenic protein kinase but also in opening up distinct opportunities for therapeutic intervention... - PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injuryTomohisa Nagoshi
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:2128-38. 2005..These data demonstrate that PI3K-dependent but Akt-independent effectors are required for full cardioprotection and suggest a mechanism by which chronic Akt activation can become maladaptive... - Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle developmentNicolas Di-Poï
Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
Mol Cell Biol 25:1696-712. 2005.... - Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell typesBettina A Dummler
Department of Clinical Biochemistry, Glostrup Hospital, 2600 Glostrup, Denmark
J Biol Chem 280:13304-14. 2005.... - The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase BMartin Schmidlin
Institute for Medical Microbiology, University of Basel, Basel, Switzerland
EMBO J 23:4760-9. 2004..In vivo and in vitro data support a model where PKB causes ARE-mRNA stabilization by inactivating BRF1 through binding to 14-3-3... - Advances in protein kinase B signalling: AKTion on multiple frontsDerek P Brazil
Conway Institute of Biomolecular and Biomedical Research, Department of Medicine and Therapeutics, University College Dublin, Belfield, Dublin 4, Ireland
Trends Biochem Sci 29:233-42. 2004 - Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restrictionHong Wa Yung
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
Am J Pathol 173:451-62. 2008..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...