Brian A Hemmings

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. ncbi Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    Jianhua Feng
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 279:41189-96. 2004
  2. pmc The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics
    Arnaud Parcellier
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 4:e5471. 2009
  3. pmc Deletion of PKBalpha/Akt1 affects thymic development
    Elisabeth Fayard
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 2:e992. 2007
  4. pmc Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 25:8259-72. 2005
  5. pmc Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
    Bettina Dummler
    Friedrich Miescher Institute for Biomedical Research, Basel CH 4058, Switzerland
    Mol Cell Biol 26:8042-51. 2006
  6. doi Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
    Arnaud Parcellier
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Cell Signal 21:639-50. 2009
  7. pmc GSK3beta regulates differentiation and growth arrest in glioblastoma
    Serdar Korur
    Laboratory of Molecular Neuro Oncology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 4:e7443. 2009
  8. pmc Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 25:11019-29. 2005
  9. pmc Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases
    Reto S Kohler
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 30:4507-20. 2010
  10. ncbi The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochem Biophys Res Commun 345:50-8. 2006

Collaborators

Detail Information

Publications73

  1. ncbi Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
    Jianhua Feng
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 279:41189-96. 2004
    ..We conclude that DNA-PK is a long sought after kinase responsible for the Ser-473 phosphorylation step in the activation of PKB...
  2. pmc The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics
    Arnaud Parcellier
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 4:e5471. 2009
    ..They are looked upon as dynamic tubular networks. We showed recently that the Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that may be released into the cytosol under apoptotic conditions...
  3. pmc Deletion of PKBalpha/Akt1 affects thymic development
    Elisabeth Fayard
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 2:e992. 2007
    ..Defects in single components of this pathway prevent thymocytes from progressing beyond early T cell developmental stages. Protein kinase B (PKB) is the main effector of the PI3K pathway...
  4. pmc Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 25:8259-72. 2005
    ..We provide insight into a potential in vivo mechanism of NDR activation through rapid recruitment to the plasma membrane mediated by hMOBs...
  5. pmc Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
    Bettina Dummler
    Friedrich Miescher Institute for Biomedical Research, Basel CH 4058, Switzerland
    Mol Cell Biol 26:8042-51. 2006
    ....
  6. doi Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
    Arnaud Parcellier
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Cell Signal 21:639-50. 2009
    ..Thus, proper maturation of CTMP is essential for its pro-apoptotic function. Finally, we demonstrate that CTMP delays PKB phosphorylation following cell death induction, suggesting that CTMP regulates apoptosis via inhibition of PKB...
  7. pmc GSK3beta regulates differentiation and growth arrest in glioblastoma
    Serdar Korur
    Laboratory of Molecular Neuro Oncology, University Hospital Basel, Basel, Switzerland
    PLoS ONE 4:e7443. 2009
    ..Drugs that inhibit GSK3, including the psychiatric drug LiCl, may deplete the GBM stem cell reservoir independently of CD133 status...
  8. pmc Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 25:11019-29. 2005
    ..We conclude that activation of NDR is a multistep process involving phosphorylation of the hydrophobic motif site Thr444/2 by MST3, autophosphorylation of Ser281/2, and binding of MOB1A...
  9. pmc Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases
    Reto S Kohler
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 30:4507-20. 2010
    ..In summary, our data indicate that hMOB2 is a negative regulator of human NDR kinases in biochemical and biological settings...
  10. ncbi The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochem Biophys Res Commun 345:50-8. 2006
    ....
  11. ncbi Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein
    Samuel J Bichsel
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 279:35228-35. 2004
    ..We show that this sequence is autoinhibitory, and our data indicate that the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition...
  12. pmc Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival
    Roland M Huber
    Department of Biomedicine, University of Basel, Basel, Basel Stadt, Switzerland
    PLoS ONE 8:e57793. 2013
    ..The alternative Notch pathway via DTX1 appears to be an oncogenic factor in glioblastoma and these findings offer new potential therapeutic targets...
  13. pmc In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis
    Banu Surucu
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 283:30025-33. 2008
    ..These findings reveal stimulus-specific regulation of PKB activation by specific upstream kinases and provide genetic evidence of PKB deregulation in DNA-PKcs(-/-) mice...
  14. doi The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Biol 19:1692-702. 2009
    ..We also addressed the regulation of human centrosome duplication by mammalian serine/threonine Ste20-like (MST) kinases, considering that MOB proteins can function together with Ste20-like kinases in eukaryotes...
  15. ncbi NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
    Anton Vichalkovski
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Curr Biol 18:1889-95. 2008
    ..Our findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade...
  16. doi MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma
    Michal Grzmil
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 71:2392-402. 2011
    ..Furthermore, they suggest MNK1-controlled translational pathways in targeted strategies to more effectively treat GBM...
  17. pmc Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice
    Zhong Zhou Yang
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, Maulbeerstrasse 66, Basel CH 4002, Switzerland
    Mol Cell Biol 25:10407-18. 2005
    ..Our results indicate isoform-specific and dosage-dependent effects of Akt on animal survival and development...
  18. ncbi DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif
    Jongsun Park
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 284:6169-74. 2009
    ..Thus, these data define the specificity of DNA-PK action as a Ser-473 kinase for PKB in DNA repair signaling...
  19. ncbi Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase
    Rastislav Tamaskovic
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 278:6710-8. 2003
    ....
  20. doi PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
    Lana Bozulic
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Mol Cell 30:203-13. 2008
    ..Furthermore, this function is apparently restricted to the PKBalpha isoform...
  21. doi Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland
    Biofactors 35:338-45. 2009
    ..In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation...
  22. pmc Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 31:1382-95. 2011
    ..These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells...
  23. pmc The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B
    Martin Schmidlin
    Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    EMBO J 23:4760-9. 2004
    ..In vivo and in vitro data support a model where PKB causes ARE-mRNA stabilization by inactivating BRF1 through binding to 14-3-3...
  24. ncbi Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
    Jianhua Feng
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 279:35510-7. 2004
    ..These findings suggest that PKB plays a critical role in controlling of the Mdm2.p53 signaling pathway by regulating Mdm2 stability...
  25. ncbi Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
    Oliver Tschopp
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Development 132:2943-54. 2005
    ..Our results provide novel insights into the physiological role of Pkb(gamma) and suggest a crucial role in postnatal brain development...
  26. doi Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway
    Elisabeth Fayard
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058, Basel, Switzerland
    Curr Top Microbiol Immunol 346:31-56. 2010
    ....
  27. ncbi Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Sci Signal 3:ra47. 2010
    ..Together, our data suggest that a reduction in the abundances of the NDR proteins results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors...
  28. ncbi Centrosome-associated NDR kinase regulates centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell 25:625-34. 2007
    ..Overall, considering that centrosome overduplication is linked to cellular transformation, our observations may also provide a molecular link between mammalian NDR kinases and cancer...
  29. ncbi Protein kinase B alpha/Akt1 regulates placental development and fetal growth
    Zhong Zhou Yang
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 278:32124-31. 2003
    ..These data represent the first evidence for the role of PKB alpha and endothelial nitricoxide synthase in regulating placental development and provide an animal model for intrauterine growth retardation...
  30. doi Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes
    Gongda Xue
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Discov 2:248-59. 2012
    ..Our results describe a novel signaling event linking PI3K/Akt hyperactivation in tumor cells to direct regulation of Twist1 activation and tumor metastasis...
  31. pmc Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo
    David F Restuccia
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Dis Model Mech 5:403-11. 2012
    ..Targeted therapeutic augmentation of specific PKBβ signaling could therefore provide a new avenue for the treatment and management of ovarian cysts...
  32. ncbi Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein
    Mario R Stegert
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Biol Chem 279:23806-12. 2004
    ..Further we show a predominant cytoplasmic localization of ectopically expressed NDR2...
  33. doi PIKKing on PKB: regulation of PKB activity by phosphorylation
    Lana Bozulic
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Curr Opin Cell Biol 21:256-61. 2009
    ..This present review concerns PKB regulation by mTORC2 and DNA-PK in a stimulus-dependent and context-dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention...
  34. ncbi PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts
    Anne Baudry
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstr 66, CH 4058, Basel, Switzerland
    J Cell Sci 119:889-97. 2006
    ..The results underscore an essential role for PKBalpha in the transcriptional program required for adipogenesis...
  35. pmc Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development
    Elena Zhuravleva
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 32:2685-97. 2012
    ..The novel mitochondrial acyl-CoA thioesterase Them5 has a critical and specific role in the cardiolipin remodeling process, connecting it to the development of fatty liver and related conditions...
  36. ncbi Mammalian NDR protein kinases: from regulation to a role in centrosome duplication
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Biochim Biophys Acta 1784:3-15. 2008
    ..How far NDR-driven centrosome overduplication could actually contribute to cellular transformation will also be discussed...
  37. doi Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control
    Elisabeth Fayard
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Sci Signal 3:re5. 2010
    ....
  38. ncbi Protein kinase B/Akt at a glance
    Elisabeth Fayard
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    J Cell Sci 118:5675-8. 2005
  39. doi PKB/Akt-dependent regulation of cell motility
    Gongda Xue
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    J Natl Cancer Inst 105:393-404. 2013
    ..We focus in particular on its direct influence on cell migration and invasion, epithelial-mesenchymal transition, and cancer metastasis...
  40. ncbi NDR kinases regulate essential cell processes from yeast to humans
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Rev Mol Cell Biol 7:253-64. 2006
    ..Combined data from yeast, worms, flies, mice and human cells now highlight the conserved and important roles of the different NDR kinases in distinct cellular processes...
  41. ncbi Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cell Cycle 10:1897-904. 2011
    ..Here, we discuss these novel cell cycle functions of NDR kinases in a broader context and elaborate on possible explanations for the opposing functions of NDR kinases in normal and tumor biology...
  42. ncbi Structure, regulation and function of PKB/AKT--a major therapeutic target
    Masahito Hanada
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    Biochim Biophys Acta 1697:3-16. 2004
    ..Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics...
  43. ncbi PKB binding proteins. Getting in on the Akt
    Derek P Brazil
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Cell 111:293-303. 2002
    ..In this review, we discuss the implications of these data in understanding the multitude of functions predicted for PKB in cells...
  44. ncbi Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1
    Michelle M Hill
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Curr Biol 12:1251-5. 2002
    ..In contrast to previous observations, however, ILK immunoprecipitates did not retain Ser473 kinase activity. Thus, we have identified a novel raft-associated PKB Ser473 kinase, implicating a role for lipid rafts in PKB signaling...
  45. ncbi NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis
    Rastislav Tamaskovic
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    FEBS Lett 546:73-80. 2003
    ..melanogaster and C. elegans. In mammalians, the LATS kinase is a tumor suppressor, negatively regulating the cyclin-dependent kinase CDK1, cell proliferation rate, and modulating cell survival...
  46. ncbi PKB and the mitochondria: AKTing on apoptosis
    Arnaud Parcellier
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Cell Signal 20:21-30. 2008
    ..In this review, we will summarize mechanisms by which PKB mediates its anti-apoptotic activities in cells and survey recent developments in understanding mitochondrial dynamics and their role during apoptosis...
  47. doi Overcoming resistance to rapalogs in gliomas by combinatory therapies
    Michal Grzmil
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Biochim Biophys Acta 1834:1371-80. 2013
    ..This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012)...
  48. doi Translation regulation as a therapeutic target in cancer
    Michal Grzmil
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 72:3891-900. 2012
    ..This review describes altered mechanisms of protein synthesis in human cancers and discusses therapeutic approaches based on the targeting of translation...
  49. doi Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease
    Gongda Xue
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochem Soc Trans 40:90-3. 2012
    ....
  50. ncbi Inhibition of protein kinase B/Akt. implications for cancer therapy
    Michelle M Hill
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Pharmacol Ther 93:243-51. 2002
    ..Since inhibition of PKB activity induces apoptosis in a range of mammalian cells, a PKB inhibitor may be effective, in combination with other anticancer drugs, for the treatment of tumors with other mutations...
  51. doi From man to mouse and back again: advances in defining tumor AKTivities in vivo
    David F Restuccia
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Dis Model Mech 3:705-20. 2010
    ..The implications of these findings on the therapeutic targeting of AKT and potential new drug targets are also explored...
  52. doi Deregulated signalling networks in human brain tumours
    Michal Grzmil
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Biochim Biophys Acta 1804:476-83. 2010
    ..This review focuses on genetic alterations leading to the activation of key deregulated pathways in human gliomas...
  53. pmc PromoterPlot: a graphical display of promoter similarities by pattern recognition
    Alessandro Di Cara
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nucleic Acids Res 33:W423-6. 2005
    ..The results are stored as an interactive SVG web page on our server...
  54. ncbi Analysis of protein kinase B/Akt
    Michelle M Hill
    Friedrich Miescher Institute, CH 4058 Basel, Switzerland
    Methods Enzymol 345:448-63. 2002
  55. ncbi Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel
    Lana Bozulic
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Sci STKE 2007:pe8. 2007
    ..Attendees gained insight into drug development, as well as increased understanding of how normal cellular processes are subverted during oncogenesis, which may lead to new targets for intervention...
  56. ncbi TAZ-mediated crosstalk between Wnt and Hippo signaling
    Alexander Hergovich
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Dev Cell 18:508-9. 2010
    ..In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades...
  57. ncbi Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 295:2088-91. 2002
    ..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila...
  58. ncbi Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
    Jing Yang
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Mol Cell 9:1227-40. 2002
    ....
  59. pmc Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization
    Derick G Wansink
    Department of Cell Biology, Nijmegen Center for Molecular Life Sciences, University Medical Center, 6500 HB Nijmegen, The Netherlands
    Mol Cell Biol 23:5489-501. 2003
    ..Our results suggest that DMPK isoforms have cell-type and location dependent substrate specificities with a role in organellar and cytoarchitectural dynamics...
  60. ncbi Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
    Jing Yang
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK
    Nat Struct Biol 9:940-4. 2002
    ..Analysis of the interactions between PKB and the GSK3beta-peptide explains how PKB selects for protein substrates distinct from those of PKA...
  61. ncbi Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase
    Nelly Marmy Conus
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006 Australia
    J Biol Chem 277:38021-8. 2002
    ..Our data identifies a novel regulatory mechanism for this pleiotropic enzyme that may be applicable to the AGC family of protein kinases given the conserved nature of the COOH-terminal hydrophobic motif containing Tyr-474...
  62. ncbi Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription
    Ivana Galetic
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Biol Chem 278:4416-23. 2003
    ..Therefore, our findings delineate a novel mechanism regulating immediate-early transcription, which may be involved in the initial steps in PKB-induced oncogenic transformation...
  63. ncbi RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1
    Dong Wook Kim
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Daejon, Korea
    Mol Endocrinol 17:1382-94. 2003
    ..In conclusion, RET/PTC-induced tyrosine phosphorylation of PDK1 may be one of the mechanisms by which it acts as an oncogenic tyrosine kinase in thyroid carcinogenesis...
  64. ncbi Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation
    Shin Young Na
    Institutes of Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Immunol 171:1285-96. 2003
    ..Thus, our observations clearly indicate a cross-talk between PKB and important signaling molecules downstream of TCR that modulate the thresholds of thymocyte selection and T cell activation...
  65. pmc Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions
    Yoshihiro Taniyama
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Mol Cell Biol 23:8019-29. 2003
    ..These observations identify a novel interaction between PDK1 and Pyk2 that regulates the integrity of focal adhesions, which are major compartments for integrating signals for cell growth, apoptosis, and migration...
  66. pmc PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
    Tomohisa Nagoshi
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:2128-38. 2005
    ..These data demonstrate that PI3K-dependent but Akt-independent effectors are required for full cardioprotection and suggest a mechanism by which chronic Akt activation can become maladaptive...
  67. ncbi Advances in protein kinase B signalling: AKTion on multiple fronts
    Derek P Brazil
    Conway Institute of Biomolecular and Biomedical Research, Department of Medicine and Therapeutics, University College Dublin, Belfield, Dublin 4, Ireland
    Trends Biochem Sci 29:233-42. 2004
  68. ncbi Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types
    Bettina A Dummler
    Department of Clinical Biochemistry, Glostrup Hospital, 2600 Glostrup, Denmark
    J Biol Chem 280:13304-14. 2005
    ....
  69. pmc Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development
    Nicolas Di-Poï
    Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 25:1696-712. 2005
    ....
  70. pmc Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
    Véronique Calleja
    Cell Biophysics Laboratory, Lincoln s Inn Fields Laboratories, London Research Institute, Cancer Research UK, London, United Kingdom
    PLoS Biol 5:e95. 2007
    ..This has important implications not only in extending our understanding of this oncogenic protein kinase but also in opening up distinct opportunities for therapeutic intervention...
  71. ncbi Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding
    Keum Jin Yang
    Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Chungnam National University, 6 Munhwa dong, Jung Gu, Taejeon 301 131, South Korea
    J Biol Chem 283:1480-91. 2008
    ..Furthermore, Tyr(9) phosphorylation is critical for the stabilization of both PDK1 and the PDK1/Src complex via Hsp90-mediated protection of PDK1 degradation...
  72. ncbi Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors
    Stephen J Fuller
    National Heart and Lung Institute NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Cell Signal 20:1564-77. 2008
    ..From a pathological viewpoint, we conclude that activities of NDR1 and NDR2 are responsive to cytotoxic stresses in heart preparations and this may represent a previously-unidentified response to myocardial ischaemia in vivo...
  73. pmc Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    Hong Wa Yung
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Am J Pathol 173:451-62. 2008
    ..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...