S M Gasser

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. pmc Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans
    Sabine Rohner
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    J Cell Biol 200:589-604. 2013
  2. pmc Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states
    Stephanie Kueng
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS Genet 8:e1002727. 2012
  3. pmc Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization
    Kerstin Bystricky
    Department of Molecular Biology and NCCR Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 168:375-87. 2005
  4. pmc Silent chromatin at the middle and ends: lessons from yeasts
    Marc Buhler
    Epigenetics Focal Area, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    EMBO J 28:2149-61. 2009
  5. pmc Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism
    Peter Meister
    Laboratory of Molecular and Cellular Biology, CNRS, Universite de Lyon, Ecole Normale Superieure, Lyon Cedex 07, France
    Genome Biol 12:R123. 2011
  6. pmc Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms
    Iris Je Stulemeijer
    Division of Gene Regulation, Netherlands Cancer Institute, Netherlands Proteomics Centre, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
    Epigenetics Chromatin 4:2. 2011
  7. ncbi The function of telomere clustering in yeast: the circe effect
    S M Gasser
    Department of Molecular Biology and Frontiers in Genetics NCCR Program, University of Geneva, CH 1211 Geneva, Switzerland
    Cold Spring Harb Symp Quant Biol 69:327-37. 2004
  8. doi Roles for nuclear organization in the maintenance of genome stability
    Shigeki Nagai
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland
    Epigenomics 2:289-305. 2010
  9. ncbi Chromosome dynamics in the yeast interphase nucleus
    P Heun
    University of Geneva, Department of Molecular Biology, Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland
    Science 294:2181-6. 2001
  10. ncbi From snapshots to moving pictures: new perspectives on nuclear organization
    P Heun
    University of Geneva, Dept. of Molecular Biology, Quai Ernest-Ansermet 30, CH-1211 4, Geneva, Switzerland
    Trends Cell Biol 11:519-25. 2001

Collaborators

  • Peter Meister
  • Kohta Ikegami
  • Kerstin Bystricky
  • Marc Buhler
  • Patrick Heun
  • Marc Gartenberg
  • Brian Kennedy
  • Leonard P Guarente
  • Harry Scherthan
  • S Perrod
  • T Laroche
  • Sabine Rohner
  • Stephanie Kueng
  • Iris Je Stulemeijer
  • M Gotta
  • Shigeki Nagai
  • B D Towbin
  • C Frei
  • K Dubrana
  • M M Cockell
  • S G Martin
  • L Maillet
  • H Renauld
  • M Cockell
  • Veronique Kalck
  • Xuefei Wang
  • Jason D Lieb
  • E Gilson
  • Monika Tsai-Pflugfelder
  • Ragna Sack
  • Mariano Oppikofer
  • Helder C Ferreira
  • Emma Roberts
  • Tim Christoph Roloff
  • D Leroy
  • Chinyen Tsai
  • M Grunstein
  • Alex W Faber
  • Kitty F Verzijlbergen
  • Tineke L Lenstra
  • Frank Cp Holstege
  • Floor Frederiks
  • Fred van Leeuwen
  • Brietta L Pike
  • Tibor van Welsem
  • B L Pike
  • A T Akhmedov
  • D Braguglia
  • F Palladino
  • S Strahl-Bolsinger
  • S Marcand
  • T Bilaud
  • C Bonnard
  • F Gaden
  • A V Kajava
  • V Brevet
  • A L Ducrest
  • G Fourel
  • A Hecht
  • N Suka
  • P Watt
  • B P Duncker
  • Y S Vassetzky
  • B Kemper
  • M Tsai-Pflugfelder
  • P Pasero
  • R Jessberger
  • C E Koering
  • K Ancelin
  • A Pollice
  • E Binet-Brasselet
  • A Formenton
  • A J Lustig
  • G Kyrion
  • C Liu
  • P Benedetti
  • B Amati
  • F Klein
  • Q Dang
  • J F Hofmann
  • D Schweizer
  • M E Cardenas
  • L Pick

Detail Information

Publications38

  1. pmc Promoter- and RNA polymerase II-dependent hsp-16 gene association with nuclear pores in Caenorhabditis elegans
    Sabine Rohner
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    J Cell Biol 200:589-604. 2013
    ....
  2. pmc Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states
    Stephanie Kueng
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS Genet 8:e1002727. 2012
    ....
  3. pmc Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization
    Kerstin Bystricky
    Department of Molecular Biology and NCCR Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 168:375-87. 2005
    ..These mutations do not, however, eliminate coordinated movement of telomere (Tel) 6R and Tel6L, which we propose stems from the territorial organization of yeast chromosomes...
  4. pmc Silent chromatin at the middle and ends: lessons from yeasts
    Marc Buhler
    Epigenetics Focal Area, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    EMBO J 28:2149-61. 2009
    ..In this review, we discuss current models for the generation of heterochromatic domains at centromeres and telomeres in the two yeast species...
  5. pmc Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism
    Peter Meister
    Laboratory of Molecular and Cellular Biology, CNRS, Universite de Lyon, Ecole Normale Superieure, Lyon Cedex 07, France
    Genome Biol 12:R123. 2011
    ..Their function in organismal development, however, is less well understood. Here we used genome-wide expression profiling to assess novel functions of the Caenorhabditis elegans HP1 homolog HPL-2 at specific developmental stages...
  6. pmc Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms
    Iris Je Stulemeijer
    Division of Gene Regulation, Netherlands Cancer Institute, Netherlands Proteomics Centre, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
    Epigenetics Chromatin 4:2. 2011
    ..abstract:..
  7. ncbi The function of telomere clustering in yeast: the circe effect
    S M Gasser
    Department of Molecular Biology and Frontiers in Genetics NCCR Program, University of Geneva, CH 1211 Geneva, Switzerland
    Cold Spring Harb Symp Quant Biol 69:327-37. 2004
  8. doi Roles for nuclear organization in the maintenance of genome stability
    Shigeki Nagai
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel, Switzerland
    Epigenomics 2:289-305. 2010
    ....
  9. ncbi Chromosome dynamics in the yeast interphase nucleus
    P Heun
    University of Geneva, Department of Molecular Biology, Quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland
    Science 294:2181-6. 2001
    ..In contrast, telomeres and centromeres provide replication-independent constraint on chromatin movement in both G1 and S phases...
  10. ncbi From snapshots to moving pictures: new perspectives on nuclear organization
    P Heun
    University of Geneva, Dept. of Molecular Biology, Quai Ernest-Ansermet 30, CH-1211 4, Geneva, Switzerland
    Trends Cell Biol 11:519-25. 2001
    ..Both the rapid oscillations of chromatin and long-range movements of chromosomes suggest new mechanisms for spatial and temporal control of transcription and other nuclear events...
  11. ncbi Long-range silencing and position effects at telomeres and centromeres: parallels and differences
    S Perrod
    Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Cell Mol Life Sci 60:2303-18. 2003
    ..These may reflect roles for heterochromatin in other chromosomal functions, like kinetochore attachment and DNA ends protection...
  12. doi Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner
    B D Towbin
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Cold Spring Harb Symp Quant Biol 75:555-65. 2010
    ..Peripheral sequestration of chromatin may, in turn, support the maintenance of silencing...
  13. ncbi The molecular biology of the SIR proteins
    S M Gasser
    Department of Molecular Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211, Geneva, Switzerland
    Gene 279:1-16. 2001
    ..Nonetheless, there have been many recent insights into their molecular structures. This review examines the impact of these results on our understanding of silencing function in budding yeast...
  14. pmc The positioning and dynamics of origins of replication in the budding yeast nucleus
    P Heun
    Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges/Lausanne, Switzerland
    J Cell Biol 152:385-400. 2001
    ..The modified chromatin structure, which would in turn retard origin firing, is both autonomous and mobile within the nucleus...
  15. pmc Ku-deficient yeast strains exhibit alternative states of silencing competence
    L Maillet
    , UMR5665 CNRS ENS, 46, , 69364 Lyon Cedex 07, France
    EMBO Rep 2:203-10. 2001
    ..These findings indicate the existence of a yKu-independent pathway of telomere clustering and Sir localization. Interestingly, this pathway appears to be under epigenetic control...
  16. pmc A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
    S Perrod
    Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges Lausanne, Switzerland
    EMBO J 20:197-209. 2001
    ..This argues that non-nuclear yHst2p can compete for a substrate or ligand specifically required for telomeric, and not rDNA repression...
  17. pmc Analysis of Sir2p domains required for rDNA and telomeric silencing in Saccharomyces cerevisiae
    M M Cockell
    Swiss Institute for Experimental Cancer Research ISREC, CH 1066 Epalinges, Switzerland
    Genetics 154:1069-83. 2000
    ..The globular core domain provides an essential silencing function distinct from that of targeting or Sir complex formation that may reflect its reported mono-ADP-ribosyl transferase activity...
  18. pmc The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing
    M Cockell
    Swiss Institute for Experimental Cancer Research ISREC, Lausanne
    J Cell Biol 129:909-24. 1995
    ..We propose that the integrity of a tertiary complex between Sir4, Sir3, and RAP1 is involved in both the maintenance of telomeric repression and the clustering of telomeres in foci near the nuclear periphery...
  19. ncbi Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast
    A Hecht
    Department of Biological Chemistry School of Medicine, University of California, Los Angeles 90095
    Cell 80:583-92. 1995
    ..Based on these interactions, we propose a model for heterochromatin-mediated transcriptional silencing in yeast, which may serve as a paradigm for other eukaryotic organisms as well...
  20. pmc The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
    M Gotta
    Swiss Institute for Experimental Cancer Research, Epalinges Lausanne, Switzerland
    J Cell Biol 134:1349-63. 1996
    ..Nonetheless, the Y' FISH is altered in a qualitative manner in sir3 and sir4 mutant strains, consistent with the previously reported phenotypes of shortened telomeric repeats and loss of telomeric silencing...
  21. ncbi Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
    B K Kennedy
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:381-91. 1997
    ..We propose that the rDNA is the AGE locus and that nucleolar function is compromised in old yeast cells in a way that may be mitigated by targeting of Sir proteins to the nucleolus...
  22. pmc Localization of Sir2p: the nucleolus as a compartment for silent information regulators
    M Gotta
    Swiss Institute for Experimental Cancer Research, Chemin des Boveresses, Epalinges Lausanne, Switzerland
    EMBO J 16:3243-55. 1997
    ..The unexpected nucleolar localization of Sir2p and Sir3p correlates with observed effects of sir mutations on rDNA stability and yeast longevity, defining a new site of action for silent information regulatory factors...
  23. ncbi Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast
    M Cockell
    Swiss Institute for Experimental Cancer Research, Epalinges Lausanne, Switzerland
    Curr Biol 8:787-90. 1998
    ..In conclusion, Sif2p resembles the Sir4p regulatory proteins Sir1p and Uth4p in that it competes for the functional assembly of Sir4p at telomeres, yet unlike Sir1p or Uth4p, it does not target Sir4p to either mating-type or rDNA loci...
  24. pmc Functional characterization of the N terminus of Sir3p
    M Gotta
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges Lausanne, Switzerland
    Mol Cell Biol 18:6110-20. 1998
    ....
  25. ncbi Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    S G Martin
    Swiss Institute for Experimental Cancer Research, Epalinges
    Cell 97:621-33. 1999
    ..Consistently, yKu- or SIR-deficient strains are hypersensitive to DNA-damaging agents. The release of yKu from telomeric chromatin may allow efficient scanning of the genome for DNA strand breaks...
  26. ncbi Semi-conservative replication in yeast nuclear extracts requires Dna2 helicase and supercoiled template
    D Braguglia
    Swiss Institute for Experimental Cancer Research, Ch des Boveresses 155, Epalinges Lausanne, CH 1066, Switzerland
    J Mol Biol 281:631-49. 1998
    ..Using this novel system we demonstrate that semi-conservative replication, but not polymerase activity per se, requires the activity of the DNA helicase encoded by DNA2...
  27. pmc Drosophila scaffold-attached regions bind nuclear scaffolds and can function as ARS elements in both budding and fission yeasts
    B Amati
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
    Mol Cell Biol 10:5442-54. 1990
    ..Two of the Drosophila SARs have autonomously replicating sequence activity in budding yeast, and three function in fission yeast, while four flanking non-SAR sequences are totally inactive in both...
  28. pmc Nuclear scaffold attachment stimulates, but is not essential for ARS activity in Saccharomyces cerevisiae: analysis of the Drosophila ftz SAR
    B Amati
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
    EMBO J 9:4007-16. 1990
    ..Efficient interaction with nuclear scaffolds from both yeast and Drosophila requires a minimal length of SAR DNA that contains reiteration of a narrow minor groove structure of the double helix...
  29. pmc The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci
    C Frei
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges Lausanne, Switzerland
    Genes Dev 14:81-96. 2000
    ..The association of Rad53p with a chromatin subfraction is Sgs1p dependent, suggesting an important role for the helicase in the signal-transducing pathway that monitors replication fork progression...
  30. pmc Topoisomerase II forms multimers in vitro: effects of metals, beta-glycerophosphate, and phosphorylation of its C-terminal domain
    Y S Vassetzky
    Swiss Institute for Experimental Cancer Research, Epalinges
    Mol Cell Biol 14:6962-74. 1994
    ..This is consistent with a model in which interactions involving the phosphorylated C-terminal domain of topoisomerase II aid either in chromosome segregation or in chromosome condensation...
  31. pmc The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human
    T Bilaud
    Laboratoire de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Ecole Normale Superieure de Lyon, France
    Nucleic Acids Res 24:1294-303. 1996
    ..TRF is likely to correspond to one of them. Based on their high affinity for the telomeric repeat, we predict that TRF and orf2 play an important role at human telomeres...
  32. ncbi Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA
    D Leroy
    Swiss Institute for Experimental Cancer Research (ISREC, CH-1066 Epalinges/Lausanne, Switzerland
    Biochemistry 40:1624-34. 2001
    ....
  33. ncbi Chromatin: a sticky silence
    S Marcand
    Laboratoire de Biologie Moleculaire et Cellulaire, l Ecole Normale Supérieure de Lyon, UMR49 CNRS ENS, France
    Curr Biol 6:1222-5. 1996
    ....
  34. ncbi Turning telomeres off and on
    K Dubrana
    Swiss Institute for Experimental Cancer Research (ISREC, Chemin des Boveresses 155, CH-1066 Epalinges/Lausanne, Switzerland
    Curr Opin Cell Biol 13:281-9. 2001
    ..Finally, the telosome refolds into a protective end structure. If telomerase is nonfunctional, recombination may occur once telomeres are open. Multiple pathways regulate these different steps, producing a highly dynamic chromosomal cap...
  35. ncbi Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure
    A T Akhmedov
    Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland
    J Biol Chem 273:24088-94. 1998
    ..Consistent with their in vitro DNA binding activity, we show that overexpression of the SMC C termini increases plasmid loss without altering viability or cell cycle progression...
  36. pmc Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast
    F Klein
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
    J Cell Biol 117:935-48. 1992
    ..Approximately 16 brightly staining foci can be identified in a diploid nucleus stained with anti-RAP1 antibodies, suggesting that telomeres are grouped together, perhaps through interaction with the nuclear envelope...