W Filipowicz

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. pmc TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    Astrid D Haase
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4508 Basel, Switzerland
    EMBO Rep 6:961-7. 2005
  2. pmc UBA1 and UBA2, two proteins that interact with UBP1, a multifunctional effector of pre-mRNA maturation in plants
    Mark H L Lambermon
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Mol Cell Biol 22:4346-57. 2002
  3. ncbi request reprint Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
  4. pmc ATP modulates siRNA interactions with an endogenous human Dicer complex
    Janice L Pellino
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    RNA 11:1719-24. 2005
  5. ncbi request reprint Relief of microRNA-mediated translational repression in human cells subjected to stress
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    Cell 125:1111-24. 2006
  6. ncbi request reprint Cyclases of the 3'-terminal phosphate in RNA: a new family of RNA processing enzymes conserved in eucarya, bacteria and archaea
    W Filipowicz
    Friedrich Miescher Institut, Basel, Switzerland
    Acta Biochim Pol 45:895-906. 1998
  7. ncbi request reprint Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
  8. ncbi request reprint Structure and biogenesis of small nucleolar RNAs acting as guides for ribosomal RNA modification
    W Filipowicz
    Friedrich Miescher Institut, Basel, Switzerland
    Acta Biochim Pol 46:377-89. 1999
  9. ncbi request reprint RNAi: the nuts and bolts of the RISC machine
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Cell 122:17-20. 2005
  10. pmc RBP45 and RBP47, two oligouridylate-specific hnRNP-like proteins interacting with poly(A)+ RNA in nuclei of plant cells
    Z J Lorković
    Friedrich Miescher Institut, Basel, Switzerland
    RNA 6:1610-24. 2000

Collaborators

Detail Information

Publications60

  1. pmc TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    Astrid D Haase
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4508 Basel, Switzerland
    EMBO Rep 6:961-7. 2005
    ..The TRBP-Dicer interaction shown raises interesting questions about the potential interplay between RNAi and interferon-PKR pathways...
  2. pmc UBA1 and UBA2, two proteins that interact with UBP1, a multifunctional effector of pre-mRNA maturation in plants
    Mark H L Lambermon
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Mol Cell Biol 22:4346-57. 2002
    ..These and other data suggest that UBP1, UBA1a, and UBA2a may act as components of a complex recognizing U-rich sequences in plant 3'-UTRs and contributing to the stabilization of mRNAs in the nucleus...
  3. ncbi request reprint Inhibition of translational initiation by Let-7 MicroRNA in human cells
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Science 309:1573-6. 2005
    ..Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression...
  4. pmc ATP modulates siRNA interactions with an endogenous human Dicer complex
    Janice L Pellino
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    RNA 11:1719-24. 2005
    ..Complex D could impinge upon the RISC assembly pathway in humans, similar to an analogous complex in Drosophila...
  5. ncbi request reprint Relief of microRNA-mediated translational repression in human cells subjected to stress
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    Cell 125:1111-24. 2006
    ..We propose that proteins interacting with the 3'UTR will generally act as modifiers altering the potential of miRNAs to repress gene expression...
  6. ncbi request reprint Cyclases of the 3'-terminal phosphate in RNA: a new family of RNA processing enzymes conserved in eucarya, bacteria and archaea
    W Filipowicz
    Friedrich Miescher Institut, Basel, Switzerland
    Acta Biochim Pol 45:895-906. 1998
    ..This article reviews properties of the human and bacterial cyclases, their mechanism of action and substrate specificity. Possible biological functions of the enzymes are also discussed...
  7. ncbi request reprint Post-transcriptional gene silencing by siRNAs and miRNAs
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Curr Opin Struct Biol 15:331-41. 2005
    ..The first structural information on protein components of the RNA interference (RNAi) and miRNA machineries is emerging, and provides some insight into the mechanism of RNA-silencing reactions...
  8. ncbi request reprint Structure and biogenesis of small nucleolar RNAs acting as guides for ribosomal RNA modification
    W Filipowicz
    Friedrich Miescher Institut, Basel, Switzerland
    Acta Biochim Pol 46:377-89. 1999
    ..In this article we review information about the biogenesis, structure and function of guide snoRNAs...
  9. ncbi request reprint RNAi: the nuts and bolts of the RISC machine
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Cell 122:17-20. 2005
    ....
  10. pmc RBP45 and RBP47, two oligouridylate-specific hnRNP-like proteins interacting with poly(A)+ RNA in nuclei of plant cells
    Z J Lorković
    Friedrich Miescher Institut, Basel, Switzerland
    RNA 6:1610-24. 2000
    ..Properties of RBP45 and RBP47 suggest they represent hnRNP-proteins participating in still undefined steps of pre-mRNA maturation in plant cell nuclei...
  11. pmc Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10
    V Pogacic
    Friedrich Miescher Institut, CH 4058 Basel, Switzerland
    Mol Cell Biol 20:9028-40. 2000
    ....
  12. pmc Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA biogenesis
    E Billy
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    EMBO J 19:2115-26. 2000
    ..Possible functions of Rcl1p in pre-rRNA processing and its relationship to the RNA 3'-phosphate cyclase are discussed...
  13. pmc The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea
    P Genschik
    Friedrich Miescher Institut, Basel, Switzerland
    EMBO J 16:2955-67. 1997
    ..coli protein has cyclase activity similar to that of the human enzyme. The conservation of the RNA 3'-terminal phosphate cyclase among Eucarya, Bacteria and Archaea argues that the enzyme performs an important function in RNA metabolism...
  14. pmc The host gene for intronic U17 small nucleolar RNAs in mammals has no protein-coding potential and is a member of the 5'-terminal oligopyrimidine gene family
    P Pelczar
    Friedrich Miescher Institut, CH 4002 Basel, Switzerland
    Mol Cell Biol 18:4509-18. 1998
    ..Similar characteristics of the transcription start site regions in snoRNA host and ribosomal protein genes raise the possibility that expression of components of ribosome biogenesis and translational machineries is coregulated...
  15. pmc Small nucleolar RNAs encoded by introns of the human cell cycle regulatory gene RCC1
    T Kiss
    Friedrich Miescher Institut, Basel, Switzerland
    EMBO J 12:2913-20. 1993
    ..These data suggest that U17 RNAs are not independently transcribed but are processed out of the RCC1 pre-mRNA or out of the spliced introns...
  16. pmc UBP1, a novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation
    M H Lambermon
    Friedrich Miescher Institut, PO Box 2543, 4002 Basel, Switzerland
    EMBO J 19:1638-49. 2000
    ..The properties of UBP1 indicate that it is an hnRNP protein that functions at multiple steps to facilitate the nuclear maturation of plant pre-mRNAs...
  17. pmc Bms1p, a G-domain-containing protein, associates with Rcl1p and is required for 18S rRNA biogenesis in yeast
    T Wegierski
    Friedrich Miescher-Institut, Basel, Switzerland
    RNA 7:1254-67. 2001
    ..The results indicate that Bms1p may act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus...
  18. pmc Activity of U-snRNA genes with modified placement of promoter elements in transfected protoplasts and stably transformed tobacco
    D Edoh
    Friedrich Miescher Institut, Basel, Switzerland
    Nucleic Acids Res 21:1533-40. 1993
    ..The results provide some clues about possible factor interactions at the promoters of plant U-snRNA genes and also offer an example of major differences in transcription between transiently and stably transformed cells...
  19. ncbi request reprint Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli
    E Billy
    Friedrich Miescher Institut, CH 4002 Basel, Switzerland
    J Biol Chem 274:34955-60. 1999
    ..The cyclase is the only known protein undergoing adenylation on a histidine residue. Sequences flanking the adenylated histidine in cyclases do not resemble those found in other proteins modified by nucleotidylation...
  20. ncbi request reprint Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon
    P Genschik
    Friedrich Miescher Institut, P O Box 2543, 4002 Basel, Switzerland
    J Biol Chem 273:25516-26. 1998
    ..The cyclase gene is nonessential as demonstrated by knockout experiments. Possible functions of the cyclase in RNA metabolism are discussed...
  21. pmc In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs
    F Dragon
    Friedrich Miescher Institut, CH 4058 Basel, Switzerland
    Mol Cell Biol 20:3037-48. 2000
    ..Moreover, we show that in vitro-reconstituted RNPs contain hGAR1 and that binding of hGAR1 does not appear to be a prerequisite for the assembly of the other H/ACA proteins...
  22. ncbi request reprint Multiple forms of the U2 small nuclear ribonucleoprotein auxiliary factor U2AF subunits expressed in higher plants
    C Domon
    Friedrich Miescher Institut, CH 4002 Basel, Switzerland
    J Biol Chem 273:34603-10. 1998
    ..The existence of multiple isoforms of U2AF may be quite general in plants because two genes expressing U2AF65 have been identified in Arabidopsis, and different isoforms of the U2AF small subunit are expressed in rice...
  23. pmc Structure and expression of the U5 snRNA gene of Arabidopsis thaliana. Conserved upstream sequence elements in plant U-RNA genes
    P Vankan
    Friedrich Miescher Institut, Basel, Switzerland
    Nucleic Acids Res 16:10425-40. 1988
    ..The coding regions in all genes are followed by the sequence CAN4-9AGTN (A/T)AA which may correspond to a termination and/or processing signal...
  24. pmc Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin
    T Kiss
    Friedrich Miescher Institute, Basel, Switzerland
    Mol Cell Biol 16:1391-400. 1996
    ..8S rRNA processing in yeast cells...
  25. ncbi request reprint The AU-rich sequences present in the introns of plant nuclear pre-mRNAs are required for splicing
    G J Goodall
    Friedrich Miescher Institut, Basel, Switzerland
    Cell 58:473-83. 1989
    ..In addition, we find that the criteria for branch site selection are relaxed, as they are in vertebrates, but a polypyrimidine tract is not necessary...
  26. pmc Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    E Billy
    Friedrich Miescher Institute for Biomedical Research, P.O. Box 2543, 4002 Basel, Switzerland
    Proc Natl Acad Sci U S A 98:14428-33. 2001
    ..We demonstrate that extracts prepared from EC cells catalyze processing of dsRNA into approximately 23-nt fragments and that Dicer localizes to the cytoplasm of EC and HeLa cells...
  27. doi request reprint Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 9:102-14. 2008
    ..This Review summarizes the current understanding of the mechanistic aspects of microRNA-induced repression of translation and discusses some of the controversies regarding different modes of microRNA function...
  28. doi request reprint Proteomics joins the search for microRNA targets
    Helge Grosshans
    Friedrich Miescher Institute for Biomedical Research, CH 4002 Basel, Switzerland
    Cell 134:560-2. 2008
    ..This approach is a powerful means to identify miRNA targets and to quantify the contribution of translational repression to posttranscriptional gene silencing by miRNAs...
  29. pmc Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression
    Jakob T Zipprich
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    RNA 15:781-93. 2009
    ..Through deletion and mutagenesis, we identified the C-terminal part of TNRC6C encompassing the RRM RNA-binding motif as a key effector domain mediating protein synthesis repression by TNRC6C...
  30. doi request reprint Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells
    Marina Chekulaeva
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Curr Opin Cell Biol 21:452-60. 2009
    ..In this report, we review current progress in understanding how miRNAs execute these effects in animals and we discuss some of the controversies regarding different modes of miRNA function...
  31. pmc The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression
    Marina Chekulaeva
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nucleic Acids Res 38:6673-83. 2010
    ..These results demonstrate a novel role for the GW/WG repeats as effector motifs in miRNA-mediated repression...
  32. ncbi request reprint The liver-specific microRNA miR-122: biology and therapeutic potential
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, Basel CH 4002, Switzerland
    Prog Drug Res 67:221-38. 2011
    ..We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases...
  33. pmc Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila
    Marina Chekulaeva
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    RNA 15:794-803. 2009
    ..Each of these domains also functions independently of poly(A) tails. These results indicate that miRNA-mediated repression is facilitated by multiple domains of GW182...
  34. pmc Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    Ramesh S Pillai
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, 4002 Basel, Switzerland
    RNA 10:1518-25. 2004
    ..These findings indicate that a primary function of miRNAs is to guide their associated proteins to the mRNA...
  35. ncbi request reprint Biogenesis of small nucleolar ribonucleoproteins
    Witold Filipowicz
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Curr Opin Cell Biol 14:319-27. 2002
    ..Cajal bodies emerge as nuclear structures important for the biogenesis and function of small nucleolar ribonucleoproteins...
  36. ncbi request reprint Single processing center models for human Dicer and bacterial RNase III
    Haidi Zhang
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Cell 118:57-68. 2004
    ..Based on these and other data, we propose that Dicer functions through intramolecular dimerization of its two RNase III domains, assisted by the flanking RNA binding domains, PAZ and dsRBD...
  37. pmc Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1",2"-cyclic phosphate
    F Nasr
    Friedrich Miescher Institut, PO Box 2543, CH 4002 Basel, Switzerland
    Nucleic Acids Res 28:1676-83. 2000
    ..Likewise, overexpression of Cpd1p had no effect on yeast growth. These results do not implicate an important role for Appr>p or Appr-1"p in yeast cells grown under standard laboratory conditions...
  38. pmc Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
    Daniela Schmitter
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4002 Basel, Switzerland
    Nucleic Acids Res 34:4801-15. 2006
    ..Taken together, our data suggest that, independent of the effect on translation, miRNAs affect levels of a few hundred mRNAs in HEK293 cells...
  39. ncbi request reprint Argonautes and company: sailing against the wind
    Suvendra N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Cell 128:1027-8. 2007
    ..AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner...
  40. pmc Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
    Haidi Zhang
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, CH 4002 Basel, Switzerland
    EMBO J 21:5875-85. 2002
    ..Additional experiments suggest that if ATP participates in the Dicer reaction in mammalian cells, it might be involved in product release needed for the multiple turnover of the enzyme...
  41. ncbi request reprint Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells
    S N Bhattacharyya
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cold Spring Harb Symp Quant Biol 71:513-21. 2006
    ..We propose that proteins interacting with the 3'UTR will generally act as modifiers altering the potential of miRNAs to repress gene expression...
  42. ncbi request reprint Role of Dicer in posttranscriptional RNA silencing
    Lukasz Jaskiewicz
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Curr Top Microbiol Immunol 320:77-97. 2008
    ..We also discuss information about Dicer-associated proteins and their role in the biogenesis of small RNAs and assembly of RISC...
  43. doi request reprint The widespread regulation of microRNA biogenesis, function and decay
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
    Nat Rev Genet 11:597-610. 2010
    ..Such regulation has an important role in the context-specific functions of miRNAs...
  44. pmc Dicer is associated with ribosomal DNA chromatin in mammalian cells
    Lasse Sinkkonen
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS ONE 5:e12175. 2010
    ..Components of the RNA silencing machinery are involved in different aspects of chromatin function in numerous organisms. However, association of RNA silencing with chromatin in mammalian cells remains unclear...
  45. ncbi request reprint Cloning and characterization of the Arabidopsis cyclic phosphodiesterase which hydrolyzes ADP-ribose 1'',2''-cyclic phosphate and nucleoside 2',3'-cyclic phosphates
    P Genschik
    Friedrich Miescher Institut, P O Box 2543, 4002 Basel, Switzerland
    J Biol Chem 272:13211-9. 1997
    ..The Arabidopsis CPDase does not have recognizable structural similarity or motifs in common with proteins deposited in public data bases...
  46. ncbi request reprint Purification of RNA 3'-terminal phosphate cyclase from HeLa cells. Covalent modification of the enzyme with different nucleotides
    O Vicente
    Friedrich Miescher Institut, Basel, Switzerland
    Eur J Biochem 176:431-9. 1988
    ..Consistent with this, the enzyme can be covalently labelled with the four [alpha-32P]NTPs...
  47. ncbi request reprint Human dicer: purification, properties, and interaction with PAZ PIWI domain proteins
    Fabrice A Kolb
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Methods Enzymol 392:316-36. 2005
    ..In this chapter we describe overexpression and purification of recombinant human Dicer, its biochemical properties, and mapping of domains responsible for Dicer-PPD protein interactions...
  48. pmc A novel microarray approach reveals new tissue-specific signatures of known and predicted mammalian microRNAs
    Iwan Beuvink
    Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, Basel, Switzerland
    Nucleic Acids Res 35:e52. 2007
    ....
  49. doi request reprint Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs
    Jacek Krol
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Cell 141:618-31. 2010
    ..Our results demonstrate that microRNA metabolism in neurons is higher than in most other cells types and linked to neuronal activity...
  50. pmc Lack of homologous sequence-specific DNA methylation in response to stable dsRNA expression in mouse oocytes
    Petr Svoboda
    Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
    Nucleic Acids Res 32:3601-6. 2004
    ..These data demonstrate that dsRNA does not directly induce DNA methylation in the trans form of this sequence in these mammalian cells...
  51. doi request reprint Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University of Basel, Basel, Switzerland
    Nat Med 15:31-3. 2009
    ..These data have implications for the prospect of targeting miRNAs for CHC therapy...
  52. doi request reprint MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
    Lasse Sinkkonen
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nat Struct Mol Biol 15:259-67. 2008
    ..The defective DNA methylation can be rescued by ectopic expression of de novo Dnmts or by transfection of the miR-290 cluster miRNAs, indicating that de novo DNA methylation in ES cells is controlled by miRNAs...
  53. ncbi request reprint MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    Geraldine Mathonnet
    Department of Biochemistry and McGill Cancer Center, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Science 317:1764-7. 2007
    ..Our results indicate that inhibition of translation initiation is the earliest molecular event effected by miRNAs. Other mechanisms, such as mRNA degradation, may subsequently consolidate mRNA silencing...
  54. pmc Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
    Nasser Tahbaz
    Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada
    EMBO Rep 5:189-94. 2004
    ..Lastly, we show that PPD proteins and Dicer are present in soluble and membrane-associated fractions, indicating that interactions between these two types of proteins may occur in multiple compartments...
  55. doi request reprint Molecular biology: the expanding world of small RNAs
    Helge Grosshans
    Nature 451:414-6. 2008
  56. pmc The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components
    Noora Kotaja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, B P 10142, 67404 Illkirch Strasbourg, France
    Proc Natl Acad Sci U S A 103:2647-52. 2006
    ..Our findings underscore the importance of posttranscriptional gene regulation and of the microRNA pathway in the control of postmeiotic male germ cell differentiation...
  57. ncbi request reprint Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana
    Andreas Hofmann
    Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 277:1419-25. 2002
    ..The ligand is bound within the active site, and the mode of binding is in agreement with the previously proposed enzymatic mechanism. Selected biophysical properties of the oxidized and the semireduced CPDase are also discussed...
  58. pmc Interferon signaling and treatment outcome in chronic hepatitis C
    Magdalena Sarasin-Filipowicz
    Department of Biomedicine, University of Basel, CH 4031 Basel, Switzerland
    Proc Natl Acad Sci U S A 105:7034-9. 2008
    ....
  59. ncbi request reprint From RNAi to epigenomes: how RNA rules the world
    Eric Westhof
    Institut de Biologie Moleculaire et Cellulaire du CNRS, Universite Louis Pasteur, 15 rue Rene Descartes, 67084 Strasbourg, France
    Chembiochem 6:441-3. 2005
  60. ncbi request reprint Repression of protein synthesis by miRNAs: how many mechanisms?
    Ramesh S Pillai
    European Molecular Biology Laboratory, Grenoble Outstation, B P 181, 38042 Grenoble Cedex 9, France
    Trends Cell Biol 17:118-26. 2007
    ..Recent data support different microRNA mechanisms and a role for cytoplasmic processing bodies in the degradation and storage of mRNAs targeted by microRNA regulators...