Vincent Dion

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. pmc Instability and chromatin structure of expanded trinucleotide repeats
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 25:288-97. 2009
  2. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
  3. pmc Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 31:3105-12. 2011
  4. pmc Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 17:1306-17. 2008
  5. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008

Collaborators

Detail Information

Publications5

  1. pmc Instability and chromatin structure of expanded trinucleotide repeats
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 25:288-97. 2009
    ....
  2. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
    ..These results validate our original findings in cultured human cells and suggest that transcription may induce NER-dependent TNR instability in neuronal tissues in humans...
  3. pmc Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 31:3105-12. 2011
    ..These studies broaden the scope of pathways involved in transcription-induced CAG repeat instability and begin to define their interrelationships...
  4. pmc Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 17:1306-17. 2008
    ..These results are consistent with normal epigenetic changes during germline development contributing to intergenerational instability of CAG repeats in mice and in humans...
  5. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008
    ..The subtle influences of demethylation on HR at the Aprt locus are not sufficient to account for its dramatic effects on repeat instability. We conclude that 5-aza-CdR promotes triplet repeat instability independently of HR...