D P Brazil

Summary

Affiliation: Friedrich Miescher Institute
Country: Switzerland

Publications

  1. ncbi request reprint Ten years of protein kinase B signalling: a hard Akt to follow
    D P Brazil
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Trends Biochem Sci 26:657-64. 2001
  2. ncbi request reprint Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase
    M M Hill
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    J Biol Chem 276:25643-6. 2001
  3. ncbi request reprint Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
    S M Maira
    Friedrich Miescher Institute, Post Office Box 2543, CH 4002 Basel, Switzerland, Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Science 294:374-80. 2001
  4. ncbi request reprint Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity
    J Park
    Friedrich Miescher Institute, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 276:37459-71. 2001
  5. ncbi request reprint Cell polarity: Scaffold proteins par excellence
    D P Brazil
    Friedrich Miescher Institute, Basel, Switzerland
    Curr Biol 10:R592-4. 2000

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Ten years of protein kinase B signalling: a hard Akt to follow
    D P Brazil
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Trends Biochem Sci 26:657-64. 2001
    ....
  2. ncbi request reprint Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase
    M M Hill
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    J Biol Chem 276:25643-6. 2001
    ..Moreover, our results suggest that inhibition of PKB signaling is involved in the proapoptotic action of staurosporine...
  3. ncbi request reprint Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
    S M Maira
    Friedrich Miescher Institute, Post Office Box 2543, CH 4002 Basel, Switzerland, Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Science 294:374-80. 2001
    ..These findings identify CTMP as a negative regulatory component of the pathway controlling PKB activity...
  4. ncbi request reprint Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity
    J Park
    Friedrich Miescher Institute, Maulbeerstrasse 66, Basel CH 4058, Switzerland
    J Biol Chem 276:37459-71. 2001
    ..Thus, these data suggest that PDK1 activity is regulated by reversible phosphorylation, possibly by a member of the Src kinase family...
  5. ncbi request reprint Cell polarity: Scaffold proteins par excellence
    D P Brazil
    Friedrich Miescher Institute, Basel, Switzerland
    Curr Biol 10:R592-4. 2000
    ..Recent studies have identified one of these proteins, Par6, as a key regulator of cell polarity and transformation via its interactions with small GTPases and atypical forms of protein kinase C...